[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.4333/KPS.2005.35.4.243

Compaction Simulator Study on Pectin Introducing Dwell Time

Kim, Hyun-Jo (Kolon Pharmaceutical Inc.)
Venkatesh, Gopi (SB Pharmaceuticals R&D)

Publication Information

Journal of Pharmaceutical Investigation / v.35, no.4, 2005 , pp. 243-247 More about this Journal

Abstract

Although many scientists have used pectin, its feasibility in terms of tablet manufacturability with a high speed machine has never been evaluated. Therefore, compactibility of different pectin types for large scale tableting operation has been evaluated. The compactibility behavior of powder pectins was studied by a compaction simulator. It was found that pectin on its own does not produce tablets of acceptable quality even at a punch velocity as low as 20 rpm (e.g. low tensile strengths, capping and lamination irrespective of applied compression force). Thus, dwell time was introduced and more hard compact was produced as relaxation time in die increases. It was concluded that frequent structural failure observed in both pectin types was due to lack of plastic deformation, poor compactibility and high elastic recovery.

Keywords

Pectin; Compactibility; Compaction simulator; Consolidation mechanism; Tableting; Punch velosity; Strain rate sensitivity; Plastic deformation;

Citations & Related Records

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