• Journal of Digital Convergence
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• v.20 no.3
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• pp.265-273
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• 2022

The purpose of this study is to take a look the situation of social enterprises under CIVID-19 Pandemic and to suggest future directions. The COVID-19 pandemic which started at the end of 2019, has influenced the various areas of our society, such as health, economic, social and networking. The virus is spread through human respiratory, and it is working as a disability factor in human focused social economy. Under the COVID-19 pandemic situation, Social entrepreneurs are being constrained in financial aspects. In the process of continuing pandemic, the size of the social economy has been expanded and cleaning & health businesses are showing economic performance. This is to tell the fact that social economy is solving COVID-19 issues based on a reciprocity and solidarity. To create a sustainable ecosystem for the social economy, we should select and promote universal and concrete future directions at the economic and social safety net building level rather than to respond to COVID-19.

• International Journal of Advanced Culture Technology
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• v.10 no.1
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• pp.204-210
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• 2022

From the 1970s to the present, the number of new infectious diseases such as SARS, Ebola virus, and MERS has steadily increased. The new infectious disease, COVID-19, which began in Wuhan, Hubei Province, China, has pushed the world into a pandemic era. As a result, Countries imposed restrictions on entry to foreign countries due to concerns over the spread of COVID-19, which led to a decrease in the movement of tourists. Due to the restriction of travel, keywords such as "Corona blue" have soared and depression has increased. Therefore, this study aims to analyze the stress meaning network of the COVID-19 era to derive keywords and come up with a plan for a travel-related platform of the Post-COVID 19 era. This study conducted analysis of travel and stress caused by COVID-19 using TEXTOM, a big data analysis tool, and conducted semantic network analysis using UCINET6. We also conducted a CONCOR analysis to classify keywords for clustering of words with similarities. However, since we have collected travel and stress-oriented data from the start to the present, we need to increase the number of analysis data and analyze more data in the future.

• International Journal of Knowledge Content Development & Technology
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• v.11 no.4
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• pp.35-51
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• 2021

This study measured the effects of fake news and propaganda on managing information on COVID-19 among the Nigerian citizenry. This study examined sources of information on COVID-19 available to the people, evaluated reasons behind spreading fake news, examined how fake news has affected the spread of COVID-19 pandemic in Nigeria, established the consequences of fake news on managing COVID-19 pandemic and as well identified ways to contain fake news at a time like this in Nigeria.It is a survey with a sample size of 375 participants selected using simple random technique. Instrument of data gathering was questionnaire widely distributed in the six geo-political zones of Nigeria using Survey monkey. Data was analysed using frequencies, counts and percentages, tables and charts. Findings revealed that people rely more on radio, television, and social media for information on COVID-19. Fake news is spread by people mostly for political reasons and intention to cause panic. In Nigeria, fake news has led to disbelief of the existence of the virus thereby leading to violation of precautionary measures among the citizenry and lack of trust in the government. Concerted effort on the part of the government is required to give public enlightenment on the danger of fake news. Also, directorate of anti-fake news should be established to censor and reprimand sources of fake news. People should always check source of information to confirm its credibility and be weary of sharing unconfirmed information especially on the social media.

• Microbiology and Biotechnology Letters
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• v.48 no.3
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• pp.252-266
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• 2020

The coronavirus disease 2019 (COVID-19) is a highly contagious pneumonia that has spread throughout the world. It is caused by a novel, single stranded RNA virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Genetic analysis revealed that, phylogenetically, the SARS-CoV-2 is related to severe acute respiratory syndrome-like viruses seen in bats. Because of this, bats are considered as a possible primary reservoir. The World Health Organization has declared the COVID-19 outbreak as a pandemic. As of May 27, 2020, more than 5,406,282 confirmed cases, and 343,562 confirmed deaths have been reported worldwide. Currently, there are no approved vaccines or antiviral drugs available against COVID-19. Newly developed vaccines are in the first stage of clinical trials, and it may take a few months to a few years for their commercialization. At present, remdesivir and chloroquine are the promising drugs for treating COVID-19 patients. In this review, we summarize the diversity, genetic variations, primary reservoirs, epidemiology, clinical manifestations, pathogenesis, diagnosis, treatment strategies, and future prospects with respect to controlling the spread of COVID-19.

• Tuberculosis and Respiratory Diseases
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• v.85 no.4
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• pp.320-331
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• 2022

Coronavirus disease 2019 (COVID-19) has become a major health burden worldwide, with over 450 million confirmed cases and 6 million deaths. Although the acute phase of COVID-19 management has been established, there is still a long way to go to evaluate the long-term clinical course or manage complications due to the relatively short outbreak of the virus. Pulmonary fibrosis is one of the most common respiratory complications associated with COVID-19. Scarring throughout the lungs after viral or bacterial pulmonary infection have been commonly observed, but the prevalence of post-COVID-19 pulmonary fibrosis is rapidly increasing. However, there is limited information available about post-COVID-19 pulmonary fibrosis, and there is also a lack of consensus on what condition should be defined as post-COVID-19 pulmonary fibrosis. During a relatively short follow-up period of approximately 1 year, lesions considered related to pulmonary fibrosis often showed gradual improvement; therefore, it is questionable at what time point fibrosis should be evaluated. In this review, we investigated the epidemiology, risk factors, pathogenesis, and management of post-COVID-19 pulmonary fibrosis.

• Journal of Convergence for Information Technology
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• v.11 no.12
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• pp.80-89
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• 2021

In order to combat the spread of COVID-19, on January 30, 2020, the World Health Organization declared that the spread of COVID-19 has met the criteria of a "Public Health Emergency of International Concern" under Article 1 of the International Health Regulations(2005) and proposed a variety of preliminary recommendations to fight against the pandemic accordingly. All of a sudden, people are ordered to wear face-masks in public-which is forbidden for different reasons in many jurisdictions. Of course, the legal world was hit by the virus as well. Needless to mention that where economic and social life will change so drastically, the legal world will change(ex. virtual hearing) as well. Most probably, it will not ever be the same after COVID-19. And where the whole legal world will change, it is easy to state the obvious, namely that COVID-19 has and will have an impact on international arbitration as well. This paper will describe how international arbitration is dealing with this new challenge.

• IMMUNE NETWORK
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• v.21 no.6
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• pp.39.1-39.18
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• 2021

The high virulent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus that emerged in China at the end of 2019 has generated novel coronavirus disease, coronavirus disease 2019 (COVID-19), causing a pandemic worldwide. Every country has made great efforts to struggle against SARS-CoV-2 infection, including massive vaccination, immunological patients' surveillance, and the utilization of convalescence plasma for COVID-19 therapy. These efforts are associated with the attempts to increase the titers of SARS-CoV-2 neutralizing Abs (nAbs) generated either after infection or vaccination that represent the body's immune status. As there is no standard therapy for COVID-19 yet, virus eradication will mainly depend on these nAbs contents in the body. Therefore, serological nAbs neutralization assays become a requirement for researchers and clinicians to measure nAbs titers. Different platforms have been developed to evaluate nAbs titers utilizing various epitopes sources, including neutralization assays based on the live virus, pseudovirus, and neutralization assays utilizing recombinant SARS-CoV-2 S glycoprotein receptor binding site, receptor-binding domain. As a standard neutralization assay, the plaque reduction neutralization test (PRNT) requires isolation and propagation of live pathogenic SARS-CoV-2 virus conducted in a BSL-3 containment. Hence, other surrogate neutralization assays relevant to the PRNT play important alternatives that offer better safety besides facilitating high throughput analyses. This review discusses the current neutralization assay platforms used to evaluate nAbs, their techniques, advantages, and limitations.

• Asia-Pacific Journal of Business
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• v.12 no.1
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• pp.71-86
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• 2021

Purpose - This study examines the awareness regarding the symptoms of COVID-19 exposures and safety distances strategies whether they were useful to resile the businesses a mid of the pandemic. Besides exploring the awareness and safety distances, the effectiveness of offering free use of protective equipment (mask, hand sanitizer, frequent hand washing, etc.) to the customers for visiting the business centers was also examined. Design/methodology/approach - This study collected 264 survey data in Bangladesh which is one of the most densely populated country and very vulnerable for COVID-19 due to its socio-economic condition. The multiple regression analysis is used to analyze the data. Findings - The findings of the study indicate that the awareness about the symptoms of virus exposures (cough, fever, diarrhea, and weakness) has significant affirmative effects to enhance the public movement for business purposes with the lower possibility to be affected by the virus. The study also indicates that safety distances and protective equipment can mediate the significant positive relationship between the awareness of the disease and the businesses' resilient capacity. Research implications or Originality - COVID-19, as an apprehensive health issue in the current world, has sharpened the uncertainty of the businesses. One essential technique as lockdown, has been followed by almost every country to protect the transmission of the virus even though the scholars criticized it due to the substantial adverse effects on the country's economy. Under this circumstances, this study provides implications to the relevant businesses by assessing the nexus between the safety distances and the proper uses of protective equipment with the business resilient.

• Biomolecules & Therapeutics
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• v.29 no.3
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• pp.273-281
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• 2021

Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic. Signaling pathways that are essential for virus production have potential as therapeutic targets against COVID-19. In this study, we investigated cellular responses in two cell lines, Vero and Calu-3, upon SARS-CoV-2 infection and evaluated the effects of pathway-specific inhibitors on virus production. SARS-CoV-2 infection induced dephosphorylation of STAT1 and STAT3, high virus production, and apoptosis in Vero cells. However, in Calu-3 cells, SARS-CoV-2 infection induced long-lasting phosphorylation of STAT1 and STAT3, low virus production, and no prominent apoptosis. Inhibitors that target STAT3 phosphorylation and dimerization reduced SARS-CoV-2 production in Calu-3 cells, but not in Vero cells. These results suggest a necessity to evaluate cellular consequences upon SARS-CoV-2 infection using various model cell lines to find out more appropriate cells recapitulating relevant responses to SARS-CoV-2 infection in vitro.

• BMB Reports
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• v.55 no.9
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• pp.465-471
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• 2022

Understanding and monitoring virus-mediated infections has gained importance since the global outbreak of the coronavirus disease 2019 (COVID-19) pandemic. Studies of high-throughput omics-based immune profiling of COVID-19 patients can help manage the current pandemic and future virus-mediated pandemics. Although COVID-19 is being studied since past 2 years, detailed mechanisms of the initial induction of dynamic immune responses or the molecular mechanisms that characterize disease progression remains unclear. This study involved comprehensively collected biospecimens and longitudinal multi-omics data of 300 COVID-19 patients and 120 healthy controls, including whole genome sequencing (WGS), single-cell RNA sequencing combined with T cell receptor (TCR) and B cell receptor (BCR) sequencing (scRNA(+scTCR/BCR)-seq), bulk BCR and TCR sequencing (bulk TCR/BCR-seq), and cytokine profiling. Clinical data were also collected from hospitalized COVID-19 patients, and HLA typing, laboratory characteristics, and COVID-19 viral genome sequencing were performed during the initial diagnosis. The entire set of biospecimens and multi-omics data generated in this project can be accessed by researchers from the National Biobank of Korea with prior approval. This distribution of large-scale multi-omics data of COVID-19 patients can facilitate the understanding of biological crosstalk involved in COVID-19 infection and contribute to the development of potential methodologies for its diagnosis and treatment.