• 대한한의학회지
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• 제30권6호
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• pp.1-8
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• 2009

Objectives: Formulas for treatment of yin or yang deficiency conditions have been commonly used in traditional Korean medicine. The aim of this study is to examine the possible inhibitory effects of yin- or yang-tonifying formulas on in vivo anti-platelet activity and in vivo anti-thrombotic activity. Methods: We tested the effects of 26 types of yin- or yang-tonifying formulas on platelet aggregation induced by collagen in human whole blood using the impedance method of aggregometry and accessed a biomarker of platelet activation using thromboxane $B_2$ immunoassay. We also tested the anti-thrombotic effects of effective candidates on experimental models of thrombosis in mice. Results: 3 types of yin-tonifying formulas and 3 types of yin-yang-tonifying formulas were selected to be the most effective candidates (p<0.01). Also, through in vivo study, the antithrombotic activities of Igyeong-tang, Gamisipjeondaebo-tang, and Gamisoyo-san-treated groups, with recovery rate of 60, 50, and 45.45%, respectively, were observed to be higher than those of the control group (saline, 36.8%) in mouse acute thrombosis. Conclusion: These results show that yin-tonifying formulas are more effective in anti-platelet and anti-thrombotic activity than yang-tonifying formulas.

• 대한한의학원전학회지
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• 제24권4호
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• pp.55-67
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• 2011

Through analyzing the frequencies of medicinal herb combinations in the prescriptions of "Bangyakhappyeon(方藥合編)", we could understand the characteristics of prescription composition and author's medical thoughts. So we conducted this study that analyze combination of 324 medicinal herbs in 467 prescriptions, and found meaningful combinations of 5,045. Among these, the most meaningful combination is the one of 10 herbs, Glycyrrhiza uralensis Fischer, Angelica gigas Nakai, Ziziphus jujube Mille, Atractylodes japonica Koidzumi, Poria cocas Wolf, Zingiber officinale, Rehmanniae radix preparata, Cinnamomum loureirii, Panax ginseng C.A.Meyer, Astragalus membranaceus. This combination is Sibjeondaebo-tang(Shiquandabu-tang) without Cnidium officinale and Paeonia japonica which compose Samul-tang(Siwu-tang). It means this combination is kind of modified Sibjeondaebo-tang(Shiquandabu-tang), which is more effective in tonifying qi than tonifying blood. Prescriptions of "Bangyakhappyeon(方藥合編)" involve herbs mostly used to improve weak and frail health and the herbs which are more effective in tonifying qi than tonifying blood. Through this study, we know the author' s one of medical view points on tonifying qi and blood, attaching importance to tonifying qi relatively to tonifying blood.

• 대한의료기공학회지
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• 제13권1호
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• pp.36-45
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• 2013

Objective : We studied whether Antaeeum and Saahm Spleen-tonifying acupuncture had effects of prolonging pregnancy in pregnant women with pre-eclampsia. Methods : We have administered Antaeeum and applied Saahm Spleen-tonifying acupuncture for 8 weeks and the patient stopped taking steroids she had taken before. Furthermore, we observed edema, fatigue, albuminuria and hypertension. Results : In consequence of administering Antaeeum and applying Saahm Spleen-tonifying acupuncture for 8 weeks, edema and fatigue were improved and albuminuria and hypertension were not changed significantly. However pregnancy was prolonged from 28 weeks to 36 weeks and the patient could give birth successfully. Conclusions : In conclusion, Antaeeum and Saahm Spleen-tonifying acupuncture have effects of prolonging pregnancy in patients with pre-eclampsia.

• Journal of Acupuncture Research
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• 제23권5호
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• pp.31-37
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• 2006

Objectives & Methods : We investigated the cases for which spleen tonifying Sa-Am acupuncture was applied in ${\ulcorner}$Sa-Am-chim-gu-jeong-jeon(舍巖鍼灸正傳)${\lrcorner}$ and classified them according to the concepts of cold-heat & deficiency-excess for a better understanding of the application of spleen tonifying Sa-Am acupuncture. Results : 1. Tonification of Spleen Sa-Am acupuncture can be used to treat heat syndromes such as deficient fire caused by collapse of the spleen qi, stagnation of evil qi or spleen yin deficiency, by way of tonifying spleen qi, activating the flow of qi and blood or harmonizing spleen yin and yang. 2. Tonification of Spleen Sa-Am acupuncture can be used to treat cold syndromes such as weakness of spleen yang by way of promoting fire to generate earth, strengthening spleen yang and raising the clear yang. 3. Tonification of Spleen Sa-Am acupuncture can be used to treat deficiency syndromes such as malnutrition or poor appetite caused by spleen deficiency by way of tonifying spleen qi. 4. Tonification of Spleen Sa-Am acupuncture can be used to treat excess syndromes such as stagnation of qi and blood, abdominal mass or toxication by way of tonifying spleen qi and promoting the flow of qi and blood.

• Journal of Acupuncture Research
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• 제31권3호
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• pp.7-18
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• 2014

Objectives : The purpose of this study is to find parameters to compare the effects of Sa-Am acupuncture with large intestine tonifying and sedating on radial pulse in healthy subjects. Methods : Sixty healthy subjects participated in this study, divided into large intestine tonifying acupuncture group, large intestine sedating acupuncture group and control group. Radial pulse was measured by 3 dimensional pulse imaging system(DMP-3000) before, right after, 30 minutes after and 60 minutes after acupuncture at Cun, Guan, and Chi in the acupuncture group and in the control group at the same time points. Results : 1. Angle of main peak and magnitude of fourier component significantly changed by integrated analysis of Cun, Guan and Chi. 2. Amplitude of H1, Pulse Power volume / min, elasticity, AIx / HR, Frequency and magnitude of fourier component significantly changed by analysis of Cun, Guan, and Chi. Conclusions : The effect of Sa-Am acupuncture with large intestine tonifying and sedating in healthy human may be observed on time, amplitude, pulse area, augmentation index and fourier components parameters. The parameters analysed in this study may be used to differentiate the effects between Sa-Am acupuncture with large intestine tonifying and sedating on radial pulse. Further studies on the effects of Sa-Am acupuncture using radial pulse are needed.

• 혜화의학회지
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• 제10권1호
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• pp.93-108
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• 2001

The purpose of this research was to investigate the effects of Sutaehwan(壽胎丸) for treatment Abortus habitualis(滑胎). I came to conculsion after considering literatures of every generation on the effects of Sutaehwan and then came to get some conclusion as follows. 1. Sutaehwan(壽胎丸) was designed to prescribe for treatment of Abortus habitualis(滑胎) 2. Sutaehwan(壽胎丸) was made use of Fetal Restlessness(胎動不安) caused by Kidney Deficiency(腎虛). 3. Sutaehwan(壽胎丸) was always used by the origin prescription itself, also used the modified prescription and the additional prescription. 4. Sutaehwan(壽胎丸) is the best quality prescription for treatment Abortus habitualis(滑胎) that due to Deficiency of Liver-Kidney Essence. Sutaehwan(壽胎丸) contains four specific herbs like Dodder Seed(兎絲子), Taxillus Twig(桑寄生), Himalayan Teasel Root(續斷), Donkey-hide Gelatin(阿膠). Dodder Seed(兎絲子) is effective the Tonifying Kidney, the Invigorating Yang and the Supplementing Essence. Taxillus Twig(桑寄生) is effective the Nourishing Blood and the Tonifying Kidney. Himalayan Teasel Root(續斷) is effective the Tonifying Liver-Kidney and the Regulation Blood. Donkey-hide Gelatin(阿膠) is effective the Tonifying Liver Blood, the Arresting Bleeding and the Supplementing Kidney Yin Fluid.

• 대한한의학원전학회지
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• 제34권3호
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• pp.21-39
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• 2021

Objectives : This paper compares and analyzes Liu Hejian's kidney fluid nourishing treatment methodology with Zhu Danxi's kidney tonifying treatment methodology. Methods : The two doctors' medical theories and treatment formulas were examined to study how their medical arguments manifested in clinical application. Results : Both doctors emphasized the kidney. Liu pursued the treatment of balance based on the theory of the original qi of the Taiyitianzhen(太乙天眞), while Zhu tried to prevent the frenetic stirring of the ministerial fire by restraining one's desires. In nourishing kidney fluid, Liu sometimes used hot medicinals to treat kidney deficiency patters, where medicinals that tonify the kidney fluid were not defined clearly. Zhu, on the other hand, defined formulas and medicinals that would tonify the kidney yin clearly. Conclusions : The tradition of emphasizing the body's yin qi based on the kidney has been continued from Liu Hejian to Zhu Danxi, during which the pathology of fire and heat were examined thoroughly. In clinical application, various and specific ways of controlling the fire heat were developed.

• Journal of Acupuncture Research
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• 제29권5호
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• pp.17-29
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• 2012

Objectives : The purpose of this study is to find the effects of Sa-Am lung tonifying acupuncture on radial pulse through the parameters difference. Methods : Forty healthy subjects participated in this study, acupuncture group and control group were divided. Compared various parameters of radial pulse between two groups, and the significantly changed 16 parameters ware measured using 3 dimensional pulse imaging system(DMP-3000) before, right after, 30 minutes after, and 60 minutes after acupuncture at Chon, Gwan, Cheok in acupucture group. Results : After lung tonifying acupuncture, radial pulse 16 parameters were showed changes significantly according to the time at each measuring location. 1. Heart rate, T2/T, T5, T5/T and W/T significantly decreased, W significantly increased. 2. Modulus of elasticity significantly decreased in left Cheok. 3. Amplitude of H4 significantly increased in left Gwan and right Cheok. 4. AIx, AIxHR significantly decreased in left Gwan and significantly increased in right Chon. 5. Area of pulse, area of W significantly increased in right Cheok. 6. Pulse energy, energy/min, EIx significantly decreased in left Cheok. 7. Maximum variation time of each parameter is showed different according to the parameter. Conclusions : Lung tonifying acupuncture exerts an influence on radial purse parameters. Further radial pulse change study on various acupuncture treatment is required.

• 대한한의학회지
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• 제31권5호
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• pp.112-123
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• 2010

Objectives: Three yin-tonifying formulae (Ssanghwa-tang, Yukmijihwang-tang and Jaeumganghwa-tang) were applied to investigate their immunological activities on antigen (Ag)-specific or Ag-non-specific immune responses in the murine macrophage cell line (RAW 264.7) and in ovalbumin (OVA)-immunized mice. Methods: This study was carried out in nitricoxide (NO) synthesis in RAW 264.7 cells and cellular proliferation in mouse splenocytes in association with three herbal formulas. C57BL/6 mice were immunized intraperitoneally with OVA/aluminum ($100\;{\mu}g/200\;{\mu}g$/mouse) on days 1, 8, and 15. Three herbal formulas were administrated to mice orally for 3 weeks from day 1. On day 22, OVA-, lipopolysaccharide (LPS)-, and concanavalin A (Con A)-stimulated splenocyte proliferation and antibodies (OVA-specific antibodies of the IgG, IgG1, and total IgM classes) in plasma were measured. Results: All three yin-tonifying formulas significantly enhanced cellular proliferation by LPS and Con A in splenocytes from OVA-immunized mice (p<0.001). Also, these herbal formulas all significantly enhanced plasma OVA-specific IgG, IgG1, and total IgM levels compared with the OVA/Alum group. Conclusion: These results suggested that the three yin-tonifying formulae could be used as stimulators of immune response.

• Journal of Acupuncture Research
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• 제32권2호
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• pp.169-185
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• 2015

Objectives : The purpose of this study is to find the effects of Sa-am liver tonifying and sedating acupuncture on radial pulse. Methods : Sixty healthy people were divided into a liver tonifying acupuncture(LTA) group, liver sedating acupuncture(LSA) group, and control group. The LTA group and LSA group received acupuncture for 20 minutes with a supine position. The Control group took a rest without receiving acupuncture. Radial pulse was measured by three dimensional pulse imaging system(DMP-3000) at four different time points (before, right after, 30 minutes after, and 60 minutes after acupuncture). We compared the three groups and figure out determined the parameters which significantly changed after acupuncture treatment. Results : 1. Pulse period, T1/T, T4/T, (T-T4)/T, T4/(T-T4), T5/T significantly changed after acupuncture. 2. H4, pulse area, systolic pulse area, diastolic pulse area, radial augmentation index(RAI), and pulse power volume / min significantly changed after acupuncture. 3. Frequency of Fourier components, ratio of frequencies of Fourier components, magnitude of Fourier components, and ratio of magnitudes of Fourier components significantly changed after acupuncture. Conclusions : LTA and LSA have an effect on the radial pulse parameters. Further studies on radial pulse change using Sa-Am acupuncture are needed.