• Journal of fish pathology
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• v.26 no.3
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• pp.139-148
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• 2013

The genus Polydora(Polychaeta, Spionidae) includes many species well known for their activity as borers. They often become harmful invaders by reducing the growth rate and meat yield of, or inducing the mortality of commercially important mollusck, abalone, Haiotis discus hannai. In 2012, the frequency of the Polydora was observed with 5~99% in live abalone and 5.3~70.3% in dead abalone shells of abalone sea-caged aquaculture system, Korea. There are many nacreous blister in the ventral margin and inner of the infestated abalone by abalone in response to the Polydora. A worm bored two holes in the shell and come in and out for ingestion the organic matters. They are more than 40 mm in length and had outstanding palps with black bars, disc form pygidium and 4 eyespots. This is the first record for the statue of Polydora infestation of sea-caged cultured abalone, Haliotis discus hannai in Korea.

• Nutrition Research and Practice
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• v.11 no.6
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• pp.470-478
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• 2017

BACKGROUND/OBJECTIVE: Orostachys japonicus A. Berger (Crassulaceae) has been used in traditional herbal medicines in Korea and other Asian countries to treat various diseases, including liver disorders. In the present study, the anti-fibrotic effects of O. japonicus extract (OJE) in cellular and experimental hepatofibrotic rat models were investigated. MATERIALS/METHODS: An in vitro hepatic stellate cells (HSCs) system was used to estimate cell viability, cell cycle and apoptosis by MTT assay, flow cytometry, and Annexin V-FITC/PI staining techniques, respectively. In addition, thioacetamide (TAA)-induced liver fibrosis was established in Sprague Dawley rats. Briefly, animals were divided into five groups (n = 8): Control, TAA, OJE 10 (TAA with OJE 10 mg/kg), OJE 100 (TAA with OJE 100 mg/kg) and silymarin (TAA with Silymarin 50 mg/kg). Fibrosis was induced by treatment with TAA (200 mg/kg, i.p.) twice per week for 13 weeks, while OJE and silymarin were administered orally two times per week from week 7 to 13. The fibrotic related gene expression serum biomarkers glutathione and hydroxyproline were estimated by RT-PCR and spectrophotometry, respectively, using commercial kits. RESULTS: OJE (0.5 and 0.1 mg/ mL) and silymarin (0.05 mg/mL) treatment significantly (P < 0.01 and P < 0.001) induced apoptosis (16.95% and 27.48% for OJE and 25.87% for silymarin, respectively) in HSC-T6 cells when compared with the control group (9.09%). Further, rat primary HSCs showed changes in morphology in response to OJE 0.1 mg/mL treatment. In in vivo studies, OJE (10 and 100 mg/kg) treatment significantly ameliorated TAA-induced alterations in levels of serum biomarkers, fibrotic related gene expression, glutathione, and hydroxyproline (P < 0.05-P < 0.001) and rescued the histopathological changes. CONCLUSIONS: OJE can be developed as a potential agent for the treatment of hepatofibrosis.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.10
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• pp.382-395
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• 2016

The purpose of this study is to examine how area characteristics influence the health of a population in a particular area by investigating how area deprivation and social capital influence self-rated health. For this study, a multi-level logistic regression was employed to analyze the data collected by Community Health Survey conducted on a target population of 229,186 living at 253 administrative areas of Korea in 2011. First, an analysis was conducted for subjects who have rated their self-health assessment as 'fair', 'poor', and 'very poor' in a 5 -item response survey. Then, a second analysis was conducted for the same subjects by excluding those with a rating of 'fair'. As a result, we found that area deprivation significantly influenced the population's health, according to our second analysis, while it was not significant according to our first analysis. Moreover, social capital was not significant in both analyses. Area deprivation-although the value of it was not so high-seems to explain the differences of individual self-rated health assessment as a contextual effect. In addition, influence of area characteristics is not limited to certain local areas, but to all local areas of Korea. Therefore, it is suggested that efforts to improve area characteristics are necessary to upgrade the individual's health level. A standardized classification system-distinguishing between good and poor self-rated health-is necessary through further comparative studies on self-rated health assessment.

• Journal of Korean Neurosurgical Society
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• v.30 no.sup1
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• pp.25-29
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• 2001

Objective : Intracranial metastasis is responsible for nearly 50% of mortalities of systemic cancers. Although its frequency is increasing and there is little doubt that improving the quality and expectancy of life is the final goal, the mode of treatment is still disputed. The authors report the postoperative motor function after surgery in patients with metastatic tumors around the motor cortex. Materials and Methods : We studied 24 patients with metastatic tumors around the central sulcus during the last 22 months. Motor function was assessed pre- and post-operatively as well as its response to corticosteroids. MRI, neuronavigation system and intraoperative ultrasonography were used for tumor localization and functional MRI and cortical stimulator were used to define the motor cortex. Results : Single metastasis was found in 13 cases(54%) and 11 cases(44%) had multiple foci. Thirteen cases were located in precentral, 7 in postcentral, and 4 in superior or middle-frontal lobe. The most common primary focus was the lung(16 cases). There was no difference in postoperative motor function improvement between the steroid responsive group and non-responsive group(92% versus 90%). Ninty-two percent of the patients showed significant improvement of motor function and lived independently but there was worsening in the upper extremity in one and in another no improvement. Whole brain radiation of 3000cGy was given in all cases and 4 patients died of recurrence in primary or intracranial focus during mean follow-up periods of 14 monthes. Conclusion : Surgery may provide substantial improvement of the motor function and quality of life of the patients with metastatic tumors around the motor cortex.

• Journal of KIISE:Computer Systems and Theory
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• v.28 no.9
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• pp.415-423
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• 2001

Recently, there are many attempts to reproduce real world fine art pieces in digital forms. The digital representations are convenient to store and/or transmit. In contrast, mobiles, or moving sculptures, such as those designed by Alexander Calder cannot to reproduced realistically by usual reproduction techniques. Since mobiles are originally designed to generate motions in response to external forces applied to it, people could not fully enjoy them through photographs or static images. We present a virtual mobile system where use can easily control the mobile and can feel the impressions that the artist originally intended to provide. A real-world mobile is reconstructed in a three-dimensional physically-based model. and then virtual wind is generated to give motions to it. The motions of the mobile are generated by constraint dynamics and impulse dynamics techniques, which are modified to fully utilize the characteristics of the mobile, and finally give interactive displays on the PC platforms. The techniques presented can easily be extended to simulate other interactive dynamics systems.

• Journal of the Earthquake Engineering Society of Korea
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• v.6 no.4
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• pp.65-73
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• 2002

It has been recognized that the damage control must become a more explicit design consideration. In an effort to develop design methods based on performance it is clear that the evaluation of the nonlinear response is required. The methods available to the design engineer today are nonlinear time history analyses, monotonic static nonlinear analyses, or equivalent static analyses with simulated nonlinear influences. Some building codes propose the capacity spectrum method based on the nonlinear static analysis(pushover analysis) to determine the earthquake-induced demand given by the structure pushover curve. These procedures are conceptually simple but iterative and time consuming with some errors. This paper presents a nonlinear direct spectrum method(NDSM) to evaluate seismic performance of structures, without iterative computations, given by the structural initial elastic period and yield strength from the pushover analysis, especially for MDF(multi degree of freedom) systems. The purpose of this paper is to investigate the accuracy and confidence of this method from a point of view of various earthquakes and unloading stiffness degradation parameters. The conclusions of this study are as follows; 1) NDSM is considered as practical method because the peak deformations of nonlinear system of MDF by NDSM are almost equal to the results of nonlinear time history analysis(NTHA) for various ground motions. 2) When the results of NDSM are compared with those of NTHA. mean of errors is the smallest in case of post-yielding stiffness factor 0.1, static force by MAD(modal adaptive distribution) and unloading stiffness degradation factor 0.2~0.3.

• Journal of the Korean Child Neurology Society
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• v.26 no.4
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• pp.284-287
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• 2018

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutation of one of two genes, TSC1 (encoding hamartin, 9q34) and TSC2 (encoding tuberin, 16p13). It invades the central nervous system and various parts of the body, causing various symptoms. Crohn's disease (CD) is a chronic immune-mediated disease that has not been clearly elucidated. It is thought to be caused by an excessive immune response of the body to bacteria that normally exist in the digestive tract with genetic factors. No cases have been reported in which both of the above-mentioned diseases occurred simultaneously. We report a case of CD in a patient with TSC. A 12-year-old boy was brought to our hospital because of abdominal pain. Skin lesions were observed in the TSC. Fundus examination revealed a hamartoma in the right retina. Brain magnetic resonance imaging revealed a subendothelial giant cell astrocytoma (SEGA). On the basis of these findings, he was diagnosed as having TSC. Blood test results showed increased levels of inflammatory markers. On abdominal ultrasonography, his colon walls were observed to be thickened with increased vascularity of the proximal ascending colon, ileocecal valve, and terminal ileum. Colonoscopy revealed discontinuous ulcerations and inflammations of the ileum, IC valve, and cecum, similar to those found in CD. Everolimus was administered orally for the SEGA but was discontinued frequently owing to the exacerbation of CD. The possibility of CD should be kept in mind in patients with TSC considering to undergo treatment for SEGA.

• Journal of Environmental Health Sciences
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• v.47 no.5
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• pp.384-397
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• 2021

Background: With volatile organic compounds (VOCs) containing aromatic and halogenated hydrocarbons such as benzene, toluene, and xylene that can adversely affect the respiratory and cardiovascular systems when a certain concentration is reached, it is important to accurately evaluate the source and the corresponding health risk effects. Objectives: The purpose of this study is to provide scientific evidence for the city of Seoul's VOC reduction measures by confirming the risk of each VOC emission source. Methods: In 2020, 56 VOCs were measured and analyzed at one-hour intervals using an online flame ionization detector system (GC-FID) at two measuring stations in Seoul (Gangseo: GS, Bukhansan: BHS). The dominant emission source was identified using the Positive Matrix Factorization (PMF) model, and health risk assessment was performed on the main components of VOCs related to the emission source. Results: Gasoline vapor and vehicle combustion gas are the main sources of emissions in GS, a residential area in the city center, and the main sources are solvent usage and aged VOCs in BHS, a greenbelt area. The risk index ranged from 0.01 to 0.02, which is lower than the standard of 1 for both GS and BHS, and was an acceptable level of 5.71×10^-7 to 2.58×10^-6 for carcinogenic risk. Conclusions: In order to reduce the level of carcinogenic risk to an acceptable safe level, it is necessary to improve and reduce the emission sources of vehicle combustion and solvent usage, and eco-car policies are judged to contribute to the reduction of combustion gas as well as providing a response to climate change.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.34 no.5
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• pp.279-286
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• 2021

In this study, we investigated the behavior characteristics of the L-type flange bolt connection, which is used to connect upper and lower flanges having L-type ring sections, by bolts. This connection is mainly used in domestic wind turbine structures, wherein it is a vital component as any imperfection could cause the collapse of the entire structural system. Therefore, understanding the behavior characteristics of the L-type flange bolt connection is imperative. In this study, the connection's response to external force was simulated using finite element (FE) analysis and the FE model was idealized to behave as a single L-type bolt flange. The variation in the bolt tension and the L-type flange stress were analyzed to understand the behavior characteristics of the connection. Moreover, the bolt-load function models proposed by Petersen, Schmidt/Neuper and VDI 2230, theoretically expressing a relation between bolt tension and external force, were compared to evaluate the suitability of the FE analysis and analyze the significant behavior characteristics of the connection. Furthermore, the changes in the bolt-load curve due to the variations in the partial dimensions of the L-type flange bolt connection were analyzed.

• The Journal of the Korea Contents Association
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• v.21 no.9
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• pp.580-594
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• 2021

The purpose of this paper is to investigate the impact on self-reliance and satisfaction of participants participating in the self-sufficiency business program of the Ulsan Metropolitan Regional Self-Sufficiency Center. A self-filled questionnaire was surveyed on self-sufficiency participants in five Borough and Country in Ulsan for 4 weeks from September 1 to 30, 2020, and final 233 copies were used in the actual analysis. As a result of the study, first, the percentage of positive responses of the participants was found to be good at 71.7%, for questions on the degree of support to the government, local governments, and administrative welfare centers. Second, in response to a system or service that would like to be supported or needed in the future, support for living expenses and support for health and medical expenses appeared and as a result of gender difference analysis, it was confirmed that there was a significant difference between support for children's education expenses and support for housing funds. Among the factors of the participant's psychological self-reliance(self-control, confidence, and willingness to work), the factor of self-control was the most significant factor, followed by confidence and willingness to work. Overall satisfaction with work was the highest among 9 satisfaction items such as salary and working hours.