• Journal of Korean Medical classics
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• v.25 no.3
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• pp.39-49
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• 2012

Objective : "Sikryochanyo"written by Jeon Soonyi is the first Food-Therapy book at Korea. In "Sikryochanyo", there are many kinds of food-Therapy including prescriptions for thirst disease. Conception of hirst disease in traditional mendicine contains diabetes in some aspects. One of the Ingeative methods in diabetes limits taking protein but "Sikryochanyo" shows several prescriptions including protein. Method : We will try to find out cases of Food-therapy for thirst disease in "Sikryochanyo" and classify several prescriptions including protein. Result : In "Sikryochanyo", several prescriptions for thirst disease including protein were treated as materia medica widely such as stomach of cow and pig, intestine of pig, head of dear, rabbit, chicken, goose, pheasant, milk and lung of sheep. Conclusion : On several types of prescriptions for thirst disease including protein there are plenty of usage with its own effectiveness.

• Journal of Korean Medical classics
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• v.24 no.1
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• pp.85-93
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• 2011

Wasting-thirst(消渴) occurs due mainly to dryness-heat(燥熱) which by depleting 'Fluid and Humor'(津液) make symptoms of thirst(口渴) swift digestion with rapid hungering(消穀善饑) frequent urination(小便頻數) according to "Internal Classic"(內經). However, the doctors of those days had a tendency to manage wasting-thirst with herbal drugs of dryness-heat or with drugs that tonifies the kidney. Liu Wansu(劉完素) thought that those kinds of drugs intensify gatro-intestinal dryness-heat and consequently could not be suitable for the patients with wasting-thirst. He said that they had mistaken about the relation between five viscera(五臟) and six climate condition(六氣) and that they did not know thoroughly on the theory of branch and root(標本). For preventing the disease of wasting-thirst, Liu Wansu(劉完素) recommended avoiding gatro-intestinal drying caused by the intake of dryness-heat diet, and warned not to deplete 'Fluid and Humor' due to stress-induced fire(火), not to damage yin qi(陰氣) through severe diseases.

• Herbal Formula Science
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• v.27 no.2
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• pp.179-187
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• 2019

Objective : The purpose of this paper is to analyze the difference between Baekho-tang(白虎湯) and Baekhogainsam-tang (白虎加人蔘湯). Methods : We compared the effect of Baekho-tang on atopic dermatitis and the effect of Baekhogainsam-tang on allergic contact dermatitis. We focused on the level of thirst. Results : After the Baekho-tang treatment, the SCORAD of atopic dermatitis patient decreased $63.8{\rightarrow}4.3$ and VAS of pruritus on atopic dermatitis patient were improved $8{\rightarrow}2$ respectively. Meanwhile, after the Baekhogainsam-tang treatment, the VAS of pruritus on allergic contact dermatitis patient was improved $7{\rightarrow}2$ and the thirst of the patient improved. Conclusions : There is a difference between Baekho-tang and Baekhogainsam-tang at the level of thirst. Baekhogainsam-tang continues to thirst hard enough to find water.

• The Journal of Korean Medical History
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• v.21 no.2
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• pp.95-113
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• 2008

Unsatisfied with the modern medicine's treatment of diabetes, patients diagnosed with the disease turn to alternative medicine for treatment. A look at the percentage of people using alternative medicine marked 72.8% in the United States and more than 60% in Korea in 2006. The most preferred form of alternative medicine turned out to be usage of dietary supplements and herbal medicine. Most of the dietary supplements and herbs that diabetic patients use largely originated from their usage in East Asian Traditional Medicine. As Western Medicine made its way into East Asia in late 18th century, excessive efforts were made to translate Western medical terminology into traditional medical terminology equivalents. In the process of doing so, wasting-thirst became a concept equivalent to diabetes. Theories regarding the pathogenic outbreak and transmission of wasting-thirst has been supplemented and progressed according to needs and even showed new tendencies. Profound understanding of wasting-thirst achieved through historical research is expected to lead to proper application of wasting-thirst treatment methods in treating modern diabetes.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.3
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• pp.265-272
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• 2012

The applicability of Diabetes Mellitus(DM) in Oriental Medicine might be placed under the category in Wasting-thirst(消渴, WT). However, because of WT having so various concepts, classification, and names in Oriental Medicine, this resulted in confusion in applying WT treatment to DM. WT occurs mainly due to dryness-heat(燥熱) which by depleting 'Fluid and Humor'(津液) makes symptoms of thirst(口渴) swift digestion with rapid hungering(消穀善饑) frequent urination(小便頻數) according to the "Internal Classic"(內經). WT was also called Sodan(消癉), Bidan(脾癉), or Sojoong(消中) in the "Internal Classic", which was caused by not only the disorder of 'five viscera' (五臟), but also the failure of 'three yin and three yang'(三陰三陽). However, the doctors of those days had a tendency to manage WT (including DM) with herbal drugs of dryness-heat or with drugs that recover the pancreas and the kidney, that have a tendency to appreciate that WT is the disease of 'five viscera'(五臟). Accoding to the "Internal Classic"(內經) and "Jinguiyaolue"(金匱要略), WT was appreciated that WT is also due to the disorder of Meridian including 'three yin and three yang'(三陰三陽) theory. Disorder of 'yang brightness'(陽明) or 'reverting yin'(厥陰) would cause Wasting-thirst(消渴), so the 'three yin and three yang'(三陰三陽) theory should be considered in WT treatments. Furthermore, 'yang brightness'(陽明) and 'reverting yin'(厥陰) all belong to 'the door'(闔) in the bolt-door-pivot(關闔樞) theory, and the mean of 'the door'(闔) is the function of storage, so we could understood WT is the wasting disease due to the disorder of 'the door'(闔) system in Meridian. WT should also be understood by the point of the bolt-door-pivot(關闔樞) theory in addition to the 'three yin and three yang'(三陰三陽) theory.

• Journal of Korean Biological Nursing Science
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• v.21 no.3
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• pp.169-177
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• 2019

Purpose: The purpose of this paper was to identify blood pressure, interdialytic weight gain, thirst and intradialytic discomfort in subjects after applying individual low-sodium dialysis fluid (1,2,3 mEq/L) to hemodialysis patients for 12 weeks. Methods: This study was a non-equivalent pre-post design. For 12 weeks, dialysate concentration was maintained at 1 mEq/L or 2 mEq/L or 3 mEq/L based on average sodium concentration of each individual, and the difference was compared after applying individually. Results: Change in blood pressure significantly decreased in the group where in pre-hemodialysis systolic pressure decreased the gradient of sodium concentration in serum sodium and dialysis solution by 2mEq/L. Interdialytic weight gain, and thirst showed significant decrease in all three groups. But in all three groups, intradialytic discomfort among dialysis showed no significant changes. Conclusion: Although application of low sodium dialysis fluid showed no change in intradialytic discomfort, lowered blood pressure, thirst, and interdialytic weight gain, which could be used for individual showing increased interdialytic weight gain and increased blood pressure. There is need for continued study on this.

• Journal of Sasang Constitutional Medicine
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• v.27 no.1
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• pp.178-188
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• 2015

Objectives The aim of this study was to examine significant improvement of motor and non-motor symptoms after treatment with Sasang constitutional medicine treatment on a Soyangin patient with early-stage Parkinson's disease. Methods The patient was treated with Soyangin's constitutional medications (herb and acupuncture) and scalp acupuncture. The progress was evaluated using the Unified Parkinson Disease Rating Scale (UPDRS) before and after treatment. The UPDRS was used to assess the overall function of patient. Results We observed a significant improvement in patient's motor and non-motor symptoms using UPDRS. The UPDRS score decreased in Part I, Part II, and Part III. Conclusions This study shows that Sasang constitutional medicine can be effective treatment for Soyangin patient with early-stage Parkinson's disease.

• YAKHAK HOEJI
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• v.46 no.5
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• pp.352-357
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• 2002

The three crude drugs of the Kalopanax pictus (Araliaceae) roots (K), Pueraria thunbergiana (Leguminosae) flowers (P), and the Rhus verniciflua (Anacardiaceae) heartwood(R) used for anti-thirst drugs in Oriental herb medicine were extracted with MeOH, respectively, and the successive fractionation of the extract gave EtOAc extract. Certain amount ratios of the three extracts were also prepared to compare the antimutagenicity in Ames test. In N-methyl-N(-nitro-N-nitrosoguanidine (MNNG; 0.4 (g/plate)-induced test, the activities of complex mixture were observed between the highest antimutagenic activity of K extract and the lowest P extract. In aflatoxin (AFB$_1$)-induced test, the EtOAc complex (K : P : R=l : 1 : 3) labeled E-113 decreased the revertants of Salmonella typhimurium TA100 by 95％, which activity were highest among other extracts or complexes mixture used. Fractionation of organic solvent mostly increased the antimutagenicity. These trends were also observed in the antimutagenicity test of the mixture of each active component of kalopanaxsaponin A, tectorigenin and sulfuretin. These results supported that many kinds of anti-thirst herb medicine in the prescription could effectively prevent cancer disease.

• The Korea Journal of Herbology
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• v.28 no.5
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• pp.53-60
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• 2013

Objectives : To prove the channel-tropism theory in herbology, we investigated the anti-diabetic effect of six herbal plants used for lower wasting-thirst in streptozotocin-induced diabetic rats. Methods : Diabetes was induced in male Sprague-Dawley rats by consecutive injection of streptozotocin (30 mg/kg i.p.) for 5 days. The rats were divided into normal control, diabetic control, and diabetic treatment with Lycii Radicis Cortex (LRC, 300 mg/kg); Corni Fructus (CF, 300 mg/kg); Bombyx Batryticatus (BB, 50 mg/kg); Lycii Fructus (LF, 300 mg/kg); Phellodendri Cortex (PC, 300 mg/kg); Epimedii Herba (EH, 300 mg/kg); and glibenclimide (10 mg/kg) as a reference drug. Herbal extracts or reference drug were administered orally for 28 days. The changes of body weight, food intake and water intake, and serological markers such as blood glucose, serum total cholesterol, triglyceride (TG), blood urea nitrogen (BUN), and creatinine (Cr) were measured. Results : The decrease of body weight and the increase of food and water intake in STZ-induced diabetic rats was improved by the administration of CF and LF. Also, the enhancement of blood glucose and serum total cholesterol, TG, BUN and Cr in STZ-induced diabetic rats was significantly inhibited by the administration of CF, BB, LF and glibenclimide. On the other hand, EH strongly inhibited the increase of BUN and Cr in the sera of STZ-induced diabetic rats. Conclusions : These results suggest that among six herbal medicines used lower emaciation of emaciation-thirst disease, CF, BB, LF and EH show a characteristics including the channel-tropism theory.

• The Korea Journal of Herbology
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• v.29 no.5
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• pp.75-81
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• 2014

Objectives : This study was performed to investigate the effect of root extract of Pueraria thunbergiana Bentham (Puerariae Radix, PR) in diabetic mice as similar as emaciation-thirst disease in Oriental medicine. Methods : C57BL/6 mice were fed high fat (HF) and high sucrose (HS) for 8 weeks, and then administrated with 90 mg/kg body weight (bw) of streptozotocin (STZ) for induction of diabetes which is similar to the middle emaciation stage. After 5 days, blood glucose levels were measured, and selected the mice with ranges above $250mg/d{\ell}$. PR water extract was administrated orally once a day for 4 weeks with high fat and high sucrose. The levels of glucose, insulin, total cholesterol, triglyceride, ${\gamma}glutamyl$ transpeptidase (${\gamma}GTP$), glutamic oxaloacetic transaminase (GOT) and glutamate pyruvate transaminase (GPT) were analysed in the serum. Also, observed their histological changes by hematoxylin and eosin (H&E) of different organs, lung, heart, pancreas, stomach, liver, and kidney. Results : PR extract significantly decreased the levels of serum glucose and insulin in diabetic mice. PR extract significantly increased the levels of triglyceride, total cholesterol, GOT and GPT in diabetic mice. In H&E stain, PR extract inhibited the histopathological changes of lung (as a channel of the upper emaciation stage in the channel-tropism theory), pancreas (as a channel of the middle emaciation stage) and kidney (as a channel of the lower emaciation stage) in diabetic damage. Conclusions : PR extract has an anti-diabetic effect in HF/HS and low-dose STZ-induced diabetic mice. This result suggests that PR follows the channel-tropism theory in the emaciation-thirst disease through the protection of lung, pancreas and kidney.