• Journal of Gastric Cancer
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• 제15권2호
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• pp.87-104
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• 2015

Purpose: To assess real-world treatment patterns, health care utilization, costs, and survival among Medicare enrollees with locally advanced/unresectable or metastatic gastric cancer receiving standard first-line chemotherapy. Materials and Methods: This was a retrospective analysis of the Surveillance, Epidemiology, and End Results-Medicare linked database (2000~2009). The inclusion criteria were as follows: (1) first diagnosed with locally advanced/unresectable or metastatic gastric cancer between July 1, 2000 and December 31, 2007 (first diagnosis defined the index date); (2) ${\geq}65$ years of age at index; (3) continuously enrolled in Medicare Part A and B from 6 months before index through the end of follow-up, defined by death or the database end date (December 31, 2009), whichever occurred first; and (4) received first-line treatment with fluoropyrimidine and/or a platinum chemotherapy agent. Results: In total, 2,583 patients met the inclusion criteria. The mean age at index was $74.8{\pm}6.0years$. Over 90% of patients died during follow-up, with a median survival of 361 days for the overall post-index period and 167 days for the period after the completion of first-line chemotherapy. The mean total gastric cancer-related cost per patient over the entire post-index follow-up period was United States dollar (USD) $70,808{\pm}56,620$. Following the completion of first-line chemotherapy, patients receiving further cancer-directed treatment had USD 25,216 additional disease-related costs versus patients receiving supportive care only (P<0.001). Conclusions: The economic burden of advanced gastric cancer is substantial. Extrapolating based on published incidence estimates and staging distributions, the estimated total disease-related lifetime cost to Medicare for the roughly 22,200 patients expected to be diagnosed with this disease in 2014 approaches USD 300 millions.

• 한국임상수의학회지
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• 제36권1호
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• pp.15-22
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• 2019

Highly pathogenic avian influenza (HPAI) is among the top infectious disease priorities in Korea and the leading cause of economic loss in relevant poultry industry. An understanding of the spatial epidemiology of HPAI outbreak is essential in assessing and managing the risk of the infection. Though previous studies have reported the majority of outbreaks occurred clustered in what are preferred to as densely populated poultry regions, especially in southwest coast of Korea, little is known about the spatial distribution of risk areas vulnerable to HPAI occurrence based on geographic information system (GIS). The main aim of the present study was to develop a GIS-based risk index model for defining potential high-risk areas of HPAI outbreaks and to explore spatial distribution in relative risk index for each 252 Si-Gun-Gu (administrative unit) in Korea. The risk index was derived incorporating seven GIS database associated with risk factors of HPAI in a standardized five-score scale. Scale 1 and 5 for each database represent the lowest and the highest risk of HPAI respectively. Our model showed that Jeollabuk-do, Chungcheongnam-do, Jeollanam-do and Chungcheongbuk-do regions will have the highest relative risk from HPAI. Areas with risk index value over 4.0 were Naju, Jeongeup, Anseong, Cheonan, Kochang, Iksan, Kyeongju and Kimje, indicating that Korea is at risk of HPAI introduction. Management and control of HPAI becomes difficult once the virus are established in domestic poultry populations; therefore, early detection and development of nationwide monitoring system through targeted surveillance of high-risk spots are priorities for preventing the future outbreaks.

• 수산해양기술연구
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• 제59권4호
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• pp.362-376
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• 2023

The IUU Fishing Index is composed of 40 indicators. These indicators were grouped by state responsibilities (flag, coastal, port, and general including market) defined in the FAO IPOA-IUU (2001) and then by type into vulnerability, prevalence, and response. A total of 152 coastal nations was surveyed. Korea's total combined IUU Fishing Index was 2.49 in 2019 and 2.91 in 2021, indicating a drop in the ranking to the third worst out of 152 countries followed by China and Russia in 2021. The indicators that increased the IUU fishing risk in 2021 compared to 2019 included seven indicators of prevalence and two indicators of response while those reducing the risk included one prevalence and one response indicator. The IUU Fishing Index revealed that many fisheries observers and monitoring, control and surveillance (MCS) practitioners active in the waters of RFMOs jurisdiction where Korean distant water vessels operate have mentioned concerns about the compliance with RFMO conservation measures or fishing practices. It suggested that strengthening management intervention in the fishing sector is needed. The primary tool for management is the MCS system. Given the logistical difficulty of oversight from land, air and at-sea, there is a need to enhance MCS strategies through logbook data, at-sea observer and electronic monitoring program. It also suggested that MSC fisheries certification and fisheries improvement projects, which are widely used for improving fishing sector performance, could contribute to the eradication of IUU fishing and the promotion of sustainable distant water fisheries.

• Clinical Nutrition Research
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• 제12권2호
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• pp.116-125
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• 2023

The present study sought to examine the association between an infant's anthropometric outcomes with maternal Dietary Inflammatory Index (DII) and Alternate Healthy Eating Index for Pregnancy (AHEI-P) scores during the third trimester of pregnancy. This prospective cohort study was applying 130 pregnant women, at the pregnancy training center in west Tehran, Iran (November 2020 to July 2021). The maternal dietary intake, and body mass index (BMI), and social economic level were evaluated. The data about birth weight, birth height, head circumference, and, gestational age at birth were extracted from each child's health records. The ultimate sample included 122 (93.8%) pairs of women/newborn children. The participants, mean age was 28.13 ± 4.66 years with gestational age between 28 to 40 weeks and the mean of BMI was 24.62 ± 3.51. Our outcomes, after adjustment for confounding factors, suggested that those newborn infants in the highest quartile of maternal DII score had a significantly lower weight (p < 0.001) and height (p = 0.05), in comparison to those in the lowest quartile, but not head circumference (p = 0.18). Moreover, after adjustment for confounding factors, results suggested that those newborn infants in the First quartile of maternal AHEI-P score had a significantly lower weight (p = 0.018) and, in comparison to those in the higher quartile. It appears that newborn infants with lower maternal DII and higher AHEI-P scores may have a better anthropometric outcome. Further longitudinal and in-depth qualitative and quantitative studies, with a longer-term follow-up, is warranted to support the integrity of our outcomes.

• Clinical and Experimental Pediatrics
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• 제51권9호
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• pp.950-955
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• 2008

목 적 : 새로 제정되어 발표된 '2007 소아청소년 성장도표'의 비만기준에 따라 우리나라 소아청소년의 과체중 및 비만 유병 현황과 추세를 분석하였다. 방 법 : '2005년도 소아청소년 신체발육 및 혈압표준치 제정사업'과 '1997년 소아청소년 발육표준치 측정조사' 자료를 이용하여 '2007년 한국 소아청소년 성장도표'의 연령별 체질량지수 95백분위수 이상이거나 성인의 비만 기준인 체질량지수 $25kg/m^2$ 이상인 경우는 백분위수와 무관하게 비만으로 정의하였다. 과체중은 연령별 체질량지수가 85백분위수 이상에서 95백분위수 미만인 경우로 정의하였다. 결 과 : 소아청소년(2-18세)의 비만 유병률은 전체 9.7%, 남아 11.3%, 여아 8.0%로 남아의 유병률이 더 높았다. 1997년에 비해 전체 1.7배(1997년 5.8%에서 9.7%) 증가하였으며 이러한 경향은 여아(1.5배, 1997년 5.5%에서 2005년 8.0%)보다 남아(1.9배, 1997년 6.1%에서 2005년 11.3%)에서 뚜렷하였다. 과체중 및 비만 유병률은 전체 19.0%, 남아 19.7%, 여아 18.2%였으며, 1997년과 비교 시 전체 1.5배(1997년 13.0%에서 2005년 19.0%), 남아 1.6배(1997년 12.4%에서 2005년 19.7%), 여아 1.3배(1997년 13.8%에서 2005년 18.2%) 증가하였다. 결 론 : 소아청소년의 과체중 및 비만은 지속적으로 증가하는 추세이며 특히 남아는 중.고등학교, 여아는 초.중학교 재학연령에서 뚜렷하였다. 이 시기의 소아청소년의 과체중 및 비만 유병 증가와 관련된 요인에 관한 후속연구가 수행되고, 이 결과에 근거하여 비만 예방 및 관리를 위한 방안을 마련하는 것이 필요하다.

• 재무관리연구
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• 제24권3호
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• pp.91-131
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• 2007

본 연구는 한국유가증권시장에서 사이드카가 차익거래와 비차익거래 종목의 주가, 변동성, 그리고 유동성에 미치는 영향을 분석하였다. 선물시장의 급등락으로부터 현물시장을 보호하려는 목적을 갖는 사이드카는 현재 모든 프로그램매매를 대상으로 하고 있으나, 현재의 제도가 바람직한지에 대해서는 논란의 여지가 있다. 사이드카가 프로그램매매 유형별로 차별적인 효과를 갖는지를 검증하기 위해 프로그램매매를 지수차익거래와 비차익거래로 나누어 사이드카가 주가, 변동성, 그리고 유동성에 미치는 영향을 분석한 결과는 사이드카가 지수차익거래와 비차익거래에 미치는 영향에 뚜렷한 차이가 없음을 보인다. 보다 구체적인 분석을 위해 가상사이드카 표본을 구성하고 실제사이드카와 가상사이드카가 차익거래와 비차익거래에 미치는 효과를 분석하였다. 가상사이드카를 이용한 분석결과는 앞서의 결과가 사이드카 발동이라는 특별한 상황의 발생전후에 시장의 주문이 한 방향으로 몰리는 일시적인 현상에 의해 부분적으로 설명될 수 있음을 보여주며, 사이드카 발동은 비차익거래에 비해 차익거래에 상대적으로 큰 영향을 미치고 비차익거래는 큰 영향을 받지 않음을 보여준다. 이는 비차익거래까지를 포함하는 모든 프로그램매매를 적용대상으로 하는 한국유가증권시장의 사이드카 제도에 대한 재검토가 필요함을 말해주는 것이다.

• 응용통계연구
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• 제23권2호
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• pp.219-234
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• 2010

시가총액에 따른 인덱스(INDEX) 투자를 했을 경우에, VaR(Value at Risk)을 종합주가지수(KOSPI)로부터 얻은 수익율의 극단 손실값들로부터 추정한다. 이를 위해, 극단값 이론 중 BM(Block Maxima) 모형을 적용하며, 극단 손실값들의 비독립적 발생을 고려하기 위하여, extremal index 역시 추정한다. 모형의 타당성을 알아보기 위해, 실패율방법을 이용한 사후검정 (back-testing) 을 실시한다. 사후검정을 통해, BM 모형을 적용한 VaR의 추정이 적절함을 알 수 있었다. 또한, 일반적으로 많이 사용되는 GARCH 모형을 이용한 VaR의 추정과 비교한다. 이를 통해, 오차가 t-분포를 따른다고 가정하는 경우, GARCH 모형을 이용한 VaR의 추정이 BM 모형을 이용한 경우와 사후 검정결과에 차이가 없음을 확인하였다. 그러나, GARCH 모형을 통한 VaR 추정은 추정시점근방의 극단 손실값들에 민감하게 반응하지만, BM 모형은 그렇지 않았다. 따라서, 현 시점으로부터 단기간동안의 손실위험은 GARCH 모형을 이용한 VaR의 추정값을 사용하는 것이 적절하며, 장기간동안의 손실위험은 BM 모형으로부터 얻은 VaR의 추정값을 사용하는 것이 적절하다.

• Journal of Korean Neurosurgical Society
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• 제65권2호
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• pp.297-306
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• 2022

Objective : Intracranial atypical meningiomas have a poor prognosis and high rates of recurrence. Moreover, up to one-third of the recurrences undergo high-grade transformation into malignant meningiomas. We aimed to investigate the clinical factors that can predict the propensity of malignant transformation from atypical to anaplastic meningiomas. Methods : Between 2001 and 2018, all patients with atypical meningioma, in whom the tumors had undergone malignant transformation to anaplastic meningioma, were included. The patients' medical records documenting the diagnosis of atypical meningioma prior to malignant transformation were reviewed to identify the predictors of transformation. The control group comprised 56 patients with atypical meningiomas who were first diagnosed between January 2017 and December 2018 and had no malignant transformation. Results : Nine patients in whom the atypical meningiomas underwent malignant transformation were included. The median time interval from diagnosis of atypical meningioma to malignant transformation was 19 months (range, 7-78). The study group showed a significant difference in heterogeneous enhancement (77.8% vs. 33.9%), bone invasion (55.6% vs. 12.5%), mitotic index (MI; 14.8±4.9 vs. 3.5±3.9), and Ki-67 index (20.7±13.9 vs. 9.5±7.1) compared with the control group. In multivariate analysis, increased MI (odds ratio, 1.436; 95% confidence interval, 1.127-1.900; p=0.004) was the only significant factor for predicting malignant transformation. Conclusion : An increased MI within atypical meningiomas might be used as a predictor of malignant transformation. Tumors at high risk for malignant transformation might require more attentive surveillance and management than other atypical meningiomas.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.607-611
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• 2015

Background: Chronic respiratory disease is an important factor for development of lung cancer. To explore the influence of hazy weather on respiratory diseases and its variation the present study was conducted. Materials and Methods: Data from air pollution surveillance from January to October 2014 and case records of visiting patients in the $263^{th}$ Hospital of Chinese PLA in the corresponding period were collected to analyze the relevance between different degrees of air pollution (hazy weather) and the number of visiting patients in Department of Respiratory Disease. Results: Air quality index (AQI) of hazy weather had significantly positive association with particulate matter 2.5 ($PM_{2.5}$) and the number of patients with 5 kinds of respiratory diseases i and different pollutants had distinct influences on various respiratory diseases. Conclusions: The degree of air pollution in Beijing City is in close association with the number of patients with respiratory diseases, in which $PM_{2.5}$ and $SO_2$ are in more significant influences on all respiratory diseases. This could have essential implications for lung cancer development in China.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제14권3호
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• pp.1043-1064
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• 2020

A kind of Subjective Imaging Effect Assessment (SIEA) method and its applications on intelligent imaging terminal design in engineering site are presented. First, some visual assessment indices are used to characterize the imaging effect: the image brightness, the image brightness uniformity, the color image contrast, the image edge blur, the image color difference, the image saturation, the image noise, and the integrated imaging effect index. A linear weighted function is employed to carry out the SIEA computation and the Analytic Hierarchy Process (AHP) technique is used to estimate its weights. Second, a SIEA software is developed. It can play images after the settings of assessment index or assessment reaction time, etc. Third, two cases are used to illustrate the application effects of proposed method: the image enhancement system design for surveillance camera and the imaging environment perception system design for intelligent lighting terminal. A Prior Sequential Stimulus (PSS) experiment is proposed to improve the evaluation stability of SIEA method. Many experiment results have shown the proposed method can realize a stable system design or parameters setting for the intelligent imaging terminal in engineering site.