• 조명전기설비학회논문지
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• 제29권4호
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• pp.11-17
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• 2015

While most switching devices are based on PN junctions, a single layer can realize a switching device in the case of vanadium dioxide($VO_2$) thin films. In this paper, bidirectional current triggering(switching) is demonstrated in a two-terminal planar device based on a $VO_2$ thin film by illuminating the film with an infrared laser at 1550nm. To begin with, a two-terminal planar device, which had a $30{\mu}m$-wide $VO_2$ conducting layer and an electrode separation of $10{\mu}m$, was fabricated. A specific bias voltage range for stable bidirectional laser triggering was experimentally obtained by measuring the current-voltage characteristics of the fabricated device in a current-controlled mode. Then, by constructing a test circuit composed of the device, a standard resistor, and a DC voltage source, connected in series, the transient response of laser-triggered current and its response time were investigated with a DC bias voltage, included in the above specific bias voltage range, applied to the device. In the test circuit with a DC voltage source of 3.35V and a $10{\Omega}$ resistor, bidirectional laser triggering could be realized with a maximum on-state current of 15mA and a switching contrast of ~78.95.

• 한국약용작물학회지
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• 제17권4호
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• pp.266-272
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• 2009

Cinnamyl alcohol dehydrogenase (CAD, EC 1.1.1.95), catalyzes the reduction of hydroxycinnamaldehydes to give hydroxycinnamyl alcohols, or "monolignols," the monomeric precursors of lignin. Lignins are important components of cell walls and lignified secondary cell walls play crucial roles in long distance transport of water and nutrients during plant growth and development and in plant defense against biotic and abiotic stresses. Here a cDNA clone containing a CAD gene, named as PgCAD, was isolated from a commercial medicinal plant Panax ginseng. PgCAD is predicted to encode a precursor protein of 177 amino acid residues, and its sequence shares high homology with a number of other plant CADS. The expression of PgCAD in adventitious roots and hairy roots of P. ginseng was analyzed using reverse transcriptase (RT)-PCR under various abiotic stresses such as salt, salicylic acid, wounding and chilling treatment that triggered a significant induction of PgCAD at different time points within 2-48 h post-treatment. This study revealed that PgCAD may help the plants to survive against various abiotic stresses.

• The Korean Journal of Physiology and Pharmacology
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• 제22권6호
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• pp.617-625
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• 2018

Neddylation is a post-translational protein modification process. MLN4924 is a newly discovered pharmaceutical neddylation inhibitor that suppresses cancer growth with several cancer types. In our study, we first investigated the effect of MLN4924 on colon cancer cells (HCT116 and HT29). MLN4924 significantly inhibited the neddylation of cullin-1 and colon cancer cell growth in a time and dose-dependent manner. MLN4924 induced G2/M cell cycle arrest and apoptosis in HCT116 and HT29 cells. Moreover, MLN4924 also triggered autophagy in HCT116 and HT29 cells via suppressing the PI3K/AKT/mTOR pathway. Inhibiting autophagy by autophagy inhibitor 3-MA or ATG5 knockdown reversed the function of MLN4924 in suppressing colon cancer cell growth and cell death. Interestingly, MLN4924 suppresses colon cell growth in a xenograft model. Together, our finding revealed that blocking neddylation is an attractive colon cancer therapy strategy, and autophagy might act as a novel anti-cancer mechanism for the treatment of colon cancer by MLN4924.

• Journal of Microbiology and Biotechnology
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• 제27권6호
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• pp.1163-1170
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• 2017

Clostridium difficile releases two exotoxins, toxin A and toxin B, which disrupt the epithelial cell barrier in the gut to increase mucosal permeability and trigger inflammation with severe diarrhea. Many studies have suggested that enteric nerves are also directly involved in the progression of this toxin-mediated inflammation and diarrhea. C. difficile toxin A is known to enhance neurotransmitter secretion, increase gut motility, and suppress sympathetic neurotransmission in the guinea pig colitis model. Although previous studies have examined the pathophysiological role of enteric nerves in gut inflammation, the direct effect of toxins on neuronal cells and the molecular mechanisms underlying toxin-induced neuronal stress remained to be unveiled. Here, we examined the toxicity of C. difficile toxin A against neuronal cells (SH-SY5Y). We found that toxin A treatment time- and dose-dependently decreased cell viability and triggered apoptosis accompanied by caspase-3 activation in this cell line. These effects were found to depend on the up-regulation of reactive oxygen species (ROS) and the subsequent activation of p38 MAPK and induction of $p21^{Cip1/Waf1}$. Moreover, the N-acetyl-$\text\tiny L$-cysteine (NAC)-induced down-regulation of ROS could recover the viability loss and apoptosis of toxin A-treated neuronal cells. These results collectively suggest that C. difficile toxin A is toxic for neuronal cells, and that this is associated with rapid ROS generation and subsequent p38 MAPK activation and $p21^{Cip1/Waf1}$ up-regulation. Moreover, our data suggest that NAC could inhibit the toxicity of C. difficile toxin A toward enteric neurons.

• 한국콘텐츠학회논문지
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• 제17권12호
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• pp.49-63
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• 2017

본 연구는 인문사회기반 융합연구 지원과제를 대상으로 연구 분야간 협력적 연계관계 구조와 그 속성을 분석하고자 하였다. 학제간 연구협력은 공동의 문제를 해결하는데 있어서 개별 연구 분야들이 보유한 지식, 정보, 자원 등을 다른 분야들과 결합하고 공유하는 상호 협력적인 연구 활동이라고 볼 수 있다. 2009년부터 2015년까지 한국연구재단이 지원한 183개 융합과제를 대상으로 98개의 연구 분야를 추출하고 이를 관계형 네트워크 데이터로 구축하여 분석을 수행하였다. 분석 결과, 다양한 분야들이 상호 연계되어 군집을 형성하고 이를 통해 협력적 융합연구 활동이 고르게 분포되는 구조적 속성을 확인할 수 있었다. 둘째, 외향 및 내향 연결 중심성이 높은 분야들이 전체 년도구간에서 학제적 연구협력의 주요 기능을 담당하는 것으로 판단되었다. 셋째, 연결자(Liaison)의 중개 역할이 전체 네트워크에서 이종 지식과 정보의 흐름을 중개하는 연구 분야의 대표적인 특성이라는 점도 확인되었다. 본 연구는 학제간 연구협력 네트워크의 구조적 속성을 파악하고 융합연구에 있어서 네트워크 방법론의 적용이 가지는 정책적 함의를 제시하였다.

• Journal of Korean Neurosurgical Society
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• 제53권3호
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• pp.194-196
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• 2013

Isolated abducens nerve paresis related to ruptured vertebral artery (VA) aneurysm is rare. It usually occurs bilaterally or ipsilaterally to the pathologic lesions. We report the case of a contralateral sixth nerve palsy following ruptured dissecting VA aneurysm. A 38-year-old man was admitted for the evaluation of a 6-day history of headache. Abnormalities were not seen on initial computed tomography (CT). On admission, the patient was alert and no signs reflecting neurologic deficits were noted. Time of flight magnetic resonance angiography revealed a fusiform dilatation of the right VA involving origin of the posterior inferior cerebellar artery. The patient suddenly suffered from severe headache with diplopia the day before the scheduled cerebral angiography. Neurologic examination disclosed nuchal rigidity and isolated left abducens nerve palsy. Emergent CT scan showed high density in the basal and prepontine cistern compatible with ruptured aneurismal hemorrhage. Right vertebral angiography illustrated a right VA dissecting aneurysm with prominent displaced vertebrobasilar artery to inferiorly on left side. Double-stent placement was conducted for the treatment of ruptured dissecting VA aneurysm. No diffusion restriction signals were observed in follow-up magnetic resonance imaging of the brain stem. Eleven weeks later, full recovery of left sixth nerve palsy was documented photographically. In conclusion, isolated contralateral abducens nerve palsy associated with ruptured VA aneurysm may develop due to direct nerve compression by displaced verterobasilar artery triggered by primary thick clot in the prepontine cistern.

• Journal of Astronomy and Space Sciences
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• 제24권3호
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• pp.219-226
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• 2007

ACE 위성이 1997년부터 2000년까지 관측한 행성간 충격파들 중에서 WIND 위성에서 관측된 Type II 태양 전파 폭발에 의한 것으로 연관되어지는 행성간 충격파 31개를 선별하였다. 이들 행성간 충격파 발생과 관련된 Type II 전파 폭발이 관측된 후에 행성 간 충격파가 인공위성들에 의해 관측될 때까지의 시간을 측정하여 행성간 충격파가 태양에서 지구까지 전달되는 전달속도를 구하였다. 이 속도와 ACE위성에서 실제 관측된 행성간 충격파의 진행속도를 비교하여 행성간 충격파의 태양 지구간 전파과정은 평균 가속도가 $-1.02m/sec^2$로 감속되는 과정임을 규명하였다. 더 나아가, 이로부터 행성간 충격파의 특성에 따른 행성간 충격파 전달 과정의 감속을 결정하는 가속도 값이 행성간 충격파의 진행속도나 마하수 등과 상관관계가 없음을 밝혀내었다.

• Nuclear Engineering and Technology
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• 제52권7호
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• pp.1517-1523
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• 2020

The widely used medical isotope technetium-99 m (^99mTc) is a daughter of Molybdenum-99 (⁹⁹Mo), which is mainly produced using dedicated research reactors from the nuclear fission of uranium-235 (²³⁵U). ^99mTc has been used for several decades, which covers about 80% of the all the nuclear diagnostics procedures. Recently, the instability of the supply has become an important topic throughout the international radioisotope communities. The aging of major ⁹⁹Mo production reactors has also caused frequent shutdowns. It has triggered movements to establish new research reactors for ⁹⁹Mo production, as well as the development of various ⁹⁹Mo production technologies. In this context, a new research reactor project was launched in 2012 in Korea. At the same time, the development of fission-based ⁹⁹Mo production process was initiated by Korea Atomic Energy Research Institute (KAERI) in 2012 in order to be implemented by the new research reactor. The KAERI process is based on the caustic dissolution of plate-type LEU (low enriched uranium) dispersion targets, followed by the separation and purification using a series of columns. The development of proper waste treatment technologies for the gaseous, liquid, and solid radioactive wastes also took place. The first stage of this process development was completed in 2018. In this paper, the results of the hot test production of fission ⁹⁹Mo using HANARO, KAERI's 30 MW research reactor, was described.

• 천문학회지
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• 제41권6호
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• pp.173-180
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• 2008

Using the MHD coronal seismology technique, we estimated the magnetic field for three spicules observed in 2008 June. For this study, we used the high resolution Ca II H line ($3968.5\;{\AA}$) images observed by the Hinode SOT and considered a vertical thin flux tube as a spicule model. To our knowledge, this is the first attempt to estimate the spicule magnetic field using the Hinode observation. From the observed oscillation properties, we determined the periods, amplitudes, minimum wavelengths, and wave speeds. We interpreted the observed oscillations as MHD kink waves propagating through a vertical thin flux tube embedded in a uniform field environment. Then we estimated spicule magnetic field assuming spicule densities. Major results from this study are as follows : (1) we observed three oscillating spicules having durations of 5-7 minutes, oscillating periods of 2-3 minutes, and transverse displacements of 700-1000 km. (2) The estimated magnetic field in spicules is about 10-18 G for lower density limit and about 43-76 G for upper density limit. (3) In this analysis, we can estimate the minimum wavelength of the oscillations, such as 60000 km, 56000 km, and 45000 km. This may be due to the much longer wavelength comparing with the height of spicules. (4) In the first event occurred on 2008 June 03, the oscillation existed during limited time (about 250 s). This means that the oscillation may be triggered by an impulsive mechanism (like low atmospheric reconnection), not continuous. Being compared with the ground-based observations of spicule oscillations, our observation indicates quite different one, i.e., more than one order longer in wavelength, a factor of 3-4 larger in wave speed, and 2-3 times longer in period.

• International Journal of Concrete Structures and Materials
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• 제9권3호
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• pp.345-367
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• 2015

Past earthquakes have signaled the increased collapse vulnerability of mainshock-damaged bridge piers and urgent need of repair interventions prior to subsequent cascading hazard events, such as aftershocks, triggered by the mainshock (MS). The overarching goal of this study is to quantify the collapse vulnerability of mainshock-damaged substandard RC bridge piers rehabilitated with different repair jackets (FRP, conventional thick steel and hybrid jacket) under aftershock (AS) attacks of various intensities. The efficacy of repair jackets on post-MS resilience of repaired bridges is quantified for a prototype two-span single-column bridge bent with lap-splice deficiency at column-footing interface. Extensive number of incremental dynamic time history analyses on numerical finite element bridge models with deteriorating properties under back-to-back MS-AS sequences were utilized to evaluate the efficacy of different repair jackets on the post-repair behavior of RC bridges subjected to AS attacks. Results indicate the dramatic impact of repair jacket application on post-MS resilience of damaged bridge piers-up to 45.5 % increase of structural collapse capacity-subjected to aftershocks of multiple intensities. Besides, the efficacy of repair jackets is found to be proportionate to the intensity of AS attacks. Moreover, the steel jacket exhibited to be the most vulnerable repair intervention compared to CFRP, irrespective of the seismic sequence (severe MS-severe or moderate AS) or earthquake type (near-fault or far-fault).