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Effects of Short-Term Supplementation of Carnitine on Plasma and Urinary Carnitine and Plasma Lipid Levels of Healthy Male Adults (단기간의 카르니틴 보충섭취가 건강한 성인남성의 혈장 카르니틴농도 및 소변내 배설량, 혈장 지질수준과 지방산조성에 미치는 영향)

  • 정은정;엄영숙;차연수;박태선
    • Journal of Nutrition and Health
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    • v.36 no.7
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    • pp.720-728
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    • 2003
  • This study was conducted to evaluate changes in plasma concentration and urinary excretion of carnitine, as well as plasma lipid level and fatty acid composition, caused by short term supplementation of carnitine in humans. Ten healthy male subjects (21.2 $\pm$ 0.5 years old) received oral carnitine supplementation (4 g/day) as tablets for two weeks. Fasting blood and random urine samples were collected from each subject both prior to and at the end of carnitine supplemention program. Following the 2 weeks of carnitine supplementation, plasma total carnitine (TCNE) concentration increased 20% (85.1 $\pm$ 7.4 vs 67.3 $\pm$ 9.1 $\mu$ mol/1, p> 0.05), while urinary excretion of total carnitine increased ten times compared to the value measured prior to the supplementation (3051 $\pm$ 692 vs 278 $\pm$ 90.1 $\mu$ mol/g creatinine, p < 0.01). Non-esterified carnitine (NEC) comprised from 71 to 88% of TCNE in plasma, and from 32 to 40% of TCNE excreted in the urine. Two weeks of carnitine supplementation in healthy adults significantly elevated plasma level of acid soluble acylcarnitine (ASAC) which is esterified mostly with short chain fatty acids (21.6 $\pm$ 1.6 $\mu$ mol/l) compared to the value measured prior to the supplementation (6.4 $\pm$ 0.8 $\mu$ mol/l) (p < 0.05). Carnitine supplementation significantly increased plasma HDL-cholesterol level (p < 0.05), and decreased the atherogenic index (p < 0.05), but failed to cause any significant change in plasma levels of total cholesterol, triglyceride, and free fatty acids. Plasma triglyceride and phospholipid fatty acid compositions were not significaly affected as well by the oral supplementation of carnitine in subjects with normal range of blood lipid levels.

The Learning Behavior of K-MOOC Learners and K-MOOC Service Recommendations (K-MOOC 학습자의 학습행태 분석 및 서비스 방향성 연구)

  • Ahn, Jun Hoo;Lee, Jee Yeon
    • Journal of the Korean Society for information Management
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    • v.37 no.3
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    • pp.221-252
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    • 2020
  • According to the participants, the current K-MOOC (Korean Massive Open Online Course) has a few problems, such as too few courses, low content quality, and useless learner management system compared to MOOCs abroad. These problems caused diminished learner motivation. Consequently, the K-MOOC service has recorded a low course completion rate despite high expenses spent to develop the contents and thus requires remedies to fix the issues. This study drew research subjects from a pool of college and graduate students representing the primary users of the K-MOOC. This study limited the research scope to the four categories: motivation, learning experience, recognition, and performance of the Biggs' 3P Learning System Model. Based on the literature review, ten variables were selected and explored how the subjects perceived four categories using the survey questionnaire. This study also examined the relationship between ten variables and generated suggestions for the instructors, course managers, and platform developers to make the K-MOOC better.

Assessment of the Cerebrospinal Fluid Effect on the Chemical Exchange Saturation Transfer Map Obtained from the Full Z-Spectrum in the Elderly Human Brain

  • Park, Soonchan;Jang, Joon;Oh, Jang-Hoon;Ryu, Chang-Woo;Jahng, Geon-Ho
    • Progress in Medical Physics
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    • v.30 no.4
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    • pp.139-149
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    • 2019
  • Purpose: With neurodegeneration, the signal intensity of the cerebrospinal fluid (CSF) in the brain increases. The objective of this study was to evaluate chemical exchange saturation transfer (CEST) signals with and without the contribution of CSF signals in elderly human brains using two different 3T magnetic resonance imaging (MRI) sequences Methods: Full CEST signals were acquired in ten subjects (Group I) with a three-dimensional (3D)-segmented gradient-echo echo-planar imaging (EPI) sequence and in ten other subjects (Group II) with a 3D gradient and spin-echo (GRASE) sequence using two different 3T MRI systems. The segmented tissue compartments of gray and white matter were used to mask the CSF signals in the full CEST images. Two sets of magnetization transfer ratio asymmetry (MTRasym) maps were obtained for each offset frequency in each subject with and without masking the CSF signals (masked and unmasked conditions, respectively) and later compared using paired t-tests. Results: The region-of-interest (ROI)-based analyses showed that the MTRasym values for both the 3D-segmented gradient-echo EPI and 3D GRASE sequences were altered under the masked condition compared with the unmasked condition at several ROIs and offset frequencies. Conclusions: Depending on the imaging sequence, the MTRasym values can be overestimated for some areas of the elderly human brain when CSF signals are unmasked. Therefore, it is necessary to develop a method to minimize this overestimation in the case of elderly patients.

The Effects of 12 Week Balance Ability Improvement Exercise to the Changes of Selected Joint Angles and Ground Reaction Forces during Down Staircase Walking (노인대상 12주간 균형능력 향상 운동이 계단 내리기 보행 시 주요 관절각 및 지면반력 변화에 미치는 영향)

  • Park, Yang-Sun;Kim, Eui-Hwan;Kim, Tae-Whan;Lee, Yong-Sik;Lim, Young-Tae
    • Korean Journal of Applied Biomechanics
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    • v.20 no.3
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    • pp.267-275
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    • 2010
  • The purpose of this study was to investigate the effects of balance ability improvement exercise program which applied to the elderly people for increasing balance, stability and range of motion. Ten elderly people and ten university students were recruited as the subjects. Kinematic data were collected by seven real-time infrared cameras while subjects walk stair descent as a pre-test. Korean folk dance exercise program was applied to the elderly for 12 weeks. Same experiment on stair descent walk was performed as post-test. Results indicated that CM movement and selected joint angle patterns of elderly group after treatment changed to the similar patterns of young group. However, ankle joint angle and vertical GRF of elderly group after treatment also increased compared to those of the elderly group before treatment. This might be explained by the fact that elderly used a different walking strategy which maximize support base for increasing stability. Overall, these results indicated that the exercise treatment may affect to adapt and improve the gait pattern of stair descent of elderly people.

Present and Prospect of Clothing Construction Research - Focus on academic associations' publication - (의복구성학 분야의 연구 현황과 전망 - 학회지를 중심으로 -)

  • Kim, Seonyoung
    • Journal of Fashion Business
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    • v.20 no.5
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    • pp.102-114
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    • 2016
  • The purpose of this study is to enable a scientific and rational approach for future research agenda setting in the clothing construction field. Through analysis of research papers on clothing construction published in domestic academic journals during the recent decade, the research trend of clothing construction in respective academic journals, research subjects, and research contents were grasped thoroughly. From all domestic academic associations' publication on garment/clothing and textiles/fashion, 7 academic journals were selected as subjects of research, in order to compare and analyze the research trend in the last ten years. The ten-year period ranged from April 2006 to March 2016, and a total of 735 papers published on clothing construction were used for analysis. The number of publications in the clothing construction area during the last decade has decreased, which is due to the increase in the number of clothing and textiles fashion-related academic journals, other than the 7 journals analyzed, and since the number of papers published in international academic journals has also increased. Body type, patterns, fitting test, and functional clothing accounted for the highest proportion of research themes in clothing construction. In terms of body type, there was an increasing tendency towards usage of 3D body measurement. In the patterns area, the 3D virtual dressing system was actively used. For functional clothing, sportswear, protective clothes, and innerwear were most widely researched, and ergonomic design together with smartwear was actively studied.

Effects on Improvement of Activities of Daily Living Through Short-Term Home Visiting Physical Therapy (단기 가정방문물리치료 시행이 일상생활동작의 개선에 미치는 효과)

  • An, Duk-Hyun
    • Physical Therapy Korea
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    • v.14 no.2
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    • pp.53-60
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    • 2007
  • The objective of this study was to discover the effects of the short-term home visiting physical therapy program involving patients with some chronic brain disorders at Gimhae City, Kyongnam. Recovery of activities of daily living (ADL) is a very important factor of rehabilitative procedures, and Functional Independence Measure (FIM) is a useful standard of evaluation for it. The FIM is widely used in brain disorder research because it measures real functional activities of daily living. We applied the physical therapy exercise program twice per week (10~15 times repeatedly); a warm-up and cool down exercise performed every ten minutes by active & active-assistive ROM and stretching exercises. Main exercises were composed of getting up & laying down in bed, standing training, walking exercise in the room, and window or wall sliding exercise using affected upper limbs for a total duration of 30 minutes. We collected the data from 20 patients with chronic brain disorders at his/her home and analyzed by means of SPSS/PC+ program (Ver. 10.0). After the six week long physical therapy exercise program, the average was $56.10{\pm}22.59$ point compared with initial $50.55{\pm}19.12$ point by FIM, improved functional ADL ability about 5.55 point, and these changed scores were statistically significant (p=.000). We also studied another factor regarding patient's satisfaction. The majority of subjects (10 people) rated the program with the maximum score of ten points (50.0%), and three people rated it a seven point program (15.0%), the other two subjects gave a rating of nine and eight points (10.0%). Because the program was effective at improving the physical ADL ability and satisfaction of each subject, we suggest continual development and implementation of a home visiting physical therapy program. Further study should involve a longer period of observation with a larger population that is involved in an individually designed home physical therapy program.

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The Changes of the Circadian Rhythm of Mood in Shift Worker (교대근무에 따른 기분의 Circadian Rhythm 변화)

  • 고성희;김명애
    • Journal of Korean Academy of Nursing
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    • v.24 no.2
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    • pp.175-189
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    • 1994
  • This study examined the daily rhythmic patterns of mood in shift workers. Ten rotating shift nurses (shift worker group) were matched with ten non-rotating student nurses (non - shift worker group) working under the same conditions at University Hospital. The subjects completed the Mood Adjective Checkist (MAC) every two or three hours from 6AM to 9-11 PM for six consecutive days. The MAC was constructed by Mansour and conversed the mood factors of Anger - Depression. Happiness, Mental, and Social. These data were analyzed by using Cosinor method. The results are summarized as follows : 1. There was no difference in mean scores for Anger - Depression, Happiness, Mental, and Social mood rhythm between the shift workers and the non - shift workers. 2. There was no difference in the amplitude of Anger - Depression, Happiness and Social mood between the two groups, but the shift workers had a higher amplitude of Mental mood. 3. The acrophases of the Anger - Depression mood were between 1:28 and 2:05, and those of Happiness, Social, and Mental mood were between 12:5 and 15:03 for both groups. There were no differences between the groups. 4. The number of the subjects with statistically significant mean cosinor rhythms for Anger-De-pression and Mental moods were higher in the shift workers than in the non-shift workers, but there were no differences between the shift workers and the non-shift workers in those of Happiness and Mental mood. This study showed that the mod manifested circadian periodicities, and a rapidly rotating shift system did not changed the circadian rhythm of mood. It is expected that this study will facilitate a better understanding of circadian rhythm in mood in the shiftworkers.

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Effects of excessive Pronation of the Foot on Knee joint Strength and Gait (발의 과도한 회내 상태가 슬관절 근력과 보행에 미치는 영향)

  • Jung, Sang-mo
    • The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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    • v.27 no.2
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    • pp.77-85
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    • 2021
  • BACKGROUND: This study aimed to determine the changes in muscle strength and walking ability in patients who complained of knee instability due to excessive pronation of the foot. METHODS: Twenty patients (ten men and ten women) who complained of instability of the knee joint due to excessive pronation of the foot participated in the experiment. In the experimental group, the internal rotation of the tibia caused by excessive adduction of the foot was maintained as external rotation, and the joint state was to recognize the movement of the joint position changed through maintenance of the muscle. This exercise was performed five times for each patient, and the muscle strength maintenance was performed for 20 seconds. In the control group, stretching and range of motion (ROM) exercises were performed. For the stretching exercise, one specific motion was performed for 20 second, and the ROM exercise was performed to confirm the change in muscle strength in the knee joint area and walking ability. RESULTS: The knee flexion and extension strength in the patients with excessive pronation of the foot differed significantly from those in the subjects from the control group (p<.05). Further, the before-after comparison of the step time and length in the evaluation of walking ability, which affects overall postural movement due to knee joint instability, revealed a significant difference between the experimental and control groups (p<.05). CONCLUSION: The patients that were subjected to manual therapy and ROM exercise for the knee joint showed improved knee joint muscle strength and walking ability compared to the subjects from the control group.

The Effect of Virtual Reality Program Combining Transcranial Direct Current Stimulation on Depression, Hand Function, Cognition, and Daily Life Activities of Patients with Mild Cognitive Disorders (경두개직류전류자극을 결합한 가상현실프로그램이 경도인지장애환자의 우울, 손기능, 인지와 일상생활활동에 미치는 영향)

  • Ko-Un Kim;Bo-Ra Kim;Tae-Gyu An
    • Journal of The Korean Society of Integrative Medicine
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    • v.11 no.1
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    • pp.53-62
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    • 2023
  • Purpose : This study evaluated the effects of transcranial direct current stimulation and a virtual reality program on the depression, hand functions, cognitive function, and activities of daily living of patients with mild cognitive impairment by dividing 20 patients with mild cognitive impairment and depression. The 20 patients were divided into a treatment group (transcranial direct current stimulation + a virtual reality program) and a control group (placebo transcranial direct current stimulation + a placebo virtual reality program). Methods : This study allocated ten subjects to the treatment group and ten subjects to the control group. The treatment was given five times per week for six weeks (30 sessions), and each session was 30 minutes. This study screened depression by using SGDS-K, a short geriatric depression scale, to examine depression before and after treatment intervention. This study also used the box and block test, NCSE, and FIM to evaluate hand functions, cognitive function, and activities of daily living, respectively. Results : The results showed that depression significantly decreased, hand functions significantly increased, cognitive function significantly improved, and activities of daily living significantly increased after intervention in the treatment and control groups. The magnitude of changes in depression, hand functions, cognitive function, and activities of daily living was significantly different between the two groups after intervention (p>.05). Conclusion : The results showed that the application of transcranial direct current stimulation and a virtual reality program could improve cognitive function, hand functions, and activities of daily living by decreasing depression. Therefore, it can be concluded that the simultaneous application of transcranial direct current stimulation and a virtual reality program is an intervention method, which can be applied for decreasing depression, enhancing hand functions, improving cognitive function, and increasing activities of daily living in patients with mild cognitive impairment.

South and North Korean Living Cultures : Their Differences and Integration(I) (남북한 생활문화의 이질화와 통합(I) -북한가정의 생활실태를 중심으로-)

  • 이기춘
    • Journal of the Korean Home Economics Association
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    • v.35 no.6
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    • pp.289-315
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    • 1997
  • Living culture, which is a pattern of peoples' everyday living, is influenced by the socio-economic conditions as well as ideology of the society. south and North Korean societies have been segregated during the past 50 years with different socio-those two societies share the same traditional culture. This project was developed to identify the differences in living cultures between South and North Korean societies, and to make suggestions for their successful integration. The first part of the project was concentrated on finding out the current living culture of North Korean families. References on North Korean living culture were reviewed, and North Korean movies related to family living were also analyzed. Besides, in depth interview was conducted with ten people who escaped from North Korean after 1990. The subjects with various demographic backgrounds were asked about lifestyles concerning food, clothing, housing, time management, consumption, child rearing, and family living that they experienced when they were in North Korea. The subjects were also asked to respond to the questionnaires measuring collectivism, materialism, and familism, which were developed for the study to find out the relationship between value orientation and lifestyles. This study revealed differences in many aspects of living cultures of South and North Korea, and relationships were suggested between value orientation and lifestyle. This exploratory study was intended to provided ground for more objective study with large number of subjects in the following year.

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