• Convergence Security Journal
• /
• v.15 no.6_2
• /
• pp.37-44
• /
• 2015

There appears a variety forms of crime type and age in accordance with the change of social structure. In this paper it is described for combining the Anomie theory of Emile Durkheim. Anomie refers to the absence of dual standards or norms. In other words, while weakening the existing norms prevailing when the new rules has not been established. That situation would cause social chaos. Rules on the dissemination and utilization of SNS due to the development of information and communication technology undermine the social norms while online regulations are being a weak state not established. In the confusion of these norms it has been shown to increase in juvenile delinquency. Social media has characteristics such as openness, accessibility, relationships, and content diversity. The social media itself is not subject to the general mechanisms of consumption and production due to growing as a kind of organism. It has characteristic to make the most content by utilizing the users to voluntarily share information. Social media using as communication, contact and information in the youth, thus the possibility of crime is high. Social media is also direct and indirect influence on youth crime but no apparent systemic regulation of this situation.

• Journal of East-West Nursing Research
• /
• v.26 no.1
• /
• pp.39-51
• /
• 2020

Purpose: The purpose of this study was to develop family support oriented physical activity program for the male elderly with sarcopenia based on social cognitive theory. Methods: This program was developed through an analysis of 18 related intervention literatures, results of a focus group interview with 5 elderly men with sarcopenia and the content validity index of the program content adequacy and applicability by 6 experts. The combined exercise with resistance exercise and aerobic exercise was constructed in accordance with the recommendations of the American College of Sports Medicine (ACSM) and experts' opinions. Results: The program consists group education sessions (5 times, 60 minutes for each) for 12 weeks and family support oriented physical activity program composed of individual intervention (sending alarm for physical activity for 10 times and telephone monitoring for 2 times). The program also reflects the concept of self-efficacy and self-regulation, which are important factors for continuing physical activity through family support. The progressive resistance exercise was developed by composing 5-6 systemic movement forms that repeat 2-3 days a week and 2-5 sets at least. Conclusion: It is proposed to standardize the family support oriented physical activity program through the further studies so that the program can be utilized for the various groups of people who need increased level of physical activities.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.23 no.2
• /
• pp.294-300
• /
• 2009

Nowadays, as the era of aging is developing remarkably fast, conventional disease treatments such as surgery or emergency therapy are now being substituted to 'health promotion' and 'health prevention through whole-life management. Recently, many oriental medicine colleges are teaching subjects related to Yangsaeng and Gigong. However, detail investigation about the exact education situation and correlation between among subjects has not been performed yet. Thus, in this research, I collected data about each oriental medicine college's Yangsaeng/Gigong-related subjects' prevalence and management situation through the analysis of 'National Education Report about Korea's Oriental Medicine Colleges' and direct investigation, First, I analyzed oriental medicine colleges' education object. Among 11 basic medicine subjects, there were 2 subjects related to Yangsaeng and Gigong. And among 13 clinical medicine subjects, there were 7 subjects related to Yangsaeng and Gigong. In these subjects, the word 'Yangsaeng' was used for 14 times. The word 'Gigong' was used for 5 times and the words 'natural medicine' and 'alternative medicine' were used for 4 times. Total class hours related to Yangsaeng and Gigong were 19.6 hours (practice classes were 4.6 hours). Each class of subjects had 'study objects'. Study objects were categorized into A (Essential) and B (Recommendation) Items. There were44 A items and 23 B items. Among 11 oriental medicine colleges all over Korea, 10 classes related to Yangsaeng and Gigong existed in 9colleges. 7 classes were included in pre-OM course and 3 classes were included in major-OM course. 6 classes were taught only for one semester and 4 classes were taught for 2 semesters. 6 classes were single unit and 4 classes were 2-units sunjects. 3 classes were held 3 hours a week. 6 classes were held 2 hours a week and one class was held an hour per week. In conclusion, each oriental medicine college should focus on the education and research about Yangsaeng and Gigong. To achieve this object, systemic regulation and specialized human resources should also be made.

• IMMUNE NETWORK
• /
• v.6 no.1
• /
• pp.20-26
• /
• 2006

Background: Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disease that is characterized by invasive synovial hyperplasia, leading to progressive joint destruction. Recent studies have described that RA is caused by virus, bacteria or outside material. Approximately 2 to 20% of RA cases arc reported to be associated with infected hepatitis C virus (HCV). However, the mechanisms underlying virus-induced RA are still unknown. Moreover, few molecular studies have addressed the inflammatory aspects of HCV-associated autoimmune RA. In this study, we aimed to determine whe ther or not another HCV core protein transactivates the IL-8 gene expression, prototypic chemokine, in synovial cell. Methods: To establish the HCV core expressing stable synovial cell line, pCI-neo-core, a plasmid encoding HCV core protein, were transfected to HIG-82 cell line that is an established cell line from rabbit periaricular soft tissue. We examined the morphological changes and cell cycle distribution of HIG-82 cells with expression of HCV core protein by inverted microscopy and flow cytometry analysis, respectively. Also, we determined the mRNA levels of Interleukin (IL)-6 and IL-8 related to the inflammation by RT-PCR and then analyzed regulation of IL-8 expression by the NF-${\kappa}B$ pathway. Results: Our study showed no significant differences in morphology and cell cycle between HIG-82 control cell line and HIG-82 expressing HCV core protein. However, expression of HCV core protein induces the IL-8 mRNA expression in HIG-82 core cells via activated NF-${\kappa}B$ pathway. Conclusion: These results suggest that HCV core protein can lead to enhanced IL-8 expression. Such a proinflammatory role may contribute to the etiologic pathogenesis in RA patients with HCV infection.

• The Plant Pathology Journal
• /
• v.31 no.2
• /
• pp.195-201
• /
• 2015

Plant growth promoting rhizobacteria (PGPR) are known to confer disease resistance to plants. Bacillus sp. JS demonstrated antifungal activities against five fungal pathogens in in vitro assays. To verify whether the volatiles of Bacillus sp. JS confer disease resistance, tobacco leaves pre-treated with the volatiles were damaged by the fungal pathogen, Rhizoctonia solani and oomycete Phytophthora nicotianae. Pre-treated tobacco leaves had smaller lesion than the control plant leaves. In pathogenesis-related (PR) gene expression analysis, volatiles of Bacillus sp. JS caused the up-regulation of PR-2 encoding ${\beta}$-1,3-glucanase and acidic PR-3 encoding chitinase. Expression of acidic PR-4 encoding chitinase and acidic PR-9 encoding peroxidase increased gradually after exposure of the volatiles to Bacillus sp. JS. Basic PR-14 encoding lipid transfer protein was also increased. However, PR-1 genes, as markers of salicylic acid (SA) induced resistance, were not expressed. These results suggested that the volatiles of Bacillus sp. JS confer disease resistance against fungal and oomycete pathogens through PR genes expression.

• Advances in Traditional Medicine
• /
• v.10 no.3
• /
• pp.173-183
• /
• 2010

Perilla frutescens var. acuta Kudo (PF) is a traditional Korean medicinal herb for allergic reaction regulation. In the present study, we investigated the effect of 30% ethanol extract powder of PF (EPPF) and rosmarinic acid (RA), the active compound of EPPF on various allergic reactions using in vivo and in vitro models. EPPF and RA significantly inhibited compound 48/48-induced systemic anaphylactic reaction and histamine release (P < 0.05). In addition, EPPF and RA significantly inhibited passive cutaneous anaphylaxis (PCA) in a dose-dependent manner (P < 0.05). These effects were stronger than those of disodium cromoglycate, the reference drug tested. EPPF and RA also significantly inhibited production of inflammatory cytokines, tumor necrosis factor-a interleukin (IL)-6, and vascular endothelial growth factor on the PCA reaction and phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated human mast cell line, HMC-1 cells (P < 0.05). Moreover, EPPF and RA showed an inhibitory effect on lipopolysaccharide (LPS)-induced IL-4 production from whole spleen cells. Finally, EPPF and RA significantly decreased IL-4-dependent IgE production by LPS-stimulated whole spleen cells (P < 0.05). In conclusion, these results indicate that EPPF has potent anti-allergic activities.

• Nutrition Research and Practice
• /
• v.10 no.1
• /
• pp.42-48
• /
• 2016

BACKGROUND/OBJECTIVES: Seaweeds have been reported to have various health beneficial effects. In this study, we investigated the potential anti-obesity and anti-inflammatory effects of four types of domestic brown seaweeds in a high-fat diet-induced obese mouse model and bone marrow-derived macrophages (BMDM). MATERIALS/METHODS: Male C57BL/6N mice were fed low-fat diet (LFD), high-fat diet (HFD) or HFD containing Undaria Pinnatifida, HFD containing Laminaria Japonica (LJ), HFD containing Sargassum Fulvellum, or HFD containing Hizikia Fusiforme (HF) for 16 weeks. RESULTS: Brown seaweed supplementation did not affect long-term HFD-associated changes in body weight or adiposity, although mice fed HFD + LJ or HFD + HF gained slightly less body weight compared with those fed HFD at the beginning of feeding. Despite being obese, mice fed HFD + LJ appeared to show improved insulin sensitivity compared to mice fed HFD. Consistently, we observed significantly reduced blood glucose concentrations in mice fed HFD + LJ compared with those of mice fed HFD. Although no significant differences in adipocyte size were detected among the HFD-fed groups, consumption of seaweeds decreased formation of HFD-induced crown-like structures in gonadal adipose tissue as well as plasma inflammatory cytokines. BMDM from mice fed HFDs with seaweeds showed differential regulation of pro-inflammatory cytokines such as IL-$1{\beta}$ and IL-6 compared with BMDM from mice fed HFD by LPS stimulation. CONCLUSION: Although seaweed consumption did not prevent long-term HFD-induced obesity in C57BL/6N mice, it reduced insulin resistance (IR) and circulation of pro-inflammatory cytokines. Therefore, seaweeds may ameliorate systemic inflammation and IR in obesity partially due to inhibition of inflammatory signaling in adipose tissue cells as well as bone marrow-derived immune cells.

• Toxicological Research
• /
• v.35 no.2
• /
• pp.119-129
• /
• 2019

As the use of cosmetics has greatly increased in a daily life, safety issues with cosmetic ingredients have drawn an attention. Drometrizole [2-(2'-hydroxy-5'-methylphenyl)benzotriazole] is categorized as a sunscreen ingredient and is used in cosmetics and non-cosmetics as a UV light absorber. No significant toxicity has been observed in acute oral, inhalation, or dermal toxicity studies. In a 13-week oral toxicity study in beagle dogs, No observed adverse effect level (NOAEL) was determined as 31.75 mg/kg bw/day in males and 34.6 mg/kg bw/day in females, based on increased serum alanine aminotransferase activity. Although drometrizole was negative for skin sensitization in two Magnusson-Kligman maximization tests in guinea pigs, there were two case reports of consumers presenting with allergic contact dermatitis. Drometrizole showed no teratogenicity in reproductive and developmental toxicity studies in which rats and mice were treated for 6 to 15 days of the gestation period. Ames tests showed that drometrizole was not mutagenic. A long-term carcinogenicity study using mice and rats showed no significant carcinogenic effect. A nail product containing 0.03% drometrizole was nonirritating, non-sensitizing and non-photosensitizing in a test with 147 human subjects. For risk assessment, the NOAEL chosen was 31.75 mg/kg bw/day in a 13-week oral toxicity study. Systemic exposure dosages were 0.27228 mg/kg bw/day and 1.90598 mg/kg bw/day for 1% and 7% drometrizole in cosmetics, respectively. Risk characterization studies demonstrated that when cosmetic products contain 1.0% of drometrizole, the margin of safety was greater than 100. Based on the risk assessment data, the MFDS revised the regulatory concentration of drometrizole from 7% to 1% in 2015. Under current regulation, drometrizole is considered to be safe for use in cosmetics. If new toxicological data are obtained in the future, the risk assessment should be carried out to update the appropriate guidelines.

• Journal of the Society of Disaster Information
• /
• v.15 no.1
• /
• pp.153-164
• /
• 2019

Purpose: This paper aims to derive improvement measures, in terms of legal and technical aspects, which can reduce effectively the casualties caused by drowing accidents. Method: Firstly, we checked the status of drowing accident management and carried out the interview of field private safety guards. field private safety guards. In addition, surveys were conducted on safety personnel and managers. Based on survey results, we are lastly analyzed the specific problems and reviews the improvement measures from technical and legal aspects. Result: As an analytical result, it was considered that supplementary supporting tools such as CCTV, monitoring devices using IoT and artificial intelligence technologies were necessary to prevent drowning accident, and qualification with limited authority should be added to the private safety guard because of the lack of regulation. Conclusion: In order to manage water safety effectively, a comprehensive water safety management system should be established that integrates people and equipment through systemic education of security personnel, authorization of enforcement, and introduction of surveillance equipment.

• Journal of Korean Society of Occupational and Environmental Hygiene
• /
• v.32 no.4
• /
• pp.393-401
• /
• 2022

Objectives: OHSMS, which was introduced by Serious Accident Punishment Act as a means for safety and health management at work place, but it is not effective according to recent statistical data. Therefore, I intend to compare the OHSMS regulations of SAPA based on ISO 45001, the international standard of OHSMS, and examine the differences and problems. Methods: The OHSMS regulation of Serious Accident Punishment Act was compared and analyzed using the content standard of ISO 45001, the international standard of OHSMS. The construction and operation aspects and differences in key concept definitions of OHSMS were analyzed in depth. Results: ISO 45001 aims to provide OHSMS with an autonomous framework to manage risks and opportunities in safety and health management, whereas Serious Accident Punishment Act aims for safety and health management through an interest and effort in safety and health management on the premise of legal responsibilities of corporations and CEO. As a result, comparing to ISO 45001 in construction and operation aspects and differences in key concept definitions of OHSMS, the OHSMS of Serious Accident Punishment Act do not cover the entire business in concept definition and construction. Conclusions: In order for Serious Accident Punishment Act to achieve its original purpose of preventing serious accidents through systemic safety and health management, it is necessary to correctly understand the contents of ISO 45001 and to revise the OHSMS regulations in a direction that can ensure predictability and feasibility.