• Archives of Pharmacal Research
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• v.9 no.3
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• pp.145-152
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• 1986

Magnetically reponsive gelatin microspheres for the targeting of drugs have been prepared using a water-in-oil emulsion technique with chemical cross-linking of the protein. The manufacturing variables affecting microsphere size, size distribution and surface characteristics have been examined as well as the magnetic responsiveness in vitro. Sesame oil was utilized for non-aqueous phase and magentic gelatin microspheres of different size from 1. 89 to 14.88 $\mu\textrm{m}$ in mean diameter could be obtained with variation of HLB values of non-ionic surfactants. The content of magnetite which uniformly distributed throughout the microspheres was 26.7% (w/w). It was possible to control the localization of magnetic gelatin microspheres at specific sites within capilary models by using external magnetic field of under 5K gauss.

• Korean Journal of Optics and Photonics
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• v.11 no.6
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• pp.395-399
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• 2000

In white light interferometry, fast and accurate localization of the fringe visibility is the most essential part in application of the principle. So much attention has been concentrated on speeding up the process, we in this study decided to investigate the results of the various peak-finding algorithms. Of the many approaches, two most simplistic algorithms were selected for their straightforwardness and robustness. Both were equally accurate in measuring the step height of a sample, but the method based on the weighted average technique proved to be truer to the surface topography. A model explaining the shortcomings of the correlation technique is presented. ented.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1993.10a
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• pp.570-574
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• 1993

This paper proposes a new method of estimating the position and heading angle of a mobile robot moving on a flat surface. The proposed localization method utilizes two passive beacons and a single rotating ultrasonic sensor. The passive beacons consist of two cylinders with different diameters and reflect the ultrasonic pulses coming from the sonar sensor mounted on the mobile robot. The geometric parameter set of beacon is acquired from the sonar scan data obtained at a single mobile robot location using a new data processing algorithm. Form this parameter set, the position and heading angle of the mobile robot is determined directly. The performance and validity of the proposed method are evaluated using two beacons and a single sonar sensor attached at the pan-tilt device mounted on a mobile robot, named LCAR, in our laboratory.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1996.04a
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• pp.778-782
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• 1996

By the use of a similar numerical method as that in the previous paper, the forming limit strain of bonded sheet metals is investigated, in which the FEM is applied and J2G(J2-Gotoh's corner theory) is utilized as the plasticity constitutive equation. Bonded two-layer sheets and sheets bonded with dissimilar sheets on both surface planes are stretched in a plane-strain state, with various work-hardening exponent n-values and thicknesses of each layer. Processes of shear-band formation in such composite sheets are clearly illustrated. It is concluded that, in the bonded state, the higher limiting strain of one layer is reduced due to the lower limiting strain of the other layer and vice versa, and does not necessarily obey the rule of linear combination of the limiting strain of each layer weighted according thickness.

• Interaction and multiscale mechanics
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• v.2 no.3
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• pp.235-261
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• 2009

This study illustrates the differences between the elasto-plastic cap model and Lade's model with Cosserat rotation through the analyses of two large-scale geosynthetic-reinforced soil (GRS) retaining wall tests that were brought to failure using a monotonically increasing surcharge pressure. The finite element analyses with Lade's model were able to reasonably simulate the large-scale plane strain laboratory tests. On average, the finite element analyses gave reasonably good agreement with the experimental results in terms of global performances and shear band occurrences. In contrast, the cap model was not able to simulate the development of shear banding in the tests. In both test simulations the cap model predicted failure loads that were substantially less than the measured ones.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2000.06a
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• pp.1704-1709
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• 2000

This paper proposes a spherical probe allowing acoustic intensity measurements in three dimensions to be made, which creates a diffracted field that is well-defined, thanks to analytic solution of diffraction phenomena. Six microphones are distributed on the surface of the sphere along three rectangular axes. Its measurement technique is not based on finite difference approximation, as is the case for the ID probe but on the analytic solution of diffraction phenomena. In fact, the success of sound source identification depends on the inverse models used to estimate inverse diffraction phenomena, which has non-linear properties. In this paper, we introduce the concept of nonlinear inverse diffraction modeling using a neural network and the idea of 3 dimensional sound source identification with several tests.

• Journal of Institute of Control, Robotics and Systems
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• v.18 no.1
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• pp.62-68
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• 2012

In this paper, a detection method of a pedestrian safety road marking was proposed. The proposed algorithm uses laser range and reflectivity of a range finder (LRF). For a detection of crosswalk marking and stop line, the DFT (Discrete Fourier Transform) of reflectivity and cross-correlation method between the reference replica and the measured reflectivity are used. A speed bump is detected through measuring an altitude difference of two LRFs which have the different tilted angle. Furthermore, we proposed a velocity constrained a detection method of a speed bump. Finally, the proposed methods are tested in on-line, on the pavement of a road. The considered road markings are wholly detected. The localization errors of both road markings are smaller than 0.4 meter.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2002.11a
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• pp.136-136
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• 2002

A rat (Rottus norvegicus) infected with C. hepatica was trapped incidentally. At necropsy, grossly yellowish-white nodules were scattered on the liver surface. Microscopically, granulomatous and fibrotic nodules containing eggs and/or adult worms of C. hepatica were detected in the liver. Septal fibrosis forming pseudolobules was observed as a diffuse change throughout the liver. In double staining with immunostaining of -SMA and toluidine blue, myofibroblasts and mast cells were generally observed within the fibrous septa with mast cells being along the myofibroblasts. In this case, we hypothesized that myofibroblast and mast cell might playa role in septal fibrosis of rat liver induced by C. hepatica infection.

• Molecules and Cells
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• v.28 no.4
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• pp.403-406
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• 2009

Rev is an essential regulatory protein for HIV-1 replication. Rev (11-20) is known as the significant region regarding the function of a nuclear entry inhibitory signal (NIS) of Rev. In this study, anticandidal effects and mechanism of action of Rev (11-20) were investigated. The result exhibited that Rev (11-20) contained candidacidal activities. To understand target site(s) of Rev (11-20), the intracellular localization of the peptide was investigated. The result showed that Rev (11-20) rapidly accumulated in the fungal cell surface. The cell wall regeneration test also indicated that Rev (11-20) exerted its anticandidal activity to fungal plasma membrane rather than cell wall. The fluorescent study using 1,6-diphenyl-1,3,5-hexatriene (DPH) further confirmed the membrane-disruption mechanism(s) of Rev (11-20). The present study suggests that Rev (11-20) possesses significant potential regarding therapeutic agents for treating fungal diseases caused by Candida species in humans.

• Parasites, Hosts and Diseases
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• v.47 no.2
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• pp.171-174
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• 2009

The antigen location of Cryptosporidium parvum, which stimulates antibody formation in humans and animals, was investigated using infected human sera. Immuno-electron microscopy revealed that antigenicity-inducing humoral immunity was located at various developmental stages of parasites, including asexual, sexual stages, and oocysts. The amount of antigen-stimulating IgG antibodies was particularly high on the oocyst wall. The sporozoite surface was shown to give stimulation on IgG and IgM antibody formation. Trophozoites implicated the lowest antigenicity to humoral immunity, both IgG and IgM, by showing the least amount of gold labeling. Immunogold labeling also provided clues that antigens were presented to the host-cell cytoplasm via feeder organelles and host-parasite junctions.