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Immunohistochemical Changes of Apoptotic Control Genes by Chronic Inhibition of Nitric Oxide in Rats

  • Bae, Hyung-Joon
    • Biomedical Science Letters
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    • v.18 no.4
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    • pp.420-427
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    • 2012
  • Sprague-Dawley (SD) rats were orally administered with NG-nitro-L-arginine methyl ester (L-NAME), which inhibits or blocks the production of nitric oxide from L-arginine in vascular endothelial cells and vessel tissue. We examined the effects of nitric oxide on some physiological changes such as blood pressure and heart rate, and confirms the apoptosis induced by the suppressed nitric oxide activity in the kidney. This study was performed to investigate correlation between the activities of nitric oxide and apoptosis by immunohistochemical changes of apoptotic control proteins with regulated chronic inhibition of nitric oxide. In the kidney from L-NAME-treated group, immunohistochemical reaction to the antigens of apoptosis inhibiting proteins such as bcl-2 and bcl-xL, exhibited a time-dependent reduction. The expression of apoptosis-inhibiting proteins such as bax and p53 increased expression in proportion to the duration of treatment. The most sensitive apoptosis regulating proteins to L-NAME were p53 in stimulation and bcl-2 in inhibition, respectively.

A Central Pressor Response to Endogenous Nitric Oxide Synthesis Inhibition in Anesthetized Rats

  • Moon, Sung-Ho;Yang, Min-Joon;Oh, Seung-Ho;Kim, Mi-Won;Yoo, Kwang-Jay;Lee, Jong-Eun;Jun, Jae-Yeoul;Yeum, Cheol-Ho;Yoon, Pyung-Jin
    • The Korean Journal of Physiology
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    • v.28 no.2
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    • pp.197-202
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    • 1994
  • The present study was aimed to determine if endogenous L-arginine-nitric oxide (NO) pathway has central, rather than peripheral, mechanisms in blood pressure regulation. Arterial blood pressure and heart rate responses to acute inhibition of the t-arginine-NO pathway were examined in rats anesthetized with thiopental (50 mg/kg, IP). An intracerebroventricular (ICV) cannula was placed in the left lateral ventricle. The right femoral artery was cannulated to measure arterial blood pressure and the vein to serve as an infusion route. $N^G-nitro-L-arginine$ methyl ester (L-NAME) was infused either intracerebroventricularly or intravenously. ICV infusion $(1.25\;{\mu}L/min)$ of L-NAME $(20\;or\;100\;{\mu}g/kg)$ per minute for 60 min) increased the mean arterial pressure and heart rate. Plasma renin concentrations(PRC) were significantly lower in L-NAME-infused group than in the control. L-Arginine $(60\;{\mu}g/min,\;ICV)$ prevented the pressor response to ICV L-NAME. The pressor response was not affected by simultaneous intravenous infusion of saralasin, but was abolished by hexamethonium treatment. Intravenous infusion $(40\;{\mu}L/min,\;10{\sim}100\;{\mu}g/kg\;per\;minute\;for\;60\;min)$ also increased blood pressure, while it decreased heart rate. These results indicate that endogenous L-arginine-NO pathway has separate central and peripheral mechanisms in regulating the cardiovascular function. The central effect may not be mediated via activation of renin-angiotensin system, but via, at least in part, activation of the sympathetic outflow.

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International Benchmarking on Factors Affecting the Number of Country Domain Name (국가도메인 네임 등록 수에 영향을 미치는 요인에 관한 국제 비교)

  • Kim, So-ra;Jun, Hyo-Jung;Kim, Tae-Sung
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.40 no.12
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    • pp.2434-2442
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    • 2015
  • With the arrival of the era of the Internet of Things (IoT), identification of an individual object is gaining significance. Internet address resources such as domain name, IP address, and OID are expected to play the role of an identifier and demand for them is also expected to increase. Accordingly, it becomes important to obtain the Internet address resources. As the Internet address resources market development, Internet address resources at the present time there is a need to gauge whether the potential to develop into industry. For this purpose, we have selected factors affecting the number of country domain name with 18 countries among OECD member countries as research target and carried out a regression analysis.

Study of matching user operation name and operation classification code (ICD-9-CM) (Through OCS program use facilitation at operating room) (사용자 수술명과 수술분류 code (ICD-9-CM) 일치율 향상에 관한 연구 (수술실 OCS program 사용 활성화를 통하여))

  • Choi, Hyang-Ha;Kim, Mi-Young;Kim, Do-Jin;Yu, Ji-Won;Chang, Jung-Hwa;Park, Su-Jung;Park, Jae-Sung
    • Quality Improvement in Health Care
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    • v.12 no.1
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    • pp.104-112
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    • 2006
  • Background : The necessity of unify and standardize codes used at hospital has been emphasized since OCS (Order Communicating System) was adopted. Therefore, the purpose of this study were to standardize operation code by continuous training of the ICD-9-CM code that is used as standard code in OCS program at operating room. Method : In 400 operation data, operation code entered in OCS program at operating room was compared to operation name recorded in medical record. In addition, a matching rate between input data of operation code by medical record department and computing input data of operation code in 3,710 cases was compared for each department. User operation name and operation code were matched and major diagnosis by operation department and operation name were also matched. Results : User operation name was reflected in operation classification code in detail, and operation code entered on user was registered. Input rate and matching rate of operation code were gradually improved after improvement activity. In particular, a matching rate was high at ophthalmology where operation name is segmented. Plastic surgery and orthopedics with a lot of emergency operation and comprehensive operation name show low input rates. Conclusions : As the medical field makes progress in computerlization, awareness of information exchange and sharing becomes higher. Among codes to classified medical institution, codes related to surgical operation are all different by user of hospital and department. Computerlization and standardization is essential. And when efforts of standardization continue in alliance with individual hospital and institution, initiative of preparing medical policy data at a national level will be accelerated.

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Strategy for English Translations of Journal Reference (참고문헌 영문화 작업에 있어 영어번역의 전략)

  • Song, Ho-Sueb
    • Journal of Acupuncture Research
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    • v.28 no.3
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    • pp.121-129
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    • 2011
  • Objectives : This study was to propose how to translate journal references into english for enhancing citation index of the journals published in the Korean Oriental Medical Society. Methods : Journal reference is mainly composed of author name, title or book name, journal name such as Index Medicus or publisher name, etc. In order to find the appropriate equivalents to the above major constituents, head words extracted from all the references of Journal of Korean Oriental Medical Society published in 2002 to 2009. A plan for English translation of the journal reference was formulated and the glossary was prepared. Plan for English translation of the journal reference : 1. Author: Author name was represented as capitalized last name and two initials of first name and listed up to six. If there are more, the first three or six authors were listed with 'et al'. 2. Terminology of traditional Korean medicine: Standard korean traditional medical terminology was one of the current representative dictionary with as much as 6040 headwords, which was needed to be translated into English in order to provide substantial equivalents available for English translation of journal reference. Therefor 4361 english equivalents were to be newly adopted except for 1679 overlapped with them in WHO-IST. Source oriented translation and target oriented translation were allowed to be appropriately selected depending on the condition. In addition, principle of English translation of acupoint,medicinal Herbs, Herbal formula and classical works were proposed. 3. Basically the names of journals should be set in italics and abbreviated according to the List of journals indexed for medline (formerly Index Medicus) published by the National Library of Medicine. however, abbreviation of korean oriental medical journals were not yet established. Thus establishment of tentative korean index medicus should be considered. Conclusions : For the enhancement of journal citation index of korean traditional medical journals, it was suggested that english translation of journal reference should be one of the alternatives enhancing citation rate.

Endonym, Geographical Feature and Perception: The Case of the Name East Sea/Sea of Japan (토착지명, 지리적 실체, 그리고 인식의 문제 -동해/일본해 표기 사례-)

  • Choo, Sung-Jae
    • Journal of the Korean Geographical Society
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    • v.44 no.5
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    • pp.661-674
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    • 2009
  • In recent academic debates within the UN Group of Experts on Geographical Names, two contrasting views evolved as regards to the status of the names of transboundary features or features beyond a single sovereignty. The partial view posits that a name is an endonym only for those portions of a feature where the name corresponds to the language used while the whole view argues that a name in its official language is an endonym for the whole feature. In either of these views, the name East Sea should be given due respect, for the Korean territorial waters at least or as an endonym for the entire sea. This paper supports the partial view that a geographical feature can be separated and each separated portion can have different name forms and status. Regarding the separation of a feature, the limits to which local people perceive as 'their' sea should be used. The name East Sea is proposed as the translated form of an endonym Donghae.

A Study on the Place Name of Migration in Three Northeast Provinces of China I : Case of the Yanbian Korean Autonomous Prefecture (중국 동북 3성의 이식지명에 관한 연구 I - 연변 조선족 자치주를 사례로 -)

  • Kim, Nam-Sin;Jin, Shizhu
    • Journal of the Korean association of regional geographers
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    • v.20 no.2
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    • pp.153-162
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    • 2014
  • This Research is to study types and distribution for place name of migration derived from Korea Peninsula by analyzing villages name of the Yanbian Korean Autonomous Prefecture. Village names of Yanbian Korean were identified as 945 out of 2,015. Place name migrated from Korea Peninsula was turned out 51 villages. Up to the present time in the Transition of China, 34 place names were disappeared, maintained place names were 16, and rehabilitated place name after loss was 1. The place name by naming method were classified as small area directed migration, large area directed migration, and merged migration. In case of small area directed migration, origin and destination is same such as Jeongeup and Muju, Cheonbuk, large area directed migration is named case by region migrants like a Gangwonchon named by people moved from GanwonDo, and merged case combine initials with each village names in case of GilseongChon by colligated Gilju and Seokseongmyeon. The results will be expected to support research information for identity and ethnical migration process.

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An Web-based Mapping by Constructing Database of Geographical Names (지명 데이터베이스 구축을 통한 웹지도화 방안)

  • Kim, Nam-Shin
    • Journal of the Korean association of regional geographers
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    • v.16 no.4
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    • pp.428-439
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    • 2010
  • Map of geographical names can give us information for understanding of region because geographical name reflects regional perception of human. This study aimed to make an web-based map by constructing database of geographical names. Main contents carried out research on methods for classification of geographical names, database construction, and mapping on the website. Geographical name classified into four categories of the physical geography, culture and historical geography, economic geography, and the other and also, 18 sub-categories by classification criteria. Geographical name designed to input by collecting geographical names from paper-based maps and vernacular place names only known to the local region. Fields of database consisted of address, coordinates, geographical name(hangeul, hanja), classification, explanation, photographs. Map of geographical names can be represented with regional geographical information. The result of research is expected to offer information for distribution of geographical names as well as regional interpretation.

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Significance of "Pre-Study Post-Designation" Strategy in Natural Monument Designation System: With Special Reference to Geologic Heritage

  • Kong, Dal-Yong;Lee, Seong-Joo
    • Journal of the Korean earth science society
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    • v.35 no.5
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    • pp.324-332
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    • 2014
  • Many problems in naming natural monuments have been repeatedly argued by many researchers, and four different types of naming problems were identified: 1) name of unknown nationality (natural monument no. 82 and 108), 2) morphological name rather than scientific name (natural monument no. 180, 295, and 409), 3) name of fable character (local cultural property of Changnyeonggun), and 4) scientifically wrong name (natural monument no. 413). Among them, two cases (case 3 and 4) using wrong names are found in natural monument of geologic heritages, which should be ascribable to a hasty designation without an accurate and thorough scientific research. In order to solve these problems and to establish an ideal policy in designating natural monument, National Research Institute of Cultural Heritage has been carrying out a research project of "Pre-study and Post-designation (PSPD)", especially targeting the rod-shaped stromatolite. It is likely that this new strategy of PSPD is a unique and the first step to solve many problems in designating and naming geologic heritages as natural monuments. As a consequence, we strongly suggest that PSPD system must be applied to natural monument designation as an institutional arrangement.