• 설비공학논문집
• /
• 제21권1호
• /
• pp.41-48
• /
• 2009

The present study has been performed to investigate the thermal characteristics of under-ventilated compartment fire which is a typical fire condition in structures. A series of fire experiments was conducted to characterize the thermally driven flow in a 2/5 scale ISO 9705 fire compartment. Three different fuels were used in this test series, methane gas, heptane pool, and polystyrene pellets fire. In order to measure accurate temperature, double shield aspirated thermocouples reducing the effect of radiative energy exchange on temperature measurement were used in addition to bare bead thermocouples. The upper layer temperature for well ventilated fire was increased with increasing heat release rate, but it was slightly decreased for under-ventilated fire. The measured temperatures in the upper layer at the front sampling location were higher than at the rear. Thermal characteristics through the doorway were also analysed for a wide range of heat release rates. This study provides a comprehensive and quantitative assessment of fire behavior for under-ventilation condition of fire.

• Journal of Pharmaceutical Investigation
• /
• 제28권3호
• /
• pp.177-183
• /
• 1998

Low toxicity, reverse thermal gelation and high drug loading capabilities suggest that poloxamer 407 gels have great potential as a topical drug delivery system. Kojic acid (KA) is an antimelanogenic agent which has been widely used in cosmetics to whiten the skin color. However, it has the drawbacks of skin irritancy due to its acidic pH. Poloxamer gels of different polymer contents were formulated to overcome the problem and compared to the cream type formulations of either w/o/w multiple emulsion cream or o/w type emulsion cream. Using Franz diffusion cells mounted with a synthetic cellulose membrane (MWCO 12,000), drug release characteristics of the formulations were evaluated by the HPLC assay of KA concentration in the receptor compartment of pH 7.4 phosphate buffered saline solutions. Drug release from w/o/w multiple emulsion cream was controlled by oil membrane, showing the apparent zero order release kinetics. The KA release from the poloxamer gels was also controlled by the gel matrix, showing that drug release increased linearly as KA contents increase, but decreased exponentially as the polymer contents increase. In the skin irritancy test, the primary irritancy index(PII) of poloxamer gel base was lower than those of multiple emulsion cream base and o/w cream. Depending on KA contents or polymer contents in the gel. PH values in poloxamer gels were ranged from 1.3 to 2.0, which are interpreted as low or negligible irritation on skin. There was a good correlation between the log value of flux in drug release and PII value in skin irritation. It was possible to conclude that the poloxamer gels containing KA might be a good candidate for an antimelanogenic topical delivery system by virtue of the controlled release of the drug and the reduced skin irritancy.

• Journal of Pharmaceutical Investigation
• /
• 제41권2호
• /
• pp.67-73
• /
• 2011

Ion exchange resins can be one of the good carriers for sustained drug release. However, the sustained release may not be enough only with themselves and hence film coating with rate controlling polymers can be applied to have a further effect on the drug release. Due to the environmental and economic issues of organic solvent for the polymer coating, aqueous polymeric systems were selected to develop dosage forms. Among the many aqueous polymeric dispersions for the film coating, EC (ethylcellulose) based polymers such as Aquacoat$^{(R)}$ ECD and Surelease$^{(R)}$ were evaluated.A fluid-bed coating was applied as a processing method. The drug release rate was quite dependent on the coating level so the release rate could be modified easily by changing different levels of the coating. The drug release rate in the Aquacoat$^{(R)}$ coated resin particles was strongly dependent on curing, which is a thermal treatment to make homogeneous films and circumvent drug release changes during storage. After dissolution test using the compressed tablets in which the coated resin particles are contained, inhomogeneous coating and even pores could be observed showing that the mechanical properties of EC were not resistant to granulation and compaction process. However, when tablets were prepared in different batches, the release profiles were almost identical showing the feasibility of the coated resin particle as incorporated into the tablet formulation.

• Tribology and Lubricants
• /
• 제17권5호
• /
• pp.358-364
• /
• 2001

Disk brake system transforms a large amount of kinetic energy to thermal energy in a short time. As the size and speed of automotive increases in recent years, the disk brakes absorbs more thermal energy. And this thermal energy can cause an unacceptable braking performance due to the high transient temperature, that is attained at the friction surface of brake disk and pad. Although these high temperatures are one of the biggest problems. In this study, the overall thermal behavior of ventilated disk brake system was investigated by numerical method. The 3-Dimensional unsteady model was simulated by using a general purpose software package “FLUENT” to obtain the temperature distributions of disk and pad. The model includes the more realistic braking method, which repeats braking and release. The effects of several parameters such as the repeated braking, inlet air velocity and thermal conductivity on the temperature distribution were investigated.

• Nuclear Engineering and Technology
• /
• 제54권7호
• /
• pp.2367-2375
• /
• 2022

In this work, we propose a new mechanistic model for the treatment of helium behaviour at the grain boundaries in oxide nuclear fuel. The model provides a rate-theory description of helium inter-granular behaviour, considering diffusion towards grain edges, trapping in lenticular bubbles, and thermal resolution. It is paired with a rate-theory description of helium intra-granular behaviour that includes diffusion towards grain boundaries, trapping in spherical bubbles, and thermal re-solution. The proposed model has been implemented in the meso-scale software designed for coupling with fuel performance codes SCIANTIX. It is validated against thermal desorption experiments performed on doped UO₂ samples annealed at different temperatures. The overall agreement of the new model with the experimental data is improved, both in terms of integral helium release and of the helium release rate. By considering the contribution of helium at the grain boundaries in the new model, it is possible to represent the kinetics of helium release rate at high temperature. Given the uncertainties involved in the initial conditions for the inter-granular part of the model and the uncertainties associated to some model parameters for which limited lower-length scale information is available, such as the helium diffusivity at the grain boundaries, the results are complemented by a dedicated uncertainty analysis. This assessment demonstrates that the initial conditions, chosen in a reasonable range, have limited impact on the results, and confirms that it is possible to achieve satisfying results using sound values for the uncertain physical parameters.

• 약학회지
• /
• 제45권6호
• /
• pp.623-633
• /
• 2001

Various bupivacaine-loaded microspheres were prepared using poly(d,1-lactide) (PLA) and poly(d,1-lactic-co-glycolide) (PLGA) by a solvent evaporation method for the sustained release of drug. The effects of process conditions such as drug loading, polymer type and solvent type on the characteristics of microspheres were investigated. The prepared microspheres were characterized for their drug loading, size distribution, surface morphology and release kinetics. Drug loading efficiency and yield of PLGA micro- spheres were higher than those of PLA microspheres. The prepared microspheres had an average particle size below 5${\mu}{\textrm}{m}$. The particle size range of microspheres was 1.65~2.24${\mu}{\textrm}{m}$. As a result of SEM, the particle size of PLA microspheres was smaller than that of PLGA microspheres. In morphology studies, microspheres showed a spherical shape and smooth surface in all process conditions. In thermal analysis, bupivacaine-loaded microspheres showed no peaks originating from bupivacaine. This suggested that bupivacaine base was molecular-dispersed in the polymer matrix of microspheres. The release pattern of the drug from microspheres was evaluated for 96 hours. The initial burst release of bupivacaine base decreased with increasing the molecular weight of PLGA, and the drug from microspheres released slowly. In conclusion, bupivacaine-loaded microspheres were successfully prepared from poly(d,1-lactide) and poly (d,1- lactic-co-glycolide) polymers with different molecular weights allowing control of the release rate.

• Archives of Pharmacal Research
• /
• 제23권4호
• /
• pp.367-373
• /
• 2000

Cholic acid, conjugated with amine-terminated poly(W-isopropylacrylamide) (abbreviated as CA/ATPNIPAAm), was synthesized by a N, N'-dicyclohexyl carbodiimide (DCC)-mediated coupling reaction. Self-assembled CA/ATPNIPAAm micelles were prepared by a diafiltration method in aqueous media. The CA/ATPNIPAAm micelles exhibited a lower critical solution temperature (LCST) at $31.5^{\circ}C$. Micelle sizes measured by photon correlation spectroscopy (PCS) were approximately 31.6 $\times$$\times$ 5.8 nm. The CA/ATPNIPAAm micelles were spherical and their thermal size transition was observed by transmission electron microscope (TEM). A fluorescence probe technique was used for determining the micelle formation behavior of CA/ATPNIPAAm in aqueous solutions using Pyrene as a hydrophobic Probe. The critical micelle concentration (CMC) was evaluated as $8.9{\times}0^{-2}$ g/L. A drug release study was performed using indomethacin (IN) as a hydrophobic model drug. The release kinetics of IN from the CA/ATPNIPAAm micelles revealed a thermo-sensitivity by the unique character of poly(N-isopropylacrylamide) i.e. the release rate was higher at $25^{\circ}C$ than at $37^{\circ}C$.

• 한국의류산업학회지
• /
• 제17권4호
• /
• pp.657-665
• /
• 2015

This study evaluated the thermoregulatory properties of functional thermal underwear ('heating underwear') in markets using a thermal manikin and human wear trials. One ordinary thermal underwear (ORD) and two functional thermal underwear (HEAT1 and HEAT2; manufactured goods, HEAT1: moisture absorbing heat release mechanism, HEAT2: heat storage, release mechanism) were chosen. Thermo-physiological and subjective responses were evaluated at an air temperature of $5.0{\pm}0.5^{\circ}C$ and air humidity of $30{\pm}5%RH$ with five male subjects ($21.6{\pm}1.3yr$ in age, $178.0{\pm}5.9cm$ in height, $68.2{\pm}5.9kg$ in body mass). Experimental conditions consisted of four ensembles that included winter clothes (Control: no underwear, ORD, HEAT1, HEAT2). Water-vapor resistance was greater in fabric of HEAT1 than others. The results were: 1) Total thermal insulation (IT) using a thermal manikin were not greater for HEAT1 (0.860clo) and HEAT 2 (0.873clo) than for ORD (0.886clo). 2) There were no significant differences in rectal temperature, mean skin temperature, heart rate and total body mass loss between the four conditions. Microclimate clothing temperature on the back was greater for ORD than for HEAT1 and HEAT2. Subjects felt more comfortable with HEAT1 than for others at rest. HEAT2 was higher in microclimate humidity when compared to other conditions. The results suggest that thermoregulatory properties of 'heating underwear' in market did not differ from those of ordinary thermal underwear in terms of total thermal insulation and thermoregulatory responses in a cold environment.

• 한국원자력학회:학술대회논문집
• /
• 한국원자력학회 1999년도 추계학술발표회요약집
• /
• pp.247-247
• /
• 1999

This paper describes a new mechanistic thermal conductivity model considering the heterogeneous microstructure of MOX fuel. Even though the thermal conductivities of MOX have been investigated numerously by experimental measurements and theoretical analyses, they show the large scattering making the performance analysis of MOX fuel difficult. Therefore, a thermal conductivity model that depends on the heterogeneous microstructure of MOX fuel has been developed by using a general two-phase thermal conductivity model. In order to apply this model for developing the thermal conductivity for heterogeneous MOX fuel, the fuel is assumed to consist of Purich particles and U02 matrix including Pu02 in solid solution. Since little relevant data on Purich particles is available, FIGARO and SiemensKWU results are only used to characterize the microstructure of unirradiated and irradiated fuel. Philliponneaus and HALDEN models are selected for the local thermal conductivities for Purich particles and matrix, respectively. Then by combining the two models, overall thermal conductivity of MOX fuel is obtained. The new proposed model estimates the MOX thermal conductivity about 10% less than the value of U02 fuel, which is in the range of MOX thermal conductivity from HALDEN. The developed thermal conductivity model has been incorporated into KAERIs fuel performance code, COSMOS, and then verified using the measured data in the FIGARO program. Comparison of predicted and measured temperatures shows the reasonable agreement within acceptable error bounds together with satisfactory results for the fission gas release and gap pressure.essure.

• 한국화재소방학회논문지
• /
• 제31권5호
• /
• pp.19-27
• /
• 2017

밀폐된 구획실 화재에서 화원의 면적 및 위치, 화재성장률, 구획 체적의 변화가 열발생률을 포함한 주요 화재특성에 미치는 영향이 검토되었다. 이를 위해 닫힌 개구부가 적용된 ISO 9705 화재실을 대상으로 Fire Dynamics Simulator (FDS)를 활용한 화재시뮬레이션이 수행되었다. 주요 결론으로서, 화원의 면적 및 위치의 변화는 최대 열발생률, 총 열량, 상층부의 최대 온도 및 화학종 농도를 포함한 구획 내의 열적 특성과 화학적 특성에 큰 영향을 주지 않음을 확인하였다. 그러나 화재성장률과 구획 체적의 증가는 최대 열발생률 및 총 열량의 증가를 가져오며, 한계산소농도의 감소 및 최대 CO 농도의 증가를 발생시킨다. 마지막으로 화재성장률과 구획 체적의 함수로 표현된 최대 열발생률의 상관식을 도출하여, 밀폐된 구획실 화재에 대한 화재성장곡선의 적용을 위한 방법론이 제안되었다.