• Proceedings of the Korean Geotechical Society Conference
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• 2005.03a
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• pp.1554-1561
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• 2005

Geotextiles form one of the two largest groups of geosynthetics and it is consisted two major types of synthetic material (Woven, Non-woven). The functions of geotextiles are separation, reinforcement, filtration, drainage and as a moisture barrier. Within these functions, however, there are a large number of applications or use areas. Although the many research scholar and engineer developed and established the design criteria and construction methodology of geosynthetics filter layer, because the lack of suitable design terminology and uncertainty of long term durability, sustainable research still needed for optimum design methodology to the complicate field conditions. Especially, more intensive research needed about under the cyclic flow condition and fine silty sand base material. In this paper, the filter model test performed under cyclic flow with various boundary conditions (period and frequency of cyclic flow, types of geosynthetic filter material, surcharge etc.).

• Proceedings of the KSME Conference
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• 2003.04a
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• pp.1254-1261
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• 2003

In this paper we present a simple and efficient robust optimal design formulation and its application to a resonant-type micro probe. The basic idea is to use the Gradient Index (GI) to improve robustness of the objective and constraint functions. In the robust optimal design procedure, a deterministic optimization for performance of MEMS structures is followed by design sensitivity analysis with respect to uncertainties such as fabrication errors and change of operating conditions. During the process of deterministic optimization and sensitivity analysis, dominant performance and uncertain variables are identified to define GI. The GI is incorporated as a term of objective and constraint functions in the robust optimal design formulation to make both performance and robustness improved. While most previous approaches for robust optimal design require statistical information on design variations, the proposed GI based method needs no such information and therefore is cost-efficient and easily applicable to early design stages. For the micro probe example, robust optimums are obtained to satisfy the targets for the measurement sensitivity and they are compared in terms of robustness and production yield with the deterministic optimums through the Monte Carlo simulation.

• Biotechnology and Bioprocess Engineering:BBE
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• v.10 no.1
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• pp.9-15
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• 2005

A bioartificial liver (BAL) is a medical device entrapping living hepatocytes or immortalized cells derived from hepatocytes. Many efforts have already been made to maintain the functions of the hepatocytes in a BAL device over a long term. However, there is still some uncertainty as to their efficacy. and their limitations are unclear. Therefore, it is important to quantitatively evaluate the metabolic functions of a BAL. In previous studies on in vitro BAL devices, two test methods, an initial bolus loading and constant-rate infusion plus initial bolus loading, were theoretically carried out to obtain physiologic data on drugs. However, in the current study, the same two methods were used as a perfusion model and derived the same clearance characterized by an interrelationship between the perfusate flow rate and intrinsic clearance. The interrelationship indicated that the CL increased with an increasing perfusate flow rate and approached its maximum value, i.e. intrinsic clearance. In addition, to set up an in vivo BAL system, the toxic plateau levels in the BAL system were calculated for both series and parallel circuit models. The series model had a lower plateau level than the parellel model. The difference in the toxic plateau levels between the parallel and series models increased with an increasing number of BAL cartridges.

• Journal of Mechanical Science and Technology
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• v.15 no.3
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• pp.392-402
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• 2001

The paper reports a multiple source modeling of low-Reynolds-number dissipation rate equation with aids of DNS data. The key features of the model are to satisfy the wall limiting conditions of the individual source terms in the exact dissipation rate equation using the wall damping functions. The wall damping functions are formulated in term of dimensionless dissipation length scale ι(sup)+(sub)D(≡ι(sub)D($\upsilon$$\xi$)(sup)1/4/$\upsilon$) and the invariants of small and large scale turbulence anisotropy tensors. $\alpha$(sub)ij(=$\mu$(sub)i$\mu$(sub)j/$\kappa$-2$\delta$(sub)ij/3) and e(sub)ij(=$\xi$(sub)ij/$\xi$-2$\delta$(sub)ij/3). The model constants are optimized with aids of DNS data in a plane channel flow. Adopting the dissipation length scale as a parameter of damping function, the applicabilities of $\kappa$-$\xi$ model are extended to the turbulent flow calculation of complex flow passages.

• Atmosphere
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• v.21 no.3
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• pp.243-256
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• 2011

This paper presents the development of new algorithm for identifying and tracking the convective cells in three dimensional reflectivity fields in Cartesian coordinates. First, the radar volume data in spherical coordinate system has been converted into Cartesian coordinate system by the bilinear interpolation. The three-dimensional convective cell has then been identified as a group of spatially consecutive grid points using reflectivity and volume thresholds. The tracking algorithm utilizes a fuzzy logic with four membership functions and their weights. The four fuzzy parameters of speed, area change ratio, reflectivity change ratio, and axis transformation ratio have been newly defined. In order to make their membership functions, the normalized frequency distributions are calculated using the pairs of manually matched cells in the consecutive radar reflectivity fields. The algorithms have been verified for two convective events in summer season. Results show that the algorithms have properly identified storm cells and tracked the same cells successively. The developed algorithms may provide useful short-term forecasting or nowcasting capability of convective storm cells and provide the statistical characteristics of severe weather.

• Journal of Nutrition and Health
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• v.43 no.3
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• pp.304-314
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• 2010

Vitamin E has been a generic term for all tocopherol and tocotrienol derivatives. The most active form of vitamin E isoforms in vivo is regarded to be $\alpha$-tocopherol which is the only form defined as vitamin E in the US Food and Nutrition Board, causing controversy over setting dietary reference intake (DRI) of vitamin E. However, most of the countries other than the US maintain the original concept that all isoforms are accepted as vitamin E but with different biopotency. The roles of the isoforms of vitamin E other than $\alpha$-tocopherol have received continuous attention. Among them those of $\gamma$-tocopherol and $\alpha$-tocotrienol have been most studied in comparison with $\alpha$-tocopherol, since $\gamma$-tocopherol comprises major form of vitamin E in many plant seeds and those of the both vitamin E have been implicated in unique physiological functions. This review summarizes findings that have led a better understanding of vitamin E absorption, transport, tissue storage and various functions common and specific to vitamin E isoforms focusing $\alpha$- and $\gamma$-tocopherol as well as tocotrienols. It is expected to help redefining vitamin E and setting its DRI for Koreans.

• Korean Journal of Ecology and Environment
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• v.42 no.4
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• pp.487-494
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• 2009

We compared spatial and temporal variations of water chemistry between high-flow year ($HF_y$) and low-flow year ($LF_y$) in an artificial lentic ecosystem of Daechung Reservoir. The differences in the rainfall distributions explained the variation of the annual inflow and determined flow characteristics and water residence time and modified chemical and biological conditions, based on TP, suspended solids, and chlorophylla, resulting in changes of ecological functions. The intense rainfall and inflow from the watershed resulted in partial disruption of thermal structure in the metalimnion depth, ionic dilution, high TP, and high suspended solids. This condition produced a reduced chlorophyll-a in the headwaters due to low light availability and rapid flushing. In contrast, reduced inflow and low rainfall by drought resulted in strong thermal difference between the epilimnion and hypolimnion, low inorganic solids, high total dissolved solids, and low phosphorus in the ambient water. The riverine conditions dominated the hydrology in the monsoon of $HF_y$ and lacustrine conditions dominated in the $HF_y$. Overall data suggest that effective managements of the flow from the watershed may have an important role in the eutrophication processes.

• Animal cells and systems
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• v.13 no.4
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• pp.357-362
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• 2009

Hesperidin, the most abundant polyphenolic compound found in citrus fruits, has been known to possess neuroprotective, sedative, and anticonvulsive effects on the nervous system. In a recent electrophysiological study, it was reported that hesperidin induced biphasic change in population spike amplitude in hippocampal CA1 neurons in response to both single spike stimuli and theta-burst stimulation depending on its concentration. However, the precise mechanism by which hesperidin acts on neuronal functions has not been fully elucidated. Here, using whole-cell patch-clamp recording, we revealed that hesperidin did not affect excitatory synaptic activities such as basal synaptic transmission and theta-burst LTP. Moreover, in a current injection experiment, spike number, resting membrane potential and action potential threshold also remained unchanged. Taken together, these results indicate that the effects of hesperidin on the neuronal functions such as spiking activity might not be attributable to either modification of excitatory synaptic transmissions or changes in membrane excitability in hippocampal CA1 neuron.

• Communications of Mathematical Education
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• v.22 no.3
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• pp.289-310
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• 2008

The purpose of study is to propose the possibilities of finding trigonometric function values using trigonometric function graphs instead of the unit circle method. And it is to discuss how to enhance relating trigonometric function value finding to graphs construction, and students conceptual understanding of the properties of trigonometric functions. The conclusions of this study are the effectiveness of function value finding using trigonometric function graphs, the use of a precise term of function value finding given general angles, consideration of a link between function value finding and graphs, and the possibility of teaching trigonometric function graphs in advance of function value finding.

• Journal of computational fluids engineering
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• v.14 no.4
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• pp.67-77
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• 2009

This paper is a continuation of a recent development on the Hermite-based divergence-free element method and deals with a non-isothermal fluid flow driven by the buoyancy force in a square cavity with temperature difference across the two sides. Two Hermite functions are considered for numerical computations in this paper. One is a cubic function and the other is a quartic function. The degrees-of-freedom of the cubic Hermite function are stream function and its first and second derivatives for the velocity field, and temperature and its first derivatives for the temperature field. The degrees-of-freedom of the quartic Hermite function include two second derivatives and one cross derivative of the stream function in addition to the degrees-of-freedom of the cubic stream function. This paper presents a brief review on the Hermite based divergence-free basis functions and its finite element formulations for the buoyancy driven flow. The present algorithm does not employ any upwinding or a stabilization term. However, numerical values and contour graphs for major flow variables showed good agreements with those by De Vahl Davis[6].