• Korean Journal of Fisheries and Aquatic Sciences
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• v.36 no.2
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• pp.100-106
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• 2003

This study was conducted to investigate the supplementary effects of vitamin C and E to moist pellet on growth and body composition in juvenile olive flounder (Paralichthys olivaceus). Four groups of diet made : moist pellet (MP) diet group was used as the control group where the ratio of raw feed and commercial compound meal is 5:5 $(CP\;30\%,\;CL\;17\%),$ vitamin C added group (VC), vitamin I added group (VE) and vitamin C and I added group (VCE). The supplementary amount of vitamin C and E corresponded to 1000 mg/kg (dry wt.) and 220mg/kg (dry wt.), respectively. Vitamin C was destroyed $50\%$ and vitamin E was destroyed $20\%$ for manufacturing process. After 8 weeks feeding trial, weight gain was $121.9\%$ in MP group, while it ranged from 180.5 to $184.9\%$ in the VC, VE and VCE group. Feed efficiency was $71.\6%$ in MP group, whereas it ranged from 78.7 to $80.6\%$ in the VC, VE and VCE group, weight gain and feed efficiency of fish fed vitamin supplemented diets were significantly higher than control group and no significant difference among the vitamin added groups was observed (p>0.05). There were no significant differences in moisture, crude protein, crude lipid, crude ash, condition factor (CF), hepatosomatic index (HSI), and visceraweight index (VWI) of body composition. Hemoglobin (Hb) was $3.79\%$ in MP group, whereas $4.99\%$ in VC group, $4.55\%$ in VE group and $5.07\%$ in VCE group; Hb was significantly higher in the vitamin added groups than the control group (p<0.05). Vitamin C retention in liver was 18.1, 20.7, 46.6, 54.0 mg/kg in MP, VE, VC and VCE groups, respectively. Vitamin E retention in liver was 25.9, 53.8, 88.2, 124.5 mg/kg in MP, VC, VE and VCE groups, respectively. These results indicate that supplementation of vitamin C and E to moist pellet diet significantly improved growth and feed efficiency of olive flounder, and the mixed addition of vitamin C (1,000 mg/kg dry wt.) and vitamin E (220 mg/kg dry wt.) did not lead to the synergy effect.

• Journal of Applied Biological Chemistry
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• v.54 no.3
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• pp.159-165
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• 2011

Rosmarinus officinalis extracts had a significant antimicrobial activity against Helicobacter pyori. Total phenolic contents and inhibition zone of rosemary extracts were estimated to be 25.7 mg/g and 14 mm at $200{\mu}g/mL$ of phenolic contents, respectively. The Sephadex LH-20 and MCI-gel CHP-20 column chromatographic separations for the phenolic extracts from R. officinalis leaves led to isolation of five acids, whose structures were determined as protocatechuic acid (A), coumaric acid (B), caffeic acid (C), chlorogenic acid (D), and rosmarinic acid (E), from interpretation of spectroscopic data including nagative fast atom bombardment (FAB)-mass, $^1H$-NMR, $^{13}C$-NMR, and IR. All isolated compounds were tested for antimicrobial activity against H. pyori. The purified single compound showed less antimicrobial activity against H. pylori than the mixed purified compounds, which generate A+B, A+E, C+D, C+E (each $200{\mu}g/disc$) excellent as large clear zone by synergy effect. These results indicate rosemary extracts are preventive agents against H. pyori.

• Journal of Technology Innovation
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• v.1 no.1
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• pp.157-169
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• 1993

최근, 시장환경 및 생산구조의 변화에 따라 이른바 첨단생산기술(advanced manufacturing technologies)의 개발과 활용이 산업계 및 학계의 큰 관심을 끌고 있다. 그러나 첨단생산기술의 급속한 기술적 발전과 전략적 가치의 증가에도 불구하고 산업에의 확산은 상대적으로 부진한 현실이다. 이러한 현상은 물론 초기 투자의 재원도달 문제에 기인한다고 말할 수 있지만 일차적으로는 적절한 대안을 선정하고 투자의 정당성을 분석하는 방법론의 미비도 그 원인으로 지적되고 있다. 본 고는 전통적(conventional) 생산기술과 비교한 첨단생산기술과 비교한 첨단생산기술의 특성에 대한 이해를 기초로, 새로운 기술대안들을 비교 분석하는 구체적인 기법의 개발에 관한 접근의 방향성과 개념의 틀(framework)을 제시하는 데 그 목적이 있다. 첨단생산기술의 대안선정과 정당성분석은 다음과 몇 가지 특성을 지니고 있다. 첫째, 투자대안의 속성이 다양하며(multi-attribute) 각각의 속성이 상위 적(conflicting)일 수 있다. 둘째, 기술대안들의 잠재적 기능이 생산체제의 신축성과 유연성(flexible)의 제고를 강조하고 있다. 셋째, 개별기술의 통합을 통해 시스템 전체의 상승효과(synergy effect)를 추구하고 있다. 따라서 이러한 특성에 대한 인식을 토대로 정량적이고 전략적인 장·단점에 대한 고려를 포함하는 종합적이고 객관적인 분석의 틀과 기법이 사용되지 않으면 첨단생산기술의 성공적인 도입과 활용은 기대하기 어려운 것이다. 새로운 생산기술의 도입이 공정의 부분적 개선을 위한 소규모 투자일 경우에는 경제성의 분석을 위해서는 전통적인 재무관리(capital budgeting) 기법들이 이용될 수 있고 직접적인 공정개선의 효과분석을 위해서는 시뮬레이션을 적용하는 것이 바람직하다고 할 수 있다. 그러나 기술대안의 규모가 크고 따라서 그 파급효과가 전체공정으로 확산되는 대규모 사업일 경우에는 다양한 장·단점들을 고려하는 종합적인 접근의 틀이 필요하게 된다. 이러한 방법들을 크게 세 가지 형태로 나누어 보면 (1) 모든 대안들에 대해, 모든 요소들에 관한 비교분석을 동시에 실시하는 동시적 접근(simultaneous approach), (2) 대안 또는 요소들을 그 성격에 따라 계층적 구조로 분할하고 단계별로 비교분석을 실시하는 계층적 접근(hierarchical approach), (3) 요소들을 속성에 따라 몇 개의 소그룹으로 나누고 각 그룹에 대해 순차적으로 대안들을 비교분석 함으로써 고려대상이 되는 대안들을 줄여나가는 순차적 접근(sequtial approach)등을 들 수 있다 이러한 접근법들의 장·단점들을 사업의 규모나 복잡성에 따라 달라지게 된다. 또한 동일한 접근방법 내에서도 구체적인 기법의 선택과 개발도 문제의 특성에 따라 달리 결정되어야 한다. 그러나 어떠한 경우에도 오늘날의 첨단생산기술에의 투자는 현금의 흐름에 대한 계량적 분석에만 의존하는 전통적인 기법만으로는 불충분하며 기업목표와 생산조직 전반에 관한 전략적 요소들을 포함하는 종합적인 접근이 바람직하다.

• Archives of design research
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• v.15 no.1
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• pp.163-170
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• 2002

Virtual Reality is the technique which makes the man experience the similar interaction behavior to the experience in the real world through virtual space. The users participating in the 3D virtual space using virtual reality technique can have the various experiences in the space desired without restrictions on time and space and then it has been applied in many application areas such as video industry, entertainment simulator, medical treatment, construction and design. The area of video among them has been highlighted as a high-added value industry. Therefore this study classifies video industry into four including movie, broadcasting, advertisement and internet and is to examine their characteristics, application cases and developmental potential. In the industry using virtual reality technique in video industry, it is implied for special elect in the area of movie and for providing the various graphic virtual word to audiences with the introduction of virtual studio and character in the area of broadcasting. It can give audiences a synergy effect by inserting 3D advertisement into virtual space in the area of advertisement. Also the implementation of 3D virtual reality such as virtual museum, virtual model house, virtual home shopping and entertainment on the web is possible with the emergence of Virtual Reality Modeling Language (VRML) and it plays the roles of more entertainments. Accordingly, this study is to seek the application methods using virtual reality technique in video industry.

• Journal of Gifted/Talented Education
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• v.20 no.1
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• pp.175-203
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• 2010

Among many factors that affect the development of the talent of gifted children, the family factor that first finds and cultivates the talent of gifted children is quite important. The researches on the family of gifted children are mostly concentrated on physical environment out of the home environment, neglecting psychological environment. Although the recreational activity of family with gifted children considerably contributes to the emotional, intellectual and social development of gifted children themselves and to the improvement of life quality of the family members, the recreation of family with gifted children has not yet been studied. Thus, the objective of this research is to present basic materials for seeking the direction to educate parents and to support family with gifted children in order to encourage synergy effect in emotional and social growth of family with gifted children by surveying the property of recreation of family with gifted children. The result of result is as follows. First, the type of family with gifted children tends to be remarkably biased to 'family-oriented activity' and 'elf-development activity.' Second, verifying the significant level of motive for recreational activity of family with gifted children at the variables such as number of family members, parents' age, parents' education level, parents' occupation, etc, it was concluded that they were not statistically significant. The result of this research suggests that education and support for efficient recreation of family with gifted children is necessary to achieve healthy talent of gifted children.

• Korean Journal of Food Science and Technology
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• v.35 no.5
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• pp.998-1002
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• 2003

Agricultural foodstuffs, usually consumed without sterilization, are frequently contaminated with foodborne pathogen B. cereus. Ethanol and sodium chloride were used to inhibit this pathogen for its effective control. Though five minutes of exposure to 20% ethanol did not inhibit the growth of B. cereus, inhibition was detected to 30% ethanol solution. As exposed longer, B. cereus was more effectively inhibited than E. coli and S. typhimurium. B. cereus, E. coli and S. typhimurium were not inhibited when exposed in a 10% sodium chloride solution for five minutes. However, these bacteria were inhibited with a combination of 10% sodium chloride and 20% ethanol solution for five minutes. Much synergistic growth inhibition on B. cereus was found at the treatment. Its viable count was reduced from $10^8cfu/ml$ to $10^2cfu/ml$ after five minutes and showed no count after ten minutes. This trend was also confirmed for the wild types of B. cereus. This method may be applied for the effective pre-treatment of many agricultural foodstuffs, especially uncooked foodstuffs, without the hazards that accompany special sanitizers and the nutritional loss from harsh sterilization.

• Korean Journal of Food Science and Technology
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• v.37 no.1
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• pp.73-77
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• 2005

Contents of isoflavone, phenolic acids, tocopherol, and anthocyanin in black soybean (Glycine max) were measured by HPLC. To compare antioxidative activities of main black soybean components, antioxidative effects of the same levels of commercial standard components were measured by Trolox equivalent antioxidant capacity assay (TEAC). Most effective component was gentisic acid followed by anthocyanin, p-coumaric acid, ferulic acid, genistein, syringic acid, and daidzein. TEAC assay results revealed genistein in isoflavone, gentisic acid in phenolic acids, p-tocopherol in tocopherol, and anthocyanin showed highest antioxidative and synergistic acitivities, with anthocyanin showing strongest synergy effect.

• Journal of the Korean Society of Food Science and Nutrition
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• v.32 no.1
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• pp.131-136
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• 2003

This research was aimed to evaluate the inhibition of oxidative changes of almond crackers by natural antioxidants (tocopherol, rosemary, and tea polyphenol). Almond crackers stored at $25^{\circ}C$ and 35$^{\circ}C$ for 70 days were evaluated with peroxide value, sensory and kinetic parameters. Results revealed that the antioxidative activity of rosemary was highy effective in inhibiting lipid oxidation at $25^{\circ}C$ and tea Polyphenol highly effective at 35$^{\circ}C$. Sensory evaluation indicated that the properties of odor and taste of almond crackers tended to positive effect with the addition of rosemary and tea polyphenol. Kinetic study in lipid oxidation showed the first order reaction at $25^{\circ}C$ and the zero order reaction at 35$^{\circ}C$. It was found that the kinetic parameter of oxidation reaction predicted for the shelf-life of almond cracker.

• Journal of Acupuncture Research
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• v.23 no.2
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• pp.73-90
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• 2006

Objectives : The effects of water extract of deer antler herbal-acupunture solution(DHS), prepared from the pilose antler of Cervus korea TEMMINCK var. mantchuricus Swinhoe (Nokyong), a traditional immunosuppressive and immune-activating Korean herbal- acupuncture, on collagen-induced arthritis(CIA:RA model) in mice was studied. Destruction of cartilage and bone are hallmarks of human rheumatoid arthritis, and controlling these erosive processes is the most challenging objective in the treatment of RA. Methods : We investigated the tissue protective effects of deer antler treatment using established murine collagen-induced arthritis(CIA) as a model. Potential synergy of low dosages of anti-inflammatory glucocorticosteroids and deer antler was also evaluated. Results : Treatment of established murine CIA with deer antler herbal-acupunture solution(DHS) $(10-50{\mu}g/day)$ suppressed disease activity and protected against cartilage and bone destruction. Although $10-50{\mu}g/day$ DHS had only a moderate effect on the inflammatory component of the disease activity, it strongly reduced cartilage pathology, as determined by histological examination. Serum cartilage oligomeric matrix protein(COMP) levels were significantly reduced, confirming decreased cartilage involvement. Histological analysis showed that bone destruction was prevented. DHS administration increased serum IL-1Ra levels and reduced anticollagen type II antibody levels. Treatment with low-dose $DHS(1{\mu}g/day)$ was ineffective in suppressing disease score, serum COMP or joint destruction. Synergistic suppression of both arthritis oseverity and COMP levels was noted when low-dose DHS was combined with prednisolone(0.05mg/kg/day), however, which in itself was not effective. Conclusion : DHS was shown to have the inhibiting effects against $IL-1{\alpha}-$ and $IL-1{\beta}-stimulated$ bone resorption. These results indicated that the DAS is not only highly stable and applicable to clinical uses in bone resorption, but also it will be served as a potent anti-inflammatory and anti-arthritic agents for treatment of human RA.

• Journal of The Korean Association For Science Education
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• v.33 no.5
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• pp.1021-1040
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• 2013

In order to explore the influences of coteaching through mentoring upon the teaching professionalism of beginning science-gifted education teachers, this case study deeply investigated the change processes in the aspects of pedagogical content knowledge (PCK). Two beginning teachers planned, performed and reflected together their science instructions for science-gifted students in secondary school during four 3-hour classes. Since the second instruction, pre-, during-, and post-mentoring were conducted, we collected various data related to teachers' planning processes, videotaped all coteaching science classes, and wrote field notes. We also recorded in-depth interviews with the teachers and the whole process of mentoring. All the data were analyzed by using the constant comparative method. The results of the analyses indicated that coteaching through mentoring positively changed the teachers' PCK. Above all, we found that coteaching and mentoring strategies generated a significant synergy effect through a mutually complementary relationship. The teachers developed deep practical knowledge about the enrichment curriculum, which placed more emphasis on developing cognitive and/or affective characteristics of science-gifted students. The teachers also improved their knowledge about the characteristics of science-gifted students and the instructional strategies appropriate for developing them. Moreover, practical knowledge about assessment domains and methods used in science-gifted education were improved. Knowledge on science content necessary for effective inquiry instruction was also improved.