• Genomics & Informatics
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• 제13권2호
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• pp.60-67
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• 2015

The leading cause of cancer mortality globally amongst the women is due to human papillomavirus (HPV) infection. There is need to explore anti-cancerous drugs against this life-threatening infection. Traditionally, different natural compounds such as withaferin A, artemisinin, ursolic acid, ferulic acid, (-)-epigallocatechin-3-gallate, berberin, resveratrol, jaceosidin, curcumin, gingerol, indol-3-carbinol, and silymarin have been used as hopeful source of cancer treatment. These natural inhibitors have been shown to block HPV infection by different researchers. In the present study, we explored these natural compounds against E6 oncoprotein of high risk HPV18, which is known to inactivate tumor suppressor p53 protein. E6, a high throughput protein model of HPV18, was predicted to anticipate the interaction mechanism of E6 oncoprotein with these natural inhibitors using structure-based drug designing approach. Docking analysis showed the interaction of these natural inhibitors with p53 binding site of E6 protein residues 108-117 (CQKPLNPAEK) and help reinstatement of normal p53 functioning. Further, docking analysis besides helping in silico validations of natural compounds also helped elucidating the molecular mechanism of inhibition of HPV oncoproteins.

• Neonatal Medicine
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• 제28권1호
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• pp.59-63
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• 2021

An important, albeit rare, cause of fetal bradycardia is long QT syndrome (LQTS). Congenital LQTS is an ion channelopathy caused by mutations in genes encoding cardiac ion channel proteins. Fetal onset of LQTS imposes high risk of life-threatening tachyarrhythmias and sudden cardiac death. Here, we report the case of a female newborn with fetal onset of bradycardia and a 2:1 atrioventricular (AV) block. After birth, a 12-lead electrocardiogram (ECG) revealed bradycardia with QT prolongation of a corrected QT (QTc) interval of 680 ms and pseudo 2:1 AV block. Genetic testing identified a heterozygous Gly402Ser (c.1204G>A) mutation in CACNA1C, confirming the diagnosis of LQTS type 8 (LQT8). The patient received propranolol at a daily dose of 2 mg/kg. Mexiletine was subsequently administered owing to the sustained prolongation of the QT interval and pseudo 2:1 AV block. One week after mexiletine inception, the ECG still showed QT interval prolongation (QTc, 632 ms), but no AV block was observed. There were no life-threatening tachyarrhythmias in a follow-up period of 13 months.

• Archives of Plastic Surgery
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• 제48권1호
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• pp.10-14
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• 2021

Soft tissue filler injections are widely used due to their immediate effects, predictable results, and high stability. However, as the use of soft tissue filler injections has increased, various complications have been reported. We report a life-threatening complication in a patient who developed sepsis and necrotizing fasciitis. A 45-year-old woman presented with right leg pain and discharge from the labia majora. The patient had received a soft tissue filler injection of unknown composition 1 year earlier and had recently undergone incision and drainage for an inflammatory cystic nodule. Antibiotic treatment was administered for cellulitis, but the infection progressed to necrotizing fasciitis and sepsis. Fasciotomy and intensive care unit treatment improved the systemic infection, but the soft tissue filler injection site did not respond to treatment for 1 month. Thus, the injection site was covered with a pedicled vertical rectus abdominis musculocutaneous flap after wide excision. The area of skin necrosis on the leg was covered with split-thickness skin grafts. Infections occurring after soft tissue filler injections are related to biofilms, and treatment is sometimes difficult. Therefore, although soft tissue filler injections have a favorable safety profile, it is important to be aware of the risk of life-threatening complications.

• Journal of Chest Surgery
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• 제38권10호
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• pp.725-728
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• 2005

환아는 생후 18개월 된 여아로 반복적인 위급한 과량의 객혈을 주소로 입원하였다. 과거력상 생후 6개월에 중증의 심비대 소견을 보이는 심방중격결손증을 진단받았으며 폐정맥 협착이 심비대에 의한 압박으로 생긴 이차적인 병변일 것이라 추정하여 심방중격결손폐쇄술만 시행하였다. 술 후 환아는 심비대와 폐정맥 협착이 완화된 소견을 보였다. 그러나 추적 관찰 중 환아는 반복적인 다량의 객혈로 다시 입원하였고 전산화단충촬영 소견 상 폐정맥 협착이 다시 심해진 것으로 판독되었으며 기관지 주변에 성상을 알 수 없는 연조직 종괴들이 좌측 기관지를 압박하고 있었다. 정확한 위치를 알 수 없는 반복적인 객혈로 인해 시험적 개흉술이 불가피하였고, 수술 소견상 좌폐정맥은 하나였으며 외견상 협착의 소견을 보였다. 좌측 기관지 주변에는 다발성 임파절 비대가 기관지를 압박하고 있었다. 또한 수술 중 다량의 객혈이 발생하여 전폐절제술을 시행할 수밖에 없었다. 술 후 병리 소견은 폐정맥 협착과 일치하였다. 환아는 2일간의 중환자실 관리 후 6일째 합병증 없이 퇴원하였다. 2개월간 추적 관찰되었으며 증상 없이 양호한 경과를 보이고 있다. 그러나 향후 지속적인 추적 관찰이 필요할 것으로 생각한다.

• 인지과학
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• 제20권1호
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• pp.51-77
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• 2009

많은 연구들은 부정과년 자극의 처리가 그 처리자의 정서 상태에 따라 다른 처리가 이루어진다는 것을 주장하였다. 정서 정보 지각의 특성은 크게 두 가지 가정에 의해 논의되었다: 주의 결속(attentional engagement)에서의 차이와 주의해제(attentional disengagement)에서의 차이. 본 연구는 Posner의 cue-target 실험 패러다임을 이용하여 정서 정보 지각이 일반 자극의 지각과 어떠한 위치에서 차이가 나는지를 규명하고자 하였다. 단어 자극을 사용한 실험1과 얼굴 자극을 사용한 실험 2 모두에서 기존의 Fox(2001)에서 나온 결과와는 다르게 정서 자극의 지각이 일반자극의 지각에 비해 주의 결속에서 빠른 반응을 나타냈으며, 이런 경향성은 불안 수준이 높은 피험자에게서만 관찰되었다. 또한, 불안 수준이 높은 피험자들은 일반 피험자들 보다 단서와 목표자극이 일치되는 조건에서 느린 반응을 보였다. 실험 1과 2의 결과가 이 효과와 정서의 혼입되어 나온 결과인가에 대한 통제 실험을 시행한 실험 3에서는 정서 자극 제시 없이 일치 불일치에 대한 결과만을 보았다. 실험 3의 결과는 실험 1과 2가 정서와 피험자의 정서 상태에 의한 결과임을 지지하였다. 따라서 본 연구는 불안이라는 정서 상태가 부정적인 자극에 대한 지각을 빠르게 하는 이유가 정서 자극에 대한 빠른 주의결속이 있기 때문임을 지지하고 있다.

• 대한기관식도과학회지
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• 제2권1호
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• pp.129-134
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• 1996

Acquired nonmalignant tracheoesophageal fistulas were formerly considered rare lesions, but they have been increasingly reported in the recent past. The pathognomonic complaints of this life-threatening lesion are strangulating sensations and frequent paroxysmal coughings occurring several seconds after the ingestion of liquids or solids. Until the past decade, this lesion was most often caused by infection, trauma, or esophageal diverticula. Complications caused by cuffed tracheal tubes are now becoming more widely noticed. Especially, tracheoesophageal fistula is one of the more unusual of these complications. Author reports two patients with tracheoesophageal fistula caused by cuffed tracheal tube.

• 대한치과의사협회지
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• 제51권12호
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• pp.637-642
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• 2013

Because the implant is regarded as a common treatment. It is clinically important that systemic and local risk factor of threatening peri implant mucosa should be considered during the process. The most risk factors are detected in clinical diagnosis, but it might be difficult and not clear to recognize systemic or combined factors. This article reviews risk factors of peri-implantitis. Local factors are biomechanics, periodontal soft tissue characteristics, infected site and oral hygiene. Systemic factors are alcohol, smoking and genetic traits.

• 한국해안해양공학회:학술대회논문집
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• 한국해안해양공학회 1996년도 정기학술강연회 발표논문 초록집
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• pp.60-63
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• 1996

Industrialization and urbanization of coastal areas in recent years have brought about a lot of coastal marine environmental problems. Water quality problems such as eutrophication or pollution by toxic chemicals are especially serious, threatening coastal ecosystems. These problems are mainly induced by anthropogenic loads of materials from the land. In order to design suitable counter measures, we should well understand the processes causing the problems. (omitted)

• Journal of Yeungnam Medical Science
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• 제37권1호
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• pp.63-66
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• 2020

Purulent pericarditis is defined as a localized pericardial infection with gross pus formation in the pericardial space. Although purulent pericarditis is now rare in the antibiotic era, it may be life-threatening. We describe a rare case of purulent pericarditis that originated from a subdiaphragmatic suppurative focus in an immunocompromised host.

• Journal of Korean Neurosurgical Society
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• 제42권5호
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• pp.400-402
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• 2007

Isolated cerebral mucoromycosis, without rhino-orbital focus, is an extremely rare but life-threatening infection of central nervous system that most commonly found in intravenous drug abuser. We present a case of isolated cerebral mucormycosis diagnosed by open biopsy and treated with amphotericin B. The patient has returned to independent living.