• Bulletin of the Korean Chemical Society
• /
• 제33권2호
• /
• pp.535-540
• /
• 2012

A series of benzamide-based histone deacetylases (HDACs) inhibitors possessing N-(aminopyridine) residue as the zinc binding site of HDAC were synthesized and evaluated. Among these derivatives, compounds with N-(2-amino-4-pyridine) benzamide moiety have been found as the most potent ones. Moreover, introduction of appropriate substituents on the terminal aryl group acting as the surface-recognition domain could significantly improve the antiproliferative activity. In particular, the compound 4k possessed favorable pharmacokinetic characteristics and exhibited potent antitumor activity on xenograft model in mice at well tolerated doses, thus suggesting a good therapeutic index.

• 한국전산구조공학회:학술대회논문집
• /
• 한국전산구조공학회 2000년도 봄 학술발표회논문집
• /
• pp.133-140
• /
• 2000

The objective of this study is to develop a damage model based on damage mechanics that can be used to analyze the mechanical behavior of structures with defects and the global behavior of damaged structures. A modified second order damage tensor that can be applied to finite element analysis is used to reflect the effect of damage. The damage stress computed from the effective stress is considered as an additional loading term acting on nodes and can represent the effect of crack surface. The accuracy of the proposed algorithm is verified by comparing the analysis results with the experimental data from other studies and the analysis results based on transverse isotropic theory. The developed damage model is applied to the analyses of structures with cracks under linear elastic condition. Numerical results show that the developed model can effectively analyze the global behavior of damaged structures.

• International Journal of Aerospace System Engineering
• /
• 제4권1호
• /
• pp.1-8
• /
• 2017

This paper proposes the load distribution control allocation technique. The proposed method is designed by combining a conventional control allocation method with load distribution ability in order to reduce the stress acting on ailerons. By designing the weighting matrix as a function of the load distribution rule, the optimal deflection angles of each surface to satisfy both control goal and load distribution can be achieved. Moreover, rule based fault-tolerant control technique is also proposed. The rules are generated by considering both dominant control surfaces and the ratio of load distribution among surfaces. The performance of the proposed method is evaluated through numerical simulations.

• Corrosion Science and Technology
• /
• 제17권2호
• /
• pp.81-89
• /
• 2018

In this study, the effect of Nb alloying element on the corrosion fatigue properties of high strength steel is investigated by conducting fatigue experiments under corrosive condition and hydrogen induced condition, potentiodynamic polarization test, tensile test and surface analyses. Nb element is added to enhance the mechanical property of medium carbon steel. This element forms MX-type phases such as carbides and nitrides which are playing an important role in the grain refinement. The grain refinement is one of the effective way to improve mechanical property because both tensile strength and toughness can be improved at the same time. However, MX-type phase precipitates can be a susceptible site to localized corrosion in corrosive environment due to the potential difference between matrix and precipitate. The obtained results showed that Nb-added steel improved corrosion fatigue property by grain refinement. However, it is degraded for hydrogen-induced fatigue property due to Nb, Ti-inclusions acting as a stronger trap.

• Geomechanics and Engineering
• /
• 제14권6호
• /
• pp.601-614
• /
• 2018

This study presents structural and parametric analyses on the behavior of an integrated and pile-bent abutment with mechanically stabilized earth wall (IPM) bridge. The IPM bridge is an integral abutment bridge (IAB) with partially protruded piles, which excludes earth pressure by means of a mechanically stabilized earth wall developed by the authors. The results of the analysis indicate that the IPM bridge, as any other IAB, is influenced to a large extent by temperature and time-dependent loads. When these loads are applied, the stress on a pile in the IPM bridge decreases as the displacement of the pile top increases, because the piles protrude from the ground surface and no soil reaction is generated on the protruded pile. Because the length of an IAB is restricted by the forces acting on its piles, the IPM bridge is an effective alternative to extend its length.

• 한국추진공학회:학술대회논문집
• /
• 한국추진공학회 2005년도 제24회 춘계학술대회논문집
• /
• pp.427-430
• /
• 2005

본 논문에서는 인공위성 소형추력기의 핵심 부품인 유량제어용 밸브내의 유동현상을 해석하였다. 이를 바탕으로 밸브 내에서 직접적인 유량 제어를 담당하는 Plunger에 작용하는 힘을 계산하였고, Plunger의 개폐에 소요되는 힘을 최소화 시키는 밸브의 설계시에 필요한 기초 자료를 제공하였다.

• Tribology and Lubricants
• /
• 제25권5호
• /
• pp.292-297
• /
• 2009

Air foil thrust bearings are the critical components available on high-efficiency turbomachinery which need an ability to endure the large axial force. Air foil bearings are self-acting hydrodynamic bearings that use ambient air as their lubricant. Since the air is squeezed by the edge of compliance-surface of bearing, hydrodynamic force is generated. In this study, we measured the air film thickness and obtained the minimum film thickness experimentally. To increase the maximum load capacity, compliance of sub-structure was controlled. From numerical analyses, it is seen that, if the air film thickness is distributed more uniformly by variable compliance, the thrust bearings can take more axial load.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 1996년도 하계학술대회 논문집 A
• /
• pp.241-243
• /
• 1996

This papar presents an analysing method of radial force densities acting on each stator tooth of an induction motor with skewed slots. Two-dimensional finite element method is used for electromagnetic Held analysis of an induction motor, and skew effects are considered by coupling several disks cut by planes perpendicular to the shaft. Radial force densities as a source of vibration are calculated along the surface elements of each stator tooth and its time harmonics are examined by discrete Fourier decomposition.

• Journal of Advanced Marine Engineering and Technology
• /
• 제25권1호
• /
• pp.155-161
• /
• 2001

Fundamental studies on the drag reduction of the circular cylinder having dimple were conducted by the measurement of the fluid force acting on the cylinder and by the flow visualization around the cylinder. The drag coefficients were changed by the shape and the geometrical arrangement of the dimple. The drag of the cylinder was reduced about 25% by the proper arrangement of the dimple. The flow field around the cylinder having dimple, which was the minimum drag, was visualized by the hydrogen bubble technique. In this case, the separation points were moved rearward and the wake region was small in comparison with that of the cylinder having no dimple.

• 대한의용생체공학회:의공학회지
• /
• 제28권6호
• /
• pp.791-797
• /
• 2007

This paper proposes a semiautomatic vertebra segmentation method that overcomes limitations of both manual segmentation requiring tedious user interactions and fully automatic segmentation that is sensitive to initial conditions. The proposed method extracts fence surfaces between vertebrae, and segments a vertebra using fence-limited region growing. A fence surface is generated by a deformable model utilizing valley information in a valley emphasized Gaussian image. Fence-limited region growing segments a vertebra using gray value homogeneity and fence surfaces acting as barriers. The proposed method has been applied to ten patient data sets, and produced promising results accurately and efficiently with minimal user interaction.