• 약학회지
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• 제43권2호
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• pp.221-227
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• 1999

The fungistatic and fungicidal activities of amphotericin B, fluconazole, miconazole, econazole, and 5-fluorocytosine against Saccharomyces cerevisiae were estimated in the presence of 1/2 minimum inhibitory concentration (MIC) and 1/2 minimum fungicidal concentration (MFC) of polygodial, respectively. Among them, the antifungal activities of miconazoles by polygodial was still shown against several yeast-like fungi including Candida albicans, Candida utilis, Cryptococcus neoformans, except for Candida krusei. The combination of polygodial with imidazole drugs against Saccharomyces cerevisiae was further examined using the macrobroth dilution checkerboard method. The fractional inhibitory concentration (FIC) and the fractional fungicidal concentration (FFC) index between polygodial and miconazole were 0.16 and 0.19, while the combination of polygodial with econazole exhibited the FIC index of 0.19 and the FFC of 0.25, respectively. These results suggest that polygodial and the imidazoles on the fungistatic and fungicidal action are highly synergistic.

• 한국에너지공학회:학술대회논문집
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• 한국에너지공학회 1995년도 춘계학술발표회 초록집
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• pp.158-162
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• 1995

Synergistic effects of mixed solvents, especially with mixtures of CS$_2$ with electron donor solvents, in inducing desired structural changes in coals were studied by solvent swelling techniques in addition to differential scanning calorimetric analyses. Mixed solvents exhibit significant synergistic efficacy in swelling the coal structure of medium bituminous rank. This synergy effect appears to be physical origin that is closely related to matching solubility parameters. Since the swollen coal structure can be obtained by mixed solvents with CS$_2$ at room temperature instead of high temperature, many possible technological pathways for economical utilization of coal might be sought.

• Journal of Microbiology and Biotechnology
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• 제20권10호
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• pp.1430-1435
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• 2010

Two angiostatic fusion proteins (hAE and hEA), differing in tandem connection manners, were constructed from human angiostatin (hAS) and endostatin (hES) proteins. These fusion proteins were then evaluated for synergistic antiangiogenic properties. The 65 kDa secreted fusion proteins, expressed in Pichia pastoris, were verified by both mass analysis and Western blotting assay. Luciferase reorter gene assay, using a VEGF promoter, revealed that the angiostatin-endostatin fusion protein (hAE), and its corresponding fusion gene delivery on human microvascular endothelial cells (HMEC-1), resulted in a more potent synergistic antiangiogenic effect than the endostatin-angiostatin fusion protein (hEA). These results suggest that the orientation of the fusion genes in hAS and hES might be an important factor in the development of therapeutic proteins.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.491-497
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• 2003

The use of both an Alpha Hydroxy Acid, Citric Acid, and a Skin Moisturizer, Glycereth-26, formulated into a hand dishwashing detergent have been shown to be synergistic in their effects on certain skin health parameters. Each ingredient was evaluated alone and together in a hand dishwashing detergent via a 9-week use test. Panelists washed dishes using the sponge method commonly used in Asian markets and a 1:7 dilution of the concentrated dish detergent. Panelist's hands were evaluated initially and at 3-week intervals for nine weeks. After nine weeks panelist's hands showed significant improvements in Moisture Absorption and Transepidermal Water Loss (TEWL). A synergistic effect on TEWL was found between the AHA and the Moisturizer. These effects, showing an improvement in the condition of the panelist's skin are impressive, particularly since they were observed from a dishwashing product that is highly diluted and at near neutral pH during the washing process.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book II
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• pp.417-423
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• 2003

The use of both an Alpha Hydroxy Acid, Citric Acid, and a Skin Moisturizer, Glycereth-26, formulated into a hand dishwashing detergent have been shown to be synergistic in their effects on certain skin health parameters. Each ingredient was evaluated alone and together in a hand dishwashing detergent via a 9-week use test. Panelists washed dishes using the sponge method commonly used in Asian markets and a 1:7 dilution of the concentrated dish detergent. Panelist's hands were evaluated initially and at 3-week intervals for nine weeks. After nine weeks panelist's hands showed significant improvements in Moisture Absorption and Transepidermal Water Loss (TEWL). A synergistic effect on TEWL was found between the AHA and the Moisturizer. These effects, showing an improvement in the condition of the panelist's skin are impressive, particularly since they were observed from a dishwashing product that is highly diluted and at near neutral pH during the washing process.

• Fisheries and Aquatic Sciences
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• 제21권7호
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• pp.18.1-18.6
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• 2018

Background: Cutaneous bacterial pathogens including Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Propionibacterium acnes are often involved in acne vulgaris. The currently available therapeutic option for these skin pathogens is an antibiotic treatment, resulting in the emergence of antibiotic-resistant bacteria. The objective of this study was to discover an alternative antibacterial agent with lower side effect from marine algae. Results: The ethanolic extract of edible brown algae Ishige okamurae exhibits potent antibacterial activity against cutaneous bacterial pathogens. Among the ethanol soluble fractions, the n-hexane (Hexane)-soluble fraction exhibited the strongest antibacterial activity against the pathogens with MIC values ranging 64 to $512{\mu}g/mL$ and with minimum bactericidal concentration values ranging 256 to $2048{\mu}g/mL$. Furthermore, the combination with Hexane fraction and antibiotics (ceftazidime, ciprofloxacin, and meropenem) exhibited synergistic effect. Conclusion: This study revealed that the I. okamurae extract exhibited a synergistic antibacterial effect against acnerelated cutaneous bacterial pathogens acquired antibiotic resistant. Thus, the results of the present study suggested that the edible seaweed extract will be a promising antibacterial therapeutic agent against antibiotic-human skin pathogens and its infections.

• 한국지반환경공학회 논문집
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• 제15권7호
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• pp.5-11
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• 2014

본 연구는 UV와 US를 함께 조사하는 UV/US 연계 공정을 통해 발생하는 시너지 효과를 조사하고, 이를 효과적으로 오염물질 처리 공정에 적용 가능한지에 대하여 연구하였다. US를 조사하는 경우에는 $H_2O_2$의 농도가 지속적으로 증가하지만, UV/US를 동시에 조사한 경우 $H_2O_2$의 농도가 증가하는 속도가 점점 감소하여 일정 농도로 수렴하는 포화속도곡선의 경향을 보였으며, US가 단독으로 조사되었을 때 생성된 $H_2O_2$와 UV/US 연계 공정을 통해 생성된 $H_2O_2$와의 차이가 오염물질 제거율 향상에 시너지 효과를 일으킨다고 판단된다. 시너지 효과를 검증하기 위해 인체에 유해한 영향을 미치는 가소제 중 하나인 bis(2-ethylhexyl) phthalate(DEHP)를 이용하여 제거실험을 실시하였다. UV와 US를 동시에 조사하는 UV/US 연계 공정의 경우 DEHP의 제거 유사 일차반응 속도상수(k1)가 $14.81{\times}10^{-3}min^{-1}$로 UV만 조사하는 경우의 $2.60{\times}10^{-3}min^{-1}$과 US만 조사하는 경우의 $10.34{\times}10^{-3}min^{-1}$보다 더 큰 것을 확인하였다. 이를 통해 UV/US 연계 공정에서 DEHP의 제거가 더 활발하게 일어남을 확인하였으며, 이는 시너지 효과에 의한 것이라 판단된다. 또한 DEHP 제거 유사 일차반응 속도상수 값을 이용하여 시너지 효과를 이론적으로 계산한 결과 시너지 효과 값은 1.15로 나타나 기준값인 1보다 큰 값을 가지므로 시너지 효과가 발생했다고 판단된다.

• Weed & Turfgrass Science
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• 제5권3호
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• pp.136-143
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• 2016

본 연구에서는 캐슈넛 오일의 살조활성 특징을 파악하고, 유해조류를 보다 효과적으로 제어할 수 있는 혼합처리제를 개발하기 위하여 실시하였다. 공시된 시험 추출물중 anacardic acid 함량이 상대적으로 높은 Ana-A가 남조류 M. aeruginosa에 대한 살조활성이 가장 높았다. Ana-A는 전체적으로 녹조류보다는 남조류에 대해 더 높은 살조활성을 가지면서 폭넓은 살조활성스펙트럼을 보였다. Ana-A에 대한 남조류 종간 반응에 있어서는 Oscillatoria tenuis ($IC_{50}=0.19{\mu}g\;mL^{-1}$)가 가장 민감하였고, 녹조류 중에서는 Chlorella vulgaris가 상대적으로 가장 민감한 반응을 나타내었다($IC_{50}=4.54{\mu}g\;mL^{-1}$). Ana-A와의 혼합처리를 통해 효능이 상승되는 화합물을 탐색한 결과, MSB와 menadione은 매우 강한 상승작용을, citric acid는 약간의 상승작용을, chrysophanol, copper sulfate, quinoclamine 등은 상가적 작용의 활성을 나타내었다. 종합적으로 볼 때, anacardic acid 고함유 캐슈넛 오일은 처리량의 최적화와 상승작용을 가지는 MSB 또는 menadione과 같은 화합물과의 혼합처리를 통해 M. aeruginosa 및 O. tenuis가 발생하는 현장의 선택적 제어를 위해 환경 친화적인 살조제로서 유용하게 활용될 수 있을 것 같았다.

• Food Science and Biotechnology
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• 제18권5호
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• pp.1263-1272
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• 2009

Danshen (Salvia miltiorrhiza Bunge) is a traditional Korean medicine that is commonly used for the treatment of inflammatory diseases such as edema, arthritis, hepatitis, and endangitis. The several extracts of danshen were tested for antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) isolated in clinic by broth microdilution method, the checkerboard, and time-kill methods to evaluate the synergistic effects of the combination of the extracts with antibiotics. The chloroform ($CHCl_3$) and n-hexane (HEX) extracts [minimum inhibitory concentration (MIC), 0.0078-0.3125${\mu}g/mL$; minimum bactericidal concentration (MBC), 0.019-0.625${\mu}g/mL$] were found to have strong antibacterial activity against MRSA. Additionally, when the $CHCl_3$ and HEX extracts were co-administered with ampicillin or oxacillin, a synergistic effect against MRSA was observed. Furthermore, a time-kill study evaluating the effects of the extracts against MRSA indicated that treatment with the $CHCl_3$ extract in combination with ampicillin or oxacillin produced rapid bactericidal activity. These results suggest that danshen extracts may have potently antimicrobial activity and thus, it can be a suitable phytotherapeutic agent for treating MRSA infections.

• Journal of Electrochemical Science and Technology
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• 제13권1호
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• pp.138-147
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• 2022

The synergistic effect of 2-chloromethylbenzimidazole (2-CBI) and potassium iodide (KI) for mild steel in 1 M hydrochloric acid solution was investigated by potentiodynamic polarization curves and electrochemical impedance spectroscopy (EIS). The results showed that, with the addition of 100 ppm potassium iodide, the inhibition efficiecy (IE) of 100 ppm 2-CBI in 1 M hydrochloric acid had been improved from 91.14% to 96.15%. And synergistic parameter of 100 ppm 2-CBI with different amounts of potassium iodide is always greater than 1. The adsorption of potassium iodide combining with 100 ppm 2-CBI obeys to the Langmuir adsorption isotherm. Thermodynamic adsorption parameters, including ∆G⁰_ads, ∆H_a and ∆S_a of the adsorption of the combinned inhibitor, as well as the E_a of the mild steel corrosion in 1 M HCl with the combinned inhibitor, were calculated.