• 동의신경정신과학회지
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• 제21권4호
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• pp.207-218
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• 2010

1. 본 증례보고에서는 세의 남성 광장공포증을 동반한 공황장애 환자에게 약 개월 동안 계지가용골모려탕(桂枝加龍骨牡蠣湯)Ex제를 주 치료 약물로 작약감초탕(芍藥甘草湯)Ex제를 보조 치료 약물로써 투여한 결과 환자의 주소증인 흉통 및 불안을 포함하여 관련 제반 증상들의 완화되는 효과를 관찰할 수 있었다. 2. Ex제는 탕제(湯劑)와 달리 휴대와 복용이 간편하므로 예기치 못한 공황발작 및 불안 발생 시 투여하기에 적합하다. 따라서 경도-중등도의 불안장애 혹은 공황장애 환자에게 계지가용골모려탕(桂枝加龍骨牡蠣湯)Ex제를 적용하여 그 효과를 검증하는 임상연구가 필요하다.

• 재활치료과학
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• 제2권1호
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• pp.48-56
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• 2013

목적 : 국내 작업치료사들에 의해 가장 많이 사용되는 지필검사인 직선이분 검사 와 알버트 검사를 관찰을 통해 행동적 무시를 평가하는 CBS와 비교하여 상관관계를 살펴보고 편측무시에 대한 민감도가 더 높은 검사 도구를 알아보고자 하는 것이다. 방법 : 기준에 따라 선정된 좌측 편마비 환자 44명을 대상으로 CBS, 직선이분검사, 알버트 검사, K-MBI를 시행하여 편측무시 정도를 비교 분석하였다. 결과 : 관찰을 통한 행동적 무시 검사인 CBS는 지필검사인 직선이분 검사, 알버트 검사와 유의한 상관관계를 보였다(p < .01). CBS가 지필검사보다 편측무시에 대한 민감도가 더 높았고, 일상생활활동과 더 높은 상관관계를 보였다(p< .01). 결론 : 본 연구의 결과를 살펴볼 때 CBS가 지필검사에 비해 편측무시를 판별하기 더 유용하며 질병부인검사도 가능한 검사도구이다. 따라서 편측무시 검사와 치료 시 CBS의 적용이 고려되어야 할 것이다.

• Journal of Preventive Medicine and Public Health
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• 제53권3호
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• pp.189-197
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• 2020

Objectives: Our aim was to answer the following questions: (1) Can mental health variance be partitioned to individual and higher levels (e.g., neighborhood and district); (2) How much (as a percentage) do individual-level determinants explain the variability of mental health at the individual-level; and (3) How much do determinants at the neighborhood- or district-level explain the variability of mental health at the neighborhood- or district-level? Methods: We used raw data from the second round of the Urban Health Equity Assessment and Response Tool in Tehran (in 2012-2013, n=34 700 samples nested in 368 neighborhoods nested in 22 districts) and the results of the official report of Tehran's Center of Studies and Planning (in 2012-2013, n=22 districts). Multilevel linear regression models were used to answer the study questions. Results: Approximately 40% of Tehran residents provided responses suggestive of having mental health disorders (30-52%). According to estimates of residual variance, 7% of mental health variance was determined to be at the neighborhood-level and 93% at the individual-level. Approximately 21% of mental health variance at the individual-level and 49% of the remaining mental health variance at the neighborhood-level were determined by determinants at the individual-level and neighborhood-level, respectively. Conclusions: If we want to make the most effective decisions about the determinants of mental health, in addition to considering the therapeutic perspective, we should have a systemic or contextual view of the determinants of mental health.

• Archives of Plastic Surgery
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• 제32권6호
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• pp.717-722
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• 2005

The authors evaluated 14 patients from July 1999 to February 2004 treated with total keloidectomy followed by postoperative radiation treatment, delivered within 24 hours or 24-36 hours after surgery. The total dose of radiation was 1200 cGy in three fractions for 4-5 days. Among the 14 patients treated, 8 patients were evaluated for following-up. The age range of these patients were from 22 to 44 years old, with the average age of 30 years. The site of keloid lesions consisted; 6 on the ear lobe, 5 on the anterior chest and 1 on the upper arm. The mean follow-up period was 29.9 months. The recurrence was evaluated with photogrammetric analysis and skin color analysis. The photogrammetric analysis was performed with planimetry for the comparison of the ratio of the reduced size to the preoperative size. The mean value of the relative size of reduction was 55% and the ratio of the ear lobes were greater than the ratio of the chests. The skin color analysis was performed with chromameter CR-300 for the analysis of color difference (E) between the surrounding normal skin and the lesion. The larger the recurred size was, similar to the original size, the larger the E value was, so the E value posses the probability of predictable objective tool of recurrence. Although verifying the effectiveness of radiation therapy following keloidectomy need more cases and long term follow-up evaluation, this therapeutic modality seems very effective in reducing the keloid size, especially in the ear lobe.

• 대한핵의학회지
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• 제27권1호
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• pp.22-27
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• 1993

Drug abuse is widespread in worldwide and has been associated with neurologic complication. Zipeprol is one of the drugs which been abused for psychological satisfaction in some adolescents. This agent is non-opioid antitussive agent, which is not legally considered as being capable of creating dependence or abuse liability at therapeutic serum levels. But it has been reported that acute or chronic overdose create neurologic complication such as convulsion as well as dependence. Recently we experienced six zipeprol abusers who admitted due to convulsion and variable neurologic symptoms. The aim of our study was to determine the role of $^{99m}Tc$-HMPAO brain SPECT in those patients. EEG and brain CT showed no abnormal finding, but brain SPECT showed focal or multiple perfusion abnormalities in frontal, parietal, occipital cortex, basal ganglia, thalamus and especially at temporal cortex. These results suggest that brain SPECT may be a useful diagnostic tool to evaluate the cerebral dysfunction infused by zipeprol abuse.

• Journal of Chest Surgery
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• 제44권2호
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• pp.165-168
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• 2011

Background: The prognosis of melanoma metastasized to other organs is very poor. There have been many studies on metastatic melanoma in Western society, but there have been few studies done in Korea because of the small number of cases. Materials and Methods: A retrospective review of 7 patients who underwent complete resection of pulmonary metastases from melanoma from January 2005 to December 2009 was performed. When the primary lesion was controlled or simultaneously controllable and no other metastatic lesion was found, pulmonary resections were performed. We analyzed the clinical prognoses after the initial melanoma diagnosis. Results: Of the seven patients, one was male and six were female. The mean age was 58.2 years (range 45~71). Six patients had a single pulmonary lesion and one patient had three lesions confined to the same lobe. The mean disease-free interval was 43.5 months (0~146 months). Before pulmonary resection, 4 patients had received systemic therapy. After pulmonary resection, 6 patients received systemic therapy. Complete resection was confirmed histologically. The metastasectomy was performed by wedge resection (6 patients) or lobectomy (1 patient). There were no mortalities or complications. After pulmonary resection, 1 patient had recurrent multiple lesions in the lung and 4 patients had metastases to other organs. The organs were the liver, brain, pleura, and lymph nodes. The mean observation time was 31.6 months and 3 patients died during observation. The mean survival was 27.7 months (14~60 months) and the 1-year and 3-year survival rates were 100% and 42%, respectively. Conclusion: When patients were selected carefully, the complete resection of pulmonary metastatic lesions was considered a major therapeutic tool.

• 대한약침학회지
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• 제21권3호
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• pp.203-206
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• 2018

Objectives: There is an increasing number of complex diseases that are progressively more difficult to be controlled using the conventional "single compound, single target" approach as demonstrated in our current modern drug development. TCM might be the new cornerstone of treatment alternative when the current treatment option is no longer as effective or that we have exhausted it as an option. Orthogonal stimulus-response compatibility group study is one of the most frequently employed formulas to produce optimal herbal combination for treatment of multi-syndromic diseases. This approach could solve the relatively low efficacy single drug therapy usage and chronic adverse effects caused by long terms administration of drugs that has been reported in the field of pharmacology and medicine Methods: The present review was based on the Science Direct database search for those related to the TCM and the development of antihypertensive TCM herbal combination using orthogonal stimulus-response compatibility group studies approach. Results: Recent studies have demonstrated that the orthogonal stimulus-response compatibility group study approach was most frequently used to formulate TCM herbal combination based on the TCM principles upon the selection of herbs, and the resulting formulated TCM formula exhibited desired outcomes in treating one of global concerned complex multi-syndromic diseases, the hypertension. These promising therapeutic effects were claimed to have been attributed by the holistic signaling mechanism pathways employed by the crude combination of herbs. Conclusion: The present review could serve as a guide and prove the feasibility of TCM principles to be used for future pharmacological drug research development.

• 대한한방소아과학회지
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• 제15권1호
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• pp.15-37
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• 2001

Objectives : The aim of this study was to investigate the usefulness and the remedical effect of Aroma therapy and Jaungo as a tool for Atopic dermatitis. Methods : We investigated 20 patients suffering from Atopic dermatitis and on the ground of it analyzed the remedical effect of Aroma therapy and Jaungo Results : 1. In distribution of nursing method, 45% was breast milk and formula, 35% was formular, 20% was breast milk. 2. The proportion of Atopic dermatitis concurred of congenital fever was 53.3%, after a disappearance of congenital fever was 46.7%. 3. That the season of symptom aggravation is not defined is 40%, next is summer 25%. The time of symptom aggravation is at night, 65%. 4. In the causes of symptom worsening, common cold and food was the best at each 33.3%. 5. In distribution of the therapeutic method, 65% was treated with oriental after occidental medicine and 30% only oriental medical care. Additional therapy except medical therapy was 60%. 6. In satisfaction degree of Aroma oil and cream therapy, 60% was not changed, 33.4% was very satisfied and satisfied. In aroma cream therapy, 55% was very satisfied and satisfied 40% was not changed. After using Jaungo therapy, 55.6% was very satisfied and satisfied, 44.4% was not changed. 7. After finishing the healing procedure, 65% was very satisfied and satisfied, 35% was not changed. Conclusions : Considering the above results, we have concluded that Aroma therapy and Jaungo have the remedical effect for Atopic dermatitis.

• 대한화장품학회지
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• 제22권2호
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• pp.132-140
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• 1996

The effect of a novel delivery system, water in oil emulsion containing chitosan hydrogel as a inner phase (W/O-C) was evaluated, and the relationships between the skin permeation, the skin primary irritation and the skin turnover rate of AHAs were discussed. We selected glycolic acid (GA), lactic acid (LA), malic acid (MA), and tartaric acid (TA) as model AHAs. The steady state fluxes of 4 AHAs across the excised hairless mouse skin increased as the molecular weights of the AHAs decreased. (GA>LA>MA>TA). The skin turnover times were shortened in all AHAs, compared with control. The skin permeation and the skin primary irritation of the LA decreased and the skin turnover time increased, as the pH increased. The maximum therapeutic index was obtained with pH 3.8, 0.5 M LA. It was suggested that the skin permeability of LA might be a main factor for prediction of the skin irritation and the skin turnover time. On the other hand, the W/O-C containing pH 3.8, 0.5 M LA indicated a good sustained release property of LA, compared with water in oil emulsion without chitosan hydrogel (W/O) or oil in water emulsion (O/W). The skin permeability and the skin irritation of AHAs from the W/O-C edcreased, compared with W/O or O/W, however the skin turnover time showed almost the same value as W/O or O/W. In conclusion, we suggest that the control of the skin permeation of AHAs would be an important tool for reducing the skin irritation and for maintaining the positive effect of AHAs, and the W/O-C system could be a potential candidate for future cosmetological application of AHAs.

• 디지털융복합연구
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• 제14권1호
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• pp.339-351
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• 2016

성적 공상은 개인의 무의식적인 측면을 반영할 뿐만 아니라 장애를 유발하거나 치료에 활용되는 등의 양면성을 갖기도 한다. 본 연구는 성적 공상의 양면성에 대해 다음과 같이 고찰하는 것을 목적으로 하였다. 첫째, 성적 공상의 정상과 비정상적인 측면이 선행연구에서 정의된 방식과 그 한계점을 살펴보았다. 둘째로, 성적 공상에 대한 강박적인 불편감, 성범죄와 성적 공상 등의 관계 등 위험 요인으로서의 문제점들을 확인하였다. 셋째, 성적 공상을 치료적인 방식으로 사용할 때의 지침과 원리 및 그 긍정적인 효과에 대해 고찰하였다. 넷째, 성적 공상의 적절한 활용을 위한 성적 공상의 측정도구와 측정방법에 대해 살펴보고 발전방향을 제시하였다. 본 연구는 성적 공상에 대한 양면적인 연구들을 정리하여 향후 연구의 방향을 제시한 것에 의의가 있으며 이와 관련한 논의를 제시하였다.