• Journal of Veterinary Science
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• v.21 no.5
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• pp.60.1-60.11
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• 2020

Background: Tumor-associated neoangiogenesis is a crucial target for antitumor therapies. Thalidomide (TAL) is a promising anti-neoangiogenetic drug that has recently been used in the treatment of several malignancies in dogs. Objectives: The aim of the study was to assess the pharmacokinetics of TAL after single oral administration in dogs. Additionally, the influence of feeding on the pharmacokinetic profile of TAL in dogs has been preliminarily investigated. Methods: Six healthy adult female Labradors were enrolled according to a randomized single-dose, 2-treatment, 2-phase, paired 2 × 2 cross-over study design. The dogs were administered a single 400 mg capsule of TAL in fasted and fed conditions. Blood was collected from 15 min to 48 h after dosing, and TAL quantified in plasma by a validated high-performance liquid chromatography method. The pharmacokinetics of TAL were analyzed using a non-compartmental approach. Results: TAL concentration was quantifiable up to 10 h and 24 h after fasted and fed conditions, respectively. C_max (fasted, 1.34 ± 0.12 ㎍/mL; fed, 2.47 ± 0.19 ㎍/mL) and T_max (fasted, 3 h; fed, 10 h) differed substantially between the 2 groups. AUC and t_1/2λz were significantly higher in fed (42.46 ± 6.64 mg × h/L; 17.14 ± 4.68 h) compared to fasted (12.38 ± 1.13 mg × h/L; 6.55 ± 1.25 h) dogs. The relative oral bioavailability of TAL for the fasted group was low (36.92% ± 3.28%). Conclusions: Feeding affects the pharmacokinetics of oral TAL in dogs, showing a delayed, but higher absorption with different rate of elimination. These findings are of importance in clinical veterinary settings, and represent a starting point for further related studies.

• Journal of the Society of Disaster Information
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• v.8 no.4
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• pp.319-327
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• 2012

This research collected work drilling report of TBM method site developed by WRITH company to TBM equipment company in Germany and analyzed work operating productivity. Based the data analyzed TBM operating productivity, This research derived and presented excavation speed(m/day) by TBM diameter (2.6m, 3.0m, 3.5m, 5.0m, 8.0m) and rock. Also, based on the excavation speed(m/day) by TBM diameter, This research estimated a day direct construction cost and total direct construction costs by applying a direct construction cost which spent on per 1m. Based on hard rock 40.0%, soft rock 30.0%, usually rock 20%, weathered rock 10.0%, TBM boring velocity, m per cost, total construction period shall estimate the construction cost and the construction period by the effective use by diameter when future applying TBM method to the basic planning stages and in the preliminary design phase.

• Asian-Australasian Journal of Animal Sciences
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• v.19 no.3
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• pp.347-355
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• 2006

A study was conducted to predict the rumen microbial protein production based on urinary excretion of purine derivatives in buffaloes fed a diet of wheat straw and concentrate (40:60) at four fixed levels of feed intake. (95, 80, 60 and 40% of preliminary voluntary feed intake) following experimental protocol of IAEA (Phase I). The buffaloes were allocated according to a $4{\times}4$ latin square design. The urinary allantoin, uric acid, total PD excretion (mmol/d) in treatments L-95, L-80, L-60 and L-40 was 20.13, 16.00, 12.96 and 9.17; 1.88, 2.12, 2.11 and 2.15; 22.01, 18.12, 15.07 and 11.32, respectively and were significantly (p<0.05) different among treatments except for uric acid. The rate of PD excretion (mmol/d) was positively correlated with the digestible organic matter intake. Variations were observed in PD and creatinine concentration in spot samples collected at 6-hour interval. However, daily PD:Creatinine ratio (PDC index) appears to be a reasonably good predictor of microbial-N supply. The contribution of basal purine excretion to total excretion of purine derivatives (PD) was determined in pre-fasting period followed by a fasting period of 6 d (Phase II). Daily PD and creatinine excretion (mmol/kg $W^{0.75}$) during fasting averaged 0.117 and 0.456 respectively for buffaloes. The excretion rates of PD decreased significantly (p<0.01) during fasting compare to pre-fasting period, the urinary creatinine excretion remained almost similar. Except for creatinine, plasma concentration of target parameters significantly (p<0.01) declined during fasting. Likewise, glomerular filtration rate (GFR) and renal clearance of allantoin and uric acid also decreased. Based on the PD excretion rates during fasting and at different levels of feed intake obtained in this study, a relationship between daily urinary PD excretion (Y-mmol) and microbial purine absorption (X-mmol) was developed for buffaloes as Y = 0.74X+0.117 kg $W^{0.75}$. The microbial N supply (g/kg DOMI) remained statistically similar irrespective of dietary treatment. The results showed that excretion of urinary purine derivatives is positively correlated with the levels of feed intake in Murrah buffaloes and thus, estimation of urinary purine derivatives and PDC index could be used to determine microbial nitrogen supply when there is large variation in level of feed intake.

• The Journal of the Korea institute of electronic communication sciences
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• v.13 no.3
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• pp.547-554
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• 2018

Wind energy is widely recognized as one of the cheapest forms of clean and renewable energy. In fact, in several countries, wind energy has achieved cost parity with fossil fuel-based sources of electricity generation for new electricity generation plants. Offshore wind energy development promises to be a significant domestic renewable energy source for the target of korea government 3020 plan. A pivotal activity during the development phase of a wind project is wind resource assessment. Several approaches can be categorized as three basic scales or stages of wind resource assessment: preliminary area identification, area wind resource evaluation, and micrositing. This study is to estimate the wind power capacity of chonnam province offshore area using three basic stages based on the six meteorological mast data. WindPRO was used, one of a well-known wind energy prediction programs and based on more than 25 years of experiences in development of software tools for wind energy project development. The design results of offshore wind power generation capacity is calculated as total 2.52GW with six wind farms in chonnam offshore area.

• Journal of Astronomy and Space Sciences
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• v.26 no.1
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• pp.99-110
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• 2009

The main purpose of the current research is to developments a real-time Hardware In-the-Loop (HIL) simulation testbed for the satellite formation flying navigation and orbit control. The HIL simulation testbed is integrated for demonstrations and evaluations of navigation and orbit control algorithms. The HIL simulation testbed is composed of Environment computer, GPS simulator, Flight computer and Visualization computer system. GPS measurements are generated by a SPIRENT GSS6560 multi-channel RF simulator to produce pseudorange, carrier phase measurements. The measurement date are transferred to Satrec Intiative space borne GPS receiver and exchanged by the flight computer system and subsequently processed in a navigation filter to generate relative or absolute state estimates. These results are fed into control algorithm to generate orbit controls required to maintain the formation. These maneuvers are informed to environment computer system to build a close simulation loop. In this paper, the overall design of the HIL simulation testbed for the satellite formation flying navigation and control is presented. Each component of the testbed is then described. Finally, a LEO formation navigation and control simulation is demonstrated by using virtual scenario.

• The Transactions of the Korea Information Processing Society
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• v.6 no.2
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• pp.485-496
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• 1999

Comparing with sequential programming, parallel programming has additional complexity due to the consideration of parallelism, communication and synchronization of processes. A synergism between users and compliers should be established, each assisting the other to produce high quality parallel programs. On the above underlying philosophy, we developed a parallel Object-Oriented specification language, POOSL, as preliminary works. However, it is still likely to hard for users to write parallel program because users have to consider grammar of POOSL and to write text-based parallel program. It would be more desirable to provide users wit visual environment for effective parallel programming. Therefore, we propose a visual programming environment. VEPO(Visual environment for Parallel Object-Oriented Programming), based on POOSL in order that users can develop parallel programs more easily and conveniently. It aims at supporting a programming environment in which users can represent their programs more naturally and visually I parallel manner with object-oriented concept and essential steps during parallel program development such as program specification, compilation, execution and animation of execution are integrated. VEPO has useful features for parallel processing. Especially, complicated parallel codes for synchronization and communication of processes are automatically generated in the translation phase, so users can be relieved of writing error-prone parallel codes. The system is targeted to the transputer-based parallel system, MC-3. The graphic user interface of VEPO was implemented using Visual C++. Visual programs descirbed on VEPO are translated into Inmos C and executed on MC-3.

• Journal of the Korean Institute of Landscape Architecture
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• v.41 no.5
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• pp.19-27
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• 2013

This paper claims that the One Million-peyong Park(hereafter abbreviated as OMP) project is different from a typical citizen participatory park project by recognizing the exceptional leadership of the Civic Committee for the One Million-pyeong Park Construction(CCOMPC) in promoting and developing the OMP project. Since 2001 the CCOMPC has published a variety of written promotional materials to inform and educate the public about the project. In terms of approaching the promotional materials, this research focuses on the use of language on how the CCOMPC justifies the OMP project, namely the OMP justification discourse, and considers the discourse as a unique form of social document that represents the perspective of the CCOMPC in explaining the local environmental issues and values of urban parks to the public. Using a discourse analysis method, this research analyzes the justification discourses and investigates how they changed over the three main development phases of the OMP: the initiation and preliminary development phase(1999-2001.2), the development phase (2001.2-2008), and the time period after the greenbelt policy release on Dunchi Island(2008-present). In each discourse, the OMP project is rationalized as a citizen participation park project that (1) aims to enhance the quality of public green space in Busan, (2) is accompanied by various community engagement programs that emphasize the value of urban nature and environmental education to expand citizen participation, and (3) has contributed to the National Urban Park Bill. This research emphasizes the role of the discourses in helping the public gain a critical understanding about the local environment and values of urban parks. By analyzing the contents of the discourses, it explains the social learning values of the OMP expressed in the discourses.