• The Journal of Asian Finance, Economics and Business
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• v.2 no.4
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• pp.31-38
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• 2015

During the last two decades the idea that central bank independence and transparency helps to maintain price stability, became popular among economists and central bankers. Many countries' governments give their monetary authorities higher independence and transparency to achieve the price stability goal. However, emerging countries such as Kazakhstan, suffer from high inflation. This inflation occurs largely due to a low level of independence and transparency of central banks. This research project measures the current level of independence and transparency of central bank of Kazakhstan. Indices were used to measure central bank independence and transparency. Central bank independence was measured by two types of indices: based on central bank laws (legal independence) and based on central banks governor's turnover (TOR). Developing countries have a weak legal framework, implying that a legal independence index cannot be appropriate to use as a measures of actual independence. Therefore, by paying attention to the other two indices, we can say that the central bank of Kazakhstan has a low level of independence and transparency. This, in turn, can be one of the causes of high inflation in Kazakhstan.

• Molecules and Cells
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• v.44 no.7
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• pp.425-432
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• 2021

Aging is associated with functional and structural declines in organisms over time. Organisms as diverse as the nematode Caenorhabditis elegans and mammals share signaling pathways that regulate aging and lifespan. In this review, we discuss recent combinatorial approach to aging research employing C. elegans and mammalian systems that have contributed to our understanding of evolutionarily conserved aging-regulating pathways. The topics covered here include insulin/IGF-1, mechanistic target of rapamycin (mTOR), and sirtuin signaling pathways; dietary restriction; autophagy; mitochondria; and the nervous system. A combinatorial approach employing high-throughput, rapid C. elegans systems, and human model mammalian systems is likely to continue providing mechanistic insights into aging biology and will help develop therapeutics against age-associated disorders.

• Annual Conference of KIPS
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• 2004.05a
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• pp.289-292
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• 2004

원자력발전소 MMIS(Man-Machine Interface System)는 발전소 공정과 관련 장비들을 감시 및 제어하고, 필요시에 보호기능을 수행함으로써 발전소를 안전하고 신뢰성 있게 운전할 수 있도록 지원하고 있다. 그러한 MMIS의 설계에 소프트웨어기반의 컴퓨터 기술이 사용된 경우, 그 설계를 구현하기 위해 사용된 소프트웨어가 설계 및 프로그래밍 오류에 취약하여, 공통유형의 소프트웨어 오류로 인해 하드웨어로써 구축된 다중성 설계를 파기시킬 수 있기 때문에 원자력 발전소의 안전 및 안정 운전과 직결되게 된다. 또한 소프트웨어는 설계공정 결함이 일반적으로 최종 결과물에서 확인될 수 있다는 점 때문에 확인 및 검증기술을 정립하고 체계적인 적용이 필수적이다. 이에 따라 본 논문에서는 현재 설계를 진행중인 SMART(System-integrated Modular Advanced ReacTor) MMIS 소프트웨어를 개발하기 위해 적용되는 확인 및 검증 규제요건을 분석하고, 소프트웨어 개발생명주기에 따른 확인 및 검증을 체계적으로 수행하기 위한 프레임웍을 제시한다.

• Annual Conference of KIPS
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• 2004.05a
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• pp.293-296
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• 2004

원자력 산업계에서는 원전 MMIS(Man-Machine Interface System)의 디지털 기술 적용을 위해 많은 노력을 기울이고 있고, 디지털 MMIS의 핵심기반기술인 고 신뢰도 소프트웨어 개발 방법론이 확립되지 못하여 소프트웨어 공통모드고장 문제, 정량적인 소프트웨어 신뢰도 보장 문제 등이 현안으로 제기되고 있다. 이에 따라 원자력 산업의 특수성인 안전성 확보에 필요한 개발기준과 규제방법 정립에 많은 연구가 수행되고 있다. 또한 이와 같이 원전 MMIS의 디지털화를 성공하기 위해서는 소프트웨어의 고 신뢰도 확보가 관건이며, 고 신뢰도와 품질을 확보하기 위한 소프트웨어 개발 지침의 정립이 요구되고 있다. 본 논문에서는 원전 소프트웨어 개발에 적용되는 규제 요건을 분석하고, SMART(System-integrated Modular Advanced ReacTor) MMIS 소프트웨어 개발에 적용될 소프트웨어 개발 지침을 제시한다

• BMB Reports
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• v.52 no.1
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• pp.70-85
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• 2019

Reduction of insulin/insulin-like growth factor 1 (IGF1) signaling (IIS) extends the lifespan of various species. So far, several longevity mouse models have been developed containing mutations related to growth signaling deficiency by targeting growth hormone (GH), IGF1, IGF1 receptor, insulin receptor, and insulin receptor substrate. In addition, p70 ribosomal protein S6 kinase 1 (S6K1) knockout leads to lifespan extension. S6K1 encodes an important kinase in the regulation of cell growth. S6K1 is regulated by mechanistic target of rapamycin (mTOR) complex 1. The v-myc myelocytomatosis viral oncogene homolog (MYC)-deficient mice also exhibits a longevity phenotype. The gene expression profiles of these mice models have been measured to identify their longevity mechanisms. Here, we summarize our knowledge of long-lived mouse models related to growth and discuss phenotypic characteristics, including organ-specific gene expression patterns.

• BMB Reports
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• v.52 no.1
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• pp.5-12
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• 2019

Organismal aging is accompanied by a host of progressive metabolic alterations and an accumulation of senescent cells, along with functional decline and the appearance of multiple diseases. This implies that the metabolic features of cell senescence may contribute to the organism's metabolic changes and be closely linked to age-associated diseases, especially metabolic syndromes. However, there is no clear understanding of senescent metabolic characteristics. Here, we review key metabolic features and regulators of cellular senescence, focusing on mitochondrial dysfunction and anabolic deregulation, and their link to other senescence phenotypes and aging. We further discuss the mechanistic involvement of the metabolic regulators mTOR, AMPK, and GSK3, proposing them as key metabolic switches for modulating senescence.

• Annual Conference of KIPS
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• 2013.11a
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• pp.886-889
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• 2013

개인의 사생활 보호를 위한 익명성 확보는 네트워크상에서 다뤄지는 주요 논점 중 하나로서, 오래전부터 연구되어 수많은 기술이 제안되어 왔다. The Amnesic Incognito Live System(이하 Tails) 역시 이 중 하나로, PELD 설계 기반 하에 모든 인터넷 커넥션을 익명화하고 해당 디바이스 디스크에 흔적을 남기지 않는 강력한 Live OS이다. 이렇듯 Tails는 익명화에 있어 완성도 높은 시스템이라고 볼 수 있으나, 아직 해당 분야의 연구가 활발치 못해 공격 기법의 분석이 부족한 실정이다. 이를 바탕으로 본 문서는 Tails를 대상으로 한 소수의 기존 공격 기법들을 TOR 기반, Memory Analysis 기반, HTTP Keepalive 기반 등으로 세분화하여 나열하는 것을 주목적으로 두고 있다. 그리고 나아가 분석을 바탕으로 새로운 공격 가능성을 도출해내는 것이 최종 목적이다.

• Kosin Medical Journal
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• v.33 no.2
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• pp.135-140
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• 2018

Endometriosis is an estrogen-dependent chronic inflammatory condition that affects women in their reproductive period and is associated with pelvic pain and infertility. Oxidative stress (OS) occurs when reactive oxygen stress (ROS) and anti-oxidants are in imbalance. OS is a potential factor involved in the pathophysiology of endometriosis. Iron-induced ROS may trigger a chain of events resulting in the development and progression of endometriosis. Endogenous ROS are correlated with increased cellular proliferation and ERK1/2 activation in human endometriotic cells. An oxidative environment leads to stimulation of the ERK and PI3K/AKT/mTOR signaling pathways that facilitate endometriotic lesion progression through adhesion, angiogenesis, and proliferation. OS is also known to be involved in epigenetic mechanisms in endometriosis. We summarize the recent knowledge in our understanding of the role of oxidative stress in the pathogenesis of endometriosis.

• Journal of Microbiology and Biotechnology
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• v.31 no.2
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• pp.171-180
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• 2021

Caffeine, a methylxanthine analog of purine bases, is a compound that is largely consumed in beverages and medications for psychoactive and diuretic effects and plays many beneficial roles in neuronal stimulation and enhancement of anti-tumor immune responses by blocking adenosine receptors in higher organisms. In single-cell eukaryotes, however, caffeine somehow impairs cellular fitness by compromising cell wall integrity, inhibiting target of rapamycin (TOR) signaling and growth, and overriding cell cycle arrest caused by DNA damage. Among its multiple inhibitory targets, caffeine specifically interacts with phosphatidylinositol 3-kinase (PI3K)-related kinases causing radiosensitization and cytotoxicity via specialized intermediate molecules. Caffeine potentiates the lethality of cells in conjunction with several other stressors such as oxidants, irradiation, and various toxic compounds through largely unknown mechanisms. In this review, recent findings on caffeine effects and cellular detoxification schemes are highlighted and discussed with an emphasis on the inhibitory interactions between caffeine and its multiple targets in eukaryotic microorganisms such as budding and fission yeasts.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.6
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• pp.439-446
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• 2022

The antitumoral effects of valdecoxib (Val), an United States Food and Drug Administration-approved anti-inflammatory drug that was withdrawn due to the side effects of increased risk of cardiovascular adverse events, were investigated in hypopharyngeal squamous cell carcinoma cells by performing a cell viability assay, transwell assay, immunofluorescence imaging, and Western blotting. Val markedly inhibited cell viability with an IC50 of 67.3 µM after 48 h of treatment, and also downregulated cell cycle proteins such as Cdks and their regulatory cyclin units. Cell migration and invasion were severely suppressed by inhibiting integrin α4/FAK expression. In addition, Val activated the cell cycle checkpoint CHK2 in response to excessive DNA damage, which led to the activation of caspase-3/9 and induced caspase-dependent apoptosis. Furthermore, the signaling cascades of the PI3K/AKT/mTOR and mitogen-activated protein kinase pathways were significantly inhibited by Val treatment. Taken together, our results indicate that Val can be used for the treatment of hypopharyngeal squamous cell carcinoma.