• Proceedings of the KIEE Conference
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• 1991.11a
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• pp.189-192
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• 1991

This paper presents a modular structure design of analog Hopfield neural network. Each multiplier consists of four MOS transistors which are connected to an op-amp at the front end of a neuron. A pair of MOS transistor is used in order to maintain linear operation of the synapse and can produce positive or negative synaptic weight. This architecture can be expandable to any size neural network by forming tree structure. By altering the connections, other nework paradigms can also be implemented using this basic modules. The stength of this approach is the expandability and the general applicability. The layout design of a four-neuron fully connected feedback neural network is presented and is simulated using SPICE. The network shows correct retrival of distorted patterns.

• Applied Microscopy
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• v.17 no.2
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• pp.41-54
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• 1987

This experiment was performed to investigate the acute and chronic effects of lead on cerebral cortex. In acute treatment, mouse were injected with lead acetate at dose of 0.3 mmole/kg body weight, and in chronic treatment, mouse were supplied 0.03 M lead acetate sol. in the place of water. After treatment, mouse were sacrificed at time intervals of 24, 48, 72, and 96 hours in acute treatment and at time intervals of 4 weeks and 8 weeks in chronic treatment. In acute treatment, acetylcholinesterase activity is reduced at 72 hours and recovered at 96 hours in homogenate, and reduced at 24 hours and recovered at 72 hours in crude synaptosomes. In chronic treatment, acetylcholinesterase activity is increased in young mouse but reduced in mother mouse. Ultrastructural changes were composed of swelling of Golgi apparatus, nerve terminals with diminished synaptic vesicles, and vacuolated myeline lamellae of myelinated axon.

• Korean Journal of Veterinary Research
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• v.11 no.1
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• pp.59-63
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• 1971

Current interest in ${\gamma}$-aminobutyric acid (GABA) has arisen from the convergence of several independent line of investigation leading to the demonstration that this and related substances are normal products of brain metabolism and that GABA has an important physiological action upon brain function as well as upon certain peripheral nervous structures. The interest for neurophysiologists has been enhanced by the importance of the discovery for the role of humoral mediator of synaptic transmission or regulator of neuronal activity in the central nervous system, particularly if it may shed some elight upon the nature of central inhibitory processes. In accordance with such an interest and importance, this work was performed in order to standardize the normal content as a preliminary investigation of so-called night active and daytime active animals GABA content in their brains when they are exposed to light and darkness. The method, through which the estimation has made in this work, was paper chromatographic method developed by Maynert and Klingman for the estimation of GABA content in animal tissues. The results obtained are summerized as follows: 1) GABA content in the cerebral cortex of house rat ranged from 90 to $310{\mu}g/gm$ of wet weight. 2) The content of GAGA ranging from 130 to $510{\mu}g/gm$ of wet weight was occurred from midbrain of the rat. 3) GABA content was ranged from 30 to $150 {\mu}g/gm$ of wet weight of the rat cerebellum. 4) The contents of fowl cerebral cortex, midbrain, and cerebellum are estimated as ranging 230-590, 250-620, $50-280{\mu}g/gm$ of wet weight, respectively. As a result, it may be concluded that among three brain tissues of both animals the midbrain is the highest region in GABA content. Fowl brain, on the other side, contains more higher GABA content than the house rat brain does.

• JSTS:Journal of Semiconductor Technology and Science
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• v.14 no.3
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• pp.356-363
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• 2014

In this paper, we propose a new memristor-based crossbar array architecture, where a single memristor array and constant-term circuit are used to represent both plus-polarity and minus-polarity matrices. This is different from the previous crossbar array architecture which has two memristor arrays to represent plus-polarity and minus-polarity connection matrices, respectively. The proposed crossbar architecture is tested and verified to have the same performance with the previous crossbar architecture for applications of character recognition. For areal density, however, the proposed crossbar architecture is twice better than the previous architecture, because only single memristor array is used instead of two crossbar arrays. Moreover, the power consumption of the proposed architecture can be smaller by 48% than the previous one because the number of memristors in the proposed crossbar architecture is reduced to half compared to the previous crossbar architecture. From the high areal density and high energy efficiency, we can know that this newly proposed crossbar array architecture is very suitable to various applications of analog neuromorphic computing that demand high areal density and low energy consumption.

• Proceedings of the KIEE Conference
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• 1993.07a
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• pp.254-257
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• 1993

This paper presents a new method to implement Hebbian learning method on artificial neural network. In hebbian learning algorithm, complexity in terms of multiplications is high. To save the chip area, we consider a new learning circuit. By calculating similarity, or correlation between $X_i$ and $O_i$, large portion of circuits commonly used in conventional neural networks is not necessary for this new hebbian learning circuit named COR. The output signals of COR is applied to weight storage capacitors for direct control the voltages of the capacitors. The weighted sum, ${\Sigma}W_{ij}O_j$, is realized by multipliers, whose output currents are summed up in one line which goes to learning circuit or output circuit. The drain current of the multiplier can produce positive or negative synaptic weights. The pass transistor selects eight learning mode or recall mode. The layout of an learnable six-neuron fully connected Hopfield neural network is designed, and is simulated using PSPICE. The network memorizes, and retrieves the patterns correctly under the existence of minor noises.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.23 no.2
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• pp.93-98
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• 2012

Botulinum toxins are the most potent toxins known to mankind. Botulinum toxin acts by blocking the cholinergic neuromuscular or the cholinergic autonomic innervation of exocrine glands and smooth muscles. Seven distinct antigenic botulinum toxins (A, B, C, D, E, F and G) produced by different strains of Clostridium botulinum have been described and only A and B type of botulinum toxins were clinically used. Toxins were consisted of a heavy chain with a molecular weight of 100 kD and a light chain with a molecular weight of 50 kD. Toxins are bound with an astounding selectivity to glycoprotein structures located on the cholinergic nerve terminal. Subsequently light chain of toxin is internalized and cleaves different proteins of the acetylcholine transport protein cascade transporting the acetylcholine vesicle from the intracellular space into the synaptic cleft. After a decade of therapeutic application of the toxin, no anaphylaxis or deaths have been reported and systemic adverse effects have not been reported so far. However the toxin's immunologic properties can lead to the stimulation of antibody production, potentially rendering further treatments ineffective. Botulinum toxin is a safe and effective treatment. Use of botulinum toxin in clinical medicine has grown exponentially in recent years, and many parts of the human body are now being targeted for therapeutic purposes.

• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.8
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• pp.49-58
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• 2015

A floating type of memristor emulator which acts like the behavior of $TiO_2$ memristor has been developed. Most of existing memristor emulators are grounded type which is built disregarding the connectivity with other memristor or other devices. The developed memristor emulator is a floating type whose output does not need to be grounded. Therefore, the emulator is able to be connected with other devices and be utilized for the interoperability test with various other circuits. To prove the floating function of the proposed memristor emulator, a Wheatstone bridge is built by connecting 4 memristor emulators in series and parallel. Also this bridge circuit suggest that it is possible to weight calculation of the neural network synapse.

• The Korean Journal of Physiology and Pharmacology
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• v.14 no.2
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• pp.113-118
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• 2010

The sensory system is developed and optimized by experiences given in the early phase of life in association with other regions of the nervous system. To date, many studies have revealed that deprivation of specific sensory experiences can modify the structure and function of the central nervous system; however, the effects of sensory overload remains unclear. Here we studied the effect of overloading the taste sense in the early period of life on the synaptic plasticity of rat hippocampus and somatosensory cortex. We prepared male and female Sprague Dawley rats with ad libitum access to a 0.1% saccharin solution for 2 hrs per day for three weeks after weaning on postnatal day 22. Saccharin consumption was slightly increased in males compared with females; however, saccharin intake did not affect chow intake or weight gain either in male or in female rats. We examined the effect of saccharin-intake on long term potentiation (LTP) formation in hippocampal Schaffer collateral pathway and somatosensory cortex layer IV - II/III pathways in the 6-week old saccharin-fed rats. There was no significant difference in LTP formation in the hippocampus between the control group and saccharin-treated group in both male and female rats. Also in the somatosensory cortex, we did not see a significant difference in LTP among the groups. Therefore, we conclude that saccharin-intake during 3~6 weeks may not affect the development of physiological function of the cortical and hippocampal synapses in rats.

• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.4
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• pp.80-87
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• 2015

Memristor is a new kind of memory device whose resistance varies depending upon applied charge and whose previous resistance state is preserved even when its power is off. Ordinary memristor has a nonlinear programming characteristics about time when a constant voltage is applied. For the easiness of programming, it is desirable that resistance is programmed linearly about time. We had proposed previously a memristor bridge configuration with which weight can be programmed nicely in positive, negative or zero. In memristor bridge circuit, two memristors are connected in series with different polarity. Memristors are complementary each other and it follows that the memristance variation is linear with respect to time. In this paper, the linearization effect of weight programming of memristor bridge synapse is investigated and verified about both $TiO_2$ memristor from HP and a nonlinear memristor with a window function. Memristor bridge circuit would be helpful to conduct synaptic weight programming.

• Journal of Microbiology and Biotechnology
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• v.28 no.5
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• pp.679-687
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• 2018

Korean red pine (Pinus densiflora) is one of the major Pinus species in Korea. Red pine bark is removed prior to the chipping process in the wood industry and discarded as waste. However, red pine bark contains a considerable amount of naturally occurring phenolics, including flavonoids, and therefore may have a variety of biological effects. In this study, we investigated if Korean red pine bark extract (KRPBE) could protect neuronal PC-12 cells from oxidative stress and inhibit cholinesterase activity. Analysis of reversed-phase high-performance liquid chromatography results revealed four phenolics in KRPBE: vanillin, protocatechuic acid, catechin, and taxifolin. The total phenolic and flavonoid contents of KRPBE were 397.9 mg gallic acid equivalents/g dry weight (DW) and 248.7 mg catechin equivalents/g DW, respectively. The antioxidant capacities of KRPBE measured using ABTS, DPPH, and ORAC assays were 697.3, 521.8, and 2,627.7 mg vitamin C equivalents/g DW, respectively. KRPBE and its identified phenolics protected against $H_2O_2$-induced oxidative cell death in a dose-dependent manner. Acetylcholinesterase and butyrylcholinesterase, which degrade the neurotransmitter acetylcholine to terminate neurotransmission in synaptic clefts, were inhibited by treatment with KRPBE and its identified phenolics. Taken together, these results suggest that KRPBE and its constituent antioxidative phenolics are potent neuroprotective agents that can maintain cell viability under oxidative stress and inhibit cholinesterase activity.