• Molecules and Cells
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• v.38 no.6
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• pp.518-527
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• 2015

Controlled release of medications remains the most convenient way to deliver drugs. In this study, we precipitated gold nanoparticles with quercetin. We loaded gold-quercetin into poly(DL-lactide-co-glycolide) nanoparticles (NQ) and tested the biological activity of NQ on HepG2 hepatocarcinoma cells to acquire the sustained release property. We determined by circular dichroism spectroscopy that NQ effectively caused conformational changes in DNA and modulated different proteins related to epigenetic modifications and c ell cycle control. The mitochondrial membrane potential (MMP), reactive oxygen species (ROS), cell cycle, apoptosis, DNA damage, and caspase 3 activity were analyzed by flow cytometry, and the expression profiles of different anti- and pro-apoptotic as well as epigenetic signals were studied by immunoblotting. A cytotoxicity assay indicated that NQ preferentially killed cancer cells, compared to normal cells. NQ interacted with HepG2 cell DNA and reduced histone deacetylases to control cell proliferation and arrest the cell cycle at the sub-G stage. Activities of cell cycle-related proteins, such as $p21^{WAF}$, cdk1, and pAkt, were modulated. NQ induced apoptosis in HepG2 cells by activating p53-ROS crosstalk and induces epigenetic modifications leading to inhibited proliferation and cell cycle arrest.

• Transactions of the Korean Society of Automotive Engineers
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• v.20 no.4
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• pp.119-124
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• 2012

Ceramics are becoming one of the most important materials due to its good mechanical properties such as high strength, hardness, chemical safety, and high modulus of elasticity. Ceramics have been used widely as a material not only for construction, but also for vehicles, planes, and bones for the human body. Despite these advantages, ceramics have some limitations in actual use due to its brittle fracture characteristic. In order to develop ceramic belt in this study, the data regarding stiffness and strain is necessary. For this purpose, the sensitivities of maximum stress value and displacement are analyzed by applying the load change on ceramic belt with finite element method program.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.11 no.4
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• pp.499-510
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• 1999

A computer program was developed for simulating performance(capacity, power consumption and etc.) of air-conditioners using compressor, fin-tube heat exchanger and capillary tube. The program consists of five modules, condenser, evaporator, compressor, capillary tube simulation modules and properties modules of refrigerant and moist air, The present program is focused on R22 only, however can be easily extended for other refrigerants such as R407C and R410A just by adding property modules. The compressor simulation module utilizes performance maps supplied by manufacturers-map-based model. The condenser and evaporator simulation modules are modeled using tube-by-tube method. Simulation results(capacity and power consumption) were compared with calorimeter test results of actual air-conditioners of window and split types, where more than 82% of the data lied within ${\pm}5$% of the predicted results.

• Transactions of Materials Processing
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• v.16 no.5 s.95
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• pp.354-359
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• 2007

Effects of forging and mechanical properties of 6061 aluminum alloy wheel for automobiles were investigated in the present study. Microstructural and tensile characteristics of automobile wheel after hot forging process using dynamic screw press were analyzed to evaluate effect of metal flow on mechanical properties. The results showed advanced mechanical properties of 6061 alloy wheel because of $Mg_2Si$ precipitation by T6, elongated grain by forging, and work hardening by dense metal flow, etc. Hot compression tests were conducted in order to characterize high temperature compression deformation behaviors and microstructural variation in the range of $300{\sim}450^{\circ}C$, in the strain rate range of $10^{-3}{\sim}10^1\;sec^{-1}$. As strain rate increased, maximum compression stress increased but it was shown the reverse linear relation between temperature and maximum stress irrelevant to strain rate variation. On the other hand, temperature and yield stress didn't have any linear relation and its relation showed big deviation by a function of strain rate and test temperature.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2010.06a
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• pp.162-162
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• 2010

In this study, optical analysis for 100W LED safety street lighting was conducted. Experimental research on such single LED was the first undertaken. simulation modeling based on optical properties of single LED has compared single LED product also designed 100W simulation modeling has compared average road illuminance with Korean Industrial Standards for LED safety street lighting(KS C7658:2009). 100W safety street lighting (model: CE180-ST-OS) designed by simulation has been also compared between product and 100W simulation modeling, and error rates have showed average 5.6[%]. Designed 100W LED safety street lighting base on simulation modeling was proven by comparison experiments. Through the simulations and the corresponding analysis, it was found that the tested 100W LED safety street lamp had reasonable performance. Design method for LED safety Street lamps have been summarized, based on the optical analysis.

• Journal of the Korea Fashion and Costume Design Association
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• v.16 no.1
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• pp.117-123
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• 2014

This paper examined dyeing using sulfur dye with nylon and the characteristics of high gauge knitting for generating high functionality including light weight, wind resistance and elasticity using fine nylon threads. Yarn tension, stitch field and knitting speed of high and fine gauge knitting were measured. The influence of reducing agents on sulfur dye, optimum dyeing conditions and fastness features in nylon dyeing were analyzed. The analysis results are presented below. When nylon (Hyoseong, 40d/34f) and spandex (Hyoseong, 20d) for use as hosiery yarn were used to knit high gauge and flat weave, 44 gauge, the effective knitting conditions were a stitch field over 8.2cm in 1 course length, yarn tension of less than 5g and knitting speed below 18rpm. Nylon dyeing using sulfur dye showed effective results when a rongalite reducing agent was used at more than 10% o.w.f. and dyeing was maintained at $98^{\circ}C$ for 30 minutes. For dyeing nylon and spandex composite using sulfur dye, color fastness in washing, water, daylight and friction were higher than Class 4 or 5, which indicated a superior property. The analysis results verified that the existing problems in nylon dyeing could be solved by using sulfur dyes that don't use heavy metals due to superior fastness and therefore quality, high gauge nylon knit products could be produced.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.26 no.9
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• pp.1914-1922
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• 2002

Operating test of power-transmission plastic spur gears were performed inspecting both characteristics of friction-wear and endurance, and suggesting endurance improvement method that either drills internal holes of tooth or inserts metallic pin in the internal hole of tooth and verifying this newly-provided method. In case of acetal gears, amount of friction-wear is observed to increase by development of plastic deformation and increase of tooth stiffness due to brittle material property of acetal. To the contrary, in case of nylon gears, suggested method is shown to drop down the tooth temperature for about 3∼10$^{\circ}C$ than original gear, thus amount of wear is reduced by over 30% and operating lift prolonged by more than 200%. Hence, suggested method is proved to be practically applicable to the plastic gears made by soft polymers such as Nylon.

• Korean Journal of Food Science and Technology
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• v.24 no.1
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• pp.54-58
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• 1992

The reological properties of commercial corn starch solutions at various concentrations($4{\sim}9%$) and temperatures($30{\sim}60^{\circ}C$) were investigated. The rheological behavior of corn starch solutions was illustrated by Herschel-Bulkley equation and exhibited pseudoplastic behavior with yield stress. The degree of pseudoplasticity of starch solution increased as the starch concentration increased but was independent on temperature. Apparent viscosity and yield stress of starch solutions were exponentially dependent on concentration and temperature. The critical concentrations for sol-gel transition and for the onset of close-packing of the starch granules were $6.22{\sim}6.52%\;and\;2.68{\sim}2.78%$ respectively.

• Carbon letters
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• v.13 no.4
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• pp.191-204
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• 2012

Carbon nanotubes (CNTs) have exceptional mechanical, electrical, and thermal properties compared with those of commercialized high-performance fibers. For use in the form of fabrics that can maintain such properties, individual CNTs should be held together in fibers or made into yarns twisted out of the fibers. Typical methods that are used for such purposes include (a) surfactant-based coagulation spinning, which injects a polymeric binder between CNTs to form fibers; (b) liquid-crystalline spinning, which uses the nature of CNTs to form liquid crystals under certain conditions; (c) direct spinning, which can produce CNT fibers or yarns at the same time as synthesis by introducing a carbon source into a vertical furnace; and (d) forest spinning, which draws and twists CNTs grown vertically on a substrate. However, it is difficult for those CNT fibers to express the excellent properties of individual CNTs as they are. As solutions to this problem, post-treatment processes are under development for improving the production process of CNT fibers or enhancing their properties. This paper discusses the recent methods of fabricating CNT fibers and examines some post-treatment processes for property enhancement and their applications.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2001.11b
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• pp.480-483
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• 2001

Epitaxial rutile-$TiO_2$ and anatase-$TiO_2$ films were grown at $800^{\circ}C$ on $Al_2O_3$ (1102) and $LaAlO_3$ (001), respectively, using pulsed laser deposition. The formation of different phases on different substrates could be qualitatively explained by the atomic arrangements at the interfaces. We also successfully deposited epitaxial rutile-$TiO_2$ and anatase-$TiO_2$ films on conductive $RuO_2$ and $La_{0.5}Sr_{0.5}CoO_{3}$ electrodes, respectively. Using a Kelvin probe, we measured the photovoltaic properties of these multilayer structures. A rutile-$TiO_2$ film grown on $RuO_2$ showed a very broad peak in the visible light region. An epitaxial anatase-$TiO_2$ film grown on $La_{0.5}Sr_{0.5}CoO_{3}$ showed a strong peak with a threshold energy of 3.05 eV.