• 비파괴검사학회지
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• 제29권4호
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• pp.299-307
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• 2009

광섬유 센서 기술은 기존의 상용 센서의 어려움을 극복할 수 있어 전자기학 잡음과 전기 쇼크의 영향이 강한 폭발환경에서도 충분히 사용이 가능하다. 최근 이러한 장점들로 인해 여러 종류의 광섬유 센서들이 활발히 연구 개발되고 있다. 또한 비파괴검사/평가 분야로써 구조 건전성 감시를 위한 광섬유 센서의 다양한 적용 연구 분야가 존재한다. 그러나 로드셀과 같은 종류의 센서들은 상대적으로 상용화가 미흡한 실정이다. 본 논문에서는 광섬유 브래그 격자 센서를 사용한 광섬유 로드셀을 보여준다. 본 로드셀의 형상은 링크타입이고, 세 개의 광섬유 브래그 격자 센서를 사용하여 세 지점의 변형률을 각기 측정한다 특히 이들 변형률은 온도와 같은 동상 잡음을 제거하기 위해 차동법을 사용하여 신호처리 된다. 더 나아가 본 로드셀의 감도, 선형성 그리고 해상도를 인장실험을 통해 성공적으로 검증하였다.

• 한국항공우주학회지
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• 제37권10호
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• pp.1017-1026
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• 2009

우주비행체의 주 전력원인 태양전지 시스템은 태양광을 직접 바라본 상태에서 운용되어, 우주의 가혹한 열적/기계적 환경에 직접 노출되므로, 제작/시험 중 발생될 수 있는 미세한 균열, 정전기 및 열 충격 등이 궤도 운용 중 태양전지 시스템의 기능상실로 이어질 가능성을 갖는다. 또한 태양전지 시스템의 전력생성 기본 유닛인 태양전지에 발생된 미세한 균열 또는 열 충격에 따른 태양전지의 내부 파손의 발견을 위해서는 고가의 장비와 복잡한 시험 절차, 그리고 많은 시간을 필요로 하게 된다. 따라서 태양전지 시스템 기능의 건전성을 쉽고, 빠르게 확인하기 위해, 정성적인 태양전지 기능 건전성 평가 방법이 요구된다. 본 논문에서는 요즘 우주비행체에서 가장 많이 사용되는 갈륨-비소 계열의 다접합 태양전지가 갖는 전계발광현상을 이용해 복잡한 반도체 구조를 가지는 태양전지의 기능 건전성을 보다 간단하고 저비용으로 그리고 빠르게 평가하는 방법에 대한 이론적, 기술적 근거를 설명하였다. 또한 이를 실제의 우주용 태양전지 시스템에 적용하기 위한 기술적 사항들과 적용 제한 조건들에 대하여 기술하였다.

• Tissue Engineering and Regenerative Medicine
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• 제15권6호
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• pp.721-733
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• 2018

BACKGROUND: Because three-dimensional (3D) models more closely mimic native tissues, one of the goals of 3D in vitro tissue models is to aid in the development and toxicity screening of new drug therapies. In this study, a 3D skin wound healing model comprising of a collagen type I construct with fibrin-filled defects was developed. METHODS: Optical imaging was used to measure keratinocyte migration in the presence of fibroblasts over 7 days onto the fibrin-filled defects. Additionally, cell viability and growth of fibroblasts and keratinocytes was measured using the $alamarBlue^{(R)}$ assay and changes in the mechanical stiffness of the 3D construct was monitored using compressive indentation testing. RESULTS: Keratinocyte migration rate was significantly increased in the presence of fibroblasts with the cells reaching the center of the defect as early as day 3 in the co-culture constructs compared to day 7 for the control keratinocyte monoculture constructs. Additionally, constructs with the greatest rate of keratinocyte migration had reduced cell growth. When fibroblasts were cultured alone in the wound healing construct, there was a 1.3 to 3.4-fold increase in cell growth and a 1.2 to 1.4-fold increase in cell growth for keratinocyte monocultures. However, co-culture constructs exhibited no significant growth over 7 days. Finally, mechanical testing showed that fibroblasts and keratinocytes had varying effects on matrix stiffness with fibroblasts degrading the constructs while keratinocytes increased the construct's stiffness. CONCLUSION: This 3D in vitro wound healing model is a step towards developing a mimetic construct that recapitulates the complex microenvironment of healing wounds and could aid in the early studies of novel therapeutics that promote migration and proliferation of epithelial cells.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.129-130
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• 1994

The science of toxicology is the understanding of the mechanisms by which exogenous agents produce deleterious effects in biological systems. The actions of chemicals such as drugs are ultimately exerted at the cellular and gene levels. Over the past decade. several in vitro alternative methods such as cultured cells for assessing the toxicity of various xenobiotics have been proposed to reduce the use of animals. In this workshop three advanced methods will be presented. These methods are novel important models for toxicologic studies. Dr. Tabuchis group has establishcd two immortalized gastric surface mucosa cell lines from the pminary cultore of gastric fundic mucosal cells of adult transgenic mice harboring a temperature sensitive simian virus 40 large T-anugen gene. As the immortalized cell lines of various tissues possess unique characteristics to maintain their normal functions for several months, these cell lines are extremely useful for not only toxicity testing but also pharmacological screening in new drug development. Professor Funatsu have studied the formation of spherical multicelluar aggregates of adult rat hepatocytes(spheroid) having tissue like structure. The sphcroid shown thre is a prototype module of an artificial liver support system. Thus, the urea synthesis activity of the artificial liver was maintained at least to days in 100％ rat blood plasma. Dr. Takezawa and his coworkers have developed a novel culture system of multicellular spheroids considered 〃organoids〃 by utilizing a thermo-responsive polymer as a substratum of anchorage dependent cells. His final goal is to reconstitute the organoids of various normal organs, e.g., liver, skin etc. and also abnormal deseased organs such as tumor.

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4903-4906
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• 2013

Background: The purpose of this study was to determine proportional rates of cervical precancerous lesions and cancer, and associations with socio-demographic variables, HIV status, and CD4 cell count. Materials and Methods: A retrospective comparative study was conducted targeting the medical records of all women over age 18 that were diagnosed histologically through colposcopy with cervical precancerous lesions and cancer from 1 December 2011 to 30 November 2012. Results: A total of 313 patient records were used for data analysis. The average age was 39.1 (SD=2.04) years. More than a third (37.1%) of the patients had CIN III or cervical cancer. There was a significant association between age, CD4 cell count, HIV status, and cervical lesions (p<0.05). Age was found to be an influential predictor of cervical lesions (OR=0.67, 95%CI: 0.46-0.98). Conclusions: There exists an association between age and cervical lesions, with presentation of cervical precancerous lesions and cervical cancer at a younger age among HIV reactive patients. The National Guidelines should be brought in line with the National HIV Counseling and Testing Policy to offer Pap smears to all sexually active women that test HIV reactive during routine HIV Testing.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2000년도 가을 학술발표논문집 Vol.27 No.2 (3)
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• pp.210-212
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• 2000

In this paper, we propose an enhanced usage parameter control algorithm, which is one of the preventive traffic control method in ATM networks and implemented it with VLSI Proposed algorithm is based on the cell loss priority bit in the ATM cell header. This algorithm can solve the measurement phasing problem in cell conformance testing in ATM networks. Proposed algorithm can minimize the cell loss ratio of high priority cell(CLP=0) and resolve the burstiness of cells which may be introduced in traffic multiplexing and demultiplexing procedure. The result of performance evaluation shows that the performance of proposed algorithm is better than that of ITU-T usage parameter control algorithm.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2006년도 춘계 학술발표회 논문집
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• pp.520-529
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• 2006

그 동안 몇 차례 오스터버그 셀$(O-cell^{\circledR})$을 이용한 양방향 말뚝 재하시험기법이 국내에 성공적으로 소개/적용된 바 있다. 이 방법은 상대적으로 새롭고 독특한 방법으로서 시험비용과 기존 재래적인 시험방법이 적용상 제한을 받는 경우나 대규모 시험에서 발생할 수 있는 문제점들을 극복할 수 있다. 국내에서는 설계목적을 위한 시험말뚝 뿐 아니라 설계하중이 큰 실제말뚝에 대한 시험이 증가하는 추세에 있다. 이 논문에서 소개하는 양방향 재하시험 방법을 적용하면 기존의 소규모 재하시험 방법에서 발생될 수 있는 주면 마찰력과 선단지지력의 분리측정이나 각각의 지지력에 대한 극한상태를 확인하지 못하는 한계를 극복할 수 있고 시험하중이 270MN을 초과하는 경우까지 적용할 수 있는 장점을 갖고 있다. 본 논문에서는 오스터버그 셀을 이용한 정적 재하시험 방법에 대하여 말뚝종류별로 상세히 기술하였으며 이 시험방법의 장점과 국내현장에 적용되었던 사례를 소개하였다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2000년도 추계종합학술대회 논문집(2)
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• pp.196-199
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• 2000

In this paper has studied an enhanced usage parameter control algorithm, which is one of the preventive traffic control method in ATM networks. The proposed algorithm is based on the CLP(Cell Loss Priority) bit in the ATM cell header. This algorithm can eliminate the measurement phasing problem in cell conformance testing in ATM networks. The proposed algorithm can minimize the cell loss ratio of high priority cell(CLP = 0) and resolve the burstiness of eel]s which may be generated in the multiplexing and demultiplexing procedure. For the performance evaluation, we have simulated the proposed algorithm with discrete time input traffic model and the results show that the performance of the proposed algorithm is better than that of ITU-T usage parameter control algorithm.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2003년도 춘계전력전자학술대회 논문집(2)
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• pp.981-986
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• 2003

Recently, a fuel cell is remarkable for new generation system. The fuel cell generation system converts the chemical energy of a fuel directly into electrical energy. The fuel cell generation is characterized by low voltage and high current. For connecting to utility, it needs both a step up converter and an inverter. The step up converter makes DC link and the inverter changes D.C to A.C. In this paper, full bridge converter and the single phase inverter are designed and installed for fuel cell. Simulation and experiment verify that fuel cell generation system could be applied for the distributed generation.

• 경영과학
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• 제26권1호
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• pp.171-182
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• 2009

We consider the inventory replenishment problem and the vehicle routing problem simultaneously in the vending machine operation. This problem is known as the inventory routing problem. We design a memory cell in the clonal selection algorithm. The memory cell store the best solution of previous solved problem and use an initial solution for next problem. In general, the other clonal selection algorithm used memory cell for reserving the best solution in current problem. Experiments are performed for testing efficiency of the memory cell in demand uncertainty. Experiment result shows that the solution quality of our algorithm is similar to general clonal selection algorithm and the calculations time is reduced by 20% when the demand uncertainty is less than 30%.