• Korean Journal of Plant Resources
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• v.32 no.4
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• pp.255-263
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• 2019

Glycyrrhizae radix is one of the most frequently prescribed ingredients in Oriental medicine, and Glycyrrhizae radix extract has been shown to exert anti-cancer effects. However, the cellular and molecular mechanisms of programed cell death (apoptosis) by Glycyrrhizae radix are poorly defined. In the present study, it was examined the molecular mechanisms of apoptosis by water extracts of Glycyrrhizae radix (GRW) in human bladder T24 cancer cells. It was found that GRW could inhibit the cell growth of T24 cells in a concentration-dependent manner, which was associated with the induction of apoptotic cell death, as evidenced by the formation of apoptotic bodies, DNA fragmentation and increased populations of annexin-V positive cells. The induction of apoptotic cell death by GRW was connected with an up-regulation of pro-apoptotic Bax protein expression and down-regulation of anti-apoptotic proteins (Bcl-2 and Bcl-xL), and inhibition of apoptosis family proteins (XIAP, cIAP-1 and cIAP-2). In addition, apoptosis-inducing concentrations of GRW induced the activation of caspase-9, an initiator caspase of the mitochondrial-mediated intrinsic pathway, and caspase-3, accompanied by proteolytic degradation of PARP. GRW also induced apoptosis via a death receptor-mediated extrinsic pathway by caspase-8 activation, resulting in the down-regulation of total Bid and suggesting the existence of cross-talk between the extrinsic and intrinsic pathways. Taken together, the present results suggest that GRW may be a potential chemotherapeutic agent for the control of human bladder cancer cells.

• Korean Journal of Construction Engineering and Management
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• v.13 no.4
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• pp.25-32
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• 2012

The current VE activity is recognizing the VE object selection in job-plan simply as formal procedure. Therefore, many problems are happening in the process of selecting VE object during the preparatory stage. As a result of trying to analysis problems through literature review and expert interview, the problems were surveyed such as the lack of connectivity between preparatory stage and analytical stage, the temporal cost-based restrictions, and lack of recognition in VE team members in the existing method of selecting subjects centering on the high-cost field. Accordingly, this study suggested the improved method of selecting VE objects in order to solve this problem in the stage of selecting VE objects. An improvement method of selecting VE objects is what selects the secondary VE subjects by applying again Fish-Bone diagram and Worth technique based on the primary VE objects, which were selected by the conventional technique of selecting objects in the high-cost field. To verify effectiveness in the proposed improvement method, it tried to apply it to the actual case of the road construction VE project. As result of, the improvement method was analyzed to be considerably effective in comparison with the existing selection method of VE objects. Therefore, the Improvement method will contribute to increasing the VE performance.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.37 no.3
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• pp.205-212
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• 2013

The objective of this study was to investigate the feasibility of replacing a conventional plate fin-tube evaporator with a spiral fin-tube evaporator by comparing the performance of domestic refrigerator-freezers adopting either the plate fin-tube evaporator or spiral fin-tube evaporator. Experiments were conducted for the domestic refrigerator-freezers using either a 2-column and 15-row plate fin-tube evaporator or three spiral fin-tube evaporators with 11, 13, and 15 tube rows (N). The optimum refrigerant charge decreased with a decrease in the number of tube rows. The power consumptions of the domestic refrigerator-freezers using the spiral fin-tube evaporators with N = 11 and 13 were 2.8% and 1.5% lower than those using the plate fin-tube evaporator, respectively. In addition, the cooling capacity of the spiral fin-tube evaporator with N = 13 was 3%-7% higher than that of the plate fin-tube evaporator under the frosting condition. In a cooling speed test, all of the evaporators showed similar performances.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.25 no.6
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• pp.549-558
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• 2012

A topology optimization method for phononic crystals is developed for the design of sound barriers, using the level set approach. Given a frequency and an incident wave to the phononic crystals, an optimal shape of periodic inclusions is found by minimizing the norm of transmittance. In a sound field including scattering bodies, an acoustic wave can be refracted on the obstacle boundaries, which enables to control acoustic performance by taking the shape of inclusions as the design variables. In this research, we consider a layered structure which is composed of inclusions arranged periodically in horizontal direction while finite inclusions are distributed in vertical direction. Due to the periodicity of inclusions, a unit cell can be considered to analyze the wave propagation together with proper boundary conditions which are imposed on the left and right edges of the unit cell using the Bloch theorem. The boundary conditions for the lower and the upper boundaries of unit cell are described by impedance matrices, which represent the transmission of waves between the layered structure and the semi-infinite external media. A level set method is employed to describe the topology and the shape of inclusions. In the level set method, the initial domain is kept fixed and its boundary is represented by an implicit moving boundary embedded in the level set function, which facilitates to handle complicated topological shape changes. Through several numerical examples, the applicability of the proposed method is demonstrated.

• Journal of Navigation and Port Research
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• v.38 no.4
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• pp.349-356
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• 2014

In the underwater communication, the performance of system is reduced because of the inter-symbol interference occur by the multi-path. In the recent years, to deal with poor channel environment and improve the throughput, the efficient concatenated structure of equalization, channel codes and Space Time Codes has been studied as MIMO system in the underwater communication. Space Time Codes include Space Time Block Codes and Space Time Trellis Codes in underwater communication. Space Time Trellis Codes are optimum for equalization and channel codes among the Space Time Codes to apply in the MIMO environment. Therefore, in this paper, turbo pi codes are used for the outer code to efficiently transmit in the multi-path channel environment. The inner codes consist of Space Time Trellis Codes with transmission diversity and coding gain in the MIMO system. And Zero Forcing method is used to remove inter-symbol interference. Finally, the performance of this model is simulated in the underwater channel.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.7
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• pp.3203-3210
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• 2013

Amid the importance of design is being emphasized as a new barometer for boosting enterprise competitiveness, high expectations are being placed on design consulting that evaluate design from a comprehensive perspective. SMEs, however, are not easy to gain access to design services compare to their counterparts - large companies. This will eventually cause them to ignore the importance of design, not to mention lack of financial resources for investing in design. With this regard, the paper analyzed the design status and design consulting performance of SMEs in industrial complex through the 2012 Design Innovation Project in Industrial Complex of Busan Design Center; also analyzed the effect of design consulting on improving competitiveness of SMEs as well as design awareness. As a result, the study found that a majority of companies do not invest in design or postponed investment, despite they are not satisfied with their design performance. However, 65.6 percent of SMEs that realized the importance of design after consulting have carried out design development, which brought about sales increase through their improved corporate images and product images. We believe design consulting played an important role for boosting awareness and competitiveness of SMEs. Eventually, we need to provide an intensified design analysis process that can facilitate SMEs. Design consulting support projects should offer practical design development programs through continuous follow-up, including interaction with state projects and design-specialized companies.

• Journal of the Korean Electrochemical Society
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• v.17 no.1
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• pp.49-56
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• 2014

As an electrolyte additive, the effects of lithium bis(oxalate)borate (LiBOB) on the electrochemical properties of a carbon-coated silicon monoxide (C-coated SiO) negative electrode are investigated. The used electrolyte is 1.3M $LiPF_6$ that is dissolved in ethylene carbonate (EC), fluoroethylene carbonate (FEC), and diethyl carbonate (DEC) (5:25:70 v/v/v) with or without 0.5 wt. % LiBOB. In the LiBOB-free electrolyte, the film resistance is not so high in the initial period of cycling that lithiation is facilitated to generate the crystalline $Li_{15}Si_4$ phase. Due to repeated volume change that is caused by such a deep charge/discharge, cracks form in the active material to cause a resistance increase, which eventually leads to capacity fading. When LiBOB is added into the electrolyte, however, more resistive surface film is generated by decomposition of LiBOB in the initial period. The crystalline $Li_{15}Si_4$ phase does not form, such that the volume change and crack formation are greatly mitigated. Consequently, the C-coated SiO electrode exhibits a better cycle performance in the later cycles. At an elevated temperature ($45^{\circ}C$), wherein the effect of film resistance is less critical, the alloy ($Li_{15}Si_4$ phase) formation is comparable for the LiBOB-free and added cell to give a similar cycle performance.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.40 no.12
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• pp.815-824
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• 2016

The fuel assembly for pressurized water reactor (PWR) consists of fuel rod bundle, spacer grid and bottom/top end fittings. The cooling water in high pressure and temperature is introduced in lower plenum of reactor core and directed to upper plenum through the subchannel which is formed between the fuel rods. The main thermal-hydraulic performance parameters for the PWR fuel are pressure drop and critical heat flux in normal operating condition, and quenching time in accident condition. The Korea Atomic Energy Research Institute (KAERI) has been developing an advanced PWR fuel, dual-cooled annular fuel and accident tolerant fuel for the enhancement of fuel performance and the localization. For the key thermal-hydraulic technology development of PWR fuel, the KAERI LWR fuel team has conducted the experiments for pressure drop, turbulent flow mixing and heat transfer, critical heat flux(CHF) and quenching. The computational fluid dynamics (CFD) analysis was also performed to predict flow and heat transfer in fuel assembly including the spent fuel assembly in dry cask for interim repository. In addition, the research cooperation with university and nuclear fuel company was also carried out to develop a basic thermal-hydraulic technology and the commercialization.

• Journal of Korea Technology Innovation Society
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• v.19 no.1
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• pp.105-136
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• 2016

This paper analyzed the qualitative evaluation indicators of the SYSTEM sector of the LINC program, which aimed at strengthening ability of regional universities through the activities of industry-academia cooperation (IAC). By using interview data and the program reports of universities, this research explored the problems of the indicators and suggested improvement measures which could lead to performance creativity. According to research results, in university system reform for activating IAC, some improvements are required as follows: limiting excessive expansion of IAC-friendly faculty evaluation; and evaluating soft aspects in the reform of academic affairs. In relation to strengthening of ability of the IAC organization, the indicators need to be amended as follows: enhancing the role of channel of IAC Foundation; strengthening the function of planning team of the IAC Foundation; and inducing development of own model of universities for IAC. As regards expansion of IAC infrastructure, it is necessary to enlarge the manpower who can develop programs of the support center in the foundation and to secure of operators for effective operation of joint-using equipments. Therefore, the indicators are required to be upgraded, considering these improvement direction.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.4 no.3
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• pp.39-54
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• 2009

As of July, 2009, Chungnam Province get DI (Direct Investment) of 2,502 corporations as the amount of 31 billion US dollars only for 3 years. Especially, Chungnam provincial governor make a excessive performance of 2.5 times comparing to the target number, 1,000 of inviting capital, that is public promise in the election. Now, the amount of inviting foreign capital is 1.2 billion dollars, at the end of this year it might be 1.4 billion dollars just in case of making a success on going negotiations. This outstanding performance comes from governor's leadership and aggressive strategies of well-trained subordinates. Chungnam Province has nation-wide multiple targets focused on interdisciplinary industries including strategic industries of display, auto-parts, steel, and oil-chemistry. Also, it has organic network system based on the very descriptive and accurate informations managing the task force team consisted of 35 competent members. In conclusion, the core competence of inviting foreign capital in a regional government is governor's strong leadership, activated organization consisted of specially well trained subordinates, and predominant differentiated strategies in details.