• 대한임상검사과학회지
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• 제54권2호
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• pp.79-94
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• 2022

COVID-19로 인한 높은 전염성과 호흡기 질환의 심각성 때문에, 전염의 확산을 더 잘 모니터링하고 예방하기 위해 경제적이고 정확한 검사가 필요하다. COVID-19 대유행의 초기 단계에서 SARS-CoV-2의 구조적 및 분자적 특성이 밝혀짐에 따라, 많은 COVID-19 진단 키트 제조업체들은 진단 테스트의 설계, 개발, 검증 및 구현에 적극적으로 투자했다. 현재, SARS-CoV-2에 대한 진단검사로써 신속한 항원, 특정 IgG 및 IgM 항체검사를 위한 면역 혈청학적 검사 그리고 분자 진단 검사가 가장 널리 사용되고 검증된 기술이다. 분자 진단 분석법은 SARS-CoV-2에 감염된 것으로 의심되는 개인에서 바이러스 RNA를 직접 검출하기 위한 gold standard이다. 항체 기반 혈청 검사는 지역사회에서 COVID-19 유병률을 결정하고 면역력을 획득한 개인을 식별하는 데 사용되는 간접 검사이다. 본 논문에서는 시판되고 FDA가 승인한 분자 및 면역학적 진단 측정을 평가하여 성능 특성을 분석하였다.

• 한국산업보건학회지
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• 제20권3호
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• pp.156-167
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• 2010

To evaluate the effect of lead biomarkers including bone lead on neurobehavioral test in retired lead workers, 131 retired lead workers without any occupational exposure to organic solvent, mercury and arsenic were agreed to participate this study. For the control subjects 56 non-occupationally lead exposed subjects were recruited from same area of retired lead workers with consideration of demographic characteristics. The mean levels of blood and bone lead of retired lead workers were significantly higher than control group and there were significant correlation among other lead biomarkers. Compared with controls without occupational lead exposure, lead exposured subjects had worse performance on 10 tests out of 12 neurobehavioral tests, but only two tests(Purdue pegboard nondominant and both hand) showed statistical significance of differences. In multiple linear regression analysis of neurobehavioral tests with lead biomarkers and demographic and lifestyle variables, age was associated negatively with 11 neurobehavioral tests, whereas log-transformed ZPP was associated with Purdue pegboard(both hand) and Santa Ana manual dexterity(non-dominant hand). On the other hand, tibia lead was associated Pursuit aiming test(correct) and Purdue pegboard(dominant hand) and calcaneal lead was associated with Purdue pegboard(dominant hand). This study confirmed that among all relevant variables age was most significantly associated with the poor performance of neurobehavioral tests. The blood lead did not have any significant association with neurobehavioral tests, but tibia and calcaneal bone lead and blood ZPP showed significant association with a few tests even after more than mean 9 years from their retirements.

• 한국해양공학회지
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• 제20권5호
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• pp.42-48
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• 2006

This paper shows theresults of centrifuge model experiments to investigate the behavior of a replacement method in dredged and reclaimed ground. For this experimental work, centrifuge model tests were carried out to investigate the behavior of a replacement method in soft clay ground. Basic soil property tests were performed to find the mechanical properties of clay soil sampled from the southern coast of Korea, which was used for the ground material in the centrifuge model tests. The reconstituted clay ground of the model was prepared by applying reconsolidntion pressure in a 1 g condition with a specially built model container. Centrifuge model tests were carried out under the artificially accelerated gravitational level of 50 g. Replacement material of lead with a certain degree of angularity was used and placed until the settlement of the replacement material embankment reached a state of equilibrium. Vertical displacement of the replacement material was monitored during tests. The depth and shape of the replacement, especially the slope of the penetrated material and the water content of the clay ground were measured after finishing tests. Model tests for investigating the stability of an embankment after backfilling were also performed to simulate the behavior of a dike treated with replacement and backfilled with sandy material. As a result of the centrifuge model test, the behavior of the replacement, the mechanism of the replacement material being penetrated into clay ground, and the depth of the replacement were evaluated.

• 한국환경독성학회:학술대회논문집
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• 한국환경독성학회 1993년도 제12회 총회 및 학술 발표회 특별강연요지집
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• pp.4-5
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• 1993

Toxicity tests in our laboratory are conducted usually with mass-reared organisms. They are under the same environmentel conditions throughout seasons and are supplied at specific age. A total of 38 species of aquatic organisms are being reared. We have attempted to establish pruified strains or to select clones of various parthenogenic organisms. The merits or demerits of our culturing test organisms are discussed. The differences in the susceptibility among clones or strains of test organism are also discussed. For a single species test, algae, daphnia, fish are often used. However, we usually use early stages, but occasionally, adults fish are used for reproduction tests. As an another important aspect, the toxicity through food chains has been studied. In this study, we select a pair of species belonging different trophic levels. The differences between single species tests and multispecies tests will be discussed. Even a single species test intends to assess the effects of chemicals on ecosystem levels, however, this idea is not applicable to ecosystems. Single species tests with standard organisms and multispecies tests are contradictory in concept. One type of multispecles tests is indoor microcosms being composed of severel species artificially assembled, and another is composed of natural components (both indoor and outdoor). We have used three types of outdoor mesocosms using ponds and three types of artificial streams. The mesocosms is useful to not only to analyze the floral or faun61 changes but also to study the fate or behaviour of chemicals in naturd environments. Lastly, usefulness of the field observation or experiments or semi-field experiments will be discussed. This will enhance the exploitation of early warning systems utilizing indicator organisms or animal behaviour.aviour.

• 한국농공학회지
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• 제36권4호
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• pp.103-116
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• 1994

The objective of this study was to determine the criteria for density and moisture content measurements made with a nuclear density meter on common materials in the construction field. The study also sought to test a full-type nuclear density meter in controlling the density of overlay layers( 2.5~5.0cm). In order to determine the accuracy and reliablility of nuclear guage measurements made on construction materials, laboratory and field tests were conducted. Wooden blocks( 65 x 45 ${\times}$ 50 cm) and a special steel compactor( 4.7kg) were constructed in order to carry out tests which were conducted on three different materials; coarse gramed soil, fine grained soil, and AC material. Throughout all laboratory and field tests, the nuclear density and moisture content were determined using Humboldt 5OOLP nuclear gauge. The tests on subgrade material entailed obtaining density measurements by means of both the sand replacement method and the nuclear density meter. The results of the sand replacement method were then compared to the readings recorded bu the meter. As in the subgrade material tests, density measurements made during AC pavement tests were also determined using the unclear meter in addition to a second means; through the core method. The meter readings and core densties were compared as was done in the tests on subgrade materials. The correlation between the results of the sand replacement test( also, the core method) and meter readings on subgrade material was then determined. Sirnilarly, the observed results were then analyzed through linear regression. The tests to determine thin-lift density by means of a full-type nuclear density meter also conducted on the overlay layers( about 4. 8cm thickness) above AC pavements at road construction sities in Korea.

• 산업기술연구
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• 제24권A호
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• pp.227-238
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• 2004

This paper is results of experimental and nunerical works on the behavior of the cut-and-cover tunnel. Centrifuge model tests were performed to simulate the behavior of the cut-and-cover tunnels having cross sections of national road and subway tunnels. Model experiments were carried out with changing the cut slope and the slope of filling ground surface. Displacements of tunnel lining resulted from artificially accelerated gravitational force up to 40g of covered material used in model tests, were measured during centrifuge model tests. In model tests, Jumunjin Standard Sand with the relative density of 80 % and the zinc plates were used for the covered material and the flexible tunnel lining, respectively. Basic soil property tests were performed to obtain it's the property of Jumumjin Standard Sand. Shear strength parameters of Jumunjin Standard Sand were obtained by performing the triaxial compression tests. Direct shear tests were also carried out to find the mechanical properties of the interface between the lining and the covered material. Numerical analysis with the commercially available program of FLAC were performed to compare with results of centrifuge model experiment In numerical modelling. Mohr-Coulomb elasto-plastic constitutive model was used to simulaye the behavoor of Jumunjin Standard Sand and the interface element between the lining and the covered material was implemented to simulate the interaction between them. Compared results between model tests and numerical estimation with respect to displacement of the lining showed in good agreements.

• 한국항공우주학회지
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• 제43권6호
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• pp.526-532
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• 2015

국내개발 헬기인 수리온의 악기상 시 운용능력을 입증하고 결빙하 운용 제한 사항을 해제하기 위하여 결빙 감항인증이 요구되고 있다. 군용헬기인 수리온의 결빙 감항인증 절차는 유사 무기체계인 UH-60과 AH-64의 사례와 S/W 기술의 성숙도를 보았을 때, 전산해석${\rightarrow}$모의결빙형상 비행시험${\rightarrow}$인공 결빙 비행시험${\rightarrow}$자연 결빙 비행시험의 4가지 방법에 의한 단계화된 추진이 고려되고 있다. 수리온의 최적 비행시험 소티와 비행시간은 인공 결빙 비행시험 20~30소티 및 20~23시간과 자연 결빙 비행시험 20~30소티 및 20~22시간이 요구되며, 효율적인 결빙 감항인증 비행시험을 위해서는 LWC $0.5{\sim}1.0g/m^3$범위의 대기온도 조건은 인공 결빙 비행시험을 추진하고, LWC $0.5g/m^3$이하의 대기온도 조건에서는 자연 결빙 비행시험이 필요하다.

• 토지주택연구
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• 제2권4호
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• pp.387-395
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• 2011

국내 건축구조물의 내진설계기준에 의하면 현장탄성파시험으로 전단파속도를 측정하여 지반을 5종으로 분류하고 이에 의해 건축물에 작용하는 지진하중을 산정하고 있으나 공정상 성토지반에 대해서는 현장탄성파시험을 할 수 없다. 이에 실내에서 간편하게 현장의 상황을 고려하여 전단파속도를 추정할 수 있는 방법을 찾고자 공진주/비틂전단시험과 각종 현장 탄성파 시험결과를 비교 분석하였다. 분석결과 성토체의 구속압을 적절히 고려할 경우 현장탄성파 시험결과와 매우 유사한 결과를 얻을 수 있었다. 또한, 공진주/비틂전단시험에 의해 최대 전단탄성계수와 구속압의 영향평가를 실시한 결과 n값이 0.434~0.561의 일반적 범위의 값을 나타내어 공진주/비틂전단시험으로도 현장지반 전단탄성계수를 유용하게 추정할 수 있는 것으로 나타났다.

• PNF and Movement
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• 제13권4호
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• pp.189-196
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• 2015

Purpose: This study aimed to examine the effects of proprioceptive neuromuscular facilitation (PNF) upper and lower limb coordinated exercises on balance in elderly women. Methods: The study was conducted with 27 elderly women who were at least 65-year-old. The subjects were randomly assigned to a PNF upper and lower limb coordinated exercise group consisting of 14 subjects and an aero step balance exercise group consisting of 13 subjects, and the exercises were performed for 30 minutes, three times per week, for eight weeks. One Leg Stance Tests (OLST), Functional Reaching Tests (FRT), Four Square Step Tests (FSST), and Timed Up and Go (TUB) tests were conducted before and after the exercises to evaluate the subjects' static balance ability and dynamic balance ability. Among the collected data, the subjects' general characteristics were evaluated using descriptive statistics, the intra-group differences of the test results before and after the intervention were compared using paired sample t-tests, and the inter-group differences in the results before and after the intervention were evaluated using independent sample t-tests. The statistical significance level was set to 0.05. Results: Among the OLST, FRT, FSST, and TUG tests, the experimental group showed positive FSST results that were statistically significantly greater than the control group; the results of the other tests were also more positive for this group, but the differences between the groups were not statistically significant. The magnitude of the effects for both groups was clinically significant. Conclusion: Since inter-limb coordinated exercises for PNF applied to elderly women were found to produce good results for both static balance ability and dynamic balance ability, these exercises can be used in exercise programs to improve balance in elderly women.

• 인간식물환경학회지
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• 제22권6호
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• pp.563-573
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• 2019

The North Korean government conducted its first nuclear test in 2006 and more recently the sixth nuclear test on September 3, 2017. In order to identify how North Korea's nuclear tests have affected the environment, a scientific approach is required. Although North Korea's nuclear tests and their environmental destruction are not a severe threat to the environment of the Korean Peninsula at this time, identifying environmental damage and taking countermeasures in advance are essential to minimize their potential threats to the environments. The purpose of this study is to study the environmental impact of North Korea's nuclear tests using Google Earth image analysis. As a method of the study, we compare Google Earth images taken before and after each nuclear test was conducted in North Korea. To overcome limitations of the suggested comparison method, we cross-checked our results with those of previous scientific research. After the 1st-3rd nuclear tests, green spaces were found to be considerably reduced. In particular, when comparing the Google Earth images before and after the second nuclear test, some ground subsidences were observed. Such subsidences can cause tunnels on the mountainsides and cracks in rocks around the mountains, leading to the release of radioactive materials and contaminating groundwater. Besides, after the 4th-6th nuclear tests, decay and deforestation were observed not in the nuclear test sites, but in their surrounding areas. Especially after the 5th and 6th nuclear tests, the topography and the forests of the surrounding areas were severely damaged. In relation to North Korea's nuclear tests and their impact on the natural environment, we need to prepare various policy measures to reduce North Korea's environmental pollution and natural environment destruction. Those policy measures include the establishment of various cooperative governance between the Korean government, the private sector, the academia, NGOs, and international organizations.