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Antioxidant Action of Ginseng : An hypothesis (인삼의 항산화 작용)

  • Lee, D.W.;Sohn, H.O.;Lim, H.B.;Lee, Y.G.;Aprikian, A.G.;Aprikian, G.V.
    • Journal of Ginseng Research
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    • v.19 no.1
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    • pp.31-38
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    • 1995
  • Antioxidant effect of Korean ginseng (Panax ginseng C.A. Meyer) was investigated in rats. Long-term administration of ginseng water extract protected the activity of liver cytosotic SOD, catalase and glutathione peroxidase from being significantly decreased with advancing age (p<0.05). It was more effective toward glutathione peroxidase than other antioxidant enzymes. However, the level of sulfhydryl compounds and its related enzymes such as glutathione reductase and glutathione-5-transferase was not significantly changed by the administration of ginseng. Liver microsomal formation of reactive oxygen species such as superoxide and hydrogen peroxide did not show a significant difference between two groups although it was slightly decreased with age, but lipid peroxidizability of microsomal membrane induced by a prooxidant was slightly lower in ginseng-treated rats. Interestingly, antioxidant capacity of plasma from ginseng treated rats on autooxidation of ok-brain homogenates was much higher than that of normal ones. However, resistance of RBC membrane against oxidative stress showed a similar tendency. The content of serum TBA reactive substances lowered consistently in the rats treated with r ginseng at all corresponding age and a significant difference between two groups was found at 24 months of age (p<0.05). Ginseng extract protected lipid peroxidation in brain and liver. This protection was more effective in the stressed rats imposed by immobilization than normal ones. In conclusion, ginseng water extract protected the age related deterioration of major antioxidant enzymes, and this effect was more striking with increasing duration of treatment. This comprehensive antioxidant action of ginseng seems to be bra certain action of ginseng other than a direct antioxidant action, which might be a long term normalizing effect through the harmony of various components.

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A Study about Long-Term Effects of Attention-Deficit Hyperactivity Disorder Medication on Height and Weight in the Korean School-Aged Boys with Attention-Deficit Hyperactivity Disorder Based on Observation of Natural Course (자연경과 관찰에 의한 주의력결핍 과잉행동장애 아동에서 장기간의 약물치료가 성장에 미치는 영향)

  • Yeom, Chan-Woo;Eun, Tae-Kyung;Park, Hoon-Sub;Lee, Kyu-Young;Kim, Eui-Joong;Joo, Eun-Jeong;Koo, Young-Jin
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.25 no.2
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    • pp.89-94
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    • 2014
  • Objectives : This study was conducted naturalistically in order to observe the long-term effects of attention-deficit hyperactivity disorder (ADHD) medications on growth rates among Korean school-aged boys with ADHD. Methods : Participants in the study were boys with ADHD aged 6 to 11 years who have taken ADHD medication, methylphenidate (extended release) or atomoxetine. They attended scheduled visits monthly or bimonthly for clinical assessment with measurement of height and weight. In this study, 35 boys with ADHD (mean age at baseline=$7.90{\pm}1.77$ years ; mean age at endpoint= $12.54{\pm}1.91$ years) were included, with a mean follow-up period of 4.64 years (${\pm}1.62$ years), ranging from 2 to 9.7 years. Height, weight, and body mass index (BMI) measurements were converted to "age-corrected Z-scores" using data from Growth Charts provided by the Korean Center for Disease Control and Prevention from 2007. Results : Age-corrected endpoint growth parameters (height, weight, BMI Z-scores) did not differ significantly from the baseline values (height t=0.027 ; weight t=-0.61 ; BMI t=-1.86, in paired t-test). Especially high correlation was observed between the baseline and endpoint height Z-scores (r=0.876, p<.001), for which the coefficient of determination $r^2$ was 0.767, meaning that the amount of variability in endpoint height Z-scores explained by the baseline height Z-scores was 76.7%. Conclusion : Our results suggested that the long-term effects of ADHD medications on growth parameters to be tolerable in Korean school-aged boys with ADHD.

A Study of the Lived Experiences of Clients Receiving Long-Term Hemodialysis (장기 혈액투석 수혜자들의 생활경험에 관한 연구)

  • 신미자
    • Journal of Korean Academy of Nursing
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    • v.27 no.2
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    • pp.444-453
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    • 1997
  • The purpose of this study was to construct a grounded theory as the basis for nursing intervention by describing and analysing the holistic lived experiences of clients receiving long-term hemodialysis. The subjects of this study were fifteen persons receiving regular hemodialysis regimen at artificial kindey treatment centers in two different university hospitals, and who were able to participate in conversation and were available for long and dup interviews. Eight of the subjects were male and seven were female and their ages ranged from 30's to 60's. The length of the hemodialysis experience ranged from two months to six years. The collection and analysis of data were done in accordance with the grounded theory methodology of Strauss & Corbin. The method to collect the data mainly depended. on long and deep interviews, participant observation and focused group interviews and the equipment used to collect data were a portable tape recorder and field notes. The study is summarized as follows : 1. The meaning of holistic lived experiences of clients receiving long -term hemodialysis was found to be uncertainty. which was identified as the core category. 2. The main categories following the core category were found to be shock, ambiguity, social support and quality of life. 3. Through the main category the type of behavior newly formed by clients receiving long-term hemodialysis was found to be as follows. That is to say, in the circumstances of shock caused by the identified fact and the ambiguity of hemodilysis they formed a quality of life based on social support, which was found to be a kind of chaotic phenomenon. 4. The lived experiences of clients receiving long-tern hemodialysis was found to include nine categories : emotional shock, feelings of isolation, burden, unclearness, dependency, help from others, coping strategies, maintenance of self-esteem and transitional life. 5. The intervening factors influencing each category are as follows : 1) The factors influencing 'emetional shock' were found to be set age, the level of knowledge received in advance, locus of control, the period of struggle against the disease before hemodialysis and whether any serious illness existed. 2) The factors influencing 'feelings of isolation' were found to be religion and the length of the hemodialysis experience. 3) The factors influencing 'burden' were found to be sex, economic situation, employment status and the length of the hemodialysis experience. 4) The factors influencing 'unclearness' were found to be sex, age, religion. economic situation, the length of the hemodiaysis experience, whether they had had a transfusion and whether there were any complications. 5) The factors influencing 'help from others' were found to be religion. economic situation, past experiences and whether family members lived together. 6) The factors influencing 'coping strategies' were foung to be age, level of education, experiences of illness and locus of control. 7) The factors influeruing 'maintenance of self-esteem' were found to be the length of the hemodialysis experience and self-actualization. 8) The factors influencing 'transitional life' were found to be age, religion, economic situation, employment status. locus of control. past experiences and whether there was a plan for a kidney transplant.

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An Experimental Study on the Resistance of Low-Heat Cement Mortar in Chemical Attack (저발열시멘트 모르터의 호학저항성에 대한 실험적 연구)

  • 문한영;신화철;김성수;강석화
    • Proceedings of the Korea Concrete Institute Conference
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    • 1998.04a
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    • pp.183-186
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    • 1998
  • This paper deals with 28, 56, 91 days age compressive strength and ratio of weight when OPC and Low-Heat cement mortar immersed in chemical solution. As a result of experiment, the resistance of Low-Heat Cement motar in chemical attack is more effective than that of OPC, because of lower $C_3$A content and Pozzolanic reactions. Especially in long term age compressive strength, Low-Heat cement mortar shows higher strength in all kind of chemical solution compared with compressive strength of OPC motar.

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A Study on the Properties of Low-Heat Cement Concrete (저발열시멘트 콘크리트의 기초적 성질에 대한 연구)

  • 문한영;김성수;신화철;강석화
    • Proceedings of the Korea Concrete Institute Conference
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    • 1997.10a
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    • pp.57-60
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    • 1997
  • The properties of Low-heat cement are especially in lower heat of hydration than that of other types of cement. In other respect, Low-heat concrete is more advantageous than OPC concrete in chemical resistance, long term age compressive strength, slump loss and resistance to seawater. This paper deals with 28 days age compressive strength and slump loss by elapsed time of mortar and concrete that made with Low-heat cement and 3 types of other cement.

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Relating Factors on Mental Health Status (Depression, Cognitive Impairment and Dementia) among the Admitted from Long-term Care Insurance (노인장기요양보험 인정자의 정신적 건강상태(우울, 인지기능장애 및 치매) 및 그의 관련요인)

  • Song, Young-Su;Kim, Tae-Baek;Bae, Nam-Kyou;Cho, Young-Chae
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.2
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    • pp.247-260
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    • 2018
  • This study examined the mental health status (depression, cognitive impairment and dementia) and its association with the related factors in the elderly people who were admitted from long-term care insurance. The study subjects were 1,488 people (male 740, female 748) aged over 70 years of age who had been recognized for long-term care insurance services in the years 2011~2014 from the National Health Insurance Corporation. The data collected from the National Health Insurance Corporation set forth a lifestyle questionnaire, itemized health screening tests, and long-term care as recognition data for research purposes. As a result, depression, cognitive impairment, and dementia of subjects increased significantly with age. As a multiple logistic regression result, the risk ratios of depression, cognitive impairment, and dementia, which indicated the mental health status, were significantly higher in women than in men, in the lower body weight group than in the overweight group, in the smoking group than in the non-smoking group, and in the drinking group than in the non-drinking group. These results suggest that the mental health status (depression, cognitive impairment, and dementia) of subjects decreased with increasing age, particularly the group with poor health related behaviors, such as smoking, drinking, and regular exercise, indicating that the mental health condition is lower than in the good group.

Long-term Behavior of Steel-Concrete Composite Girders due to Concrete Shrinkage (콘크리트 건조수축에 의한 합성거더의 장기거동)

  • Bae, Doo Byong;Youn, Seok Goo;Ham, Sang Hee
    • Journal of Korean Society of Steel Construction
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    • v.16 no.6 s.73
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    • pp.807-818
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    • 2004
  • Experimental tests and theoretical methods of the analysis of the concrete shrinkage behaviors of steel-concrete composite girders are described herein. Steel-concrete composite test specimens were fabricated in the laboratory, and long-term behaviors such as deflections, curvatures, and strains were measured for one year. Test results were compared to the analytical results obtained by using the age-adjusted effective modulus method (AEMM). In addition, composite girders have been analyzed to investigate the effects of several parameters on the concrete shrinkage behaviors. From the long-term test results, it could be used to validate AEMM for the evaluation of the shrinkage behavior of composite girders. Because the shrinkage of the reinforced concrete slab in composite girders may lead to large tensile stresses in the concrete section, the transverse cracking of the slab could occur both in the positive and negative regions. Therefore, if the cracking of concrete would be ignored,it might lead to an overestimation of the stresses of the steel section of composite girders. Based on this research, it is proposed that the effect of transverse concrete cracking on the shrinkage behavior of steel-concrete composite bridges be considered.

A Study on the Selection of Pricing Factors for Used Bulk Carriers (중고 벌크선의 가격결정요인 선정에 관한 연구)

  • Yang, Yun-Ok
    • Journal of Navigation and Port Research
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    • v.41 no.4
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    • pp.181-188
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    • 2017
  • In the existing ship sales market, prices determined based on the prices of similar ship types that recently traded. ince the 2008 financial crisis, ship prices have fluctuated, and ship price criteria have become ever more necessary to the imminent value of the ship. Therefore, this research used the hedonic price model to estimate imminent values of ships. In this study, the influence on ship prices was analyzed by the value of each characteristic and an estimated functional formula was. Out of the four models suggested by the hedonic price model, an optimal model was selected with variance inflation factors and a stepwise selection. For this, the influence of determinants of ship prices was analyzed based on actually traded ships and characteristic data. The selected model s the Log-Line model; as a result of regression analysis, eight variables, including DWT, Age, Market Value, Short-Term Charter, Long-Term Charter, Enbloc, Special Survey Due and Builder were to affect the ship price model. This model is expected to be useful for objective and balanced ship price evaluation.

An Investigation on the Status of Care-giving for the Demented Elderly and Desire for In-house Care Services (치매노인의 부양실태와 재가복지서비스 욕구조사)

  • Lee, Sui-Il;Kim, Ki-Tae;Jeong, Ihn-Sook;Park, Nam-Hee;Lee, Kyung-Nam;Kim, Mung-Soo;Kim, Jung-Soon
    • Research in Community and Public Health Nursing
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    • v.14 no.3
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    • pp.385-396
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    • 2003
  • Purpose: The purpose of this study is to examine the status of care-giving for the demented elderly and to find out the need of community in-house care services-day care services, short-term care services, home help services, and home care services. Method: It analyzed the data of 186 old people having dementia, and caregivers. Data were collected for five days, in September 2002. Results: The caregivers were mostly women and the burden for the care giving was high (87.5%). They used community care services, that is, day care services (26.5%), home care services (21.6%), home help services 00.8%), short-term care services (6.2%). Caregivers' age and education level were significant factors in the demand for day care services. Caregivers' education level was a statistically significant factor in the demand for short-term care services and home help services. Caregivers' age and education level were significant factors in the demand for home care services. Conclusions: It is necessary to expand the financial aid for the active implementation of daytime protection for dementia-patients under medical treatment at home and to promote patients' recovery. It is necessary to enhance home help services and home care services, and to establish many day care centers and short term care centers. Through this, it will prevent caregivers from becoming burnt out due to the burden of care giving.

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The Relationship between the Quality of Life, Care Services, and Family Support of Elderly Residents in Long-Term Care Facilities (노인요양 시설 노인의 삶의 질과 시설 서비스, 가족 지지의 관계)

  • Shin, Seung-Ho;Shin, So-Hong
    • The Journal of the Convergence on Culture Technology
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    • v.7 no.2
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    • pp.227-237
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    • 2021
  • The aim of this study is to identify the influence of care services on the quality of life of elderly residents in long-term care facilities, and to determine the mediating effect of family support. The subjects of the study were 192 older adults living in long-term care facilities in the Daegu and Gyeongsangbuk-do region. The collected data were analyzed using the SPSS 22.0 program, and the methods used include descriptive statistics, t-test, ANOVA, Pearson correlation analysis, and regression analysis. The results of the study found that the subjects' quality of life differed depending on their age, education, income level of their children, reasons for admission, and length of stay. The factors that influenced their quality life included age, education, the income level of their children, reasons for admission, length of stay, and care services. The study also revealed that family support was the mediating effect in the relationship between care services and quality of life. The results of the study will provide insight in establishing a nursing intervention plan to improve the quality of life of elderly residents in care facilities.