• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.7011-7016
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• 2013

Background: The liver fluke, Opisthorchis viverrini, and the associated incidence of subsequent cholangiocarcinoma (CCA) are still a public health problem in Thailand, and praziquantel (PZQ) remains the antihelminthic drug of choice for treatment. Evidence in hamsters shows that repeated infection and PZQ treatments could increase the risk of CCA. However, the existing evidence in humans is inconclusive regarding increased risk of CCA with frequency of PZQ intake. Objectives: To investigate the relationship between number of repeated PZQ treatments and CCA in patients with O viverrini infection. Materials and Methods: The reviewed studies were searched in EMBASE, MEDLINE, ProQuest, PubMed and SCOPUS from inception to October, 2012 using prespecified keywords. The risk of bias (ROB) of included studies was independently assessed by two reviewers using a quality scale from the Newcastle-Ottawa Scale (NOS). Risk effect of PZQ was estimated as a pooled odds ratio (OR) with its 95% confidence interval (95%CI) in the random-effects model using DerSimonian and Laird's estimator. Results: Three studies involving 637 patients were included. Based on the random effects model performed in two included studies of 237 patients, the association between PZQ treatments and CCA was not statistical significant with a pooled OR of 1.8 (95%CI; 0.81 to 4.16). Conclusions: The present systematic review and meta-analysis provides inconclusive evidence of risk effect of PZQ on increasing the risk of CCA and significant methodological limitations. Further research is urgently needed to address the shortcomings found in this review, especially the requirement for histological confirmation.

• 디지털콘텐츠학회 논문지
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• 제19권2호
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• pp.415-423
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• 2018

최근, 컴퓨터 분야의 기계 학습(Machine Learning)과 딥러닝(Deep Learning) 등 컴퓨터 관련 학습이 각광을 받고 있다. 이들은 인공 신경망(Artificial Neural Network)을 이용하여 가장 하위 레벨로부터 학습을 시작하여, 최상위 레벨까지 그 결과를 전달하여 최종 결과를 산출하는 방식이다. 하위레벨로부터의 체계적인 학습을 통한 효과적인 성장 및 교육 방안에 대한 연구는 다양한 분야에서 이루어지고 있으나, 체계적인 규칙과 방법에 기반한 모델은 찾아보기가 힘들다. 이에, 본 논문에서는 성장 및 융합 모델인, TNT 모델(Transitive Nested Triangle Model)을 처음으로 제안한다. 제안하는 모델은 기하학적인 형태를 통해 형성된 각 기능들이 유기적 계층 관계를 형성하여, 상위로 성장 및 융합하면서, 그 결과가 반복 사용되는 순환적 재귀 모델이다. 즉, '수평적 형제 병합에 이은 상위로의 융합(Horizontal Sibling Merges and Upward Convergence)'의 분석적 방법이다. 이러한 모델은 공학, 디지털공학, 인문학, 예술학 등에 모두 적용될 수 있는 기본기적 이론으로, 본 연구에서는 제안하는 TNT 모델을 설명하는 것에 그 초점을 둔다.

• Journal of Preventive Medicine and Public Health
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• 제52권1호
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• pp.1-13
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• 2019

Objectives: In recent years, serious concerns have been raised regarding the impacts of rising temperatures on health. The present study was conducted to investigate the relationship between elevated temperatures and kidney disease through a systematic review and meta-analysis. Methods: In October 2017, 2 researchers independently searched related studies in PubMed and Embase. A meta-analysis was conducted using a random-effects model, including only studies that presented odds ratios, relative risks, or percentage changes, along with 95% confidence intervals (CIs). The characteristics of each study were summarized, and the Egger test and funnel plots were used to evaluate publication bias. Results: Eleven studies that met the criteria were included in the final analysis. The pooled results suggest an increase of 30% (95% CI, 20 to 40) in kidney disease morbidity with high temperatures. In a disease-specific subgroup analysis, statistically significant results were observed for both renal colic or kidney stones and other renal diseases. In a study design-specific subgroup analysis, statistically significant results were observed in both time-series analyses and studies with other designs. In a temperature measure-specific subgroup analysis, significant results were likewise found for both studies using mean temperature measurements and studies measuring heat waves or heat stress. Conclusions: Our results indicate that morbidity due to kidney disease increases at high temperatures. We also found significant results in subgroup analyses. However, further time-series analyses are needed to obtain more generalizable evidence.

• 대한불안의학회지
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• 제15권1호
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• pp.20-28
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• 2019

Objective : The purpose of this study was to compare and analyze effectiveness of various psychotherapies of depressive symptoms in patients with anxiety disorders by means of a systemic review. Methods : A systematic search using key words was conducted using EMBASE, MEDLINE and CENTRAL. Results : Five studies were included in this systematic review. The Scottish Intercollegiate Guidelines Network (SIGN) was used for quality assessment. Diagnostic-specific cognitive behavioral therapies for various anxiety disorders (ds CBT) were also effective in reducing comorbid depression. Transdiagnostic cognitive behavioral therapies targeting anxiety and depression (tCBT-AD) were not superior than ds CBT for anxiety disorders. Mindfulness-based stress reduction (MBSR) was more effective than traditional cognitive behavioral therapy. Conclusion : ds CBT relieves anxiety symptoms as well as depressive symptoms comorbid with anxiety disorders effectively. In addition, MBSR is more successful for anxiety disorders with co-occurring depression by focusing broadly on the shifting relationship to internal experience rather than focusing narrowly on specific symptoms.

• 한국산학기술학회논문지
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• 제22권1호
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• pp.104-115
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• 2021

본 연구의 목적은 체계적 문헌고찰을 통해 국내 급성기 병원 간호인력 배치 수준과 환자 건강 결과 간의 관계에 대한 연구를 체계적으로 평가하기 위함이다. 2009년 1월부터 2018년 12월까지 CINAHL, Pubmed, EBSCOhost, RISS, Dbpia 데이터베이스에 출판된 급성기 병원 간호인력 배치 수준과 환자 건강 결과 간의 관계에 대한 연구를 검색하였다. 국내 급성기 병원 간호 인력 배치 수준과 환자 건강 결과에 대한 관계를 파악한 연구 13편을 체계적으로 고찰하였다. 대부분의 연구에서 국내 급성기 병원의 간호 인력 배치 수준이 높을수록 환자 건강 결과가 제고됨을 확인하였다. 하지만, 몇몇 연구에서는 간호 인력과 환자 건강 결과 간의 유의한 관계가 없는 것으로 확인되었다. 이처럼 일관되지 않은 연구 결과는 연구들마다 서로 다른 측면의 간호 인력과 환자 건강 결과를 측정했기 때문인 것으로 사료된다. 이는 이와 관련한 지속적인 연구가 필요함을 시사한다. 환자 건강결과 향상을 위해 적정 수준의 환자 대 간호사 비율을 산정하고 이를 바탕으로 간호사들을 배치하는 전략 및 가이드라인을 세우기 위한 지속적인 노력이 필요하다.

• 생체재료학회지
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• 제22권4호
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• pp.279-289
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• 2018

Background: Cell behavior is the key to tissue regeneration. Given the fact that most of the cells used in tissue engineering are anchorage-dependent, their behavior including adhesion, growth, migration, matrix synthesis, and differentiation is related to the design of the scaffolds. Thus, characterization of the scaffolds is highly required. Micro-computed tomography (micro-CT) provides a powerful platform to analyze, visualize, and explore any portion of interest in the scaffold in a 3D fashion without cutting or destroying it with the benefit of almost no sample preparation need. Main body: This review highlights the relationship between the scaffold microstructure and cell behavior, and provides the basics of the micro-CT method. In this work, we also analyzed the original papers that were published in 2016 through a systematic search to address the need for specific improvements in the methods section of the papers including the amount of provided information from the obtained results. Conclusion: Micro-CT offers a unique microstructural analysis of biomaterials, notwithstanding the associated challenges and limitations. Future studies that will include micro-CT characterization of scaffolds should report the important details of the method, and the derived quantitative and qualitative information can be maximized.

• 디지털융복합연구
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• 제19권3호
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• pp.195-202
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• 2021

본 연구는 치매교육으로 제공한 국내·외 가상현실 프로그램의 특성, 효과, 적용 전략 등을 확인하는 체계적고찰 연구이다. 연구방법은 2020년 7월까지 국내·외에서 발표된 문헌을 대상으로 국외는 CINAHL, Cochrane, EMBASE, Pubmed 전자 데이터베이스를 사용하였으며, 국내는 RISS, KISS, DBpia에 대한 검색을 시행하였다. 선정기준과 배제기준을 근거로 최종 6편의 논문이 분석에 사용되었다. 분석결과 선정된 문헌의 연구대상자는 비전문 간병인 2편(33.3%), 일반인 1편(16.7%), 간호학생과 의학 및 약학대 학생을 포함한 학생들 3편(50.0%)이었다. 가상현실 프로그램은 총 5개(공감능력, 치매 지식과 편안감을 포함한 치매태도, 자신의 능력에 대한 신뢰, 양자관계척도)영역에 효과가 있었으며, 이 중 공감능력에 대한 평가가 가장 많았으며 공감능력을 측정한 연구의 75%에서 가상현실 프로그램이 유의한 효과를 나타내었다. 본 연구 결과를 통해 공감을 기반으로 한 인간중심적 간호에 가상현실 기술을 활용할 수 있음을 확인하였다.

• 대한통합의학회지
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• 제11권3호
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• pp.185-194
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• 2023

Purpose : This study aimed to investigate the relationship between the characteristics of hemodialysis patients and the occurrence of sarcopenia through a comprehensive literature review. Methods : A systematic literature search was conducted to identify eligible studies in the Cochrane library, PubMed and Embase. In this review, we included all papers published since the initiative's inception and summarized results as of december 2022. Studies that investigated association between sarcopenia diagnosis and hemodialysis patients (aged≥18 years) were included. Ultimately, 16 studies met our selection criteria. The risk of bias was assessed using the Newcastle-Ottawa scale. Results : Fourteen of the sixteen studies (88 %) reported that significant association between sarcopenia diagnosis and hemodialysis patients. However, two studies reported no association between sarcopenia diagnosis and hemodialysis patients. As a factor statistically related to sarcopenia in hemodialysis patients, Mortality (6 studies, 38 %), age (5 studies, 31 %), body composition (4 studies, 25 %), physical activity (2 studies, 13 %), diabetes (2 studies, 13 %), cardiovascular abnormalities (1 studies, 6 %), nutritional status (3 studies, 19 %), and gender (3 studies, 19 %). Conclusion : Our findings highlight the necessity of developing a physical therapy program that accurately reflects the health status of hemodialysis patients. To further investigate the association between the diagnosis of sarcopenia and hemodialysis patients, it is recommended to conduct large-scale longitudinal studies using standardized diagnostic criteria and evaluation methods, as well as analyze potential risk factors. Consequently, this study emphasizes the importance and potential of developing physical therapy programs that effectively address the health consequences associated with hemodialysis. The significance of this research lies in its ability to provide valuable insights and lay the foundation for future studies focused on developing preventive and therapeutic interventions targeting muscle wasting syndrome resulting from hemodialysis.

• 한국간호교육학회지
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• 제30권2호
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• pp.124-139
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• 2024

Purpose: This systematic review aims to provide an overview of research related to grit among nursing college students in South Korea. Methods: A literature search was done using RISS, KISS, and KCI to identify studies written in Korean from 2010 to 2023. Results: A total of 210 articles were searched, and a final 26 articles were selected in the analysis based on inclusion and exclusion criteria. Three researchers independently coded the characteristics and key content of each paper, including research objectives, methodology, study participants, grit measurement methods, and the relationship between grit and other variables. Subsequently, these coded findings were used to collectively analyze and derive overarching themes through discussion. The analysis results indicated that grit was influenced by factors such as academic major satisfaction, academic performance, and resilience. Grit was found to be a psychological factor affecting nursing students, influencing both major-related competencies and career-related factors. Conclusion: The findings of this review contribute to a deeper understanding of grit within the specific demographic of nursing college students in South Korea and may inform future research and educational practices. In addition, this systematic review provides a comprehensive understanding of the literature on grit among nursing college students in South Korea and serves as a valuable resource for future research and educational interventions in this context.

• Journal of Yeungnam Medical Science
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• 제41권2호
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• pp.74-79
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• 2024

Patient-physician interaction (PPI) is an important area in medical education, but in-depth discussions on the content of the outcome of patient-doctor education are rare. Therefore, in this study, we will systematically analyze the research on PPI education in Korea. In this study, papers searched with keywords related to PPI education from Korea's academic journal service were targeted according to a systematic literature analysis method. The scope of the study was to include papers published in academic journals that are candidates for Korea Citation Index registration, excluding dissertations, research reports, posters, conference presentations, books, and internet materials. The content included papers targeting medical education and medical school students was set as the range. As a result of the analysis, although communication between PPI has many positive effects in the PPI in medical education at medical schools, obstacles do occur, and various ways to overcome them were suggested. Therefore, although medical interview training between patients and doctors in medical schools is necessary, it was analyzed as being based on overseas research or lacking in specific content. The core of PPI education appears to be medical interviews, and it seems necessary to discuss whether empathy or patient-centered medical care are appropriate as the main principles of PPI education in Korea. Therefore, education on the patient-doctor relationship is an important element in medical humanities and medical humanities education, and it is expected that research and education on this will progress more actively.