• 대한기계학회:학술대회논문집
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• 대한기계학회 2000년도 춘계학술대회논문집A
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• pp.585-590
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• 2000

Problems involved in the numerical analysis on the forced oscillation of nonlinear oscillators such a microbubble oscillation under ultrasound and Duffing oscillator were discussed. One of the problems is proper choice of the time scale of the driving force. which is related to the numerical artifacts due to the mismatch between the natural frequency of an oscillator(or bubble) and the characteristic frequency of the applied force. Such problem may occur in a nonlinear oscillator whose behavior is crucially dependent on the frequency of the applied force. The artificial resonance problem during the numerical evaluation of such nonlinear systems was also discussed.

• Reproductive and Developmental Biology
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• 제28권4호
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• pp.267-273
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• 2004

Maturation of oocytes is maintained by complex procedures along with follicular genesis and is a critical step for embryonic development. Purine known as an oocyte maturation regulator is present in follicular fluid. In this study, the roles of guanosine as a strong inhibitor of GVBD and a modulator of cyclic GMP concentration in ooyctes were revealed. Denuded immature oocytes were treated with guanosine, and the maturation rates and cGMP concentration of oocytes were measured. GVBD was blocked in a concentration dependent manner by guanosine, but this effect was reversible. However, GVBD was lagged yet not significant by adenosine. Both guanosine and adenosine modified cGMP concentration in oocytes. The characteristic of the guanosine-treated oocyte was significantly higher cGMP compared with the adenosine-treated oocyes at initial time of the maturation. Based these results, guanosine may be a strong and reversible GVBD inhibitor. Although the precise mechanism of guanosine presently is unclear, the results suggest that guanosine may lead the accumulation of cGMP in oocyte cytoplasm, which in turn suppresses GVBD.

• 한국건축시공학회지
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• 제13권1호
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• pp.20-28
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• 2013

Flexure toughness of Steel Fiber Reinforced Concrete (SFRC) shows a time-dependent characteristic due to the hydration process of the cement matrix in the SFRC system. The effect of two important factors, water/cement (w/c) ratio and fiber volume fraction, on the flexure toughness development of SFRC were investigated. Three different SFRC mixtures with hooked-end steel fibers were tested using a four-point bending testing configuration. Each mixture was tested at five different ages. The results showed that the post-peak toughness of SFRC developed at an earlier age than the first-crack toughness.

• 약학회지
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• 제39권6호
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• pp.689-694
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• 1995

Sphingolipids play important roles in cell regulation and signal transduction. Recently, a sphinogomyelin cycle has been described in which activation of neutral sphingomyelinase leads to the breakdown of sphingomyelin and the generation of ceramide. Ceramide, in turn, has emerged as a candidate intracellular mediator for the action of certain cell agonists and has multiple biologic actions. Ceramide is a potent suppressor of cell growth and an inducer of apoptosis. The present studies show that exposure of IM-9 cells to ceramide resulted in internucleosomal cleavage of DNA, yielding laddered patterns of oligonucleosomal fragments characteristic of apoptosis. DNA fragmentation induced by ceramide was also confirmed by diphenylamine assay. The effect of ceramide on cell cycle progression was also studied. The addition of ceramide increase G$_{1}$ phase distribution in cell cycle. Cell cycle-related cyclin D$_{1}$ gene expression was decreased in a time-dependent manner. These results suggest that apoptosis induced by ceramide is related to cell cycle associated with the alteration of cell cycle in IM-9 cells.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2000년도 하계학술대회 논문집
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• pp.29-32
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• 2000

In this paper, an analytical model for I-V characteristics of a HEMTs is Proposed. The developed model takes into account the temperature dependence of drain current. In high-speed ICs for optical communication systems and mobile communication systems, temperature variation affects performance; for example the gain, efficiency in analog circuits and the delay time, power consumption and noise mrgin in digital circuits. To design such a circuit taking into account the temperature dependence of the current-voltage characteristic is indispensible. This model based on the analytical relation between surface carrier density and Fermi potential including temperature dependent coefficients.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 하계학술대회 논문집 B
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• pp.834-836
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• 2003

This paper describes the optimal design, construction and performance evaluation of coaxial shunts used in high current testing laboratory for current measuring system. These shunts, which are of tubular type coaxial shunts, the currents to be measured range from Amperes to several kiloAmperes, and the frequency of the signals has a bandwidth from DC to megaHertz. The shunt must have the mechanical strength to support the forces produced by the transient current, above all, the measuring capabilities of shunt are dependent upon short response time and it must be as free as possible of inductive effects. In this paper presents both characteristic of shunt and design of tubular type coaxial shunt.

• 한국신뢰성학회지:신뢰성응용연구
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• 제17권4호
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• pp.316-324
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• 2017

Purpose: The purpose of this study is to determine the replacement cycle applied age replacement policy by reliability analysis based on railway vehicle contactor's failure history data. Method: We performed reliability analysis based on railway vehicle contactor's failure history data. We found a suitable distribution by goodness of fit test and predicted the reliability through estimation of scale & shape parameter. Considering cost information we determined the replacement cycle that minimize the opportunity cost. Result: Suitable distribution was the Weibull and scale parameter & shape parameter are estimated by reliability analysis. The replacement cycle was predicted and MTTF, $B_6$ percentile life were suggested additionally. Conclusion: We confirmed that failure rate type of railway vehicle contactor is degradation model having a time dependent characteristic and examined the replacement cycle in our country's operating environment. We expect that this study result contribute to railway operation agency for maintenance policy decision.

• 대한조선학회논문집
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• 제34권1호
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• pp.77-86
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• 1997

최근들어 안전하고 합리적인 구조를 설계하기 위하여 구조물의 내충돌 또는 내충격에 대한 요구와 관심이 높아지고 있는데, 이러한 문제들은 아주 짧은 시간동안에 대변형이 일어나는 비선형문제라는 특징이 있다. 구조재료는 변형속도가 빨라짐에 따라 정적인 범주에서 보이는 거동과는 달리 변형률 의존적인 거동을 보인다. 따라서 대변형 소성문제인 충돌해석 등에는 종래 사용하여 온 변형률 비의존 재료구성방정식으로는 한계가 있다. 이 논문에서는 이러한 점을 개선하기 위하여 연강의 소성거동을 잘 나타낼 수 있는 소성슬립모델을 채용하고, 비선형경화를 도입하여 변형도 적용범위를 확장한 대변형 탄소성 변형률의존 재료구성방정식을 제시하였다. 본 구성방정식의 특징으로 항복조건과 하중조건이 필요없기 때문에 계산이 간편하며, 전위밀도와 속도로써 소성을 표현하기 때문에 보다 물리적인 의미를 가지고 금속재료의 소성현상을 나타낼 수 있다.

• Structural Engineering and Mechanics
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• 제54권5호
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• pp.1017-1044
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• 2015

This study aimed to investigate the random vibration characteristic of train-slab track-bridge interaction system subjected to both track irregularities and earthquakes by use of pseudo-excitation method (PEM). Each vehicle subsystem was modeled by multibody dynamics. A three-dimensional rail-slab- girder-pier finite element model was created to simulate slab track and bridge subsystem. The equations of motion for the entire system were established based on the constraint condition of no jump between wheel and rail. The random load vectors of equations of motion were formulated by transforming track irregularities and seismic accelerations into a series of deterministic pseudo-excitations according to their respective power spectral density (PSD) functions by means of PEM. The time-dependent PSDs of random vibration responses of the system were obtained by step-by-step integration method, and the corresponding extreme values were estimated based on the first-passage failure criterion. As a case study, an ICE3 high-speed train passing a fifteen-span simply supported girder bridge simultaneously excited by track irregularities and earthquakes is presented. The evaluated extreme values and the PSD characteristic of the random vibration responses of bridge and train are analyzed, and the influences of train speed and track irregularities (without earthquakes) on the random vibration characteristic of bridge and train are discussed.

• 대한수의학회지
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• 제43권4호
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• pp.641-648
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• 2003

Changes of plasma DNA contents and serum biochemical values were measured in rats administered with $HgCl_2$ to investigate the in vivo cytotoxic effects of mercury and examine the usefulness of these changes as indicators of mercury exposure and diagnosis of mercury poisoning. Rats were given once intraperitonealy $HgCl_2$(0.13. 0.32. 0.8 and 2 mg/kg b.w) and the changes of plasma DNA contents and serum biochemical values were measured at the time of 2, 4, 8, 24, 48 and 72 hours after the administration of $HgCl_2$. Plasma DNA contents began to increase from 2 hours after the administration of $HgCl_2$ in all the treatment groups significantly compared to control with dose-dependent pattern. The levels of plasma DNA reached to peak at 48 hours as 2.77, 7.60, 15.46 and 16.51 times higher than control in each treatment group of 0.13, 0.32, 0.8 and 2 mg/kgb.w, respectively and remained to be higher until 72 hours after the administration. The values of creatine kinase, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, blood urea nitrogen and glucose of serum were increased, however the values of alkaline phosphatase, total protein and triglyceride were decreased. These changes of increase and decrease showed dose-dependent pattern but the starting time, maintenance and magnitude of change were various and characteristic according to serum biochemical indices. Among the changes of serum biochemical values, those of aspartate aminotransferase, lactate dehydrogenase and blood urea nitrogen were apparently and significantly increased compared to control from 2 to 72 hours by the administration of 2 mg/kg $HgCl_2$. This study demonstrates that plasma DNA and serum biochemical values such as aspartate aminotransferase, lactate dehydrogenase, blood urea nitrogen and etc. are valuable as biomarkers for mercury exposure assessment and diagnosis of mercury poisoning.