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Major ginsenosides from Panax ginseng promote aerobic cellular respiration and SIRT1-mediated mitochondrial biosynthesis in cardiomyocytes and neurons

  • Huang, Qingxia;Lou, Tingting;Lu, Jing;Wang, Manying;Chen, Xuenan;Xue, Linyuan;Tang, Xiaolei;Qi, Wenxiu;Zhang, Zepeng;Su, Hang;Jin, Wenqi;Jing, Chenxu;Zhao, Daqing;Sun, Liwei;Li, Xiangyan
    • Journal of Ginseng Research
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    • v.46 no.6
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    • pp.759-770
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    • 2022
  • Background: Aerobic cellular respiration provides chemical energy, adenosine triphosphate (ATP), to maintain multiple cellular functions. Sirtuin 1 (SIRT1) can deacetylate peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) to promote mitochondrial biosynthesis. Targeting energy metabolism is a potential strategy for the prevention and treatment of various diseases, such as cardiac and neurological disorders. Ginsenosides, one of the major bioactive constituents of Panax ginseng, have been extensively used due to their diverse beneficial effects on healthy subjects and patients with different diseases. However, the underlying molecular mechanisms of total ginsenosides (GS) on energy metabolism remain unclear. Methods: In this study, oxygen consumption rate, ATP production, mitochondrial biosynthesis, glucose metabolism, and SIRT1-PGC-1α pathways in untreated and GS-treated different cells, fly, and mouse models were investigated. Results: GS pretreatment enhanced mitochondrial respiration capacity and ATP production in aerobic respiration-dominated cardiomyocytes and neurons, and promoted tricarboxylic acid metabolism in cardiomyocytes. Moreover, GS clearly enhanced NAD+-dependent SIRT1 activation to increase mitochondrial biosynthesis in cardiomyocytes and neurons, which was completely abrogated by nicotinamide. Importantly, ginsenoside monomers, such as Rg1, Re, Rf, Rb1, Rc, Rh1, Rb2, and Rb3, were found to activate SIRT1 and promote energy metabolism. Conclusion: This study may provide new insights into the extensive application of ginseng for cardiac and neurological protection in healthy subjects and patients.

Remarkable impact of steam temperature on ginsenosides transformation from fresh ginseng to red ginseng

  • Xu, Xin-Fang;Gao, Yan;Xu, Shu-Ya;Liu, Huan;Xue, Xue;Zhang, Ying;Zhang, Hui;Liu, Meng-Nan;Xiong, Hui;Lin, Rui-Chao;Li, Xiang-Ri
    • Journal of Ginseng Research
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    • v.42 no.3
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    • pp.277-287
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    • 2018
  • Background: Temperature is an essential condition in red ginseng processing. The pharmacological activities of red ginseng under different steam temperatures are significantly different. Methods: In this study, an ultrahigh-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry was developed to distinguish the red ginseng products that were steamed at high and low temperatures. Multivariate statistical analyses such as principal component analysis and supervised orthogonal partial least squared discrimination analysis were used to determine the influential components of the different samples. Results: The results showed that different steamed red ginseng samples can be identified, and the characteristic components were 20-gluco-ginsenoside Rf, ginsenoside Re, ginsenoside Rg1, and malonyl-ginsenoside Rb1 in red ginseng steamed at low temperature. Meanwhile, the characteristic components in red ginseng steamed at high temperature were 20R-ginsenoside Rs3 and ginsenoside Rs4. Polar ginsenosides were abundant in red ginseng steamed at low temperature, whereas higher levels of less polar ginsenosides were detected in red ginseng steamed at high temperature. Conclusion: This study makes the first time that differences between red ginseng steamed under different temperatures and their ginsenosides transformation have been observed systematically at the chemistry level. The results suggested that the identified chemical markers can be used to illustrate the transformation of ginsenosides in red ginseng processing.

Exploration of Chinese-Korean Cooperative Multimedia Design Education

  • Jiang, Zheng-Qing;Lee, Dong-Hun
    • International Journal of Contents
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    • v.5 no.4
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    • pp.69-74
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    • 2009
  • This paper has done a study of Chinese-Korean cooperative multimedia design education. Sino-Korean school of multimedia was set up by Shanghai University of Engineering Science (SUES) and Korea Dongseo University in October 2002. We have created "3.5+0.5 Teaching Model". In this model, Chinese and Korea professors take courses together. Firstly, paper points our the Chinese government policy background of Chinese-Foreign Cooperation in running schools and the development of Chinese-Korean cooperative multimedia design education in SUES. Secondly, by analyzing the multimedia design industry to understand the Chinese multi-media design education. Thirdly, paper made in-depth studies for "3.5+0.5 Teaching Model" so as to draw the experience of successes and problems. Through analysis of "Questionnaires for students' learning and living conditions in Dongseo University in 2009" by spss 16.0, paper made a research of mode of "A semester studying in Korea". Finally, paper points out the development direction of Chinese-Korean cooperative multimedia design.

A Study on the Pronunciation of Chinese Characters in 『Huangdineijing』 - Focused on 『Leijing』 - (『황제내경(黃帝內經)』의 한자독음(漢字讀音)에 대한 고찰(考察) - 『유경(類經)』을 중심으로 -)

  • Yuk, Sangwon
    • Journal of Korean Medical classics
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    • v.32 no.3
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    • pp.1-15
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    • 2019
  • Objectives : The purpose of this study is to find the pronunciations suitable for the meanings of Chinese characters because the pronunciations of Chinese characters with multi-pronunciations in the "Huangdineijing" are written differently in Chinese character dictionaries(字典) and in Korean Medical dictionaries(韓醫學辭典) respectively. Methods : First, the annotations for pronunciations in the "Leijing" were searched, upon which the frequently mispronounced 16 Chinese characters in the "Huangdineijing" were selected. Then these selected Chinese characters were compared and considered with reference to Chinese character dictionaries(published in China and Korea), and Korean Medical dictionaries. Results & Conclusions : It was discovered that in "Leijing" there were 1,537 annotations that used 'FanQie(反切)', 'Pronunciation(音)', 'Replaceable character(通用)', 'Same character (同字)', 'Four intonations(四聲)' etc. In some places, there were additional meanings of the Chinese characters. It was found that 16 Chinese characters were susceptible to wrong pronunciations in the "Huangdineijing", for which the appropriate pronunciations in regards to the meaning of the sentences were determined.

A Study on the Chinese Characters Originated in Japan in Japanes in Industrial Standard (일본공업규격 "정보교환용한자부호" 에 포함된 일본한자에 대한 연구)

  • Lee Choon-Tack
    • Journal of the Korean Society for Library and Information Science
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    • v.22
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    • pp.219-257
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    • 1992
  • Among the Chinese Characters originated in Japan, some of them are very ancient in their origin and others come to exist as different forms by being used widely in forged books in Chinese. These Characters can be divided into three groups. First, the Chinese Characters whose forms are different. Most of these are 'hoiui' (회의)character, being made by imitating the forms of the original Chinese Letters. These characters do have meaning but not pronunciation. This is one distinct feature of Chinese Characters originated in Japan. Second, the Chinese Characters whose meaning has been assigned by the Japanese people. These letters can be grouped into two. One is the letters whose meanings are entirely different from original Chinese Characters, and the other is the letters whose meanings are not known although their pronunciations are known. It can be explained that the letters with different forms are made because of the ignorance of letter's existence. Or, the letters were made on purpose in ordoer to be used in different meanings. Third, the Characters with a partial modification of original Chinese Characters. Among the Characters in three groups above, pure Japanese-made Chinese Characters are those in group one and three since those in group two are Chinese Letters whose meanings (or pronunciation) only are Japanese. As a results of detailed investigation of pure Japanese-made Chinese Character in JIS X 0208-1990, the followings are discovered: 1. Pure Japanese-made Chinese Characters are 147 in numbers. 2. The Characters which were originally Chinese but now considered to be Japanese-made are 5 in numbers. Among these letters, 39 Characters are not listed in TaeHanHwaSaJon(Whose fame is well known as the authoritative dictionary of Chinese Characters), 47 Characters are not found in the dictionaries of Chinese Characters compiled in Korea. 3. 14 Characters seem to be Japanese-made Chinese Characters although it cannot be said so with accuracy because of various meanings found in several dictionaries of Chinese Characrters.

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Study of the Professionalization of Education for Traditional Chinese Medicine (중의학 교육의 전문화에 대한 연구)

  • Kwon, Young-Kyu;Lee, Hyun-Ji
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.19 no.4
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    • pp.860-864
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    • 2005
  • Nowadays most of scholarship is based on the western model. Traditional Chinese Medical education system also follows the western medical education. In the views of medical sociology, it shows very interesting phenomenon that the modernization of traditional area follows the western model of modernization. Moreover, it provides a good chance to discuss whether modernization and westernization of tradition is real development or not. Traditional Chinese Medicine had been the only institutional medicine in China for a long time. But the status of Traditional Chinese Medicine has been changed very rapidly since modern era. Shanghai Traditional Chinese Medical School was established in 1916. But National Party government tried to abolish Traditional Chinese Medicine and it met a crisis of maintenance. But the situation has been dramatically changed when Communist Party got the power in 1949. The Communist Government needed a chief medical service. And Traditional Chinese Medicine could meet the condition. Traditional Chinese Medicine could provide also the ideology of national superiority. Therefore, Traditional Chinese Medicine has been protected and developed by the assistance of the Communist Party. In the process, Traditional Chinese Medical education has been professionalized.

Survey on the Status and Needs of Korean Food Consumption for the Development of Home Meal Replacement for Chinese and Japanese (중국인, 일본인 대상 가정식사 대용식 개발을 위한 한식섭취 현황 및 요구도 조사)

  • Han, Gyusang;Choi, Jiyu;Kwon, Sooyoun
    • Journal of the East Asian Society of Dietary Life
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    • v.27 no.4
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    • pp.420-430
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    • 2017
  • This study investigated the status of Korean food consumption and the need for home meal replacement of Korean food for Chinese and Japanese in order to export Korean food to China and Japan. In total, 78.2% of Chinese and 33.0% of Japanese showed significant differences in their experiences of visiting Korea. The most common place to consume Korean food was a Korean restaurant for Chinese (55.8%), whereas Japanese (44.9%) consumed Korean food at Korean restaurants in Japan. In the purchasing experience of Korean home meal replacement, 59.2% of Chinese and 40.5% of Japanese responded that they had 'purchase experience', and the reason for purchasing was 'delicious' (32.5%) for Chinese and 'convenience' (34.8 %) for Japanese. The place to purchase Korean home meal replacement was large marts in both countries. Most Chinese (92.2%) and Japanese (62.1%) respondents said they were willing to buy Korean home meal replacement. Both Chinese (54.8 %) and Japanese (48.0%) said that 'taste' was the most important factor to consider when developing Korean home meal replacement. The favorite tastes were 'spicy' (35.3%) for Chinese and 'savory' (38.8%) for Japanese. For the taste of Korean home meal replacement, Chinese answered that the product should be developed by maintaining 'Korean traditional taste as it is' (57.7%), whereas Japanese responded 'change according to the taste of Japanese' (65.2%). For the preferred packaging form of home meal replacement, Chinese preferred 'vacuum' package while the Japanese preferred 'frozen'. The results of this study can be used as basic data for domestic food companies to establish marketing strategies to enter the Chinese and Japanese home meal replacement markets.

Chemistry Study on Protective Effect against·OH-induced DNA Damage and Antioxidant Mechanism of Cortex Magnoliae Officinalis

  • Li, Xican;Fang, Qian;Lin, Jing;Yuan, Zhengpeng;Han, Lu;Gao, Yaoxiang
    • Bulletin of the Korean Chemical Society
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    • v.35 no.1
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    • pp.117-122
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    • 2014
  • As a Chinese herbal medicine used in East Asia for thousands years, Cortex Magnoliae Officinalis (CMO) was observed to possess a protective effect against OH-induced DNA damage in the study. To explore the mechanism, the antioxidant effects and chemical contents of five CMO extracts were determined by various methods. On the basis of mechanistic analysis, and correlation analysis between antioxidant effects & chemical contents, it can be concluded that CMO exhibits a protective effect against OH-induced DNA damage, and the effect can be attributed to the existence of phenolic compounds, especially magnolol and honokiol. They exert the protective effect via antioxidant mechanism which may be mediated via hydrogen atom transfer (HAT) and/or sequential electron proton transfer (SEPT). In the process, the phenolic-OH moiety in phenylpropanoids is oxidized to the stable quinine-like form and the stability of quinine-like can be ultimately responsible for the antioxidant.

A Comparative Analysis of the Safety Awareness of Korean and Chinese Construction Workers

  • Zhang, Zhen;An, Sung-Hoon
    • Journal of the Korea Institute of Building Construction
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    • v.12 no.4
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    • pp.433-441
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    • 2012
  • Accompanied by Chinese strong economic growth rates and development of demand for the construction industry, Chinese construction industry has already become one of the largest construction markets in the world. Unfortunately, the frequent occurrence of safety incidents on Chinese construction sites is a large obstacle for other countries construction companies seeking to enter the Chinese construction market. This study aims to analyze and compare the safety awareness of Chinese and Korean construction workers. Our research showed that the safety awareness of Korean construction workers is far higher than that of their Chinese counterparts, particularly in terms of the efficiency of safety education and the observance of safety rules. The development of a safety management plan based on these results will contribute to reducing the frequency of accidents on Chinese construction sites.