• Title/Summary/Keyword: the Mediating Effect

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The impact of organizational socialization tactics on newcomers' organizational citizenship behaviors: The mediating effect of perceived organizational support (조직사회화 기법이 신입사원의 조직시민행동에 미치는 영향: 조직지원인식의 매개효과를 중심으로)

  • Kyungmin Kim
    • Korean Journal of Culture and Social Issue
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    • v.24 no.4
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    • pp.519-539
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    • 2018
  • This study investigates the impact of organizational socialization tactics on newcomers' organizational citizenship behaviors. We explains this relationship with the concept of perceived organizational support, which refers to the extent to which individuals perceive that the organization recognizes their contributions and takes care of their well-being. We expect that the more institutionalized the organization's socialization tactics are, the more organizational support individuals perceive, consequently increasing the performance of organizational citizenship behaviors. We performed a survey targeting 450 newcomers in domestic companies, and adopted 382 data for path analyses based on the structural equation modeling. As the result, in all the three dimensions of socialization tactics (content, context, social), the extent to which socialization tactics are institutionalized is positively related to the perception of organizational support. It also has the positive relationship with individuals' organizational citizenship behaviors, being fully mediated by the perceived organizational support. More specifically, context socialization tactics shows the highest level of impact both on the perceived organizational support and organizational citizenship behaviors, whereas social tactics has the lowest level of impact. These results imply that the range of effects the organizational socialization has on the newcomers' attitudes and behaviors should be more extended and detailed.

Development and characterization of a fully functional small anti-HER2 antibody

  • Gao, Jie;Li, Bohua;Li, Huimei;Zhang, Xunmin;Zhang, Dapeng;Zhao, Lei;Wang, Chong;Fang, Chen;Qian, Weizhu;Hou, Sheng;Kou, Geng;Wei, Huafeng;Shi, Shu;Wang, Hao;Guo, Yajun
    • BMB Reports
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    • v.42 no.10
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    • pp.636-641
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    • 2009
  • The penetrating of monoclonal antibodies (mAbs) into solid tumor may be hampered by their large size. The antibody mimetics, composed of two complementarity-determining regions (CDRs) through a cognate framework region (FR), have been demonstrated to have the capacity to penetrate tumors superior to its parental intact IgG. In this study, we used CDR and FR sequences from the humanized anti-HER2 monoclonal antibody trastuzumab to design four antibody mimetics. Then these antibody mimetics were fused to human IgG Fc to generate mimetics-Fc small antibodies. One of the four mimetics-Fc antibodies binds well to HER2-overexpressing SK-BR3 cells and effectively inhibits the binding of trastuzumab. This mimetics-Fc, denoted as HMTI-Fc, was shown to be effective in mediating antibody-dependent cellular cytotoxicity and exhibit an antiproliferative effect in SK-BR3 cells. To our knowledge, the HMTI-Fc antibody shown here is the smallest fully functional antibody and may have a potential for treatment of cancer.

Study of the Effects of Supplier Monitoring on Shop floor Productivity (공급사 모니터링이 현장생산성에 미치는 영향에 관한 연구)

  • Cho, BooYun;Kang, Gi-Choon;Hyun, MinCheol
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.12
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    • pp.7025-7039
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    • 2014
  • Focal companies (hereafter called buyers) adopt outsourcing practices from a supply chain management strategy to be competitive. Buyers face the bridge transfer after outsourcing contracts, and the monitoring practices would be the only control mechanism left to prevent losing control over the suppliers. This study suggests the set of monitoring practices (i.e., capability, activity and outcome monitoring) as the independent variables to enhance the buyer-supplier collaboration and supplier's performance. In addition the buyer's efforts of monitoring are assumed to influence the buyer's shop floor productivity mediated by the supplier's performance and buyer-supplier collaboration. The results showed that the monitoring practices are meaningful antecedents to the supplier's performance and buyer-supplier collaboration, which fully mediates between the monitoring practices and buyer's shop floor productivity. The mediating role of the buyer-supplier collaboration between activity monitoring and shop floor productive has been rejected, because the negative effect of activity monitoring on buyer-supplier collaboration conflicts with the positive impact of buyer-supplier collaboration on shop floor productive. The theoretical contribution and managerial implications with limitations have been discussed.

Mediating Effects of Perceived Risk and Usefulness between Online Information Credibility and Intention to Use (온라인 정보의 신뢰성 및 정보 활용의도 사이의 지각된 위험과 유용성의 매개효과에 관한 연구)

  • Sun, Jonghak;Yoon, Jung-Hyeon
    • Management & Information Systems Review
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    • v.33 no.4
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    • pp.99-118
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    • 2014
  • Using the theory of attribution, this study investigates the determinants if controllability and explores underlying dimensions of online information credibility, and then investigates if the credibility of online information influences the users' intention to use the online information for evaluating or judging the involved products. Moreover, as a research attempt to investigate the impacts of online information credibility, this study examines whether the main effect of perceived online information credibility on the intention of using online information to make a decision of purchase is mediated by both perceived risk and perceived usefulness. A total of 287 survey forms were collected from online consumers. We examined reliability by exploring internal consistency of the multiple item scales in the overall sample. Convergent and discriminant validity were also examined for evidence of construct validity. Then, PLS technique was employed to test the research model. As a result of analyzing data from a dataset of 287 responses via PLS technique, it is found that (1) both sources (controllability and stability) of perceived credibility are significantly associated with both perceived risk and perceived usefulness, and (2) perceived risk as well as perceived usefulness partially mediate the link between the two sources of credibility and intention to use. The findings of this study also suggest that the two dimensions of online information credibility influence information recipient's intention to use. Moreover, the online information including descriptions about controllability and stability can trigger potential consumers to perceive risk about consumption of the informed products and services. Therefore, providing online information with highly described controllability and stability can increase not only the credibility of the online information itself, but also the intention to use the online information through perceived risk and usefulness.

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An Empirical Test of the Interactionist Model on the Relationship Between Household Income, Main Caregiver Depression, and Youth Aggression (가구소득, 주양육자 우울, 청소년 공격성 간의 종단적 상호교류관계 검증 : 자기회귀교차지연모델을 이용하여)

  • Kim, Dong Ha;Um, Myung-Yong
    • Korean Journal of Social Welfare Studies
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    • v.47 no.1
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    • pp.151-178
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    • 2016
  • The primary goal of the current study was to investigate the longitudinal relationship between household income, main caregiver depression, and youth aggression from the interactionist perspective. The data were derived by combining the 2006, 2009 and 2012 survey waves from the Korean Welfare Panel Study. This data set covered the full span of adolescence from elementary to high school. The study utilized 561 families as the final sample and conducted autoregressive cross-lagged analysis. As a result, the early income status, main caregiver depression and youth aggression were likely maintained over time. Second, the results provided support for a reciprocal relationship between income and main caregiver depression. On the other hand, the reciprocal relationship between main caregiver depression and youth aggression was not found in the current study. Finally, the mediating effect of main caregiver depression between income and youth aggression was not found in the present study. In conclusion, the results of this study support the interactionist model in that the association between family income and main caregiver depression involves reciprocity and mutual influence across time. These findings have major implications for policy and interventions in regards to low-income families.

A Study on the Diffusion of Chinese Creator's Contents among Korean YouTube Users: Using Social Network Analysis of Creator Fengtimo's YouTube Video Network (중국 크리에이터 영상콘텐츠의 국내 소비에 대한 네트워크 구조와 확산 영향요인 연구 - '펑티모' 동영상의 유튜브 비디오 네트워크 분석을 중심으로 -)

  • Son, Jaeyoung
    • Korean Association of Arts Management
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    • no.57
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    • pp.59-84
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    • 2021
  • This study examined the structure of YouTube video network and the factors for the diffusion of Chinese creator's videos through the case of famous Chinese creator Fengtimo. There is few interest to the diffusion of Chinese contents among Korean researchers, while they have been studied the consumption of Hallyu(Korean wave) contents overseas. Using the data that YouTube Data API offers, this study analysed the video network that the comments of which are same users with NodeXL tools and the regression model with JASP tools. The study found that there are three groups of the YouTube channels of that network. They are domestic official accounts of Fengtimo, foreign officail accounts of Fengtimo and individual creators' accounts. The official accounts share the videos of Fengtimo's songs and entertainment contents for the fans, where the individual creators share their own meme videos(UGC). The significant factors for the diffusion in the YouTube video network are comments, likes, out-degree, dislikes, in-degree and betweenness centrality. There are significant difference between official channel and indivisual groups on the views. And degree and betweenness centrality have mediating effect. It is necessary to conduct more research on that subject with many other cases if we want to get to know the generalized explanation.

The Antecedents and Outcomes of Customer Satisfaction and the Formation Process of Brand Preference and Repurchase Intention in Service Industries (서비스 산업에서의 고객만족 선. 후행요인과 브랜드선호도 및 재구매의도 형성과정)

  • Jang, Hyeong-Yu
    • Journal of Global Scholars of Marketing Science
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    • v.16 no.3
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    • pp.61-86
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    • 2006
  • The main purpose of this study is to conceptualize and investigate the relationships between the antecedents and outcomes of customer satisfaction and the linking variables of brand preference and repurchase intention in service industries. To achieve this objective, the study tries to validate the structural equation model and causal relationships among the model's elements involving antecedents to customer satisfaction(perceived quality, value, equity), consequences(brand preference, repurchase intention), and moderating variable/switching cost, customer loyalty). Empirical findings are as follows: First, the effect of two antecedents/perceived quality and value) on customer. satisfaction was accepted but perceived equity was rejected. Second, I found out that there were direct or indirect relationships between the mediating variables/switching cost, customer loyalty, brand preference) and repurchase intention. This means that the proper management concerned with indirect path is probably more important for the success of services industries. Third, the direct effects of customer satisfaction and switching cost on repurchase intention were not significant against the existing studies excepting brand preference. This implies that repurchase intention was mainly intensified by the indirect path, 'customer loyalty${\rightarrow}$brand preference${\rightarrow}$repurchase intention' and 'switching cost${\rightarrow}$brand preference${\rightarrow}$repurchase intention.' The service marketers make efforts not only to strengthen the direct casual linkage but also to consolidate the indirect connections leading to create repurchase intention. Finally, the proper management of these structural relationships will help clarify the role of service marketer resulting in increasing sustainable competitive advantage in service industries.

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Nitric oxide(NO) mediating non-adrenergic non-cholinergic(NANC) relaxation in the boar retractor penis muscle II. Comparison of the relaxant properties induced by nonadrenergic, noncholinergic nerve stimulation and S-nitrosothiols in the porcine retractor penis muscle (Nitric oxide에 의한 수퇘지 음경후인근의 비아드레날린 비콜린 동작성 이완 II. 비아드레날린 비콜린성 신경의 전장자극과 S-nitrosothiols에 의한 돼지 음경후인근의 이완 효과 비교)

  • Mun, Kyu-whan;Kim, Tae-wan;Kang, Tong-mook;Lee, Wan;Yang, Il-suk
    • Korean Journal of Veterinary Research
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    • v.35 no.3
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    • pp.459-469
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    • 1995
  • As S-nitrosothiols were proposed as nitrergic carriers in vascular and nonvascular smooth muscle, we have investigated the relaxant properties of several S-nitrosothiols in the porcine retractor penis(PRP) muscle and compared them with the effects of exogenously added NO, electrical field stimulation(EFS) of NANC nerves and sodium nitroprusside(SNP). Also the influences of oxyhemoglobin and hydroquinone on the relaxant responses were investigated. In addition, effects of NO on membrane potentials and its involvement in the generation of inhibitory junction potential(IJP) were investigated with conventional intracellular microelectrode technique. The results were summerized as follows. 1. Frequency-dependent relaxations of PRP muscle were induced by EFS to NANC nerve. Tetrodotoxin($1{\times}10^{-6}M$) abolished the relaxations of PRP muscle induced by EFS, and L-NAME(($2{\times}10^{-5}M$) and methylene blue($4{\times}10^{-5}M$) inhibited the relaxations. L-NAME-induced inhibition of the relaxations was reversed by L-arginine($1{\times}10^{-3}M$), but not by D-arginine. 2. Exogenous NO($1{\times}10^{-5}-1{\times}10^{-4}M$), sodium nitroprusside(($1{\times}10^{-7}-1{\times}10^{-4}M$) induced dose-dependent relaxations of PRP muscle. All S-nitrosothiols($1{\times}10^{-7}-1{\times}10^{-4}M$) tested relaxed the PRP muscle in dose-dependent manner and the potency order was SNAP>GSNO>CysNO>SNAC. 3. Oxyhemoglobin($5{\times}10^{-5}M$) blocked the relaxation induced by exogenous NO and inhibited EFS-, S-nitrosothiols-, and SNP-induced relaxation. 4. Hydroquinone($1{\times}10^{-4}M$) also abolished the relaxations induced by exogenous NO, and reduced the relaxations induced by S-nitrosothiols, but did not affect EFS- and SNP-induced relaxations. 5. SNP($2{\times}10^{-6}-5{\times}10^{-6}M$) relaxed muscle strips but the membrane potentials were not affected. 6. EFS with several pulses(1ms, 2Hz, 80V) produced an inhibitory junction potential(IJP) with muscle relaxation. They were abolished by TTX($2{\times}10^{-6}M$). $N^G$-nitro-$_{\small{L}}$-arginine(L-NNA, $2{\times}10^{-5}M$) abolished the muscle relaxation, but had no effect on IJP.

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Structural Relationships of Cognitive, Emotional, and Behavioral Evaluations of Coffee Shops (커피 전문점의 인지적, 감정적, 그리고 행위적 평가의 구조적 관계)

  • KIM, Jin-Young
    • The Korean Journal of Franchise Management
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    • v.13 no.3
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    • pp.31-43
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    • 2022
  • Purpose: Service quality is a topic of constant interest in marketing research and practitioners. Service quality is an important factor influencing performance even in the context of coffee shops, and research on service quality management strategies continues by coffee shop researchers and practitioners. The service quality of coffee shops is a source of competitive advantage and is an important factor in enhancing customer and business performance. This study aims to identify the effects of cognitive evaluation on emotional and behavioral responses using a cognitive-emotional-behavioral framework and SOR model in the coffee shop context. Cognitive evaluation (service quality) consists of tangibles, responsiveness, assurance, reliability, and empathy dimensions. Research design, data, and methodology: In the proposed model, positive and negative emotions and satisfaction mediate the relationship between service quality and money to spend and visit frequency. The data were collected from customers who visited a coffee shop within the last 1 month. The survey was conducted for about one month. Among a total of 300 distributed questionnaires 261 responses were used for data analysis. The data were analyzed using frequency analysis, measurement model analysis, and structural equation modeling analysis with SPSS 28.0 and SmartPLS 4.0. Results: Tangibles, responsiveness, assurance, and empathy had significant positive effects on positive emotion, while only reliability had a significant negative effect on negative emotion. Both positive and negative emotions had significant positive effects on customer satisfaction, but not on money to spend and visit frequency. Lastly, customer satisfaction had significant positive effects on money to spend and visit frequency. Conclusions: The study revealed the relative weight of cognitive factors on customer emotions and confirmed the validity of SOR model. The fact that tangibility is the most important factor in increasing positive emotions and reliability is the most important factor in reducing negative emotions provides a direction for emotional branding strategies using the service quality mix of coffee shops. This study confirmed the full mediating role of satisfaction between positive and negative emotions and consumer behaviors (money to spend and visit frequency). This infers that when a coffee shop increases customer satisfaction through customer emotion management, the customer's money to spend and visit frequency in the coffee shop increases.

A Study on the Effects of Discrimination Experience on Self-image and Self-esteem among the Korean elderly: Moderating Effects of Social and Economic Activity Participation (노인의 차별경험이 자아이미지와 자아존중감에 미치는 영향에 관한 연구: 사회·경제적 참여의 조절효과를 중심으로)

  • Ahn, Joonhee;Kim, Seongyong
    • 한국노년학
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    • v.29 no.4
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    • pp.1645-1663
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    • 2009
  • The purpose of the study is to analyze the mediating effects of self-image on the relationship between experience of discrimination and self-esteem among the elderly in Korea. Furthermore, it is to explore whether these effects are moderated by social and economic activity participation. Data were collected from a cross-sectional survey of 543 community-dwelling Korean older adults (age≥65) drawn from community and senior centers in the mid-size city in Korea. The statistical analysis was performed by a structural equation modeling using LISREL statistical program. The results are fourfold. First, experiences of discrimination exerted the negative effects on physical, dispositional, and competent self-images of the elderly. Second, dispositional and competent self-image brought down by discriminative experiences lowered the levels of self-esteem. Third, social activity participation moderated the negative effects of discrimination experiences on physical and dispositional self-images. It also moderated the effects of dispositional self-image on self-esteem. Fourth, economic activity participation did not show moderating effects on the relationship between experience of discrimination and self-images. Meanwhile, it moderated the effect of competent self-image on self-esteem. These results demonstrate that to improve self-esteem of the elderly population, social welfare policies should make effort to reduce discrimination toward the elderly. Furthermore, social welfare organizations should also try to implement diverse community based programs geared for enhancing social and economic activities for elderly. Limitations and directions for future research are also discussed.