• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.3111-3111
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• 2001

The implementation of NIR and chemometrics in the Pharmaceutical industries is still in strong progress, both regarding qualitative and quantitative applications and beneficial results are seen. Looking at the development so far, NIR will change the pharmaceutical industry even more in the future. This presentation will address the experiences and progress achieved regarding the application and implementation of quantitative methods for determination of content uniformity and assay of tablets with less than 10% w/w of active, using Near Infrared transmittance spectroscopy in combination with PLS. Also qualitative methods for identification of the same tablets by Near Infrared reflectance spectroscopy will be discussed. Four commercial tablet strengths are formulated and produced from two different compositions by direct compression. Three different strengths are dose proportional, i.e. fixed concentration by varying in size. The aim was to replace the conventional primary methods for analysing content uniformity, assay and identification by NIR. Studies were performed on comparing transmittance versus reflectance spectroscopy for both applications on the dose proportional tablets. The model for determination of content uniformity and assay was developed to cover both coated and uncoated tablets, whereas the qualitative model was developed to identify coated tablets only. The impact of the tablet formulation, tablet size and coating, resulted in individual models far each composition The best calibration was achieved using diffuse reflectance for the identification purposes and diffuse transmittance for the quantitative determination of the active content within the tablets. As NIR in combination with other techniques opens up the possibility of total quality management within the production, the transfer of the above-mentioned models from a laboratory based approach to an at-line approach at H.Lundbeck will be addressed too.

• 콘크리트학회논문집
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• 제23권3호
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• pp.347-352
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• 2011

한중 콘크리트 타설시 발생되는 초기 동해로 인한 피해를 방지하고 조강성을 향상시키기 위해 열풍기 사용을 통한 보양, 결합수와 골재의 가열 및 시멘트 사용량을 늘리는 방법, 급결제 및 촉진제를 사용하는 등 다양한 방법이 사용되고 있다. 하지만 이러한 방법은 사용상의 어려움과 에너지 소비 및 생산비의 증가에 따른 경제성 감소 등의 문제점을 가지고 있다. 이중 급결제 및 촉진제의 사용은 경제적 이지만 수화 초기부터 급격하게 반응하여 급결하는 특성 때문에 작업성의 확보가 어렵다는 문제점을 가지고 있다. 이에 이 논문에서는 기존 의약 분야에서 주로 이용되는 약물의 고형 투여 형태인 정제(Tablet)화 방법을 이용하여 급결제와의 응결 시간을 비교하였고, 이 결과를 토대로 콘크리트의 물리적 특성 및 역학적 특성 시험을 실시하여 일정 시간 동안 작업이 가능하고 초기동해 방지 및 조강성이 향상 되는지 확인 하였다. 그 결과 급결제 및 타블렛의 경우 사용량이 증가 할수록 응결 시간이 줄어드는 것을 확인하였고, 콘크리트의 물리적 역학적 시험에서는 경시 변화에 대하여 Control과 비교 타블렛0.5%, 1.0%가 일정 시간 동안 작업 시간 확보가 가능함을 확인하였을 뿐만 아니라 조기 강도에서도 급결제 0.5%와 타블렛 0.5%, 1.0%가 뛰어난 조기 강도 발현 특성을 보여주었다.

• 약학회지
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• 제58권1호
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• pp.40-46
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• 2014

Drugs with a narrow therapeutic index (NTI) require very precise dosing. Warfarin and digoxin are the examples of NTI-drugs and dosing of them varies widely for different patients. However, in South Korea, only two strengths of warfarin and one of digoxin are commercially available. This is a big barrier for the precise dispensing and has potential safety risks to patients, particularly to elderly patients. To find a potential solution to the problem, an analysis of the prescribed doses and dispensing patterns of those drugs was performed. Data were collected by computer-facilitated prescription review in a university hospital. The period screened was from May 1st, 2012 to April 30th, 2013. All the prescriptions with either warfarin or digoxin tablets were selected for this study and dispensing patterns were analyzed according to the prescribed doses. A total of 17,017 warfarin prescriptions were analyzed; 8,148 for inpatient prescriptions, 8,869 for outpatient prescriptions, respectively. Of the 23 kinds of prescribed doses, 2 mg (19.9%) was most frequent, followed by 3 mg (13.2%) and 2.5 mg (11.7%). By analyzing the dispensing patterns, 60.3% (10,253) of the prescriptions required pill splitting and 72.0% of them were for the patients 65 years old and over. On the other hand, 4,350 digoxin prescriptions were included in this study. Of the 6 kinds of prescribed doses, 0.125 mg (71.2%) was most frequent, followed by 0.0625 mg (20.2%). Among the prescriptions for digoxin, 92.0% (3,998) should be split and 65.7% of them were for the patients aged 65 years and over. Despite limitations of strengths, various doses of warfarin and digoxin were prescribed. Furthermore, more than half of the prescriptions that required pill splitting were for elderly patients. The results from this study suggest that different strengths of warfarin and digoxin should be provided for accuracy of dispensing and safety for patients receiving them.

• Journal of Pharmaceutical Investigation
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• 제35권4호
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• pp.243-247
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• 2005

Although many scientists have used pectin, its feasibility in terms of tablet manufacturability with a high speed machine has never been evaluated. Therefore, compactibility of different pectin types for large scale tableting operation has been evaluated. The compactibility behavior of powder pectins was studied by a compaction simulator. It was found that pectin on its own does not produce tablets of acceptable quality even at a punch velocity as low as 20 rpm (e.g. low tensile strengths, capping and lamination irrespective of applied compression force). Thus, dwell time was introduced and more hard compact was produced as relaxation time in die increases. It was concluded that frequent structural failure observed in both pectin types was due to lack of plastic deformation, poor compactibility and high elastic recovery.

• Archives of Pharmacal Research
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• 제28권4호
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• pp.493-501
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• 2005

Effect of solvents on physical characteristics and release characteristics of monolithic acetaminophen (APAP) hydroxypropylmethylcellulose (HPMC) matrix granules and tablets were examined. Various types and amounts of solvents were employed for granulation and coating. APAP and other excipients were mixed and were then wet-granulated in a high-speed mixer. The dried granules were then directly compressed and film-coated with low viscosity grade HPMC. As the amount of water increased, the size of granules also increased, showing more spherical and regular shape. However, manufacturing problems such as capping and lamination in tableting occurred when water was used alone as a granulating solvent. The physical properties of HPMC matrix granules were not affected by the batch size. The initial release rate as well as the amount of APAP dissolved had a tendency to decrease as the water level increased. Addition of nonaqueous solvent like ethanol to water resulted in good physical properties of granules. When compared to water/ethanol as a coating solvent, the release rate of film-coated HPMC matrix tablets was more sensitive to the conditions of coating and drying in methylene chloride/ethanol. Most of all, monolithic HPMC matrix tablet when granulated in ethanol/water showed dual release with about $50\%$ drug release immediately within few minutes followed by extended release. It was evident that the type and amount of solvents (mainly water and ethanol) were very important for wet granulation and film-coating of monolithic HPMC matrix tablet, because the plastic deforming and fragmenting properties of material were changed by the different strengths of the different solvents.

• International Journal of Contents
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• 제12권4호
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• pp.23-30
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• 2016

For a library to be able provide information services and fulfill its function as a knowledge convergence center capable of responding to various information demands, the development of next-generation information systems based on the latest information and communication technology is needed. The development of mobile information services using portable devices such smart phones and tablet PCs and information systems which incorporate the concepts of cloud computing, SaaS (Software as a Service), annotation and Library2.0 is also required. This paper describes a library information system that utilizes collective intelligence and cloud computing. The information system developed for this study adopts the SaaS-based cloud computing service concept to cope with the shift in the mobile service paradigm in libraries and the explosion of electronic data. The strengths of such a conceptual model include the sharing of resources, support of multi-tenants, and the configuration and support of metadata. The user services are provided in the form of software on-demand. To test the performance of the developed system, the efficiency analysis and TTA certification test were conducted. The results of performance tests, It is encouraging that, at least up to 100MB, the job time is approximately linear and with only a moderate overhead of less than one second. The system also passed the level-3 or higher criteria in the certification test, which includes the SaaS maturity, performance and application program functions.

• International Journal of Contents
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• 제8권4호
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• pp.12-20
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• 2012

For a library to be able provide information services and fulfill its function as a knowledge convergence center capable of responding to various information demands, the development of next-generation information systems based on the latest information and communication technology is needed. The development of mobile information services using portable devices such smart phones and tablet PCs and information systems which incorporate the concepts of cloud computing, SaaS (Software as a Service), annotation and Library2.0 is also required. This paper describes a library information system that utilizes collective intelligence and cloud computing. The information system developed for this study adopts the SaaS-based cloud computing service concept to cope with the shift in the mobile service paradigm in libraries and the explosion of electronic data. The strengths of such a conceptual model include the sharing of resources, support of multi-tenants, and the configuration and support of metadata. The user services are provided in the form of software on-demand. To test the performance of the developed system, the efficiency analysis and TTA certification test were conducted. The results of performance tests, It is encouraging that, at least up to 100MB, the job time is approximately linear and with only a moderate overhead of less than one second. The system also passed the level-3 or higher criteria in the certification test, which includes the SaaS maturity, performance and application program functions.

• 재활치료과학
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• 제8권1호
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• pp.51-62
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• 2019

목적: 본 연구의 목적은 다양한 인지기능 수준을 가진 고령자를 위한 실감객체 기반 인지재활시스템을 개발하고, 사용성을 검증하는 것이다. 방법: 사용성 연구는 시스템의 강점과 약점을 확인하기 위해 15명의 환자 집단과 4명의 작업치료사 집단에 설문조사를 실시하였으며 응답에 근거한 수정을 통해 시스템을 보완 및 개선하였다. 응답자들은 세 종류의 훈련-실행기능 훈련, 기억력 훈련, 집중력 훈련을 20분~30분간 경험해본 후, 구조화된 설문에 응답하였으며 설문의 영역은 각 훈련 영역별 콘텐츠, 중앙처리장치이자 화면 제시 매체인 태블릿 PC 및 실감객체를 포함하는 하드웨어, 시스템 이용에 따른 만족도로 구성되었다. 결과: 설문 응답 결과 환자 집단과 작업치료사 집단 모두에게 가장 흥미로웠던 영역은 실행기능으로 나타났고 가장 흥미롭지 않은 영역은 집중력으로 나타났다. 하드웨어 사용성 설문에서 태블릿 PC의 화면의 크기가 부적절하다는 응답이 6건, 실감객체의 크기가 부적절하다는 응답이 5건으로 나타났다. 시스템 이용에 대한 만족도 설문에서 전체 응답자의 40%가 시스템에 만족하는 것으로 응답하였다. 결론: 본 시스템은 훈련과제를 수행하기 위해 필요한 실감객체 도구의 조작이 용이하다는 점과 사용자의 요구에 따라 인지훈련의 영역을 쉽게 선택하여 훈련할 수 있다는 점, 사용자의 수행도에 의해 난이도가 자동으로 조정된다는 점을 특징으로 갖는다. 본 시스템에서 입력장치로 사용되는 실감객체도구는 양손에 쥐고 사용함으로써 훈련환경을 자연스러운 일상에서의 도구 사용과 유사하도록 고안하였다. 본 시스템은 지역사회 인지 재활전문가 부족의 대안으로 사용가능 할 것으로 기대된다.

• 만화애니메이션 연구
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• 통권30호
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• pp.169-199
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• 2013

만화에서의 다양한 연출은 웹툰의 대중화와 함께 세로 스크롤 연출이 기존의 출판만화의 페이지 연출과 대립하는 양상을 보이며 새로운 장르를 구축해냈다. 많은 출판만화의 연구가 페이지를 위시한 컷 연출에 초점을 두고 있지만, 웹툰에는 페이지의 개념이 없다. 대중 지향의 만화는 시대의 변화에 따라 구심점이 지면에서 컴퓨터 모니터로 옮겨가며 매체의 특성 또한 달라졌으며, 매체는 점점 다원화되고 있다. 스마트폰의 유행으로 인한 모바일의 강세, 공교육에서의 태블릿 PC의 보급화 전망과 같이, 만화는 급변하는 매체환경에 속해있다. 이러한 상황에서도 만화의 변하지 않는 중요한 정체성중의 하나를 꼽자면 그림과 텍스트의 조합이 만들어 내는 연출이다. 이 논문에서는 허영만의 작품을 중심으로 만화 의태어인 효과태가 가진 상징어적인 특성과 효용가치를 분석하였다. 효과태는 단지 소리뿐만이 아니라 모양, 느낌, 상태 등을 전달하며 문학적 상상구조를 발동시킴으로써 함축적 특성을 가진다. 현대국어의 장점인 다양한 언어 표현과 자모체계는 미세한 어감과 정서의 차이점을 느끼게 해주며 직접 경험과 간접 경험을 통한 기억을 떠올려서 뉘앙스화하기 때문이다. 이러한 특징들로 인해서 허영만의 대표작들은 상업성과 작가성을 동시에 지니고 오랜 세월동안 대중과의 소통을 해왔으며 한국적인 만화의 소양을 풍부하게 가지고 있다. 허영만의 만화에 나타난 효과태의 특징은 만화의 표현과 전달에 있어서 일반적인 기대 이상으로 효과태가 미치는 영향이 크다는 것을 알 수가 있다. 피수용자인 독자는 그림과 글 사이에서 적극적으로 지적인 추리를 하면서 그 과정 자체를 즐기며, 그러한 과정에 대사 텍스트 이상으로 상상력을 자극하는 장치가 효과태이며, 효과태는 상징적 구조를 장점으로 하는 독자의 능동적 참여 장치이다.