• The Journal of Internal Korean Medicine
• /
• v.44 no.1
• /
• pp.1-11
• /
• 2023

Objective: There are currently no disease-modifying medications or definite long-term sustainable interventions for patients with Parkinson's disease (PD), indicating an unmet treatment need. Our goal was to create a long-term sustainable intervention for PD patients that can be used in Korean medicine clinics. Methods: The Meridian Activation Remedy System (MARS) was created to stimulate a patient's 12 meridians and sinew channels using a combination of acupoint stimulation and exercise. The acupoints and motions used in MARS were selected through literature studies and expert advice. The methodologies were refined using observational and case studies. With slow and fast movements, the MARS intervention was intended to activate both slow- and fast-twitch muscle fibers. Intradermal acupuncture and motion that shift the center of gravity were employed to enhance the patient's balance and proprioception. In addition, the intervention included alternating movement exercises to address the complex cognitive decline commonly occurring in PD patients. Results: The following acupoints were chosen for the MARS intervention: bilateral Hegu (LI4), Houxi (SI3), Waiguan (TE5), Neiguan (PC6), Zhongchong (PC9), Yuji (LU10), Zusanli (ST36), Yanglingquan (GB34), Taichong (LR3), Kunlun (BL60), and Taixi (KI3). We also developed actions that can stimulate the body's 12 meridians. Conclusion: We developed the MARS intervention, which combines acupuncture and exercise, to address the unmet therapeutic needs of PD patients. We hope that with additional research, the MARS intervention can be set as an effective therapeutic program for PD patients.

• Journal of Korean Academy of Nursing
• /
• v.34 no.1
• /
• pp.63-71
• /
• 2004

Purpose: This study was to identify the influencing factors of the compliance level to a therapeutic regimen after a bone mineral densitometry test. Method: The sample for the study was 95 people who took the bone mineral densitometry test from March, 2002 to July, 2002. Data was collected by mail using aself reporting questionnaire on the selected variables such as the compliance level, self efficacy, health locus of control, susceptibility, severity, usefulness, barrier, and self esteem. Results: The average compliance level was 63.93. Through multiple regression, three independent variables including chance health locus of control on personality, the result of bone mineral density and self-efficacy were entered in the model as the significant determinants of the compliance level after a bone mineral densitometry test. The coefficients of determination of each variable were 10.9%, 8.3% and 8.1% respectively. Conclusion: The identification of the determinants of the compliance level to the therapeutic regimen after bone mineral densitometry is expected to contribute to the development of an intervention program to improve the compliance level to the therapeutic regimen in osteoporosis patients.

• Childhood Kidney Diseases
• /
• v.27 no.1
• /
• pp.1-10
• /
• 2023

Pediatric nephrotic syndrome (NS) is a clinical syndrome characterized by massive proteinuria, hypoalbuminemia, and generalized edema. Most childhood NS cases are idiopathic (with an unknown etiology). Traditional therapeutic approaches based on immunosuppressive agents largely support the key role of the immune system in idiopathic NS (INS), especially in the steroid-sensitive form. Although most previous studies have suggested the main role of T cell dysfunction and/or the abnormal secretion of certain glomerular permeability factors, recent studies have emphasized the role of B cells since the therapeutic efficacy of B cell depletion therapy in inducing and/or maintaining prolonged remission in patients with INS was confirmed. Furthermore, several studies have detected circulating autoantibodies that target podocyte proteins in a subset of patients with INS, suggesting an autoimmune-mediated etiology of INS. Accordingly, a new therapeutic modality using B cell-depleting drugs has been attempted, with significant effects in a subset of patients with INS. Currently, INS is considered an immune-mediated disorder caused by a complex interplay between T cells, B cells, soluble factors, and podocytes, which may vary among patients. More in-depth investigations of the pathogenic pathways of INS are required for an effective personalized therapeutic approach and to define precise targets for therapeutic intervention.

• Journal of International Academy of Physical Therapy Research
• /
• v.10 no.1
• /
• pp.1725-1733
• /
• 2019

Background: In some clinical guidelines followed in clinical practice, nonsurgical treatments are recommended as the primary intervention for patients with lumbar disc herniation (LDH). However, the effect of a therapeutic exercise program based on stabilization of the lumbar spine for treatment of multilevel LDH has not been evaluated thoroughly. Objective: To investigate the effects of therapeutic exercise on pain, physical function, and magnetic resonance imaging (MRI) findings in a patient with multilevel LDH. Design: Case Report Methods: A 43-year-old female presented with low back pain, radicular pain and multilevel LDH (L3-L4, L4-L5, L5-S1). The therapeutic exercise program was conducted. in 40-min sessions, three times a week, for 12 weeks. Low back and radicular pain, lumbar disability, and physical function were measured before and after 6 and 12 weeks of the exercise program. MRI was performed before and after 12 weeks of the program. Results: After 6 and 12 weeks of the therapeutic exercise, low back and radicular pain and lumbar disability had decreased, and lumbar range of motion (ROM) was improved bilaterally, compared with the initial values. Also improved at 6 and 12 weeks were isometric lumbar strength and endurance, and the functional movement screen score. The size of disc herniations was decreased on MRI obtained after 12 weeks of therapeutic exercise than on the pre-exercise images. Conclusions: We observed that therapeutic exercise program improved spinal ROM, muscle strength, functional capacity, and size of disc herniation in LDH patient.

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 2008.04a
• /
• pp.77-86
• /
• 2008

It's been known that overexpression of the oncoprotein Her2 (eu/ErbB2), transmembrane receptor protein, occurs in human breast cancer. Her2-positive breast cancer patients who have Her2 overexpression show less therapeutic efficacy with enhanced metathesis and increased resistance to chemotherapy. So far, a humanized monoclonal antibody against Her2 protein called Herceptin is the only drug approved by Food and Drug Administration for treatment of Her2-overexpressing breast tumors. However, antibody therapy of Herceptin may not be ideal method for therapeutic intervention of Her2 protein expression. The therapeutic intervention of Her2 protein expression may be more efficiently achieved by inhibiting the expression of Her2 gene rather than by down-regulating the Her2 protein already overexpressed. Here, we found that the interaction of two proteins of ESX (an epithelial-restricted transcription factor) and DRIP130/CRSP130/Sur2 (a Ras-linked subunit of human mediator complexes) mediates the expression of Her2 gene. The association of ESX with Sur2 is mediated by a small hydrophobic face of 8-amino acid helix in ESX, suggesting that the ESX-Sur2 interaction can be a new novel target for Her2-positive cancer. The process to develop potent ESX-Sur2 interaction inhibitors targeting for Her2-positive cancer therapeutics will be discussed.

• The Journal of Korean Physical Therapy
• /
• v.10 no.1
• /
• pp.53-65
• /
• 1998

The main purpose of this paper is to analyze the modes of therapeutic intervention. The emphasis is on the neurophysiological perpective arising out of neurological principles and developmental concepts. The obtained results are as follows. 1. The important hypostheses predicted that the group intervened by neurodevelopmental approach would improve motor function better than the group done by traditional approach and it was proved that neurodevelopmental approach was more effective in gross motor region(P<.01) 2. In the comparison of type of involovement, neurodevelopmental intervention group in spastic type showed improvements in the region of gross motor.(P<.001) 3. In the comparision of degree of disorder, neurodevelopmental intervention group showed improvement of motor function in all the gross motor region in the mild, moderate and severe case.(P<.001) 4. In the comparison of ages of intervention beginning, the group of child between 25-36, 49-60 and 61-72 months(P<.001) intervened by neurodevelopmental approach showed improvements of motor function. 5. In the comparison of intervention duration, neurodevelopmental intervention group showed improvements of motor function in gross motor region according to intervention durstion(P<.001)

• Journal of Korean Academy of Nursing
• /
• v.37 no.6
• /
• pp.994-1002
• /
• 2007

Purpose: This study was to identify the effects of hope intervention on hope and depression of cancer patients staying at home. Methods: The study design was a randomized control group design. The subjects consisted of forty cancer patients randomly selected who were registered at S-Gu Public Health Center. Hope intervention, which was composed of hope assessment, hope objective setting, positive self identity formation, therapeutic relationships, spiritual & transcendental process improvement, positive environmental formation and hope evaluation, was provided from November 20, 2006 to January 26, 2007. Results: The 1-1 hypothesis, "The experimental group which received hope intervention will have a higher score of hope than the control group", was supported(t=-3.253, p= .003). The 1-2 hypothesis, "The experimental group which received hope intervention will have a higher level of hope index than the control group", was supported (t=-4.001, p= .000). Therefore the 1st hypothesis, "The experimental group which received hope intervention will have a higher level of hope than the control group" was supported. The 2nd hypothesis, "The experimental group which received hope intervention will have a lower level of depression than the control group", was not supported (t=1.872, p= .070). Conclusion: Hope intervention is an effective nursing intervention to enhance hope for patient with cancer.

• Journal of The Korean Society of Integrative Medicine
• /
• v.4 no.1
• /
• pp.73-83
• /
• 2016

PURPOSE : The purpose of this study to suggest the exercise programs for improving the function and structure by applying the Masan university scoliosis program exercise method and electrical therapy method to the scoliosis patient. METHODS : The subjects were 18 patients who were diagnosed with scoliosis. They were randomly assigned either to a Masan university scoliosis program exercise group (n=11) that received Masan university scoliosis program exercise program or to a electrical therapy group (n=7). Flexibility, static balance, dynamic balance, and spinal angles were measured by using one leg standing with closed eyes, functional reach test, and Cobb's angle, respectively. The chest expansion were calculated using differences of chest circumference between maximum inspiration and maximum expiration. RESULT : Masan university scoliosis program group before and after the intervention there was a difference in the static balance, spine angle(p<.05). Masan university scoliosis program group before and after the intervention there was a difference in the flexibility, static balance, spine angle, chest expansion (p<.05). CONCLUSION : These results revealed that Masan university scoliosis program exercise program improved flexibility, static standing balance, spine angle, used as scoliosis management and intervention. Therefore, it is expected to be used as a method for the treatment and prevention in the process of rehabilitation of patients with scoliosis.

• Korean Journal of Biological Psychiatry
• /
• v.18 no.4
• /
• pp.217-224
• /
• 2011

Subsyndromal bipolar symptoms are common during maintenance treatment and appear to be associated with relapse into an episode of the same polarity. This implies subsyndromal symptoms are an important problem in recurrent bipolar disorder and require more additive and infallible therapeutic intervention. Undetected, untreated subsyndromal states lead patients to have poor prognosis and quality of life. The combination of a long undetected illness and significant psychosocial impairment renders early identification and intervention vital for the treatment of bipolar disorders. Methods for early identification includes finding prodromes, using screening tools such as the HCL-32 (Hypomania Checklist-32) and the BSDS (bipolar spectrum diagnostic scale). Various augmentation treatment methods would be needed to reduce subsyndromal symptoms, especially, psychosocial treatment has the potential to help patients address the multiple psychosocial problems associated with this chronic illness. To overcome difficulties of diagnosing subsyndromal disorder and to treat it appropriately, a staging system was suggested by some researchers. It assumes that earlier stages have better prognosis and require simpler therapeutic regimens. Staging may assist in treatment planning and prognosis of bipolar disorder, and emphasize the importance of early intervention. Further research is required in this exciting and novel area.

• Korean Journal of Social Welfare
• /
• v.40
• /
• pp.157-190
• /
• 2000

As the Law on the Prevention of Domestic Violence was enacted in Korea, it has become necessary to work on how to intervene effectively in Korean men who batter. The purpose of this study is to establish the framework of the intervention model which is relevant to Korean wife-batterers. In the States, the psychoanalytic model, cognitive-behavioral model, and feminist model are most widely used with men who batter. As yet, the consensus on which model is most effective has not been reached. In this study, each model is reviewed briefly. And then it is suggested that in the light of Korean culture the educational model is more relevant than therapeutic model. Several points are also suggested, which need to be considered when feminist model is used in Korean culture. It is also insisted that the integrated model based on ecological theory is necessary to intervene effectively in such a multi-dimensional problem as domestic violence. For the group intervention, it is suggested to use educational model primarily and to use therapeutic model complementarily. Based on the framework suggested in this study, to develop the specific structure of the program, to implement it, and to test its effectiveness will be the tasks of the future researches.