• 교육녹색환경연구
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• 제14권3호
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• pp.1-8
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• 2015

본 연구는 친환경 인증을 받은 학교시설을 대상으로 예비인증 거쳐 본인증을 획득한 시설에서 친환경건축물인증 제도의 부문별 적용 및 득점 비율을 분석하여 문제점을 도출하고, 향후 친환경 인증학교시설 계획에 있어 설계자 및 관련 담당자에게 기초자료를 제공함에 목적이 있다. 본 연구의 범위는 2010 개정친환경건축물 인증 기준 이후 인증을 받은 신축 학교시설을 대상으로 하며 예비심사를 거쳐 본 인증을 획득한 10개교를 분석 대상으로 하였다. 분석 내용은 녹색건축 인증기준 2013 학교시설 인증심사기준(별표4)의 7개 평가 부문에 대해서 적용시설 및 득점비율을 조사 분석하였다.

• 한국컴퓨터정보학회논문지
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• 제26권10호
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• pp.185-198
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• 2021

인터넷 기술의 발달로 기존의 추천 알고리즘은 사용자나 항목의 심층적인 특성을 학습할 수 없기 때문에 본 논문은 이 문제를 해결하기 위해 AMITI(주의 메커니즘 및 개선된 TF-IDF)에 기반한 추천 알고리즘을 제안했다. CNN(Convolutional Neural Network)에 2중 주의 메커니즘을 도입함으로써 CNN의 특징 추출 능력이 향상되고, 항목 특징에 다른 선호도 가중치가 할당되며, 사용자 선호도와 더 일치하는 권고사항이 달성되었다. 대상 사용자에게 항목을 추천할 때 점수 데이터와 항목 유형 데이터를 TF-IDF와 결합하여 권장 결과의 그룹화를 완료하였다. 본 논문에서 진행한 MovieLens-1M 데이터 세트에 대한 실험 결과는, AMITI 알고리즘이 권장 사항의 정확도를 향상시키고 프레젠테이션 방법의 순서와 선택성을 향상시킨다는 것을 보여준다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.1897-1900
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• 2015

Purpose: To evaluate acute toxicity in nasopharyngeal cancer (NPC) patients treated with intensity modulated radiotherapy (IMRT)/volumetric modulated arc therapy (VMAT) with or without cisplatin-based chemotherapy. Materials and Methods: A total of 45 newly diagnosed, histologically proven non-metastatic NPC patients treated with IMRT between May 2010 and December 2012, were evaluated retrospectively, 37 planned with Eclipse and 8 with Prowess Panther treatment planning system. The doses to the planning target volumes of primary tumor and involved lymph nodes, high risk region, and uninvolved regional nodal areas were 70 Gy, 60 Gy, and 54 Gy respectively and delivered simultaneously over 33 fractions to 39 patients. Another 6 patients irradiated with sequential boost technique. Some 84.4% of patients received chemotherapy. Acute toxicities were graded according to the Radiation Therapy Oncology Group scoring criteria and Common Terminology Criteria for Adverse Events (CTCAE) for chemotherapy side effects. Results: Median age was 43 years (14-79) and all patients were WHO type II. Grade 1 mucositis and dysphagia were observed in 17 (37.8%), and 10 (22.2%) patients, respectively. The incidence of acute grade 2 mucositis and dysphagia was 55.6% and 68.9%, respectively. The most common chemoradiotherapy related acute toxicities were nausea, leucopenia and thrombocytopenia. Grade 3 toxicity was detected in 13 (28.8%) cases. No grade 4 toxicity was occurred. Mean weight loss was 9%. None of the patients required the insertion of percutaneous endoscopic gastrostomy for nutritional support. Radiation therapy was completed without interruption in all patients. Conclusions: IMRT is a safe and effective treatment modality, and well tolerated by patients in the treatment of nasopharyngeal carcinoma. No unexpected side effects were observed.

• The Journal of Korean Physical Therapy
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• 제30권5호
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• pp.193-198
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• 2018

Purpose: The purpose of this study was to analysis of effectiveness between cognitive function assessment scores and gaming cognitive rehabilitation system in children with intellectual impairment. Methods: Five children (male=5, $age=10.00{\pm}0.80$) with intellectual impairment participated in this study and were randomly assigned to the experiment that played (received) gaming cognitive rehabilitation system (Neuroworld). The children were applied 2 times a week for 30 minutes during 3 months. The children were assessed K-WSIC-VI (Korean-Wechsler intelligence scale for children-fourth edition) and recorded that gained score in gaming cognitive rehabilitation system before and after intervention. K-WSIC-VI contained five primary index scores: verbal comprehension index, visual spatial index, fluid reasoning index, working memory index, and processing speed index. Gaming cognitive rehabilitation system scoring was composed visual recall, target recall, sequence recall, selective attention, continuous attention, and exploration. Results: In the intelligence quotient (IQ) of K-WSIC-VI, there were significant increased in all children. The visual recall item was highest effective in all children. However, sequential recall showed the lowest improvement in all children. The performance speed of selective attention item was decreased, this means that children's skills have improved. Also, their ability to explore has improved significantly. Conclusion: In conclusion, gaming cognitive rehabilitation system was significant effectiveness in cognitive function in some categories for children with intellectual impairment. However, the visual recall and performance speed don't represent of all cognitive function. Therefore, further studies will need to verify by applying more subject and longer duration.

• Genomics & Informatics
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• 제14권2호
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• pp.53-61
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• 2016

Toxoplasma gondii is an intracellular Apicomplexan parasite and a causative agent of toxoplasmosis in human. It causes encephalitis, uveitis, chorioretinitis, and congenital infection. T. gondii invades the host cell by forming a moving junction (MJ) complex. This complex formation is initiated by intermolecular interactions between the two secretory parasitic proteins-namely, apical membrane antigen 1 (AMA1) and rhoptry neck protein 2 (RON2) and is critically essential for the host invasion process. By this study, we propose two potential leads, NSC95522 and NSC179676 that can efficiently target the AMA1 hydrophobic cleft, which is a hotspot for targeting MJ complex formation. The proposed leads are the result of an exhaustive conformational search-based virtual screen with multilevel precision scoring of the docking affinities. These two compounds surpassed all the precision levels of docking and also the stringent post docking and cumulative molecular dynamics evaluations. Moreover, the backbone flexibility of hotspot residues in the hydrophobic cleft, which has been previously reported to be essential for accommodative binding of RON2 to AMA1, was also highly perturbed by these compounds. Furthermore, binding free energy calculations of these two compounds also revealed a significant affinity to AMA1. Machine learning approaches also predicted these two compounds to possess more relevant activities. Hence, these two leads, NSC95522 and NSC179676, may prove to be potential inhibitors targeting AMA1-RON2 complex formation towards combating toxoplasmosis.

• 지능정보연구
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• 제13권4호
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• pp.79-90
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• 2007

영상의 품질을 측정하는 것은 영상처리에서 매우 중요한 문제이다. 지금까지 영상 품질을 측정하기 위한 다양한 방법들이 제시되었고, 이들은 수학적인 관점에서 영상의 품질을 적절히 표현해주고 있다. 그러나, 수학적인 측정과 인간의 시각에 의해서 측정되는 품질은 서로 다를 수 있고 영상이 전달되는 최종 대상체는 인간의 시각이기 때문에 이를 고려한 영상품질 측정 방법이 필요하다. 본 논문에서는 사람의 시각적 특성을 고려하여 영상 품질을 측정할 수 있는 통계적 방법을 제시하였다. 사람의 시각은 영상의 전체적인 품질을 판단하면서도 국부적인 위치에서의 품질을 판단하며, 전체적인 영상의 품질보다는 국부적인 위치에서의 품질이 시각적인 영상품질 판단에 미치는 영향이 크다. 본 논문에서는 영상을 세그먼트화하고 각 세그먼트화된 영상에서 얻어진 영상 품질 값에 스코어링을 하는 통계적 기법을 사용하여 시각에 의한 판단과 유사한 결과를 얻었다.

• Journal of Korean Neurosurgical Society
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• 제67권3호
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• pp.333-344
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• 2024

Objective : Markers of neuroinflammation during ischemic stroke are well characterized, but additional markers of neural damage are lacking. The study identified associations of behavioral disorders after stroke with histologic neural damage and molecular biological change. Methods : Eight-week-old, 25 g male mice of the C57BL/6J strain were subjected to middle cerebral artery occlusion (MCAO) to induce ischemic stroke. The control group was a healthy wild type (WT), and the experimental group were designed as a low severity MCAO1 and a high severity MCAO2 based on post-stroke neurological scoring. All groups underwent behavioral tests, realtime polymerase chain reaction, triphenyltetrazolium chloride (TTC) staining and Hematoxylin and Eosin staining. One-way analysis of variance was used to analyze statistical significance between groups. Results : In TTC staining, MCAO1 showed 29.02% and MCAO2 showed 38.94% infarct volume (p<0.0001). The pro-inflammatory cytokine interleukin (IL)-1β was most highly expressed in MCAO2 (WT 0.44 vs. MCAO1 2.69 vs. MCAO2 5.02, p<0.0001). From the distance to target in the Barnes maze test, WT had a distance of 178 cm, MCAO1 had a distance of 276 cm, and MCAO2 had a distance of 1051 (p=0.0015). The latency to target was 13.3 seconds for WT, 27.9 seconds for MCAO1, and 87.9 seconds for MCAO2 (p=0.0007). Prospero homeobox 1 (Prox1) was most highly expressed in MCAO2 (p=0.0004). Doublecortin (Dcx) was most highly expressed in MCAO2 (p<0.0001). Conclusion : The study demonstrated that histological damage to neural cells and changes in brain mRNA expression were associated with behavioral impairment after ischemic stroke. Prox1 and Dcx may be biomarkers of neural damage associated with long-term cognitive decline, and increased expression at the mRNA level was consistent with neural damage and long-term cognitive dysfunction.

• 한국콘텐츠학회논문지
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• 제18권3호
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• pp.486-498
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• 2018

본 연구는 일 지역 대학생의 성격유형을 분석하여 선호경향에 따른 학습법을 통한 자기주도학습에 도움이 되는 기초자료를 제공하고자 시행된 서술적 조사연구이다. 본 연구는 2017년 9월 18일부터 22일까지 K대학교 10개 학과 695명을 대상으로 MBTI form $M^{(R)}$ 을 자기 기입식으로 작성하여 자동채점하였다. 수집된 자료는 SPSS Win 22.0 Program을 이용하여 대상자의 16가지 성격유형, 성격별 심리기능 및 기질에 대해 기술통계, Chi-square test로 분석하였다. 성별에 따른 성격유형의 선호경향의 차이는 판단기능에서는 남학생은 T유형(사고형)이, 여학생은 F유형(감정형)이 높은 선호도로 나타났으며 행동양식 및 생활양식의 차이에서는 여학생은 J유형(판단형)이, 남학생은 P유형(인식형)이 높은 선호도로 나타났다. 또한 학과별 및 계열별에 따라 성격유형, 심리기능 및 기질에서 유의한 차이가 있었다. 따라서 성격유형이 성별, 학과 및 계열별에 따라 차이가 있는 것으로 나타나 개인의 선호경향을 반영한 학습법에 관한 매뉴얼 개발이 필요하리라 사료된다.

• Journal of Plant Biotechnology
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• 제29권4호
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• pp.223-228
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• 2002

본 연구실에서 개발된 particle inflow gun (PIG)은 조작이 간편하고, 사용비용도 저렴하며, 식물 세포 내의 유전자 도입효율이 높은 특징을 갖고 있다. PIG 장비를 이용하여 벼 캘러스 내로의 유전자 도입 조건을 검토하기 위해서 사용된 vector는 pIG121Hm으로서 T-DNA 내부에 intron GUS ($\beta$-glucuronidase)와 hygromycin 및 kanamycin 저항성 유전자를 포함하고 있다. 또한 벼 캘러스 내에 물리적으로 DNA를 도입할 때에 DNA 도입 효율과 관계가 높은 요인들을 GUS의 발현빈도를 통하여 조사하였다. 그 결과 gold particle에 DNA를 부착하는 과정에 사용되는 spermidine과 calcium chloride의 경우 무첨가구에 비해 16 mM의 spermidine과 1.5 M의 calcium chloride 첨가구에서 GUS 발현율이 각각 2배, 3배 증가하였다. 그리고 1회 분사되는 gold particles양이 2 mg의 경우 가장 높은 GUS 발현율을 보여주었으며, 또한 PIG장비의 분사거리와 헬륨의 압력은 벼의 배양세포의 경우 12cm의 분사거리에서 3.5 bar (50 psi)의 헬륨압력으로 분사하였을 때 GUS 발현율이 가장 높았다. 이상의 결과에서 PIG 장비를 이용한 유전자 도입은 본 연구에서 검토한 최적의 조건을 이용하였을 경우 기존에 많이 사용되고 있는 Biolistic Gun (Bio-Rad 사)과 거의 비슷한 유전자 도입효율을 보여 주었다. 특히 PIG 장비의 경우 조작이 매우 간편하고, 분사에 사용되는 일회용 부품이 필요하지 않기 때문에 대량의 반복실험을 필요로 하는 연구에서 손쉽게 사용되리라 기대된다.

• 대한두경부종양학회지
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• 제19권1호
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• pp.9-15
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• 2003

Purpose: To introduce our early experience with intensity-modulated radiotherapy (IMRT) in the treatment of nasopharyngeal carcinoma. Methods and Materials: Eight patients who underwent IMRT for no disseminated nasopharyngeal carcinoma at the Asan Medical Center between September 2001 and November 2002 were evaluate by prospective analysis. According to the 1997 American Joint Committee on Cancer staging classification, 5 had Stage III, and 3 had Stage IVB disease. The IMRT plans were designed to be delivered as a 'Simultaneous Modulated Accelerated Radiation Therapy' (SMART) using the 'step and shoot' technique with a MLC (multileaf collimator). Daily fractions of 2.2-2.5Gy and 1.9-2Gy were prescribed and delivered to the GTV and CTV and clinically negative neck node, respectively. The prescribed dose was 70A-79.0Gy to the gross tumor volume (GTV), 60Gy to the clinical target volume (CTV) and metastatic nodal station, and 46Gy to the clinically negative neck. All patients also received weekly cisplatin during radiotherapy. Acute and late normal tissue effects were graded according to the Radiation Therapy Oncology Group (RTOG) radiation morbidity scoring criteria. Results: Follow-up period was ranging from 5 to 18 months. All patients showed complete response and loco-regional control rate was 100% but one patient died of malnutrition due to treatment related toxicity. There were no Grade 3 or 4 xerostomia and all patients had experienced improvement of salivary gland function. Conclusion: 'Simultaneous Modulated Accelerated Radiation Therapy' (SMART) boost intensity-modulated radiotherapy technique allows parotid sparing as evidenced both clinically and by dosimetry. Initial tumor response and loco-regional control was promising. It is clinically feasible. A larger population of patients and a long-term follow-up are needed to evaluate ultimate tumor control and late toxicity.