The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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A Trend of Yin-tonifying Formulas Compared with Yang-tonifying Formulas on Anti-platelet and Anti-thrombotic Activity

  • Jeon, Won-Kyung (TKM Converging Research Division, Korea Institute of Oriental Medicine) ;
  • Yoo, Bo-Kyung (TKM Converging Research Division, Korea Institute of Oriental Medicine) ;
  • Ahn, Sang-Young (TKM Information Research Division, Korea Institute of Oriental Medicine) ;
  • Lee, Ju-Hyun (Herbal Quality Control Center, Korea Institute of Oriental Medicine) ;
  • Ahn, Sang-Woo (TKM Information Research Division, Korea Institute of Oriental Medicine) ;
  • Ko, Byoung-Seob (Herbal Quality Control Center, Korea Institute of Oriental Medicine)
  • Published : 2009.11.30
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Abstract

Objectives: Formulas for treatment of yin or yang deficiency conditions have been commonly used in traditional Korean medicine. The aim of this study is to examine the possible inhibitory effects of yin- or yang-tonifying formulas on in vivo anti-platelet activity and in vivo anti-thrombotic activity. Methods: We tested the effects of 26 types of yin- or yang-tonifying formulas on platelet aggregation induced by collagen in human whole blood using the impedance method of aggregometry and accessed a biomarker of platelet activation using thromboxane $B_2$ immunoassay. We also tested the anti-thrombotic effects of effective candidates on experimental models of thrombosis in mice. Results: 3 types of yin-tonifying formulas and 3 types of yin-yang-tonifying formulas were selected to be the most effective candidates (p<0.01). Also, through in vivo study, the antithrombotic activities of Igyeong-tang, Gamisipjeondaebo-tang, and Gamisoyo-san-treated groups, with recovery rate of 60, 50, and 45.45%, respectively, were observed to be higher than those of the control group (saline, 36.8%) in mouse acute thrombosis. Conclusion: These results show that yin-tonifying formulas are more effective in anti-platelet and anti-thrombotic activity than yang-tonifying formulas.

Keywords

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