• Molecules and Cells
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• v.38 no.4
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• pp.373-379
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• 2015

Pyruvate kinase M2 isoform (PKM2), a rate-limiting enzyme in the final step of glycolysis, is known to be associated with the metabolic rewiring of cancer cells, and considered an important cancer therapeutic target. Herein, we report a novel PKM2 activator, PA-12, which was identified via the molecular docking-based virtual screening. We demonstrate that PA-12 stimulates the pyruvate kinase activity of recombinant PKM2 in vitro, with a half-maximal activity concentration of $4.92{\mu}M$, and effectively suppresses both anchorage-dependent and -independent growth of lung cancer cells in non-essential amino acid-depleted medium. In addition, PA-12 blocked the nuclear translocalization of PKM2 in lung cancer cells, resulting in the inhibition of hypoxia response element (HRE)-mediated reporter activity as well as hypoxia-inducible factor 1 (HIF-1) target gene expression, eventually leading to the suppression of cell viability under hypoxia. We also verified that the effects of PA-12 were dependent on PKM2 expression in cancer cells, demonstrating the specificity of PA-12 for PKM2 protein. Taken together, our data suggest that PA-12 is a novel and potent PKM2 activator that has therapeutic implications for lung cancer.

• KIISE Transactions on Computing Practices
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• v.22 no.8
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• pp.375-380
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• 2016

The proliferation of online social networking services (OSNSs) and smartphones has enabled people to easily make friends with a large number of users in the online communities, and interact with each other. This leads to an increase in the usage rate of OSNSs. However, individuals who have immersed into their digital lives, prioritizing the virtual world against the real one, become more and more isolated in the physical world. Thus, their socialization processes that are undertaken only through lots of face-to-face interactions and trial-and-errors are apt to be neglected via 'Add Friend' kind of functions in OSNSs. In this paper, we present a friend recommendation system based on the on/off-line contextual information for the OSNS users to have more serendipitous offline interactions. In order to accomplish this, we modeled both offline information (i.e., place visit history) collected from a user's smartphone on a 3D tensor, and online social data (i.e., friend relationships) from Facebook on a matrix. We then recommended like-minded people and encouraged their offline interactions. We evaluated the users' satisfaction based on a real-world dataset collected from 43 users (12 on-campus users and 31 users randomly selected from Facebook friends of on-campus users).

• Journal of the Institute of Convergence Signal Processing
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• v.10 no.4
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• pp.274-279
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• 2009

The flow of a universal system-level design methodology consists of system specification, system-level hardware/software partitioning, co-design, co-verification using virtual or physical prototype, and system integration. In this paper, verification environments based-on SystemVerilog and SystemC, one is native-code co-verification environment which makes prompt functional verification possible and another is SystemVerilog layered testbench which makes clock-level verification possible, are implemented. In native-code co-verification, HW and SW parts of SoC are respectively designed with SystemVerilog and SystemC after HW/SW partitioning using SystemC, then the functional interaction between HW and SW parts is carried out as one simulation process. SystemVerilog layered testbench is a verification environment including corner case test of DUT through the randomly generated test-vector. We adopt SystemC to design a component of verification environment which has multiple inheritance, and we combine SystemC design unit with the SystemVerilog layered testbench using SystemVerilog DPI and ModelSim macro. As multiple inheritance is useful for creating class types that combine the properties of two or more class types, the design of verification environment adopting SystemC in this paper can increase the code reusability.

• KIPS Transactions on Software and Data Engineering
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• v.5 no.6
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• pp.307-312
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• 2016

Markerless tracking for augmented reality using Homography can augment virtual objects correctly and naturally on live view of real-world environment by using correct pose and direction of camera. The RANSAC algorithm is widely used for estimating Homography. CS-RANSAC algorithm is one of the novel algorithm which cooperates a constraint satisfaction problem(CSP) into RANSAC algorithm for increasing accuracy and decreasing processing time. However, CS-RANSAC algorithm can be degraded performance of calculating Homography that is caused by selecting feature points which estimate low accuracy Homography in the sampling step. In this paper, we propose feature point filtering method based on CS-RANSAC for efficient planar Homography estimating the proposed algorithm evaluate which feature points estimate high accuracy Homography for removing unnecessary feature point from the next sampling step using Symmetric Transfer Error to increase accuracy and decrease processing time. To evaluate our proposed method we have compared our algorithm with the bagic CS-RANSAC algorithm, and basic RANSAC algorithm in terms of processing time, error rate(Symmetric Transfer Error), and inlier rate. The experiment shows that the proposed method produces 5% decrease in processing time, 14% decrease in Symmetric Transfer Error, and higher accurate homography by comparing the basic CS-RANSAC algorithm.

• Science of Emotion and Sensibility
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• v.25 no.1
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• pp.103-114
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• 2022

Global virtual reality (VR) and augmented reality (AR) markets are growing as VR and AR become a new source of revenue for industries around the world. In the edutech sector, an industry that combines traditional education, research on new innovative educational models and business models are scarce, and improvements are needed in the technology group and business environment to realize edutech in detail. Therefore, this study aims to define the elements strategically required for VR Toon development by comparing and analyzing the characteristics of existing touch panel-based display Toon and VR Toon content experiences. Tablet PC Toon and VR Toon were selected to conduct the research. Thirty people (19 men and 11 women) from their teens through their forties were surveyed using questionnaires. The questionnaires were formulated through a quantitative method by using AttrakDiff with a 7-point scale (-3: negative words to 3: positive words). Qualitative evaluations were also performed addressing nine concepts (satisfaction, novelty, operability, creativity, understanding, education, interest, participation, expressiveness). As a result, the usability test results of educational content using tablet personal computers and VR equipment were analyzed from the viewpoint of user experience to define elements expected to be strategically required for VR Toon development.

• Journal of the Korean Association of Geographic Information Studies
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• v.26 no.4
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• pp.130-144
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• 2023

Recently, various positioning technologies are being researched based on signal-based positioning and image-based positioning to obtain accurate indoor location information. Among these, various studies are being conducted on image positioning technology that determines the location of a mobile terminal using images acquired through cameras and sensor data collected as needed. For video-based positioning, a method of determining indoor location is used by matching mobile terminal photos with virtual landmark images, and for this purpose, it is necessary to build indoor spatial information about various landmarks such as billboards, vending machines, and ATM machines. In order to construct indoor spatial information on various landmarks, a panoramic image in the form of a road view and accurate 3D survey results were obtained through c 13 buildings of the Electronics and Telecommunications Research Institute(ETRI). When comparing the 3D total station final result and the terrestrial lidar panoramic image coordinates, the coordinates and distance performance were obtained within about 0.10m, confirming that accurate landmark construction for use in indoor positioning was possible. By utilizing these terrestrial lidar achievements to perform 3D landmark modeling necessary for image positioning, it was possible to more quickly model landmark information that could not be constructed only through 3D modeling using existing as-built drawings.

• Information Systems Review
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• v.23 no.3
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• pp.159-176
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• 2021

Obviating user churn is a prominent strategy to capitalize on online games, eluding the initial investments required for the development of another. Extant literature has examined factors that may induce user churn, mainly from perspectives of motives to play and game as a virtual society. However, such works largely dismiss the service aspects of online games. Dissatisfaction of user needs constitutes a crucial aspect for user churn, especially with online services where users expect a continuous improvement in service quality via software updates. Hence, we examine the relationship between a game's quality management and its user base. With text mining and survival analysis, we identify complaint factors that act as key predictors of user churn. Additionally, we find that enjoyment-related factors are greater threats to user base than usability-related ones. Furthermore, subsequent quasi-experiment shows that improvements in the complaint factors (i.e., via game patches) curb churn and foster user retention. Our results shed light on the responsive role of developers in retaining the user base of online games. Moreover, we provide practical insights for game operators, i.e., to identify and prioritize more perilous complaint factors in planning successive game patches.

• Information Systems Review
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• v.21 no.3
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• pp.63-86
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• 2019

As the use of ICT became a part of daily social life, online community has emerged as a new type of social organization. Online community is a virtual space which enables many people to participate and contribute together to collective knowledge. Anonymity in online communities can encourage active social participation by people with various social constraints, however, anonymity can also lead to serious social pathology. As a result, it is necessary to study on what is fundamentally influencing human behavior and how people's behavior is controlled in anonymous online community. This study focuses on human identity and investigate the factors affecting human behavior control in anonymous online environment by examining various aspects of identity in online discussion community. This study empirically verifies the causal relationship between factors, including social & technical anonymities, various identity dimensions, intrinsic motivation to participate in the community, group norm conformity, and quality of discussion. It also analyzes the difference between groups by the level of anonymity, gender, age, community usage period, and discussion topic. Based on the findings, this research provides theoretical and practical implications for online community management strategies and a better culture on Internet discussion.

• Journal of the Korean Association of Geographic Information Studies
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• v.9 no.4
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• pp.12-21
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• 2006

Recently, Very large and high resolution geological data from aerial or satellite imagery are available. Many researches and applications require to do realtime visualization of interest geological area or entire planet. Important operation of wide-spreaded terrain realtime visualization technique is the appropriate model resolution selection from pre-processed multi-resolution model hierarchy depend upon participant's view. For embodying such realtime rendering system with large geometric data, Preprocessing multi-resolution hierarchy from large scale geological information of interest area is required. In this research, recent Cubic multiresolution 4-8 tile hierarchy is selected for global planetary applications. Based upon the tile hierarchy, It constructs the selective terminal level tile mesh for original geological information area and starts to sample individual generated tiles for terminal level tiles. It completes the hierarchy by constructing intermediate tiles with low pass filtering in bottom-up direction. This research embodies series of efficient cubic 4-8 tile hierarchy construction mechanism with out-of-core storage. The planetary scale Mars' geographical altitude data and image data were selected for the experiment.

• Progress in Medical Physics
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• v.27 no.1
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• pp.8-13
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• 2016

Dual energy cone-beam CT can distinguish two materials with different atomic compositions. The principle of dual energy cone-beam CT based on modulation layer is that higher energy spectrum can be acquired at blocked x-ray window. To evaluate the possibility of modulation layer based dual energy cone-beam CT, we analyzed x-ray spectrum for various thicknesses of modulation layers by Monte Carlo simulation. To compare with the results of simulation, the experiment was performed on prototype cone-beam CT for 50~100 kVp with CdTe XR-100T detector. As the result of comparing, the mean energy of energy spectrum for 80 kVp are well matched with that of simulation. The mean energy of energy spectrum for 80 and 120 kVp were increased as 1.67 and 1.52 times by 2.0 mm modulation layer, respectively. We realized that the virtual dual energy x-ray source can be generated by modulation layer.