Metabolic features and regulation in cell senescence |
Kwon, So Mee
(Department of Biochemistry, Ajou University School of Medicine)
Hong, Sun Mi (Department of Biochemistry, Ajou University School of Medicine) Lee, Young-Kyoung (Department of Biochemistry, Ajou University School of Medicine) Min, Seongki (Department of Biochemistry, Ajou University School of Medicine) Yoon, Gyesoon (Department of Biochemistry, Ajou University School of Medicine) |
1 | Trifunovic A, Wredenberg A, Falkenberg M et al (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429, 417-423 DOI |
2 | Balaban RS, Nemoto S and Finkel T (2005) Mitochondria, oxidants, and aging. Cell 120, 483-495 DOI |
3 | Miquel J, Economos AC, Fleming J and Johnson JE Jr (1980) Mitochondrial role in cell aging. Exp Gerontol 15, 575-591 DOI |
4 | Park SY, Choi B, Cheon H et al (2004) Cellular aging of mitochondrial DNA-depleted cells. Biochem Biophys Res Commun 325, 1399-1405 DOI |
5 | Yoon G, Kim HJ, Yoon YS, Cho H, Lim IK and Lee JH (2002) Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression. Biochem J 366, 613-621 DOI |
6 | Yoon YS, Byun HO, Cho H, Kim BK and Yoon G (2003) Complex II defect via down-regulation of iron-sulfur subunit induces mitochondrial dysfunction and cell cycle delay in iron chelation-induced senescence-associated growth arrest. J Biol Chem 278, 51577-51586 DOI |
7 | Byun HO, Jung HJ, Kim MJ and Yoon G (2014) PKCdelta phosphorylation is an upstream event of GSK3 inactivationmediated ROS generation in TGF-beta1-induced senescence. Free Radic Res 48, 1100-1108 DOI |
8 | Yoon YS, Lee JH, Hwang SC, Choi KS and Yoon G (2005) TGF beta1 induces prolonged mitochondrial ROS generation through decreased complex IV activity with senescent arrest in Mv1Lu cells. Oncogene 24, 1895-1903 DOI |
9 | Byun HO, Jung HJ, Seo YH et al (2012) GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) beta1-induced senescence. Exp Cell Res 318, 1808-1819 DOI |
10 | Kang HT and Hwang ES (2009) Nicotinamide enhances mitochondria quality through autophagy activation in human cells. Aging Cell 8, 426-438 DOI |
11 | Kurz T, Terman A, Gustafsson B and Brunk UT (2008) Lysosomes and oxidative stress in aging and apoptosis. Biochim Biophys Acta 1780, 1291-1303 DOI |
12 | Kim YM, Shin HT, Seo YH et al (2010) Sterol regulatory element-binding protein (SREBP)-1-mediated lipogenesis is involved in cell senescence. J Biol Chem 285, 29069-29077 DOI |
13 | Ballinger SW (2013) Beyond retrograde and anterograde signalling: mitochondrial-nuclear interactions as a means for evolutionary adaptation and contemporary disease susceptibility. Biochem Soc Trans 41, 111-117 DOI |
14 | Jones AW, Yao Z, Vicencio JM, Karkucinska-Wieckowska A and Szabadkai G (2012) PGC-1 family coactivators and cell fate: roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria-nucleus signalling. Mitochondrion 12, 86-99 DOI |
15 | Poyton RO and McEwen JE (1996) Crosstalk between nuclear and mitochondrial genomes. Annu Rev Biochem 65, 563-607 DOI |
16 | Finley LW and Haigis MC (2009) The coordination of nuclear and mitochondrial communication during aging and calorie restriction. Ageing Res Rev 8, 173-188 DOI |
17 | Pizzimenti S, Briatore F, Laurora S et al (2006) 4-Hydroxynonenal inhibits telomerase activity and hTERT expression in human leukemic cell lines. Free Radic Biol Med 40, 1578-1591 DOI |
18 | Wallace DC (2005) A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet 39, 359-407 DOI |
19 | Biswas G, Adebanjo OA, Freedman BD et al (1999) Retrograde Ca2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk. EMBO J 18, 522-533 DOI |
20 | Butow RA and Avadhani NG (2004) Mitochondrial signaling: the retrograde response. Mol Cell 14, 1-15 DOI |
21 | Passos JF, Saretzki G, Ahmed S et al (2007) Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biol 5, e110 DOI |
22 | von Zglinicki T, Petrie J and Kirkwood TB (2003) Telomere-driven replicative senescence is a stress response. Nat Biotechnol 21, 229-230 |
23 | Kim YM, Byun HO, Jee BA et al (2013) Implications of time-series gene expression profiles of replicative senescence. Aging Cell 12, 622-634 DOI |
24 | Korovila I, Hugo M, Castro JP et al (2017) Proteostasis, oxidative stress and aging. Redox Biol 13, 550-567 DOI |
25 | Rubinsztein DC, Marino G and Kroemer G (2011) Autophagy and aging. Cell 146, 682-695 DOI |
26 | Seo YH, Jung HJ, Shin HT et al (2008) Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation. Aging Cell 7, 894-907 DOI |
27 | Kurz DJ, Decary S, Hong Y and Erusalimsky JD (2000) Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells. J Cell Sci 113 (Pt 20), 3613-3622 DOI |
28 | Urbanelli L, Buratta S, Sagini K, Tancini B and Emiliani C (2016) Extracellular Vesicles as New Players in Cellular Senescence. Int J Mol Sci 17 |
29 | Lopez-Otin C, Blasco MA, Partridge L, Serrano M and Kroemer G (2013) The hallmarks of aging. Cell 153, 1194-1217 DOI |
30 | Byun HO, Lee YK, Kim JM and Yoon G (2015) From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes. BMB Rep 48, 549-558 DOI |
31 | Munoz-Espin D and Serrano M (2014) Cellular senescence: from physiology to pathology. Nat Rev Mol Cell Biol 15, 482-496 DOI |
32 | Hwang ES, Yoon G and Kang HT (2009) A comparative analysis of the cell biology of senescence and aging. Cell Mol Life Sci 66, 2503-2524 DOI |
33 | Matsumura T, Zerrudo Z and Hayflick L (1979) Senescent human diploid cells in culture: survival, DNA synthesis and morphology. J Gerontol 34, 328-334 DOI |
34 | Boffoli D, Scacco SC, Vergari R, Solarino G, Santacroce G and Papa S (1994) Decline with age of the respiratory chain activity in human skeletal muscle. Biochim Biophys Acta 1226, 73-82 DOI |
35 | Larsson NG (2010) Somatic mitochondrial DNA mutations in mammalian aging. Annu Rev Biochem 79, 683-706 DOI |
36 | Zhang Y, Zhao L, Wu Z, Chen X and Ma T (2017) Galantamine alleviates senescence of U87 cells induced by beta-amyloid through decreasing ROS production. Neurosci Lett 653, 183-188 DOI |
37 | Moore SA, Peterson RG, Felten DL and O'Connor BL (1981) Glycogen accumulation in tibial nerves of experimentally diabetic and aging control rats. J Neurol Sci 52, 289-303 DOI |
38 | Kim YM, Song I, Seo YH and Yoon G (2013) Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells. Endocrinol Metab (Seoul) 28, 297-308 DOI |
39 | Ishii N, Fujii M, Hartman PS et al (1998) A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes. Nature 394, 694-697 DOI |
40 | Krishnan KJ, Greaves LC, Reeve AK and Turnbull DM (2007) Mitochondrial DNA mutations and aging. Ann N Y Acad Sci 1100, 227-240 DOI |
41 | Schafer MJ, White TA, Iijima K et al (2017) Cellular senescence mediates fibrotic pulmonary disease. Nat Commun 8, 14532 DOI |
42 | Lezza AM, Boffoli D, Scacco S, Cantatore P and Gadaleta MN (1994) Correlation between mitochondrial DNA 4977-bp deletion and respiratory chain enzyme activities in aging human skeletal muscles. Biochem Biophys Res Commun 205, 772-779 DOI |
43 | Labbadia J and Morimoto RI (2015) The biology of proteostasis in aging and disease. Annu Rev Biochem 84, 435-464 DOI |
44 | Nacarelli T, Azar A and Sell C (2015) Aberrant mTOR activation in senescence and aging: A mitochondrial stress response? Exp Gerontol 68, 66-70 DOI |
45 | Xu S, Cai Y and Wei Y (2014) mTOR Signaling from Cellular Senescence to Organismal Aging. Aging Dis 5, 263-273 |
46 | Kuk JL, Saunders TJ, Davidson LE and Ross R (2009) Age-related changes in total and regional fat distribution. Ageing Res Rev 8, 339-348 DOI |
47 | Madeo F, Zimmermann A, Maiuri MC and Kroemer G (2015) Essential role for autophagy in life span extension. J Clin Invest 125, 85-93 DOI |
48 | Demidenko ZN, Zubova SG, Bukreeva EI, Pospelov VA, Pospelova TV and Blagosklonny MV (2009) Rapamycin decelerates cellular senescence. Cell Cycle 8, 1888-1895 DOI |
49 | Huo Y, Iadevaia V and Proud CG (2011) Differing effects of rapamycin and mTOR kinase inhibitors on protein synthesis. Biochem Soc Trans 39, 446-450 DOI |
50 | Burkewitz K, Zhang Y and Mair WB (2014) AMPK at the nexus of energetics and aging. Cell Metab 20, 10-25 DOI |
51 | Serrano M (2012) Dissecting the role of mTOR complexes in cellular senescence. Cell Cycle 11, 2231-2232 DOI |
52 | Fay JR, Steele V and Crowell JA (2009) Energy homeostasis and cancer prevention: the AMP-activated protein kinase. Cancer Prev Res (Phila) 2, 301-309 DOI |
53 | Ogrodnik M, Miwa S, Tchkonia T et al (2017) Cellular senescence drives age-dependent hepatic steatosis. Nat Commun 8, 15691 DOI |
54 | Lafargue A, Degorre C, Corre I et al (2017) Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation. Free Radic Biol Med 108, 750-759 DOI |
55 | Hernandez-Segura A, Nehme J and Demaria M (2018) Hallmarks of Cellular Senescence. Trends Cell Biol 28, 436-453 DOI |
56 | Hanks S, Coleman K, Reid S et al (2004) Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat Genet 36, 1159-1161 DOI |
57 | Baker DJ, Childs BG, Durik M et al (2016) Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan. Nature 530, 184-189 DOI |
58 | Bhat R, Crowe EP, Bitto A et al (2012) Astrocyte senescence as a component of Alzheimer's disease. PLoS One 7, e45069 DOI |
59 | Murakoshi M, Osamura Y and Watanabe K (1985) Mitochondrial alterations in aged rat adrenal cortical cells. Tokai J Exp Clin Med 10, 531-536 |
60 | Wu WB, Menon R, Xu YY et al (2016) Downregulation of peroxiredoxin-3 by hydrophobic bile acid induces mitochondrial dysfunction and cellular senescence in human trophoblasts. Sci Rep 6, 38946 DOI |
61 | Tandler B and Hoppel CL (1986) Studies on giant mitochondria. Ann N Y Acad Sci 488, 65-81 DOI |
62 | Yoon YS, Yoon DS, Lim IK et al (2006) Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1. J Cell Physiol 209, 468-480 DOI |
63 | Westermann B (2002) Merging mitochondria matters: cellular role and molecular machinery of mitochondrial fusion. EMBO Rep 3, 527-531 DOI |
64 | Skulachev VP (2001) Mitochondrial filaments and clusters as intracellular power-transmitting cables. Trends Biochem Sci 26, 23-29 DOI |
65 | Ono T, Isobe K, Nakada K and Hayashi JI (2001) Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria. Nat Genet 28, 272-275 DOI |
66 | Takai D, Inoue K, Goto Y, Nonaka I and Hayashi JI (1997) The interorganellar interaction between distinct human mitochondria with deletion mutant mtDNA from a patient with mitochondrial disease and with HeLa mtDNA. J Biol Chem 272, 6028-6033 DOI |
67 | Song M, Franco A, Fleischer JA, Zhang L and Dorn GW 2nd (2017) Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence. Cell Metab 26, 872-883 e875 DOI |
68 | Finkel T and Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408, 239-247 DOI |
69 | Chae S, Ahn BY, Byun K et al (2013) A systems approach for decoding mitochondrial retrograde signaling pathways. Sci Signal 6, rs4 DOI |
70 | Jazwinski SM and Kriete A (2012) The yeast retrograde response as a model of intracellular signaling of mitochondrial dysfunction. Front Physiol 3, 139 DOI |
71 | Shiloh Y (2003) ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 3, 155-168 DOI |
72 | Lee HC and Wei YH (2001) Mitochondrial alterations, cellular response to oxidative stress and defective degradation of proteins in aging. Biogerontology 2, 231-244 DOI |
73 | Raha S and Robinson BH (2000) Mitochondria, oxygen free radicals, disease and ageing. Trends Biochem Sci 25, 502-508 DOI |
74 | Sohal RS, Ku HH, Agarwal S, Forster MJ and Lal H (1994) Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech Ageing Dev 74, 121-133 DOI |
75 | Henle ES, Han Z, Tang N, Rai P, Luo Y and Linn S (1999) Sequence-specific DNA cleavage by Fe2+-mediated fenton reactions has possible biological implications. J Biol Chem 274, 962-971 DOI |
76 | Oikawa S, Tada-Oikawa S and Kawanishi S (2001) Site-specific DNA damage at the GGG sequence by UVA involves acceleration of telomere shortening. Biochemistry 40, 4763-4768 DOI |
77 | Furumoto K, Inoue E, Nagao N, Hiyama E and Miwa N (1998) Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci 63, 935-948 DOI |
78 | Kenyon C (2005) The plasticity of aging: insights from long-lived mutants. Cell 120, 449-460 DOI |
79 | Spasic MR, Callaerts P and Norga KK (2009) AMP-activated protein kinase (AMPK) molecular crossroad for metabolic control and survival of neurons. Neuroscientist 15, 309-316 DOI |
80 | Holzenberger M, Dupont J, Ducos B et al (2003) IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421, 182-187 DOI |
81 | Miyauchi H, Minamino T, Tateno K, Kunieda T, Toko H and Komuro I (2004) Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J 23, 212-220 DOI |
82 | Demoulin JB, Ericsson J, Kallin A, Rorsman C, Ronnstrand L and Heldin CH (2004) Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins. J Biol Chem 279, 35392-35402 DOI |
83 | Gertz HJ, Cervos-Navarro J, Frydl V and Schultz F (1985) Glycogen accumulation of the aging human brain. Mech Ageing Dev 31, 25-35 DOI |
84 | Porstmann T, Santos CR, Lewis C, Griffiths B and Schulze A (2009) A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size. Biochem Soc Trans 37, 278-283 DOI |
85 | Horton JD, Shah NA, Warrington JA et al (2003) Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci U S A 100, 12027-12032 DOI |
86 | Shimomura I, Shimano H, Horton JD, Goldstein JL and Brown MS (1997) Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J Clin Invest 99, 838-845 DOI |
87 | Mazucanti CH, Cabral-Costa JV, Vasconcelos AR, Andreotti DZ, Scavone C and Kawamoto EM (2015) Longevity Pathways (mTOR, SIRT, Insulin/IGF-1) as Key Modulatory Targets on Aging and Neurodegeneration. Curr Top Med Chem 15, 2116-2138 DOI |
88 | Wirth M, Joachim J and Tooze SA (2013) Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage. Semin Cancer Biol 23, 301-309 DOI |
89 | Maurer U, Preiss F, Brauns-Schubert P, Schlicher L and Charvet C (2014) GSK-3 - at the crossroads of cell death and survival. J Cell Sci 127, 1369-1378 DOI |
90 | Li TY, Lin SY and Lin SC (2013) Mechanism and physiological significance of growth factor-related autophagy. Physiology (Bethesda) 28, 423-431 DOI |
91 | Cuervo AM (2008) Autophagy and aging: keeping that old broom working. Trends Genet 24, 604-612 DOI |
92 | Cuervo AM and Wong E (2014) Chaperone-mediated autophagy: roles in disease and aging. Cell Res 24, 92-104 DOI |
93 | Kim YM, Seo YH, Park CB, Yoon SH and Yoon G (2010) Roles of GSK3 in metabolic shift toward abnormal anabolism in cell senescence. Ann N Y Acad Sci 1201, 65-71 DOI |
94 | Emerling BM, Weinberg F, Snyder C et al (2009) Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio. Free Radic Biol Med 46, 1386-1391 DOI |
95 | Nacarelli T, Azar A and Sell C (2016) Mitochondrial stress induces cellular senescence in an mTORC1-dependent manner. Free Radic Biol Med 95, 133-154 DOI |