• Journal of Dental Rehabilitation and Applied Science
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• v.39 no.1
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• pp.21-31
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• 2023

Purpose: This study aimed to investigate the effects of mental health factors on oral symptoms and the relationship between the two in Korean adolescents. Materials and Methods: Raw data of 54,948 Korean adolescents among the participants of the 17^th Korean Youth Health Behavior Survey conducted in 2021 by the Korea Disease Control and Prevention Agency were analyzed in this study. Results: Mental health factors evaluated in this study included sadness and despair, suicidal thoughts, suicide attempt, loneliness, stress, depression, and anxiety. Our findings showed that all mental health factors were associated with oral symptoms. Particularly, factors affecting dental pain were suicidal thoughts, stress, anxiety, loneliness, depression, sadness, and despair. Further, all mental health factors affected ulorrhagia. Conclusion: In conclusion, the findings in this study are expected to contribute to the development of programs for the intervention of key mental health factors affecting oral symptoms to improve overall health in Korean adolescents.

• The Journal of the Convergence on Culture Technology
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• v.8 no.3
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• pp.51-60
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• 2022

This study is to explore the existence reflection and transcendence to overcome depression in terms of the perspective and the hick of the treatment.,The suicide rate in Korea is the number one OECD country (2006-2019), and depression is spreading more recently.,Depression is a civilized disease connected to the abolition of materialism in the competition of a rapid industrial society, and there is a limit to overcoming depression by medication alone.,The purpose of this study is to define depression as a personal history and to recognize depression as a part of literature therapy and to explore ways to overcome it.,This study is an attempt to use the 'self-narrative' of Korean literature therapy and to reexamine the arguments from the perspective of the poetic therapy, which is to draw the suppressed feelings into the human being through the medium of the poetic work.,This is meaningful in integrating the divided self and freeing from the suppressed emotions to live a free life.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1982.05a
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• pp.5.2-5
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• 1982

With the improvement of living standard and socioenvironmental change, esophageal stricture due to acetic acid, Hcl, insecticides and lye has led to decrease remarkably. Esophageal stricture has decreased because of immediate treatment and adequate management. However there are still sporadic incidents of esophageal stricture due to inadequate treatment and uncooperation of patients. The authors recently have experienced seven severe cases of esophageal stricture. All six patients were treated with 18-51 French Sippy esophageal dilating bougie. One patient was transfered to thoracic surgery department due to complete esophageal obstruction. Case 1. A 23 year old housewife who ingested Hcl for suicide. After Witzel's operation, she visited to dilate esophageal first constriction stircture due to swallowing difficulty postoperation 2 months later. We were treated successfully. Case 2. A case of esophageal stricuture in the second and third physiologic constriction part. The patient was 51 years old man who ingested lye accidently, and was dilated by bougination. Case 3. The patient was 43 year-old man who ingested acetic acid as a mistake and was treated inadequately at hopsital. Inspite of treatment, esophageal stricture developed at the third physiologic part. We are trying to dilate the esophagues now. Case 4. The patient was 55 year-old woman who had ingested Hcl for the purpose of suicidal attempt. 2 months later gastroduodenal anastomoisis due to pyloric region stenosis, the first physiologic constriction stricture was dilated successfully. Case 5. The patient was 41 year-old woman who ingested Hcl for suicide 4 months ago. There was indwelled orogastric tube for 1 month but esophageal stricture developed at the first and 3rd constriction part. She was treated by using a bougination. Case 6. An athlete 21 year old man, ingested acetic acid 2 spoonful per 3 days by purpose in order to soften the bone for last 14 months. There was complete esophageal obsturction in esophagogram and transferred to the thoracic surgery department. Case 7. A 3 year-old girl was ingested lye at a accident. She had a bougination for 16 months under the general anesthesia for dilation due to whole irregular esophageal stricture. She developed lower esophageal perforation, but healed eventually.

• Korean journal of communication and information
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• v.61
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• pp.5-27
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• 2013

Media coverage of depression, the mental disorder, is on the high rise following the soaring number of reported celebrity suicide. This study is an exploratory attempt to get a glance on how online news media are portraying depression. The content analysis results indicate that celebrity was the most cited source, outnumbering the others such as non-celebrity patients and experts. More than half of the sample attributed the cause of depression to socio-psychological factors. Medical consultation was the most reported means of treating depression among the sample, while over the half did not suggest any treatment methods at all. Overall, celebrity related news were less likely to talk about the cause and treatment methods. In addition, the more neuro-biological factors were designated as the main cause of depression in the articles, the more chances of treatment method of all kinds were brought up. The frame of human interest dominated a little less than half of the articles examined, and only few reported positive outcome or achievements after coping with depression.

• Journal of The Korean Society of Clinical Toxicology
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• v.11 no.1
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• pp.9-18
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• 2013

Purpose: Antidotes for toxicological emergencies can be life-saving. However, there is no nationwide stocking and delivery system for emergency antidotes in Korea. We report on a two-year experience of a nationwide stocking and delivery trial for emergency antidotes at emergency departments in Korea. Methods: An expert panel of clinical toxicologists reviewed and made a list of 15 stocked antidote. These antidotes were purchased or imported from other countries and delivered from 14 antidote stocking hospitals nationwide 24 hours per day, seven days per week. Results: From August 1, 2011 to April 30, 2013, 177 patients with acute poisoning, with a median age of 48.5 years, were administered emergency antidotes. The causes of poisoning were intentional in 52.0% and 88.0% were intentional as a suicide attempt. Regarding clinical severity, using the poisoning severity score, 40.7% of patients had severe to fatal poisoning and 39.0% had moderate poisoning according to clinical severity. The most frequent presenting symptom was neurologic deficit, such as altered mentality (62.7%). alerted mentality (62.7%). Emergency antidotes were administered as follows: methylene blue (49 cases), flumazenil (31), N-acetylcysteine (25), glucagon (17), 100% ethanol (15), cyanide antidote kit (12), anti-venin immunoglobulin (5), pyridoxine (4), hydroxocobalamine (2), and deferoxamine (1). The median time interval from antidote request to delivery at the patient's bedside was 95 minutes (interquartile range 58.8-125.8). Conclusion: Findings of this study demonstrated the possibility of successful operation of the nationwide system of emergency antidotes stocking and delivery in Korea.

• Journal of The Korean Ophthalmological Society
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• v.59 no.11
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• pp.1097-1102
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• 2018

Purpose: To report a case of toxic optic neuropathy caused by chlorfenapyr ingestion accompanied by central nervous system involvement. Case summary: A 44-year-old female visited our clinic complaining of reduced visual acuity in both eyes for 7 days. She had ingested a mouthful of chlorfenapyr for a suicide attempt 2 weeks prior to the visit. Gastric lavage was performed immediately after ingestion at the other hospital. Her best-corrected visual acuity was finger count 30 cm in the right eye and hand motion in the left eye. Both pupils were dilated by 5.0 mm and the response to light was sluggish in both eyes. A relative afferent pupillary defect was detected in her left eye. Funduscopy revealed optic disc swelling in both eyes. Magnetic resonance imaging of the brain showed a symmetric hyper-intense signal in the white matter tract including the internal capsule, corpus callosum, middle cerebellar peduncle, and brainstem. The patient was diagnosed with toxic optic neuropathy induced by chlorfenapyr ingestion, and underwent high-dose intravenous corticosteroid pulse therapy. Three days later, the best-corrected visual acuity was no light perception in both eyes. Three months later, optic atrophy was observed in both eyes. Optical coherence tomography revealed a reduction in the thicknesses of the retinal nerve fiber layer and ganglion cell and inner plexiform layer in the macular area. Conclusions: Ingestion of even a small amount of chlorfenapyr can cause severe optic nerve damage through the latent period, despite prompt lavage and high-dose steroid treatment.

• Journal of Life Science
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• v.31 no.12
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• pp.1120-1127
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• 2021

Depression has a negative impact on social functioning due to its high prevalence and increased suicide rate, and is a disease with a high economic burden. Depression is related to diverse brain-related phenomena, such as neuroinflammation, synaptic dysfunction, and cognitive deficit. As antidepressant drugs used in clinical trials have shown poor therapeutic effects, antidepressant drugs that show rapid efficacy urgently need to be developed. Although studies on various genes, proteins, and signaling pathways related to depression have been conducted, the pathogenesis of depression has not been clearly elucidated. Sirtuin 1 is a nicotinamide-adenine dinucleotide- (NAD+-) dependent histone deacetylase and is involved in cell differentiation, apoptosis, autophagy, and cancer metabolism. Recent genetic studies found that sirtuin 1 is a potential target gene for depression. In addition, preclinical studies reported that sirtuin 1 signaling affects depression-like behavior. In this review, we attempt to present up-to-date knowledge of depression and sirtuin 1. We describe the various roles of sirtuin 1 in the regulation of glial activation, circadian rhythm, neurogenesis, and cognitive function and the effects of its expression on depression. Further, we discuss the effect of sirtuin 1 on the impairment of neural plasticity, one of the key mechanisms of depression, and the associated mechanisms of sirtuin 1.

• Korean Journal of Culture and Social Issue
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• v.29 no.1
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• pp.1-23
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• 2023

The purpose of this study was to validate the Suicidal Ideation Attributes Scale(SIDAS) which can measure the severity of suicidal ideation in a sample of 399 Korean adults. For this purpose, an online survey was conducted for two weeks from July 2020 to August 2020. First, there were differences in SIDAS scores among groups divided by gender, residence status, depression and anxiety symptoms, suicidal ideation, suicidal plan, suicidal preparation, and suicidal attempt. Second, correlations between SIDAS, C-SSRS suicidal ideation intensity question(3 items), and the Rosenberg Self-efficacy (RSE) were examined to confirm the validity of SIDAS. As a result, correlations between the SIDAS and suicidal ideation intesity items of C-SSRS were significant in all items, while correlations between the SIDAS and RSE items were negative or insignificant. Third, as a result of the confirmatory factor analysis of SIDAS on all respondents and respondents with suicidal ideation, a single factor structure was appropriate for both groups. Internal consistency of SIDAS was also good. Lastly, as a result of identifying the variables affecting the suicidal plan over the past year, controllability and age were identified as significant predictive variables. SIDAS which was designed to be administered through web, can be appropriately used in Korea. It was confirmed that SIDAS is a reliable and valid suicidal ideation scale which is applicable to adults in Korea.

• Korean Journal of Psychosomatic Medicine
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• v.24 no.2
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• pp.174-183
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• 2016

Objectives : The aim of this study is to evaluate difference of somatic symptoms of anxiety disorder and major depressive disorder and domainal association with suicidal idealization, plan, and attempts. Methods : A total of 359 adults diagnosed with major depressive disorder and anxiety disorder of last one year participated. Participants interviewed with certain sections of Korean version of Composite International Diagnostic interview of CIDI. Sections of interests includes questionnaires regarding somatic symptoms and suicidal idea, plan and attempts of last one year. Results : Chest pain shows more prevalence in major depressive disorder. Symptoms of Headache and loose stool are more prevalent in anxiety disorder. Difficulty in equilibrium and fainting spells are more common somatic complaints of co-diagnosis states of anxiety disorder and major depressive disorder. Comparing 3 domains of pain symptoms, gastrointestinal symptoms and pseudo-neurological symptoms, pain symptom domains, gastrointestinal symptoms domain shows significant statistic difference between diagnosis. Average somatic symptom numbers of each symptom domains increase through suicidal idealization, plan and attempt, accordingly. Conclusions : Our finding shows some of somatic symptoms are more prevalent at certain diagnosis. Since increasing numbers of somatic complaints of each symptom domains goes with the suicidal idealization to suicidal attempts, proper psychiatric evaluation and consultations are crucial for patients with numerous somatic complaints in non-psychiatric clinical settings.