• Journal of the Korea Convergence Society
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• v.9 no.11
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• pp.209-216
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• 2018

This study aimed to investigate the association of the muscle activity around the neck of the operator(dental hygienists') according to the change in the patient's neck angle during a direct visual inspection on the maxillary right-side molar palatal surface. The operators were $4^{th}$ year dental hygiene students, who are future dentalhy gienists, having accurate understanding on and awareness of the location of the operation site, hand fixation, and how to use the tools. Data on the change in the muscle activity around the neck were collected by using surface electromyography and neck goniometer. SPSS statistics 20 was used for statistical analyses including Shapiro-wilk test and one-way ANOVA. As a result, the activities of the operator upper trapezius, cervical erector spinae, and levator scapulae muscles significantly decreased when the patient's head was angled compared to when it was not. For the angle of the operator head, the head bend significantly decreased when the patient's head was angled than when it was not. Based on the study results, it is expected that angling the patient's head when treating his or her teeth will decrease the excessive muscle activity around the neck of the operator, and will reduce muscle fatigue. Therefore, angling the head of the patient while treating his or her teeth is recommended. This suggests that muscle pain caused by repetitive actions in the wrong posture can be reduced.

• Journal of Mechanical Science and Technology
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• v.17 no.10
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• pp.1475-1484
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• 2003

The EDM processing characteristics of one of the nickel-based heat resistant alloys, Hastelloy- X, were investigated under the various EDM conditions and analyzed in terms of surface integrity. This alloy is commonly used as a material for the hot gas path component of gas turbines and it is difficult to machine by conventional machining methods. The primary EDM parameter which was varied in this study were the pulse-on time. Since the pulse-on time is one of the main factors that determines the intensity of the electrical discharge energy, it was expected that the machining ratio and the surface integrity of the specimens would be proportionally dependent on the pulse-on duration. However, experimental results showed that MRR (material removal rate) and EWR (electrode wear rate) behaved nonlinearly with respect to the pulse duration, whereas the morphological and metallurgical features showed rather a constant trend of change by the pulse duration. In addition the heat treating process affected the recast layer and HAZ to be recrystallized but softening occurred in recast layer only. A metallurgical evaluation of the microstructure for the altered material zone was also conducted.

• Journal of Korea Society of Industrial Information Systems
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• v.16 no.3
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• pp.65-72
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• 2011

Multi-touch display system has recently attracted world wide attention due to easy accessibility to the various interactive media without any specialized equipments. Especially, Microsoft Sphere(R) shows a considerable promise in treating non-fiat multi-touch display. The distinctive feature of the system is a stable multi-touch interaction on a spherical display. To extend the possibility of the interactions to the more various display surfaces, this paper propose a multi-touch interaction system in the circumstance of the irregular convex surface. The proposed method can be used efficiently in various tangible interface, for example, the interactive diorama system at the exhibition or the tangible arcade game.

• Natural Product Sciences
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• v.23 no.1
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• pp.9-15
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• 2017

DF formula is comprised of three traditional herbs, Ephedra intermedia, Rheum palmatum and Lithospermum erythrorhizon, and locally used for treating of the metabolic diseases, such as obesity and diabetes in Korea. We tried to optimize the extraction conditions of two major components, (-)-ephedrine and (+)-pseudoephedrine, in DF formula using response surface methodology with Box-Behnken design (BBD). The experimental conditions with 70% for EtOH concentrations, 4.8 hour for extraction hours and 8.7 times for the solvent to material ratio were suggested for the optimized extraction of DF formula with the highest amounts of (-)-ephedrine and (+)-pseudoephedrine in the designed model.

• Journal of the Korean Society of Clothing and Textiles
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• v.20 no.5
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• pp.728-737
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• 1996

The purpose of this study is to investigate the change of the chemical properties of wool treated with six kinds of alkali (NaOH, Naac03, NH40H, NH2CH3CH30H, TMAH and BTMAH) with or without CTAB. Content of bound fatty acid liberated from wool surface, elemental composition and allw6rden time were measured to compare the surface modification of untreated and alkali treated wool. Also, the chemical degradation of the fiber was investigated by measuring cystine contents and urea-hydrogensulfite solubility. The result were as follows: 1. By the alkali treatment of wool, the covalently bound fatty acid of the epicuticle was removed and the allworden time was shortened, and in the case of wool treated with TMAH, BTMAH, the allw6rden sacs were formed unevenly and rarely. Also, cystine contents and urea-hydrogensulfite solubility were decreased by alkali treatment on wool. 2. The modification of epicuticle and the chemical degradation of wool were occurred due to alkaline hydrolysis in the order of TMAH, BTMAH > NaOH, Na3c03> NH2CH3CHaOH, NH40H. 3. As a treating time increased, the modification of epicuticle and chemical degradation of wool were accelerated. By the addition of CTAB to the alkali solution, the modification of epicuticle was increase, and the cystine contents and urea-hydrogensulfite solubility were reduced than that of wool teated with alkli without CTAB due to reduction of negative charge on the wool surface by the adhesion of CTAB.

• Bulletin of the Society of Naval Architects of Korea
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• v.24 no.2
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• pp.47-54
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• 1987

Linear and nonlinear hydrodynamic force, which acts on submerged circular and eilliptic cylinders in oscillations as well as in advancing motion, are investigated as an initial-boundary value problem using a numerical method, which makes use of the source distribution on the body surface and the spectral method for treating the free surface waves. In the numerical code developed here, the boundary condition at the body surface is linearized. Using the numerical code so attained, nonlinear effects for different forward speeds and of the large-amplitude motion are computed. One of the major findings is that, when the forward speed is large, the added mass has its minimum and the damping force change rapidly around the frequency corresponding to the speed-frequency parameter, $\tau$=0.25, Compared to the result of Grue's [10], who used linear theory to get abrupt changes in values of the added mass and the damping force at the frequency corresponding to $\tau$=0.25, the present study, which takes nonlinear effects into account, shows much smoother variations near the frequency.

• Biomolecules & Therapeutics
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• v.27 no.1
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• pp.78-84
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• 2019

Cell therapeutic agents for treating degenerative brain diseases using neural stem cells are actively being developed. However, few systems have been developed to monitor in real time whether the transplanted neural stem cells are actually differentiated into neurons. Therefore, it is necessary to develop a technology capable of specifically monitoring neuronal differentiation in vivo. In this study, we established a system that expresses cell membrane-targeting red fluorescent protein under control of the Synapsin promoter in order to specifically monitor differentiation from neural stem cells into neurons. In order to overcome the weak expression level of the tissue-specific promoter system, the partial 5' UTR sequence of Creb was added for efficient expression of the cell surface-specific antigen. This system was able to track functional neuronal differentiation of neural stem cells transplanted in vivo, which will help improve stem cell therapies.

• The Journal of Korean Society for Radiation Therapy
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• v.18 no.1
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• pp.21-28
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• 2006

Purpose: The purpose of this study is to find a optimal beam spoiler condition on the dose distribution near the surface, when treating a squamous cell carcinoma of the head and neck and a lymphatic region with 10 MV photon beam. The use of a optimal spoiler allows elivering high dose to a superficial tumor volume, while maintaining the skin-sparing effect in the area between the surface to the depth of 0.4 cm. Materials and Methods: The lucite beam spoiler, which were a tissue equivalent, were made and placed between the surface and the photon collimators of linear accelerator. The surface-dose, the dose at the depth of 0.4 cm, and the maximum dose at the dmax were measured with a parallel-plate ionization chamber for $5{\times}5cm\;to\;30{\times}30cm^2$ field sizes using lucite spoilers with different thicknesses at varying skin-to-spoiler separation (SSS). In the same condition, the dose was measured with bolus and compared with beam spoiler. Results: The spoiler increased the surface and build-up dose and shifted the depth of maximum dose toward the surface. With a 10 MV x-ray beam and a optimal beam spoiler when treating a patient, a similer build-up dose with a 6 MV photon beam could be achieved, while maintaining a certain amount of skin spring. But it was provided higher surface dose under SSS of less than 5 cm, the spoiler thickness of more than 1.8 cm or more, and larger field size than $20{\times}20cm^2$ provided higher surface dose like bolus and obliterated the spin-sparing effect. the effects of the beam spoiler on beam profile was reduced with increasing depths. Conclusion: The lucite spoiler allowed using of a 10 MV photon beam for the radiation treatment of head and neck caner by yielding secondary scattered electron on the surface. The dose at superficial depth was increased and the depth of maximum dose was moved to near the skin surface. Spoiling the 10 MV x-ray beam resulted in treatment plans that maintained dose homogeneity without the consequence of increased skin reaction or treat volume underdose for regions near the skin surface. In this, the optimal spoiler thickeness of 1.2 cm and 1.8 cm were found at SSS of 7 cm for $10{\times}10cm^2$ field. The surface doses were measured 60% and 64% respectively. In addition, It showed so optimal that 94% and 94% at the depth of 0.4 cm and dmax respectively.

• Molecules and Cells
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• v.43 no.4
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• pp.384-396
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• 2020

Breast cancer is one of the most common life-threatening malignancies and the top cause of cancer deaths in women. Although many conventional therapies exist for its treatment, breast cancer still has many handicaps to overcome. Cancer stem cells (CSCs) are a well-known cause of tumor recurrences due to the ability of CSCs for self-renewal and differentiation into cell subpopulations, similar to stem cells. To fully treat breast cancer, a strategy for the treatment of both cancer cells and CSCs is required. However, current strategies for the eradication of CSCs are non-specific and have low efficacy. Therefore, surface biomarkers to selectively treat CSCs need to be developed. Here, 34 out of 641 surface biomarkers on CSCs were identified by proteomic analysis between the human breast adenocarcinoma cell line MCF-7 and MCF-7-derived CSCs. Among them, carcinoembryonic antigen-related cell adhesion molecules 6 (CEACAM6 or CD66c), a member of the CEA family, was selected as a novel biomarker on the CSC surface. This biomarker was then experimentally validated and evaluated for use as a CSC-specific marker. Its biological effects were assessed by treating breast cancer stem cells (BCSCs) with short hairpin (sh)-RNA under oxidative cellular conditions. This study is the first to evaluate the biological function of CD66c as a novel biomarker on the surface of CSCs. This marker is available as a moiety for use in the development of targeted therapeutic agents against CSCs.

• The Journal of Korean Physical Therapy
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• v.25 no.1
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• pp.16-22
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• 2013

Purpose: This study evaluated the validity of measuring paravertebral muscle function with 3D-NEWTON (Hanmed, Korea) by assessing the correlation between Biodex (Biodex, USA) and surface electromyography (EMG). Methods: Nineteen healthy adults participated. The function of their paravertebral muscle was measured in three ways. Maximum endurance time was measured in seconds when 3D-NEWTON was inclined forward for assessing extensor function, and inclined backward for assessing flexor function. Using surface EMG, maximum muscle activity was obtained from the eractor spinae and rectus abdominis during the 3D-NEWTON measurement. Maximum muscle activity was the mean activity from 10 seconds when the root mean squared firing data was highest. Through Biodex the peak torques of the extensor and flexor were measured during isometric exercises. The Spearman correlation coefficiencts from 3D-NEWTON, surface EMG, and Biodex were calculated. Results: The data from surface EMG and Biodex were statistically correlated when measured for flexor function, but less so for extensor function. In the case of 3D-NEWTON, the correlation coefficient with Biodex was 0.50 (p=0.05), while the coefficient with surface EMG was 0.53 (p=0.02) when measured for extensor function. Similarly, the correlation coefficienct with Biodex was 0.60 (p=0.01), while the surface EMG was 0.51 (p=0.03) for flexor function. Conclusion: 3D-NEWTON was a useful method for measuring paravertebral muscle function and can give helpful information for treating people with diseases associated with the lumbar spine.