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Gleason's Grading of Prostatic Adenocarcinoma: Inter-Observer Variation Among Seven Pathologists at a Tertiary Care Center in Oman

  • Qureshi, Asim;Lakhtakia, Ritu;Bahri, Maiya AL;Haddabi, Ibrahim Al;Saparamadu, Anna;Shalaby, Asem;Riyami, Marwa Al;Rizvi, Gauhar
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권11호
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    • pp.4867-4868
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    • 2016
  • Prostatic adenocarcinoma is the commonest solid malignancy seen in Omani elderly males 60-80 years of age. The Gleason grade is the most widely used grading system for prostatic carcinoma and is recommended by the World Health Organization. A peer review was carried out at the Pathology Department of Sultan Qaboos University Hospital (SQUH), Oman, to assess the quality of reporting at the center. The aim of this study was to determine inter-observer variation among 7 pathologists working at a tertiary care center in Oman. A total of 47 consecutive prostatic biopsies were interdependently reviewed by seven pathologists and the results obtained were compared with each other and the original diagnosis. This peer review indicated a fair inter-observer agreement (0.482) among 7 pathologists in the department, with fair to moderate agreement when the results were compared to the reported diagnosis, comparable to the published literature. Dual and sub-specialty reporting are being instituted to improve the performance in this vital aspect of pathology.

Colorectal Cancer Patient Characteristics, Treatment and Survival in Oman - a Single Center Study

  • Kumar, Shiyam;Burney, Ikram A;Zahid, Khawaja Farhan;Souza, Philomena Charlotte D;Belushi, Muna AL;Mufti, Taha Dawood;Meki, Waeil AL;Furrukh, Muhammad;Moundhri, Mansour S AL
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권12호
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    • pp.4853-4858
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    • 2015
  • Background: Colorectal cancer is the most common gastrointestinal cancer in Oman with an increasing incidence. We here report the presenting features, treatment outcomes and survival in a University hospital in Oman and compare our data with regional and international studies. Materials and Methods: Medical records of patients with colorectal cancer were reviewed retrospectively between June 2000 and December 2013 and were followed until June 2014. Results: A total of 162 patients were diagnosed with colorectal cancer. The majority were males (58.6%), with a median age of 56 years. Rectum was involved in 29.6% of patients, followed by ascending and sigmoid colon. The majority of patients had stage III (42.6%) and stage IV (32.7%) disease at presentation. K-Ras status was checked for 79 patients, and 41 (51.9%) featured the wild type. Median relapse free survival was 22 months. Median overall survival for all patients was 43 months. Observed 5 year overall survival (OS) for stages I, II and III was 100%, 60% and 60% respectively. On Log rank univariate analysis, age, BMI, diabetes, hypertension, metformin use, stage, clinical nodal status for rectal cancer, pathological T and nodal status, site of metastasis, surgical intervention, chemotherapy, radiotherapy, chemotherapy regimen, no of cycles of chemotherapy, response, RFS, site of recurrence and administration of $2^{nd}$ line chemotherapy were significant factors affecting OS. On Cox regression multivariate analysis none of the factors independently affected the OS. Conclusions: The majority of patients present with advanced disease and at young age. The survival rates are comparable to the published regional and international literature.

Microbial Consortia in Oman Oil Fields: A Possible Use in Enhanced Oil Recovery

  • Al-Bahry, Saif N.;Elsahfie, Abdulkader E.;Al-Wahaibi, Yahya M.;Al-Bimani, Ali S.;Joshi, Sanket J.;Al-Maaini, Ratiba A.;Al-Alawai, Wafa J.;Sugai, Yuichi;Al-Mandhari, Mussalam
    • Journal of Microbiology and Biotechnology
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    • 제23권1호
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    • pp.106-117
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    • 2013
  • Microbial enhanced oil recovery (MEOR) is one of the most economical and efficient methods for extending the life of production wells in a declining reservoir. Microbial consortia from Wafra oil wells and Suwaihat production water, Al-Wusta region, Oman were screened. Microbial consortia in brine samples were identified using denaturing gradient gel electrophoresis and 16S rRNA gene sequences. The detected microbial consortia of Wafra oil wells were completely different from microbial consortia of Suwaihat formation water. A total of 33 genera and 58 species were identified in Wafra oil wells and Suwaihat production water. All of the identified microbial genera were first reported in Oman, with Caminicella sporogenes for the first time reported from oil fields. Most of the identified microorganisms were found to be anaerobic, thermophilic, and halophilic, and produced biogases, biosolvants, and biosurfactants as by-products, which may be good candidates for MEOR.

Biochemical Changes in Sorghum Leaves Infected with Leaf Spot Pathogen, Drechslera sorghicola

  • Khan, A.J.;Deadman, M.L.;Al-Maqbali, Y.M.;Al-Sabahi, J.;Srikandakumar, A.;Rizvi, S.G.
    • The Plant Pathology Journal
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    • 제17권6호
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    • pp.342-346
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    • 2001
  • The physiological changes in sorghum (Sorghum vulgare Pers.) leaves infected with Drechslera sorghicola were investigated through five recognizable stages of disease development. Water-soaked yellowish brown spots developed two days after inoculation, turned brown with yellow halo, enlarged and coalesced at later stages of disease development. Healthy and infected leaves were analyzed for different biochemical constituents. The chlorophyll contents were decreased significantly with the progress of infection. The levels of reducing and total sugars increased while non-reducing sugars decreased to a significant extent with the progress of disease. The concentration of total phenolics, orthodihydroxy phenols, free and glycosidic phenols showed significant changes due to infection, whereas basic and acid phenols showed little or no change with disease development. Levels of phenolic compounds increased four days after inoculation and decrease thereafter, but the concentration was higher at every stage of disease development relative to healthy tissues. Polyphenol oxidase and peroxidase enzyme activities increased to varying degrees at different stages of infection. Analysis of protein fractions showed a significant increase with the progress of disease.

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The Effect of Distribution Project Manager Leadership and Performance of Project Team Members with the Mediation Role of Self-Efficacy

  • SHOKORY, Suzyanty Mohd;ZAINOL, Zuraidah;AWANG, Marinah;ABDUL HAMID, Suriani;RAMDAN, Mohamad Rohieszan
    • 유통과학연구
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    • 제20권9호
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    • pp.29-38
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    • 2022
  • Purpose: The purpose of this study to determine the effect of distribution transformational and transactional project manager leadership style on the extra-role performance of project team members using multi-level modelling analysis. Research design, data and methodology: The role of psychological factors as the mediating variable namely is self-efficacy in the effect of project manager's leadership style on the project team members' performance was also studied using the Monte Carlo bootstrapping method. The sample of the study consisting of 370 project team members from 74 contractors registered with the Construction Industry Development Board in the Klang Valley was selected using a simple random sampling and a survey using a questionnaire. Results: The findings showed that the transformational leadership of project managers was a dominant predictor of extra-role performance of project team members. Furthermore, the study show the self-efficacy of project team members acted as a mediator in the relationship between transformational and transactional leadership of project manager leadership on the extra-role performance of project team members. Conclusions: The findings are expected to be used by the relevant parties in planning, arranging and implementing efforts to improve the work performance and ensure that projects are implemented according to the specified specifications.

Civil Servant Commitment on Giving Cash Waqf: Does Trust Matter?

  • Rifadli D. KADIR;Hilmy BAROROH;Luqmanul Hakiem AJUNA;Wiwin KONI;Supandi RAHMAN;Sri Apriyanti HUSAIN
    • 유통과학연구
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    • 제21권12호
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    • pp.35-45
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    • 2023
  • Purpose: This study analyzes civil servants' trust in cash waqf institution and their relationship with commitment. We use Key Mediating Variables (KMV) Theory with variables such as board benevolence, board integrity, board ability, board opportunism, communication, and accountability to predict the trust and commitment of civil servants in providing cash waqf. Research design, data and methodology: We used a quantitative research approach and an online questionnaire distributed to civil servants in Gorontalo Province; 410 respondents were obtained. Structural Equation Modeling (SEM) was used, utilizing the SEM-PLS software to analyze the data. Result: This study found that the variables board benevolence, board ability, board integrity, board opportunism, communication, and accountability affected trust. As for the variable of accountability, the hypothesis was rejected Conclusion: The communication variable of cash waqf institutions has a strong influence in increasing the confidence of civil servants in providing cash endowments. However, trust in waqf institutions may diminish due to low accountability and poor governance of cash waqf institutions. The trust of civil servants in cash waqf institutions in the future will increase their commitment to waqf.

Experimental performance investigation of compound parabolic cavity receiver having single absorber tube

  • Omar Al-Nabhani;Saud Al-Kalbani;Azzam Al-Alawi;Afzal Husain
    • Advances in Energy Research
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    • 제8권3호
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    • pp.155-163
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    • 2022
  • The current study presents experimental research on a parabolic trough collector with tube and cavity receivers. The primary concentrating parabolic reflector is designed for an aperture area of 2×2 m2 with mirror-polished stainless steel sheet reflectors. The cavity receiver consists of a compound parabolic secondary reflector and a copper tube. Both the conventional tube receiver and the cavity receiver tube are coated with black powder. The experiments are carried out to compare the efficiency of the cavity receiver with the tube receiver for fluid temperature rise, thermal efficiency, and overall losses. The experiments showed significantly higher fluid temperature rise and overall efficiency and lower thermal losses for the cavity receiver compared to the tube receiver within the parameters explored in this study.

Ameliorative Effects of Pomegranate Peel Extract against Dietary-Induced Nonalcoholic Fatty Liver in Rats

  • Al-Shaaibi, Siham N.K.;Waly, Mostafa I.;Al-Subhi, Lyutha;Tageldin, Mohamed H.;Al-Balushi, Nada M.;Rahman, Mohammad Shafiur
    • Preventive Nutrition and Food Science
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    • 제21권1호
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    • pp.14-23
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    • 2016
  • Non-alcoholic fatty liver disease (NAFLD) is caused by fat accumulation and is associated with oxidative stress. In this study, we investigated the potential protective effect of pomegranate (Punica granatum L.) peel extract (PPE) against oxidative stress in the liver of rats with NAFLD. Sprague-Dawley rats were fed a high fat diet (HFD), 20% corn oil, or palm oil for 8 weeks in the presence or absence of PPE. The control group was fed a basal diet. The progression of NAFLD was evaluated histologically and by measuring liver enzymes (alanine transaminase and aspartate transaminase), serum lipids (triglycerides and total cholesterol), and oxidative stress markers. The HFD feeding increased the body weight and caused NAFLD, liver steatosis, hyperlipidemia, oxidative stress, and elevated liver enzymes. Administration of PPE ameliorated the hepatic morphology, reduced body weight, improved liver enzymes, and inhibited lipogenesis. Furthermore, PPE enhanced the cellular redox status in the liver tissue of rats with NAFLD. Our findings suggest that PPE could improve HFD-induced NAFLD via abolishment of hepatic oxidative damage and hyperlipidemia. PPE might be considered as a potential lead material in the treatment of NAFLD and obesity through the modulation of lipid metabolism.