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Antimutagenic Effect of the Extract Complex of Korean Anti-thirst Herb Medicines  

박건영 (부산대학교 식품영양학과)
정근옥 (부산대학교 식품영양학)
이경태 (경희대학교 약학대)
최종원 (경성대학교 약학대)
정현주 (상지대학교 응용식물과학)
박희준 (상지대학교 응용식물과학부)
Publication Information
YAKHAK HOEJI / v.46, no.5, 2002 , pp. 352-357 More about this Journal
Abstract
The three crude drugs of the Kalopanax pictus (Araliaceae) roots (K), Pueraria thunbergiana (Leguminosae) flowers (P), and the Rhus verniciflua (Anacardiaceae) heartwood(R) used for anti-thirst drugs in Oriental herb medicine were extracted with MeOH, respectively, and the successive fractionation of the extract gave EtOAc extract. Certain amount ratios of the three extracts were also prepared to compare the antimutagenicity in Ames test. In N-methyl-N(-nitro-N-nitrosoguanidine (MNNG; 0.4 (g/plate)-induced test, the activities of complex mixture were observed between the highest antimutagenic activity of K extract and the lowest P extract. In aflatoxin (AFB$_1$)-induced test, the EtOAc complex (K : P : R=l : 1 : 3) labeled E-113 decreased the revertants of Salmonella typhimurium TA100 by 95％, which activity were highest among other extracts or complexes mixture used. Fractionation of organic solvent mostly increased the antimutagenicity. These trends were also observed in the antimutagenicity test of the mixture of each active component of kalopanaxsaponin A, tectorigenin and sulfuretin. These results supported that many kinds of anti-thirst herb medicine in the prescription could effectively prevent cancer disease.
Keywords
anti-thirst; antimutagenicity; extract mixture; Kalopanax pictus; Pueraria thunbergiana; Rhus verniciflua;
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Times Cited By KSCI : 1  (Citation Analysis)
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