• The Plant Pathology Journal
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• v.29 no.2
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• pp.174-181
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• 2013

The plant growth-promoting rhizobacterium Ochrobactrum lupini KUDC1013 elicited induced systemic resistance (ISR) in tobacco against soft rot disease caused by Pectobacterium carotovorum subsp. carotovorum. We investigated of its factors involved in ISR elicitation. To characterize the ISR determinants, KUDC1013 cell suspension, heat-treated cells, supernatant from a culture medium, crude bacterial lipopolysaccharide (LPS) and flagella were tested for their ISR activities. Both LPS and flagella from KUDC1013 were effective in ISR elicitation. Crude cell free supernatant elicited ISR and factors with the highest ISR activity were retained in the n-butanol fraction. Analysis of the ISR-active fraction revealed the metabolites, phenylacetic acid (PAA), 1-hexadecene and linoleic acid (LA), as elicitors of ISR. Treatment of tobacco with these compounds significantly decreased the soft rot disease symptoms. This is the first report on the ISR determinants by plant growth-promoting rhizobacteria (PGPR) KUDC1013 and identifying PAA, 1-hexadecene and LA as ISR-related compounds. This study shows that KUDC1013 has a great potential as biological control agent because of its multiple factors involved in induction of systemic resistance against phytopathogens.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.31 no.4
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• pp.108-116
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• 2018

Objectives : A Report on the Improvement of korean medical treatment of Secondary Raynaud's Syndrome Caused by Systemic Sclerosis. Methods : We treated a Secondary Raynaud's syndrome 59-year-old woman with herbal medicine and acupuncture treatment for 3 months. The evaluation of treatment was confirmed by photographs before and after treatment, VAS, and palm skin temperature. Results : After treatment, the color of both fingernails and finger skins recovered from white to purplish red, and Raynaud phenomenon and palm flaring were decreased. VAS decreased from 8 to 2 and palm skin temperature increased by left hand 1.4 degrees right hand 1.2 degrees. Conclusions : It was shown that korean medical treatment was effective in the conservative treatment of Secondary Raynaud's syndrome caused by systemic sclerosis.

• Journal of Periodontal and Implant Science
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• v.40 no.5
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• pp.249-253
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• 2010

Purpose: The purpose of this study was to evaluate the improvement of periodontal health of generalized aggressive periodontitis (GAgP) diagnosed patients treated with non-surgical periodontal therapy accompanying systemic antibiotics administration. Methods: Two patients with GAgP were chosen for this study. Clinical indices were taken and a radiographic examination was performed at the baseline of the study and they were treated by periodontal therapy accompanying systemic antibiotics administration. Post-surgical visits were scheduled at regular intervals to check clinical and radiographic changes. Results: Through non-surgical periodontal therapy accompanying systemic antibiotics administration, GAgP patients showed decreased probing pocket depth, sulcus bleeding index, and increased attachment level and clinical index when comparing the initial and six month follow up data. In the six month follow-up radiographic examination after non-surgical periodontal therapy, resolution of the bony defect was observed. Conclusions: Non-surgical therapy combined with systemic antibiotics administration in GAgP patients is suggested to be an effective approach to enhance the periodontal health.

• Journal of Veterinary Clinics
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• v.37 no.4
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• pp.227-230
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• 2020

A 8-year-old spayed female Korean short-haired cat was presented with respiratory distress. CBC, serum chemistry analysis, plain radiography, and abdominal ultrasonography were performed. Besides hypertrophic cardiomyopathy (HCM) suspected by the thoracic radiograph, a tubular, tortuous soft tissue structure was detected at the region of the left retroperitoneal cavity on the abdominal radiograph. On the abdominal ultrasonography, a shunt vessel is identified caudo-lateral to the left kidney region. These findings are consistent with spleno-systemic shunts in cats. Furthermore, portal hypertension and diffuse hepatic lesion were also identified. Although the cause of a shunt vessel is not easy to diagnose, it is important to include spleno-systemic shunt into differential diagnosis list, when convoluted, tubular soft tissue opacity is seen on the digital radiography (DR). This report will allow clinicians to raise awareness of complications of portosystemic shunt (PSS) and better treat PSS suspected feline patients when the advanced modalities such as computed tomography and magnetic resonance imaging are not available.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.13 no.2
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• pp.89-97
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• 2013

Purpose: We retrospectively investigated individuals who hadbeen identified by neonatal screening as potential galactosemia patients to determine the etiology of galactosemia. Methods: One hundred fifty-three patients referred to Korea Genetics Research Center due to high galactose level detected by neonatal screening test between February 2005 and May 2013 were examined. Galactose and galactose-1-phosphate levels were measured by using a fluoro metric microplate reader. Lactose free diet was initiated immediately after confirmed by urine Clinitest. If reducing sugar was negative, we employed abdominal sonogram and echocardiogram to check for possible porto-systemic shunt. Results: Fifteen patients were diagnosed with galactosemia. One patient had galactokinase (GALK) deficiency; four had UDP galactose-4-epimerase (GALE) deficiency; two had citrin deficiency; and four had porto-systemic shunt. Two had unknown causes of galactosemia. Conclusion: In addition to genetic defects of GALT, GALK and GALE, citrin deficiency or porto-systemic shunt could also cause galactosemia. It is crucial to carry out differential diagnosis to determine the cause of galactosemia.

• Journal of The Korean Society of Integrative Medicine
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• v.6 no.4
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• pp.183-189
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• 2018

Purpose : As age increases, a low-level systemic inflammatory state develops and the levels of anti-aging hormones decrease. The vagus nerve activates parasympathetic nerves and promotes sulfation and secretion of neurotransmitter in the brain. Therefore, the purpose of this study was to investigate the effects of electrical vagus nerve stimulation on systemic inflammation (CRP) and anti-aging hormone (DHEA-S) levels in elder people. Methods : A total of 30 healthy elder people participated in this study, randomly divided into two groups of 15 subjects. Electrical vagus nerve stimulation was applied to the experimental group for 4 weeks. CRP and DHEA-S levels were compared with those of the control group. Results : The CRP level was significantly lower in the experimental group than in the control group. In the experimental group, there was a significant decrease in CRP before and after the intervention. However, the DHEA-S level was not significantly different between groups. Conclusion : Electrical vagus nerve stimulation may alleviate the low-level systemic inflammatory state found in elderly people. These results suggest that it may have the effect of reducing the degenerative inflammatory diseases of the elderly and delaying aging.

• Kosin Medical Journal
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• v.33 no.3
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• pp.468-476
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• 2018

Perioperative anaphylaxis, although rare, is a severe, life-threatening unexpected systemic hypersensitivity reaction. Simultaneous administration of various drugs during anesthesia, the difficulty of communicate with patients in sedation and anesthesia, and coverage of the patient with surgical drapes are considered to be factors that impede early recognition of anaphylactic reactions. It is very important to perform an intradermal skin test because antibiotics are the most common cause of perioperative anaphylaxis. We report a case of negative-intradermal skin test antibiotic anaphylaxis mistaken for local aesthetic systemic toxicity without increase of serum tryptase for confirmative diagnostic biomaker during surgery under brachial plexus block. It is not possible to exclude the danger of anaphylaxis completely, even if it is negative-intradermal skin test and normal tryptase level. Therefore, anesthesiologists should be closely monitored and treated early for antibiotics related hypersensitive reaction, like other medicines during anesthesia.

• Journal of the Korean Society of Safety
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• v.36 no.4
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• pp.88-98
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• 2021

Korean industry has achieved dramatic growth in a short time through continuous technical innovations. However, safety consciousness and management have not kept pace with industry growth. The characteristics of industrial accidents in socio-technical systems have become so complicated that it has been challenging for safety professionals to implement effective preventive measures because it is difficult to determine what is happening in the complex workplace. Thus far, they have focused on technical improvements and the requirements of OSH regulations to avoid legal responsibility. Accordingly, this study has used the systemic analysis method to explain the emergence of something unexpected in complex and multi-layered business structures, which is usually related to the variabilities of humans and organizations. This study chose a shipyard where a few fatal accidents had occurred because the shipbuilding industry includes numerous variabilities, including obtaining orders, manpower supply, procurement, etc. Systemic analysis progressed using FRAM based on two accident cases related to the truss platform used in LNG vessels. The outcome shows that each function within the system has its variabilities and has become coupled or dependent on other functions, increasing the possibility of accidents. This analysis method can provide OSH professionals with practical techniques for explaining what is happening in a complex socio-technical system and how to take proper measures.

• Journal of Veterinary Clinics
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• v.39 no.2
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• pp.81-86
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• 2022

A female, 14-year-old, African penguin (Spheniscus demersus) weighing 2.5 kg with the anorexia for one day and 22 months history of bumblefoot was found dead in aquarium. Grossly, severe bumblefoot in the central surface of the right foot, severe enlarged liver and kidneys with orange color were observed. Histopathologically, pinkish amorphous materials were accumulated in liver, spleen, kidney, and stomach. The pinkish materials in the liver, kidney, spleen, and stomach were confirmed as amyloid with typical orange color reactions using Congo red stain under the light microscope and with bright red color expressions using Congo red stain under the fluorescence microscope. Based on the typical gross and histopathologic findings and special staining, this case was confirmed as systemic amyloidosis. A long period time of moderate bumblefoot might be closely associated with the occurrence of systemic amyloidosis in the captive penguin.

• Journal of Sasang Constitutional Medicine
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• v.34 no.4
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• pp.68-80
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• 2022

Objectives This study is to report a significant improvement in a Taeeumin patient with systemic contact dermatitis after eating urushiol chicken by herbal medicine treatment. Methods The patient had complaints of erythema, swelling, pruritus, scaly skin, and facial flushing. We treated the patient with an herbal medicine 'Galgeunhaegi-tang' for three months. We evaluated the treatment outcome of systemic contact dermatitis using the Three Item Severity(TIS) score every visit and facial flushing by Image color summarizer at the first and last visit. Results After the treatment, the severity of the patient's skin complaints lessened from moderate to mild. The Image color summarizer showed a minor decrease in the normalized red color level and a significant increase in the brightness level and facial color percentage. Conclusions The patient diagnosed with systemic contact dermatitis, treated with Galgeunhaegi-tang for three months, showed a significant improvement in skin complaints with brighter and even facial color.