• 한국산학기술학회:학술대회논문집
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• 한국산학기술학회 2011년도 추계학술논문집 1부
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• pp.170-173
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• 2011

Therapeutic hypothermia(TH) improves neurological outcomes and reduces mortality among survivors of out-of-hospital cardiac arrest. Animal and human studies have shown that TH results in improved salvage of the myocardium, reduced infarct size, reduced left ventricular remodeling and better long-term left ventricular function in settings of regional myocardial ischemia. This study is to investigate the effect of TH on post-resuscitation myocardial dysfunction and survival time after cardiac arrest and resuscitation in a rat model of myocardial infarction (MI). Thoracotomies were performed in 10 Male Sprague-Dawley rats weighing 450-550 g. MI was induced by ligation of the left anterior descending coronary artery (LAD). Ninety min after LAD ligation, ventricular fibrillation induction and subsequent cardiopulmonary resuscitation was performed before defibrillation attempts. Animals were randomized to two groups: a) Acute MI-Normothermia b) Acute MI-Hypothermia ($32^{\circ}C$ for 4 h). Myocardial functions, including cardiac output, left ventricular ejection fraction, and myocardial performance index were measured echocardiographically together with duration of survival. Ejection fraction, cardiac output and myocardial performance index were $54.74{\pm}9.16$, $89.00{\pm}8.89$, $1.30{\pm}0.09$ respectively and significantly better in the TH group than those of the normothermic group at the first 4 h after resuscitation($32.20{\pm}1.85$,$41.60{\pm}8.62$,$1.77{\pm}0.19$)(p=0.00). The survival time of the hypothermic group ($31.8{\pm}14.8$ h) was greater than that of the normothermic group($12.3{\pm}6.5$ h, p<0.05). This study suggested that TH attenuated post resuscitation myocardial dysfunction in acute MI and would be a potential strategy in post resuscitation care.

• 한국정보통신학회논문지
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• 제11권7호
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• pp.1387-1393
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• 2007

기존의 단층 퍼셉트론은 출력 노드가 선형 분리 가능한 패턴들만을 분류할 수 있고 XOR과 같은 비선형 문제에 대해서는 분류할 수 없는 단점이 있다. 퍼지 단층 퍼셉트론은 퍼지 소속 함수(Fuzzy Membership Function)를 적용하여 단층 구조로 XOR 문제와 같은 고전적인 문제를 개선하였다. 그러나 퍼지 단층 퍼셉트론은 기존의 단층 퍼셉트론과 마찬가지로 결정 경계선이 진동하는 경우가 생기며 초기 가중치의 범위와 학습률에 따라 수렴성이 매우 낮아지는 단점이 있다. 따라서 본 논문에서는 바이어스항을 도입하여 결정 경계선이 진동하는 것을 방지하여 수렴성을 개선시키고 선형 활성화 함수를 제안하고 학습률과 모멘텀 개념을 도입 한 개선된 델타규칙을 적용함으로써 학습 시간을 단축시키는 개선된 퍼지 단층 퍼셉트론 알고리즘을 제안한다. 제안된 방법과 퍼지 단층 퍼셉트론간의 학습 성능을 분석하기 위하여 인공 신경망에서 벤치마크로 사용되는 XOR 문제와 패턴 분류에 적용하여 Epoch 수와 수렴성을 비교한 결과, 제안된 방법이 기존의 퍼지 단층 퍼셉트론보다 학습 시간이 적게 소요되고 수렴성이 개선된 것을 확인하였다.

• 대한의용생체공학회:의공학회지
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• 제40권5호
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• pp.143-150
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• 2019

To evaluate the toxicity of ophthalmic drug, the Draize test and Bovine Corneal Opacity and Permeability (BCOP) test commonly used. In Draize test, experimental animals were under stress and pain due to long-term exposure of drug. In addition, regarding physiological functions, animal model is not perfectly reflected a human eye condition. Although some models such as $EpiOcular^{TM}$, HCE model, LabCyte Cornea-Model, and MCTT $HCE^{TM}$ were already presented advanced cornea ex-vivo model to replace animal test. In this sense, cornea tissue structure mimicked ex-vivo toxicity model was fabricated in this study. The corneal epithelial cells (CECs) and keratocytes (CKs) isolated from rabbit eyeball were seeded on non-patterned silk film (n-pSF) and patterned silk film (pSF) at $32,500cells/cm^2$ and $6,500cells/cm^2$. Sequentially, n-pSF and pSF were stacked to mimic a multi-layered stroma structure. The thickness of films was about $15.63{\mu}m$ and the distance of patterns was about $3{\mu}m$. H&E stain was performed to confirm the cell proliferation on silk film. F-actin of CKs was also stained with Phalloidin to observe the cytoskeletal alignment along with patterns of the pSF. In the results, CECs and CKs were shown the good cell attachment on the n-pSF and pSFs. Proliferated cells expressed the specific phenotype of cornea epithelium and stroma. In conclusion, we successfully established the ex-vivo cornea toxicity model to replace the eye irritation tests. In further study, we will set up the human ex-vivo cornea toxicity model and then will evaluate the drug screening efficacy.

• Biomaterials and Biomechanics in Bioengineering
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• 제2권3호
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• pp.143-157
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• 2015

Successful integration of cementless femoral stems using porous surfaces relies on effective periimplant bone healing to secure the bone-implant interface. The initial stages of the healing process involve protein adsorption, fibrin clot formation and cell osteoconduction onto the implant surface. Modelling this process in vitro, the current work considered the effect of fibrin deposition on the responses of human mesenchymal stromal cells cultured on ferritic fibre networks intended for magneto-mechanical actuation of in-growing bone tissue. The underlying hypothesis for the study was that fibrin deposition would support early stromal cell attachment and physiological functions within the optimal regions for strain transmission to the cells in the fibre networks. Highly porous fibre networks composed of 444 ferritic stainless steel were selected due to their ability to support human osteoblasts and mesenchymal stromal cells without inducing untoward inflammatory responses in vitro. Cell attachment, proliferation, metabolic activity, differentiation and penetration into the ferritic fibre networks were examined for one week. For all fibrin-containing samples, cells were observed on and between the metal fibres, supported by the deposited fibrin, while cells on fibrin-free fibre networks (control surface) attached only onto fibre surfaces and junctions. Initial cell attachment, measured by analysis of deoxyribonucleic acid, increased significantly with increasing fibrinogen concentration within the physiological range. Despite higher cell numbers on fibrin-containing samples, similar metabolic activities to control surfaces were observed, which significantly increased for all samples over the duration of the study. It is concluded that fibrin deposition can support the early attachment of viable mesenchymal stromal cells within the inter-fibre spaces of fibre networks intended for magneto-mechanical strain transduction to in-growing cells.

• 항공우주시스템공학회지
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• 제12권1호
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• pp.35-41
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• 2018

무인기는 관측, 통신중계, 정보 수집 등 여러 분야에서 다양한 목적으로 활용되고 있다. 최근 개발되는 무인기는 장시간 체공을 하면서 현재 수준보다 정밀하고 다량의 정보 수집이 가능하도록 고사양의 성능이 요구되고 있다. 현재, 국내에서는 인공위성의 일부 기능 대체를 목적으로 성층권에서 장기간 비행하기 위한 고고도 장기체공무인기가 개발되고 있다. 본 연구는 고고도 장기체공 무인기용으로 개발 중인 기체구조에 대한 구조 건전성 평가의 일환으로 동체 및 미익 체결부에 대한 안전여유 계산을 통하여 구조 건전성을 평가하였다. 그 결과로, 개발 중인 무인 비행체의 기체 구조 체결부에 대한 설계 타당성을 확인하였다.

• 보건행정학회지
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• 제31권4호
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• pp.387-398
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• 2021

Moon Jae-in Care can be seen as a 2.0 version of Roh Moo-Hyun Care. Just as Roh Care failed to achieve its coverage rate goal and 30% share of public beds, Moon Care also failed to achieve its expected goal. The reason is that it followed Roh Care's failed strategy. Failure to control non-covered services has led to a long way to achieve a 70% coverage rate and induced the expansion of voluntary indemnity insurance, resulting in increased public burden. The universal coverage of non-covered services caused an immediate backlash from doctors. And Moon government also failed to control the private insurance market. The expansion of publicly owned beds has not become realized and has not obtained public support. Above all, it failed to overcome the resistance of doctors and failed to obtain consent from budget power groups in the cabinet for public investment. It was also insufficient to win the support of civic groups. Communication with interested groups failed and the role of private health care providers was neglected. The next government should also continue to strengthen health care coverage, but it should prioritize preventing medical poor and create a consensus with both medical providers and consumers for the control of non-covered services. Ahead of the super-aged society, the establishment of linkage between medical services and long-term care and visiting health care or welfare services is an important task. All public and private provisions and resources should be utilized in the view of a comprehensive public health perspective, and public investment should be input in sectors where public medical institutions can perform more effective functions. The next government, which will be launched in 2022, should design a new paradigm for health care in the face of a period of transformation, such as the coming super-aged society in 2026 and the Fourth Industrial Revolution, and recognize that the capabilities of the health care system represent the nation's overall capacity.

• 지역연구
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• 제35권1호
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• pp.47-57
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• 2019

본 연구의 목적은 계량분석을 통해 우리나라 지역내총생산에 영향을 미치는 주요 요인별 영향력을 분석하는 것이다. 본 연구는 분석대상 지역으로 대구광역시를 선정했는데 대구광역시는 영남 지역의 중추기능을 지속적으로 수행해 왔으며, 우리나라 섬유 화학제품 등의 수출 전략기지로 지위하고 있다. 또한 영남 지역에 도달하는 주요 수입화물의 기종점 역할을 수행하는 등 이처럼 대구 지역은 우리나라 수출입 무역 확대와 국가경제 성장에 기여하는 바가 높다. 이를 위해 본 연구는 공적분모형(Co-integration Model)과 벡터오차수정모형(Vector Error Correction Model; VECM)을 사용하여 대구 지역내총생산에 영향을 미치는 장기균형함수를 추정하였다. 본 연구는 우리나라 지역내총생산에 영향을 미치는 주요 요인들의 영향력을 정량적인 방식을 통해 추정하고 장기 균형 시점의 총생산으로부터 괴리가 발생했을 때 얼마나 빠른 속도로 장기균형으로 수렴하는가를 추정하였다는 점에서 의의가 있다.

• 한국환경과학회지
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• 제28권6호
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• pp.571-579
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• 2019

In this study, monthly average values of BOD, COD, and TOC observed for 10 years (2008-2017) in the Nam River were estimated, and monthly variations of BOD, COD, and TOC were analyzed. Monthly average COD was always higher than monthly average BOD; monthly average TOC was high from June to September when rainfall was high. Monthly correlation coefficients between BOD and COD ranged from 0.57 to 0.94, those between BOD and TOC from 0.45 to 0.93, and those between COD and TOC from 0.75 to 0.93. The correlation coefficients were high from November to February when rainfall was low. Regression analyses for monthly average water quality data of the Nam River classified into dry season (October to April) and wet season (May to September) were conducted. Correlation coefficients were higher in the dry season than those in the wet season, and the determination coefficients of linear regression functions for BOD and COD with TOC were also higher in the dry season than those in the wet season. From this study, it can be concluded that it is appropriate to use monthly data to analyze the correlations among BOD, COD, and TOC in the stream. To analyze the relationship between TOC flowing into the stream and BOD/COD, it was found that seasonal characteristics should be considered.

• 한국해양공학회지
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• 제33권3호
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• pp.222-228
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• 2019

An extreme value analysis (EVA) is essential to obtain a design value for highly nonlinear variables such as long-term environmental data for wind and waves, and slamming or sloshing impact pressures. According to the extreme value theory (EVT), the extreme value distribution is derived by multiplying the initial cumulative distribution functions for independent and identically distributed (IID) random variables. However, in the position mooring of DNVGL, the sampled global maxima of the mooring line tension are assumed to be IID stochastic variables without checking their independence. The ITTC Recommended Procedures and Guidelines for Sloshing Model Tests never deal with the independence of the sampling data. Hence, a design value estimated without the IID check would be under- or over-estimated because of considering observations far away from a Weibull or generalized Pareto distribution (GPD) as outliers. In this study, the IID sampling data are first checked in an EVA. With no IID random variables, an automatic resampling scheme is recommended using the block maxima approach for a generalized extreme value (GEV) distribution and peaks-over-threshold (POT) approach for a GPD. A partial autocorrelation function (PACF) is used to check the IID variables. In this study, only one 5 h sample of sloshing test results was used for a feasibility study of the resampling IID variables approach. Based on this study, the resampling IID variables may reduce the number of outliers, and the statistically more appropriate design value could be achieved with independent samples.

• 한국광학회지
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• 제30권2호
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• pp.48-58
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• 2019

구면 초점 초음파 측정기에 의해 구형의 광 흡수체로부터 측정된 시간(즉, 펄스 형태 광원) 및 주파수 영역(즉, 처프 형태 광원) 광음향 신호의 신호 대 잡음비(signal-to-noise ratio)를 이론 및 시뮬레이션으로 분석하였다. 이전 문헌과 마찬가지로 시간 영역 광음향 측정에 의한 신호 대 잡음비 값이 주파수 영역 광음향 측정의 경우보다 더 높았는데 이 근본적인 이유를 최대허용노광량(maximum permissible exposure)에 따른 광원의 세기와 주파수 필터링을 통한 두 측정 모드의 광음향 스펙트럼들에 대한 분석을 통해 이해하였다. 또한, 분석의 결과로서 주파수 영역 광음향의 처프 형태 광원에 대한 정합 필터링에 더해 DC 스펙트럼 부분을 제거하니 신호 대 잡음비가 5 dB 정도 상승하는 것을 발견하였다. 특히, 주파수 필터 함수의 주파수 상한 값의 변화에 따라 신호대 잡음비 값이 급격하게 변동하였는데 신호 대 잡음비가 최대가 되는 주파수 상한 값이 두 광음향 측정 모드에서 서로 다르게 나타남을 관찰하였다.