• YAKHAK HOEJI
• /
• v.37 no.5
• /
• pp.511-519
• /
• 1993

The short and variabke transit of drug throught GI tracj and the inter-and intra-subject variations of the transit restrict the sustained drug absorption after oral adminstration. These restrictions may be solved by retaining the dosage forms in the stomach. Then the dosage form will act as a platform which releases the drug slowly and makes the GI absorption occur for a long time. In this study, as the platforms, PVP hydrogels were synthesized by chemical and y-irradiation method in the cylindrical test tube. The chemical method means the synthesis of the hydrogel by heating the mixed solution of N-vinyl-2-pyrrolidone [monomer], acrylated albumin [crosslinking agent], 2, 2'-agobis(2-methylpropionitrile) [initiator] and proxyphylline [drug] at $65^{\circ}C$ for 5 hr. The $\gamma$-irradiation method means the synthesis of the hydrogel by irradiation with $^{60}$ Co $\gamma$-ray of the mixed solution of the monomer, acrylated albumin, and flurbiprofen [drug] at room temperature with total 0.2 Mrad for 3 hr. Our intention is to design the hydrogel tablet (diameter : 1.20 cm, thickness : 0.60 cm) which swells in the gastric fluid after oral administration to such a size that passing through the pylorus could be inhibited during the period of drug release. After releasing drug, the hydrogel should be degraded by the enzymeatic digestion in the stomach, or by hydrolysis and eventually solubilized. Thus, in votro tests were performed to examine the factors that affect swelling and drug release from the PVP hydrogels. Experimental results show that the hydrogels swell to a size larger than the diameter of the pylorus(l.3$\pm$0.7 cm) and the hydrogel prepared by the chemical method is digested by pepsin. But the hydrogel prepared by the $\gamma$-irradiation method was not digested by the pepsin and just collapsed with time. Thus, the swelling of the hydrogel synthesized by $\gamma$-irradiation was independent albumin acrylation time and pepsin concentration. But drug content and radiation dose affected the swelling and drug release kinetics of the hydrogel. Drug release from the hydrigels was prolonged up to about 24 hr. Therefore, it was concluded that by adjusting these factors, the albumin-crosslinked PVP hydrogel synthesized by $\gamma$-irradiation method is expected to be retained in the stomach for up to 60hr and be a potential platform of drugs for long-term GI absorption.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.31 no.1
• /
• pp.97-103
• /
• 1986

In order to investigate the important morphological traits, and grain yield and its components on basis of regional variation of barley plant, Olbori was tested at 3 locations Suwon, Daejeon and Jinju for 3 years. It needed seven days around 15$^{\circ}C$ of daily average temperature for seed emergence. 104 to 144 days for Daejeon and 135 to 142 for Jinju after sowing are needed for productive tillers according to the different sowing dates, and % of productive tillers were ranged on 37-77%, showing higher value at the southern region. Young spike elongated slowly at early stage, and after floret differentiation it appeared rapid development with 1.05-1.95 mm elongating per day. Analysis of variance indicated that only number of kernels/spike showed significant differences among locations, but every traits related to grain yields revealed the significant differences among different sowing dates. Little differences between locations existed on grain yield but its large variation appeared between sowing dates, especially indicating more variation at northern regions.

• Economic and Environmental Geology
• /
• v.29 no.5
• /
• pp.545-559
• /
• 1996

Rare metal (Nb-Zr-REE) ore deposits are located in the Chungju area. Geotectonically, the rare metal ore deposits are situated in the transitional zone between Kyeonggi massif and Okcheon belt. The rare metal deposits are distributed in Kyemyeongsan Formation which consist of schist and alkaline igneous rocks. Alkali granite has suffered extensive post-magmatic metasomatism and hydrothermal processes. The ore contains mainly Ce-La, Ta-Nb, Y, Y-Nd, Nd-Th group minerals. More than 15 RE and REE minerals are found in the ore deposits. Allanite, one of the Ce-La rich REE minerals belonging to the epidote group, is the most common mineral in the studied area. The allanite- bearing rocks may be devided into seven types by features of occurrence and mineral associations; zircon type (ZT), allanite-vein type (AT), feldspar type (KT), fluorite type (FT), quartz-mica type (QT), iron-oxide type (MT), and amphibole type (HT). The allanite veins (AT) and zircon rich rocks (ZT) contain the highest total REE contents. Differences in REE abundance can be interpreted in terms of varying portions of magmatic hydrothermal fluid. Petrographical and chemical data are presented for allanites which were collected from different types. The allanites show wide variations in optical properties, due in part to differences in their chemical composition (depending on the types) and to the degree of crystallinity of the individual specimens. Allanite metamicts in biotite are generally surrounded by well developed pleochroic haloes. Usually, allanite is accompanied by zircon and other REE-bearing minerals. CaO and total REE contents $({\sum}RE_2O_3)$ range from 9.29 to 18.79% and 11.66 to 26.31%, respectively. Also, SiO, (28.87~32.61%), $Al_2O_3$ (8.30~16.88%), and $Fc_2O_3$ (16.74~24.38%) contents show varying contents from type to type. The ${\sum}RE_2O_3$ of allanite has positive relationships with $Fe_2O_3$ and negative relaton with CaO, $SiO_2$, and $Al_2O_3$ Backscattered electron microscope images (BEl) of allanite shows that the its mineral composition and texture is very complex. The allanite-bearing hosts show distinct light REE enrichment with strong negative Eu anomaly except for HI. The HT has an almost flat REE distribution pattern with a small negative Eu anomaly. The chemical variation of the allanites with occurrences and mineral association can be related to condition of temperature and oxidation states in precipitation environment.

• The Journal of Engineering Geology
• /
• v.14 no.4 s.41
• /
• pp.401-416
• /
• 2004

We have collected shale specimens from the Pungam Basin in Kangwon province and investigated change of physical properties by freezing and thawing in water as well as in acidic fluid. The temperature range was $-20{\pm}2^{\circ}C\~15{\pm}2^{\circ}C$. Specimens were frozen for 12 hours and thawed in water for 8 hours. Then, they were saturated in the vacuum chamber for 4 hours to make specimens fully saturated. This procedure was 1 cycle. We have measured absorption, ultrasonic velocity, shore hardness, slake durability and uniaxial compressive strength at every 5th cycles. The physical properties increased or decreased as freezing and thawing cycles increased. Uniaxial compressive strength decreased by 0.40MPa per cycle in water and by 0.48MPa in acidic fluid. Elastic constant also decreased by 0.21GPa per cycle in water and by 0.30GPa in acidic fluid. Absorption increased by $0.29\%$ and $0.37\%$ per cycle in water and acidic fluid, respectively. These results indicate that decrease in uniaxial compressive strength, elastic constant and absorption by freezing and thawing in acidic fluid is more rapid than in water. Ultrasonic velocities, shore hardness and slake durability show no differences in water and acidic fluid. When we compared our results with the temperatures in the Hongchon during the winter season, $6\~12$ cycles may be equivalent to 1 year.

• 한국해양학회지
• /
• v.30 no.5
• /
• pp.493-511
• /
• 1995

Analysis of the Late Quaternary benthic foraminifera in the cores from the western part of the East Sea, Korea, indicates several distinct changes in the paleoenvironments during the deposition. The palecology of biofacies of Cores PC-1 from the upper slop and PC-2 from the rise shows several distinct changes in bottom water temperatures during the late Quaternary. The Core PC-4 from the Ulleung Basin generally consists of agglutinated genus, Muiliammina, and anaerobic calcareous genus, Bolivina, in biofacies, suggesting that the anoxic bottom condition was prevailed during the deposition. Benthic foraminiferal rare or barren zones in the Cores indicate the limits of water circulation caused by lower sea-level in the regions during the glacial period through the Late Quaternary. The changes of benthic foraminiferal biofacies reflect temporal and spacial variations in overall bottom environments, such as bottom water temperature, dissolved oxygen, and water circulation pattern. The benthic foraminiferal data can be used to interpret paleoclimatic conditions and predict global sea-level changes, and the results of these studies should be useful to understand the evolutional history of the East Sea through the Late Quaternary.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
• /
• v.16 no.4
• /
• pp.155-168
• /
• 2011

Coastal boundary current flows along the eastern boundary of the Yellow Sea and its speed was about 0.l m/s during the summer 2007. In order to find major factors that affect the coastal boundary current in the eastern Yellow Sea, three-dimensional numerical model experiments were performed. The model simulation results were validated against hydrographic and current meter data in the eastern Yellow Sea. The eastern boundary current flows along the bottom front over the upper part of slopping bottom. Strength and position of the current were affected by tides, winds, local river discharge, and solar radiation. Tidal stirring and surface wind mixing were major factors that control the summertime boundary currents along the bottom front. Tidal stirring was essential to generate the bottom temperature front and boundary current. Wind mixing made the boundary current wider and augmented its north-ward transport. Buoyancy forcing from the freshwater input and solar radiation also affected the boundary current but their contributions were minor. Strong (weak) tidal mixing during spring (neap) tides made the northward transport larger (smaller) in the numerical simulations. But offshore position of the eastern boundary current's major axis was not apparently changed by the spring-neap cycle in the mid-eastern Yellow Sea due to strong summer stratification. The mean position of coastal boundary current varied due to variations in the level of wind mixing.

• Food Science of Animal Resources
• /
• v.31 no.3
• /
• pp.477-483
• /
• 2011

In this study, the most preferred trans fatty acid analysis methods, AOAC 996.06 and the Korea Food and Drug Administration official method, were reviewed and modified to apply to dairy products and dairy products imported into the Republic of Korea for evaluating trans fatty acid (TFA) content. The Rose-Gottlieb method for total fat analysis was validated with accuracy and precision parameters by analyzing infant formula standard reference material provided by the National Institute for Standards and Technology. The accuracy and precision data satisfied the CODEX guidelines. TFAs were analyzed with a resolution of 1.5 for 45 min using the modified oven temperature program. This modified method was applied to 45 dairy products from 11 countries. Average TFA contents in these imported dairy products ranged from 0.1 to 5.4 g per 100 g product. The majority of dairy products imported into the Republic of Korea were cheeses. TFA contents in the cheeses were 0.1 to 2.4 g per 100 g cheese. TFA contents in other dairy products were 1.7 to 5.4 g per 100 g product. These TFAs content variations can be explained by the trans fatty acids naturally present in ruminant milk formed by bacterial bio-hydrogenation in the rumen of cows and the different vegetable fat used as ingredients in the final products.

• Journal of Environmental Science International
• /
• v.18 no.10
• /
• pp.1089-1101
• /
• 2009

In this paper, changes in the intensity (e.g., central pressure and maximum sustained wind speed) of Tropical Cyclone (TC) in summer in the regions located at $30^{\circ}N$ in East Asia from 1988 to 1991 were found. The intensity of TC from 1991 to 2007 was much higher than that of TC from 1965 to 1988. The reason for this was that the frequency of TCs passing China from 1991 to 2007 was much lower than that of TCs from 1965-1988 because a northeasterly wind caused by high-pressure circulation in East Asia got severer along the East Asian coast. Instead, TCs moved from the eastern region of the Tropical West Pacific to Korea and Japan mainly after passing the East China Sea due to the low-pressure circulation strengthened in the subtropical waters of East Asia. In addition, low Vertical Wind Shear (VWS) was created along the mid-latitude regions of East Asia and the main path of TCs from 1991 to 2007. Most of the regions in the Northwestern Pacific showed higher Sea Surface Temperature (SST) from 1991 to 2007, and had a good environment where TCs were able to maintain a higher intensity on the mid-latitude. In particular, a low sensible heat flux occurred due to high snow depth in East Asia in the spring of 1991 to 2007. Accordingly, the lower layer of East Asia showed high-pressure circulation, and the sea surrounding East Asia showed low-pressure circulation. Thus, the typical west-high, east-low pattern of winter atmospheric pressure was shown. The possibility of snowfall in East Asia in spring to be used as a factor for predicting the summer intensity of TC in the mid-latitude regions of East Asia was insinuated. The characteristics of TC in a low-latitude region were the same in Korea. The latest intensity of TCs got higher, and the landing location of TCs gradually changed from the west coast to the south coast.

• Journal of Advanced Marine Engineering and Technology
• /
• v.41 no.3
• /
• pp.182-190
• /
• 2017

All liquids contain a small amount of gaseous components and the amount of gases dissolved in a liquid is in accordance with Henry's Law. In a multi-stage thermal-type seawater desalination plant, as the supplied seawater undergoes variations in temperature and pressure in each evaporator, the gases dissolved in the seawater are discharged from the liquid. The discharged gases are carbon dioxide, nitrogen, oxygen, and argon, and these emitted gases are non-condensable. From the viewpoint of convective heat transfer, the evaluation of non-condensable gas released during a vacuum evaporation process is a very important design factor because the non-condensable gases degrade the performance of the cooler. Furthermore, in a thermal-type seawater desalination plant, most evaporators operate under vacuum, which maintained through vacuum system such as a steam ejector or a vacuum pump. Therefore, for the proper design of a vacuum system, estimating the non-condensable gases released from seawater is highly crucial. In the study, non-condensable gases released in a thermal-type seawater desalination plant were calculated quantitatively. The calculation results showed that the NCG releasing rate decreased as the stage comes getting a downstream and it was proportional to the freshwater production rate.

• Ocean and Polar Research
• /
• v.27 no.2
• /
• pp.149-159
• /
• 2005

Samples were collected from five stations in February, May, July, and September 2004 to investigate seasonal variations in the phytoplankton community and the relationship between dominant genera and environmental factors in Asan Bay. In February, microphytoplankton contributed 80% to the total chlorophyll a. Diatom dominated the phytoplankton community, accounting for 85.9% of the total cell number, followed by dinoflagellates (6%). Dominant species were Skeletonema costatum and Thalassiosira spp. Abundant diatom, including S. costatum and Thalassiosira spp., may be affected by water temperature and silicate at Station 1 and 2 in February 2004. In May, the nanophytoplankton contribution to total phytoplankton was higher than in other seasons. However, abundance of S. costatum and Thalassiosira spp. decreased, since the growth of S. costatum and Thalassiosira spp. might be limited by phosphates (P) resulting from low P concentration and a high DIN:DIP ratio in the outer region. In July, dominant phytoplankton groups were diatom (39%), cryptophyceae (28%), and cyanophyceae (20%). Dominant genera were Oscillatoria spp. and phytoflagellate of a monad type in the inner region (Station 1 and 2), whereas S. costatum was dominant in the outer region (Station 4 and 5). In September, dominant phytoplankton were diatom (69%) and cryptophyceae (28%). Dominant genera were phytoflagellate of the monad type, S. costatum in the inner region, while Chaetoceros spp. was dominant in the outer region.