• Nuclear Engineering and Technology
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• v.52 no.10
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• pp.2196-2203
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• 2020

A dryout mechanism model for rectangular narrow channels at high pressure conditions is developed by assuming that the Kelvin-Helmholtz instability triggered the occurrence of dryout. This model combines the advantages of theoretical analysis and empirical correlation. The unknown coefficients in the theoretical derivation are supported by the experimental data. Meanwhile, the decisive restriction of the experimental conditions on the applicability of the empirical correlation is avoided. The expression of vapor phase velocity at the time of dryout is derived, and the empirical correlation of liquid film thickness is introduced. Since the CHF value obtained from the liquid film thickness should be the same as the value obtained from the Kelvin-Helmholtz critical stability under the same condition, the convergent CHF value is obtained by iteratively calculating. Comparing with the experimental data under the pressure of 6.89-13.79 MPa, the average error of the model is -15.4% with the 95% confidence interval [-20.5%, -10.4%]. And the pressure has a decisive influence on the prediction accuracy of this model. Compared with the existing dryout code, the calculation speed of this model is faster, and the calculation accuracy is improved. This model, with great portability, could be applied to different objects and working conditions by changing the expression of the vapor phase velocity when the dryout phenomenon is triggered and the calculation formula of the liquid film.

• Journal of Broadcast Engineering
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• v.9 no.1
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• pp.74-82
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• 2004

In digital broadcasting, applications are computer programs executed by the set-top box(TV receiver) , and synchronized applications are those that perform tasks at the specified moments in the underlying video. This paper describes important concepts, standards, and skills needed to implement synchronized applications and explains how to integrate them to implement these applications. This Paper assumes the European data broadcasting standard, DVB-MHP. In DVB-MHP, scheduled stream events are recommended as a means of synchronizing applications with video streams. In this method, the application receives each stream event, and executes the action associated with the stream event at the time specified in the stream event. Commercially available stream generators, i.e., multiplexers, do not generate transport streams that support scheduled stream events. So we used a stream generator implemented in our lab. We implemented a synchronized application where the actions triggered by stream events are to display graphic images. We found that our synchronized application processes scheduled stream events successfully. In our experimentation, the stream events were synchronized with the video and the deviation from the intended time was within 240 ㎳, which is a tolerance for synchronization skew between graphic images and video.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.703-712
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• 2016

Monoclonal antibodies with specific antigens have been widely used as targeted therapy for cancer. Hep88 mAb is a monoclonal antibody which shows specific binding with anti-cancer effects against the HepG2 cell line. However, its mechanisms of action are still not completely understood. We examined cell cycling and apoptosis by flow cytometry and mRNA expression of factors involved in apoptosis and paraptosis in Hep88 mAb-treated HepG2 cells by real-time PCR. The cell-cycle analysis demonstrated that growth-inhibitory activity was associated with G2/M cell cycle arrest. Hep88 mAb induced a significant increase in apoptotic cell populations in a dose- and time-dependent manner. The mRNA expression results also suggested that the process triggered by Hep88 mAb involved up-regulation of tumor suppressor p53, pro-apoptotic Bax, Cathepsin B, Caspase-3 and Caspase-9, with a decrease of anti-apoptotic Bcl-2 - thus confirming paraptosis and apoptosis programmed cell death. These findings represent new insights into the molecular mechanisms underlying the anti-cancer properties of Hep88 mAb in liver cancer cells.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.1
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• pp.125-131
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• 2017

Status epilepticus is the most common serious neurological condition triggered by abnormal electrical activity, leading to severe and widespread cell loss in the brain. Lithium has been one of the main drugs used for the treatment of bipolar disorder for decades, and its anticonvulsant and neuroprotective properties have been described in several neurological disease models. However, the therapeutic mechanisms underlying lithium's actions remain poorly understood. The muscarinic receptor agonist pilocarpine is used to induce status epilepticus, which is followed by hippocampal damage. The present study was designed to investigate the effects of lithium post-treatment on seizure susceptibility and hippocampal neuropathological changes following pilocarpine-induced status epilepticus. Status epilepticus was induced by administration of pilocarpine hydrochloride (320 mg/kg, i.p.) in C57BL/6 mice at 8 weeks of age. Lithium (80 mg/kg, i.p.) was administered 15 minutes after the pilocarpine injection. After the lithium injection, status epilepticus onset time and mortality were recorded. Lithium significantly delayed the onset time of status epilepticus and reduced mortality compared to the vehicle-treated group. Moreover, lithium effectively blocked pilocarpine-induced neuronal death in the hippocampus as estimated by cresyl violet and Fluoro-Jade B staining. However, lithium did not reduce glial activation following pilocarpine-induced status epilepticus. These results suggest that lithium has a neuroprotective effect and would be useful in the treatment of neurological disorders, in particular status epilepticus.

• Journal of Ocean Engineering and Technology
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• v.21 no.6
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• pp.72-80
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• 2007

The tsunami that resulted from the Central East sea Earthquake, which registered 7.7 on the Richter scale, that occurred over the entire water region in Akita on May. 26, 1983 and the tsunami that was triggered by the Southwest off Hokkaido Earthquake (7.8 on the Richter scale) that occurred in Southwest off Hokkaido on July 12, 1993 are representative cases that led to considerable damage in life and property, not only in Japan but also in Korea. In this study, multi-grid method was used in order to reproduce sufficiently the shoaling effect that occurs as water depth becomes shallow in the shallow water region and moving boundary condition was introduced to consider the runup in the coastal region. For the tsunamis that exerted considerable effect on the East Sea coast of Korea that were caused by the Central East Sea Earthquake in 1983 and the Southwest off Hokkaido Earthquake in 1993, characteristics like water level rise and propagation in the East Sea coast will be examined using numerical simulations. At the same time, these values will be compared with observed values. In addition, maximum water level rise and change in the water level with respect to time that were caused by the tsunamis were examined at each location along the East sea coast. Usefulness of numerical analysis was verified by comparing with observed values.

• The Research Journal of the Costume Culture
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• v.10 no.1
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• pp.37-48
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• 2002

The following paper deals with the interaction between an Austrian art trend from the late 19th century until World War I, the Vienna Separatist Movement, and the Vienna Workshop dress and its ornaments in part designed by the artists belonging to the former mentioned school. Gustav Klimt′s paintings along with his photographs and pictures and articles published in the "Wiener Mode" magazine were subject of analysis. The focus was on Klimt′s paintings with female themes whereby a comparative analysis was made between the development of the forms, hues and ornaments of clothing and the style of paintings at that time. The whole development was classified into three phases. The first period from 1897∼1905 marks the birth of the Vienna Separatists along with the clothing reform movement. The heyday of the Separatists represents the second phase from 1906∼1913 and the decline of the very school and the Vienna Workshop period lasts from 1913∼1918. Refromed dresses were started to be recognized as alternatives, from 1897 when the Separatists started to gain foot until 1o05, and Kimt and Van de Velde published designs that were comfortable and elegant. From 1906 to 1913 the expressionism and Reform Mode of the Vienna artists started to flourish. But during the War the Separatist Movement, which triggered the modernazation of Vienna declined and instead the decorative art of Vienna Workshops started to develop. The asymmetric design of the dress, exotic patterns, shades of complementary colors and reformed clothing were frequently used by Kimt and other Separatists. This is an instance where fashion design directly influenced art and different branches can reflect the same aesthetic standards within the same time frame.

• Biomolecules & Therapeutics
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• v.22 no.3
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• pp.213-222
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• 2014

Abnormal adaptation of the stress-response system following traumatic stress can lead to alterations in the hypothalamic-pituitaryadrenal (HPA) axis that may contribute to the development of post-traumatic stress disorder (PTSD). The present study used several behavioral tests to investigate the anxiolytic-like and antidepressant activity of L-tetrahydropalmatine (L-THP) in an experimental rat model of anxiety and depression induced by single prolonged stress (SPS), an animal model of PTSD. Male rats were treated intraperitoneally (i.p.) with vehicle or varied doses of THP 30 min prior to SPS for 8 consecutive days. Daily THP (50 mg/kg) administration significantly increased the number and duration of open arm visits in the elevated plus maze (EPM) test, reduced the anxiety index, increased the risk assessment, and increased the number of head dips over the borders of the open arms after SPS. THP was also associated with increased time spent at the center of the open field, reduced grooming behaviors in the EPM test, and reduced time spent immobile in the forced swimming test (FST). It also blocked the decrease in neuropeptide Y (NPY) and the increase in corticotrophin-releasing factor (CRF) expression in the hypothalamus. This is the first study to determine that THP exerts pronounced anxiolytic-like and antidepressant effects on the development of the behavioral and biochemical symptoms associated with PTSD, indicating its prophylactic potential. Thus, THP reversed several behavioral impairments triggered by the traumatic stress of SPS and is a potential non-invasive therapeutic intervention for PTSD.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• v.9 no.1
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• pp.667-670
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• 2005

As security and surveillance have become the center of interest, remote controlled CCTV(Closed-Circuit Television) market has been formed while rapid development of digital image compression technology and Internet triggered the advent of web cameras. The characteristic of web camera is that it can provide users with higher quality image than CCTV at any place where Internet access is available. However, As for the system administrator, the existing web camera have disadvantage in that they allows users only. who are connected to the server of the web camera, to see the image from it. In this paper, in order to make up for this defect, designed multi-vision interface showing multi images on single screen and, for the purpose of the improvement in efficiency, the functions of saving images and of scheduling the time to save the images.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.05a
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• pp.172-175
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• 2002

The technique of induced discharge by a pulsed CO2 laser is being applied to control electrical discharge path, material processing, triggered lightning for protecting the power equipments. In this paper, we have investigated about the characteristics of the induced discharge at atmospheric conditions by using a plasma channel, which is produced when a pulsed CO2 laser radiation is focused by a focusing mirror as a trigger source. A plasma channel produced by laser radiation has an effect on decreasing the threshold voltage and inducing the discharge in both needle electrodes. We have confirmed a delay time between a produced plasma channel and an electrical discharge after laser radiation. We provided the decreased voltage lower than the natural discharge voltage between electrode type of needles and was induced the discharge by forming a plasma channel between them. In this research we could understand the time delay of induced discharge by laser radiation, and the characteristics of the discharge cause by the decrease in the threshold voltage, and the polarity effect by changes of plasma channel positions between two electrodes.

• The Korean Journal of Zoology
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• v.30 no.2
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• pp.193-209
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• 1987

Patterns of amylase secretion in mouse pancreatic fragments were studied over a period of time after the tissue was stimulated by acetyicholine and MNNG. MNNG is known to activate guanylate cyclase and thus increase the cGMP concentration in the pancreatic acinar cell. These amylase secretion patterns were studied to investigate the role of cGMP in reaction cascade during secretion response of the tissues stimulated by acetyicholine. Cellular response of amylase secretion in the pancreas by acetyicholine was divided into two phases. During the first phase, zymogen granules which had existed in the cells were secreted by the action of $Ca^2$+ and calmodulin immediately after secretagogue administration, this being known as the initial response. When the tissue was stimulated by acetylcholine in a $Ca^2$+-deficient medium or one containing trifluoperazine as a calmodulin antagonist, this initial response was reduced. In the second phase, newly formed zymogen granules were secreted as sustained response after protein synthesis was triggered by secretagogue. This response was provoked by an activation of protein kinase C. When either cycloheximide as a protein synthesis inhibitor or dibucaine as a protein kinase C inhibitor were added to the incubation medium, this sustained response was remarkablely depressed in the pancreatic fragments stimulated with acetylcholine. In the pancreatic acinar cell, phosphatidylinositol turnover plays an important role in the secretion response and hexachlorocyclohexane inhibits this phosphatidylinositol turnover. The pancreatic tissue treated with the hexachlorocyclohexane exhibited inhibition on both initial and sustained responses of amylase secretion by acetylcholine. MNNG also accelerated amylase secretion from the tissue gradually along incubation time. The 22 minutes fraction of the pancratic secretion after administration of both acetylcholine and MNNG showed higher amylase activity than the neighboring fractions. Guanylate cyclase potentiated the sustained response. Even if it is experimented with an indirect method, guanylate cyclase was found responsible for activation of the sustained response of a step prior to the action of protein kinase C. As conclusion, it was considered that amylase secretion in mouse pancreatic fragments stimulated by acetylcholine is a three phasic response.