• KDI Journal of Economic Policy
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• 제46권1호
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• pp.21-51
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• 2024

Since the Global Financial Crisis of 2008-2009, the importance of nonbank financial institutions in macroprudential management has increased significantly. Consequently, major countries and international financial institutions have been actively discussing and implementing macroprudential supervision and regulation for non-bank financial institutions (NBFI). In this context, this paper analyzes the systemic risk of both banks and non-bank sectors (securities firms and insurance companies) in South Korea over different time periods. Using the widely recognized ΔCoVaR methodology for measuring systemic risk, the analysis reveals that systemic risk increased substantially across all three sectors (banks, securities firms, and insurance companies) during the Global Financial Crisis, the European Sovereign Debt Crisis, and the COVID-19 pandemic. Although the banking sector exhibited relatively high systemic risk compared to the securities and insurance sectors, the relative differences in systemic risk varied across the different crisis periods. Notably, during the margin call crisis in March of 2020, the gap in systemic risk between the banking and securities sectors decreased significantly compared to that during both the Global Financial Crisis and the European Sovereign Debt Crisis, indicating that securities firms had a more substantial impact on risk in the overall financial system during this period. Furthermore, I analyze the impact of the issuance of equity-linked securities (ELS) by financial institutions on systemic risk, as measured by ΔCoVaR, finding that an increase in the outstanding balance of ELS issuance by financial institutions had an impact on increasing ΔCoVaR during the three crisis periods. These findings underscore the growing importance of non-bank financial institutions in relation to South Korea's macroprudential management and supervision. To address this evolving landscape, enhanced monitoring and regulatory measures focusing on non-bank systemic risk are essential components of maintaining financial stability in the country.

• Clinical and Experimental Pediatrics
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• 제45권7호
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• pp.847-854
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• 2002

목 적: 신생아 집중치료실에 장기간 입원 중인 환아는 입원중 전신성 감염을 일으킬 위험이 있다. 이미 항생제를 투여 받고 있는 환아에서 전신 감염 증상이 발현하면, 전신성 칸디다증은 장기간의 amphotericin B의 투여가 필요하며 세균 감염증은 감수성 있는 항생제로의 교체를 필요로 한다. 본 연구에서는 미숙아인 저출생 체중아를 대상으로 전신성 칸디다증의 임상증상과 증상 발현시의 검사 소견을 전신성 세균 감염증과 비교함으로써 이들 소견의 조기 감별 진단 상의의를 조사하였다. 방 법 : 1997년 1월부터 2001년 6월까지 경북대학교병원 신생아 집중치료실에 입원했던 미숙아 중 저출생 체중아 중에서 배양검사로 확인된 전신성 칸디다증 20례와 전신성 세균 감염증 23례를 대상으로 하여 이들의 의무 기록을 후향적으로 조사하였다. 결 과: 전신성 칸디다증 환아(이하 칸디다군)의 출생시 체중은 $1,290{\pm}290g$으로 전신성 세균 감염증 환아(이하 세균군)의 $1,530{\pm}430g$보다 유의하게 작았으며, 총 정맥 영양, 항생제 투여, 중심 카테테르, 기관 삽관, $H_2$ 차단제 사용의 빈도가 더 높았다. 임상 양상에 있어서는 서맥 동반 무호흡 및 호흡 곤란이 두 군의 주된 발현시 증상으로, 발현 빈도는 칸디다군(90%)에서 세균군(61%)에 비해 높았다. 증상 발현시 시행한 검사 소견에서 혈소판 감소증과 백혈구 감소증이 동반된 경우가 칸디다군 7례(35%), 세균군 2례(9%)로 두 군 사이에 유의한 차이를 보였다(P=0.03). 균은 대부분 혈액에서 배양되었으며(칸디다군 19례, 세균군 19례), 그 외에 요, 중심 카테테르, 뇌척수액 등에서 배양되었다. 감염균은 칸디다군은 Candida albicans가 15례, 세균군은 Klebsiella pneumoniae와 Enterobacter cloacae가 각각 5례로 가장 빈번하였다. 결 론 : 신생아 집중치료실에 장기 입원 중 전신 감염증 증상을 보이는 환아에서 호흡기 증상과 함께 검사상 혈소판 감소 단독 또는 혈소판 감소증과 백혈구 감소증이 동반된 경우에는 전신성 칸디다 감염증 가능성이 높을 것으로 사료된다.

• International Journal of Industrial Entomology and Biomaterials
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• 제6권1호
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• pp.11-14
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• 2003

Systemic fungicides viz., Bavistin and Beyleton are reported to have curative effect against the infection of Beauveria bassiana in silkworm Bombyx mori L. To understand the influence of the systemic fungicides on the disease suppression/development, hematological studies were carried out. There was an increase in the percent total hemocyte count, granulocyte and plasmatocyte in silkworm treated with the systemic fungicides. It possibly indicates the influence of systemic fungicide on the hemocyte mediated defense system leading to the higher resistance and suppression of disease development.

• Archives of Pharmacal Research
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• 제20권1호
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• pp.24-28
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• 1997

In the present study, a pharmacokinetic model to address the effects of the diffusional barrier between splanchnic bed and enterocytes on the extent of presystemic and systemic intestinal elimination of drugs was developed. The model is composed of five compartments, ie., gut lumen, enterocyte, splanchnic bed, liver and central compartments. The equations for various pharmacokinetic parameters important for estimating the quantitative differences between presystemic and systemic intestinal and hepatic elimination of drugs were derived. A simulation study demonstrated that the diffusions[ barrier present between splanchnic blood and enterocytes can have significant effects on oral bioavailability and systemic clearance of drugs. In conclusion, the model can be useful for a better understanding of the effects of diffusional barrier on the extent of administration-route dependent intestinal and hepatic elimination of drugs, especially those with high hydrophilicity and/or charge(s) under physiological conditions.

• 대한한방소아과학회지
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• 제24권3호
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• pp.68-75
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• 2010

Objectives: This study is to report a case that has an effective result to systemic type juvenile idiopathic arthritis patient with an oriental medicine treatment. Methods: We treated the patient with an oriental medicine and tapered down with the western medicine. We followed up the laboratory blood tests every two or three months and through telephone at least six days in a week. Results: The symptoms of systemic type juvenile idiopathic arthritis were vanished and the patient maintains his condition with oriental medicine treatment after discontinued all Disease-Modifying Antirheumatic Drugs(DMARDs). His ESR, CRP levels and other blood test results were back to normal range. Now he is in clinical remission status. Conclusions: According to the result, the oriental medicine treatment is considered to be effective on the systemic juvenile idiopathic arthritis and further studies will be needed with more cases.

• Molecules and Cells
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• 제44권7호
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• pp.529-537
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• 2021

Most animals face frequent periods of starvation throughout their entire life and thus need to appropriately adjust their behavior and metabolism during starvation for their survival. Such adaptive responses are regulated by a complex set of systemic signals, including hormones and neuropeptides. While much progress has been made in identifying pathways that regulate nutrient-excessive states, it is still incompletely understood how animals systemically signal their nutrient-deficient states. Here, we showed that the FMRFamide neuropeptide FLP-20 modulates a systemic starvation response in Caenorhabditis elegans. We found that mutation of flp-20 rescued the starvation hypersensitivity of the G protein β-subunit gpb-2 mutants by suppressing excessive autophagy. FLP-20 acted in AIB neurons, where the metabotropic glutamate receptor MGL-2 also functions to modulate a systemic starvation response. Furthermore, FLP-20 modulated starvation-induced fat degradation in a manner dependent on the receptor-type guanylate cyclase GCY-28. Collectively, our results reveal a circuit that senses and signals nutrient-deficient states to modulate a systemic starvation response in multicellular organisms.

• 한국치위생학회지
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• 제22권3호
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• pp.189-197
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• 2022

Objectives: The purpose of this study was to investigate the level of systemic disease-related knowledge among dental hygienists and analyze the effect on their job performance, empowerment, and satisfaction to provide basic data for expanding education on systemic diseases among dental hygienists and improving their job performance, empowerment and satisfaction. Methods: A survey was conducted among dental hygienists working in Busan and Gyeongsangnam-do region, South Korea, from October 27 to November 10, 2020, with a total of 245 questionnaires included in the final analysis. Results: Results of analysis revealed an average score for systemic disease-related knowledge among dental hygienists of 16.53±3.33 points and the higher the systemic disease-related knowledge, the higher the job performance, empowerment, and satisfaction. The higher the coronary artery disease knowledge and respiratory and infectious disease knowledge, the higher the job performance, and the higher the respiratory and infectious disease knowledge, the higher the job empowerment and job satisfaction. Conclusions: This study revealed that the higher dental hygienists' level of systemic disease-related knowledge, the higher their job performance, empowerment, and satisfaction. Therefore, this study suggests that dental hygienists' education on systemic disease-related knowledge should be expanded, and diverse systemic disease education programs should be developed for application in clinical practice.

• International Journal of Industrial Entomology and Biomaterials
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• 제6권1호
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• pp.103-106
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• 2003

Among silkworm diseases, white muscardine is the most virulent and contagious disease caused by Beauveria bassiana and common during winter and rainy seasons. The disease is managed at present by practicing the silkworm body and rearing seat disinfection to prevent the spread of white muscardine during silkworm rearing as the available methods do not cure the silkworms against white muscardine. The use of systemic fungicide was suggested recently to control white muscardine. The present study investigated the practicability of application aspect of systemic fungicide as spray, It is observed that 3 times feeding of systemic fungicide through mulberry leaf, fed immediately after third, fourth moult and on $4^{th}$ day of final instar as most effective in suppressing the multiplication of the fungus in silkworm. Spraying of the systemic fungicide on mulberry in the rearing house, air-dried and feeding was suggested as suitable application method. Alternately the spraying of the systemic fungicide on mulberry in mulberry garden 6 hrs prior to feeding was also suggested as a method for the control of white muscardine in silkworm rearing.

• The Plant Pathology Journal
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• 제33권2호
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• pp.206-211
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• 2017

The effect of temperature on the rate of systemic infection of potatoes (Solanum tuberosum L. cv. Chu-Baek) by Potato virus Y (PVY) was studied in growth chambers. Systemic infection of PVY was observed only within the temperature range of $16^{\circ}C$ to $32^{\circ}C$. Within this temperature range, the time required for a plant to become infected systemically decreased from 14 days at $20^{\circ}C$ to 5.7 days at $28^{\circ}C$. The estimated lower thermal threshold was $15.6^{\circ}C$ and the thermal constant was 65.6 degree days. A systemic infection model was constructed based on experimental data, using the infection rate (Lactin-2 model) and the infection distribution (three-parameter Weibull function) models, which accurately described the completion rate curves to systemic infection and the cumulative distributions obtained in the PVY-potato system, respectively. Therefore, this model was useful to predict the progress of systemic infections by PVY in potato plants, and to construct the epidemic models.

• The Journal of Asian Finance, Economics and Business
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• 제7권2호
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• pp.107-117
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• 2020

The research objective of the paper is to clarify the factors influencing system risks of listed companies in Vietnam, with a focus on clarifying the relationship and quantifying the impacts of ownership structure on systemic risk of listed companies. The data used in this study included financial statements and stock price data of listed companies on the Ho Chi Minh City Stock Exchange and Hanoi Stock Exchange of Vietnam stock market in the period from 2010 to 2017. The paper used the method of estimation in establising the regression models to choose among three models: Random Effect Model, Fixed Effect Model or Pooled OLS for regression using Stata statistical software. The research results showed that state ownership and ownership by foreign investors were positively related to systemic risk, while ownership by domestic investors had a reverse relationship with systemic risk of listed companies in Vietnam. In addition, as a control variable, both company size and profitability had an effect on the systemic risk of listed companies in the research sample. Based on the research results, the authors interpreted some of the implications in order to minimize systemic risks in the operation of listed companies in Vietnam.