• Journal of Industrial Technology
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• v.26 no.B
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• pp.163-171
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• 2006

Human immunodeficiency virus type 1 (HIV-1) integrase plays a critical role in the life cycle of the HIV virus. An ability to accurately map its electrostatic potential, and then use this information to predict the manner in which DNA will bind to the active site of the catalytic domain could provide a foundation for inhibitory design. Attempts to discern the crystal structure of HIV-1 integrase have proven problematic, especially in the region of enzymatic activity, that being those residues involved in the catalysis of the integration of viral DNA into the host cell. However, there is a structural correlation in to the region of interest with avian sarcoma virus (ASV), so a homology model utilizing this similarity was constructed to approximate the behavior/structure of the undetermined portions of the HIV-1 integrase crystal. After this model was constructed and its energy minimized, electrostatic calculations were carried out on the substance, so that an electrostatic potential map was constructed. Using this information, it was determined that DNA binding was oriented so as to exploit the regions of positive potential nearby the active site, as well as the positive potential of the magnesium cofactors.

• Child Health Nursing Research
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• v.11 no.1
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• pp.90-98
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• 2005

Purpose: To provide basic information for developing a nursing program by examining health risk behavior of students rewriting college entrance examinations. Method: Data were gathered using questionnaires from 804 examinees in Seoul and Gyeonggi Province and analyzed with the SAS program using t-test, ANOVA, Scheffe's test, and Pearson correlation coefficients. Results: The mean score for health risk behaviors was 17.70 and the highest score for sub-areas of health risk behavior was drinking alcohol while substance use ranked lowest. There were significantly different scores for health risk behavior according to the following general characteristics; frequency of rewriting college entrance examinations, parents' marital status, level of father's education, grades, satisfaction with rewriting of college entrance examinations, parents' health concerns, need for health education and health status. Each behavior had positive or negative correlation with more than one other behavior. A negative correlation was found between health risk behavior and family support and self-esteem, while positive correlations were found between health risk behavior and general stress, studying stress and anxiety. Conclusion: This study suggest that these results be used to developed a prevention program to decrease health risk behaviors by promoting family support and self esteem and decreasing stress and anxiety.

• Membrane and Water Treatment
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• v.9 no.3
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• pp.195-203
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• 2018

N-acetylcysteine (NAC) has been widely used as an initial mucolytic agent and is generally used as an antioxidant to help alleviate various inflammatory symptoms. NAC reduces bacterial extracellular polymeric substances (EPS) production, bacterial adhesion to the surface and strength of mature biofilm. The efficacy has been shown to inhibit proliferation of gram-positive and gram-negative bacteria. In membrane bioreactor (MBR) processes, which contain a variety of gram negative bacteria, biofilm formation has become a serious problem in stable operation. In this study, use of NAC as an inhibitor of biofilm contamination was investigated using the center for disease control (CDC) reactors with MBR sludge. Biomass reduction was confirmed with CLSM images of membrane surfaces by addition of NAC, which was more efficient as the concentration of NAC was increased to 1.5 mg/mL. NAC addition also showed decreases in EPS concentrations of the preformed biofilm, indicating that NAC was able to degrade EPS in the mature biofilm. NAC addition was also effective to inhibit biofilm formation by MBR sludge, which consisted of various microorganisms in consortia.

• Journal of Korean Library and Information Science Society
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• v.35 no.3
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• pp.1-22
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• 2004

The students were instructed to prepare the materials for the reading discussion as they read books by the analytical reading, in order to make them know the efficient method of the reading discussion as activity of after reading. As the results, They understood the plot and substance of the book, comprehend the whole subject and selected the subject of the discussion better after they read books by the analytical reading than after they didn't. But it's not satisfactory to communicate their own ideas mutually during the reading discussion as before.

• Journal of Power System Engineering
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• v.9 no.4
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• pp.51-57
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• 2005

In order to prevent the environmental pollution, the dryers are commonly used to treat sludge that one of sewages is polluting the quality of water. Generally, the drying method is various as to the property of material and use. Rotary dryer is a good apparatus to treat them. The rotary dryer is the way that is to make substance transmission and heating using hot air between sludge particles and heated gas. In this paper, we performed a numerical analysis of the inner air flow of the 3-pass rotary dryer through the changing rotational speed from 3rpm to 10rpm. In this result, we found that 3rpm is effective to dry material in terms of heat transfer because large scale velocity fluctuation is occurred inside the first and second drum. Also we confirmed that 5rpm and 8rpm showed up uniform flow at the center area of the first drum.

• The Korean Journal of Food And Nutrition
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• v.33 no.3
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• pp.223-236
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• 2020

In this study, a safety evaluation was conducted to confirm if the Enterococcus faecium CKDB003 strain obtained by selection from a mixed fermentation of fruit and milk is suitable for use as a probiotic. The MIC value for the 10 antibiotics specified in the EFSA guidance was below the acceptable cut-off value. The antibiotic resistance genes aac(6')-li, eatAv, and msr(C) exist by whole genome sequencing, but are in the chromosome and not in the plasmid, thus confirming that there is no possibility of transmission to other microorganisms. It was confirmed that cytolysin (cylA, cylB, cylI, cylL-l, cylL-s, cylM, cylR1, cylR2), aggregation substance (asa1, asp1), collagen adhesion (ace), enterococcal surface protein (esp), endocarditis antigen (efaA), hyaluronidase (hyl) and gelatinase (gelE) were not present in the genome by examining the genes of factors related to virulence. Also, the biochemical analysis showed no toxic enzyme activities, and no virulence genes were detected by the PCR method. Thus, the E. faecium CKDB003 strain can be safely used as a health functional food probiotic, based on the results of the safety assessment.

• Journal of fish pathology
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• v.13 no.1
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• pp.1-6
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• 2000

The antibacterial activity of marine bacterium(Pseudomonas aeruginosa JYMB1-3) was assayed against Vibrio anguillarum with the aim of evaluating the possible use for biocontrolling fish disease as probiotic strain. Inhibition test on the solid medium showed that vibrios were especially sensitive to the JYMB1-3. Edwardsiella tarda, Streptococcus sp. and Staphylococcus epidermidis were also sensitive to that strain, however the antibacterial abilities were varied to the pathogens. The vibriostatic activity of antibacterial substance produced from $10^7$ cells of the strain for 24 hours was equivalent to $2.5{\mu}g$ of chloramphenicol.

• Journal of the Korean Society of Food Culture
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• v.7 no.1
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• pp.81-90
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• 1992

The Guk had lessened to use Gang, Whak, Tang. The Guk was classified into cooking method as a soup stock, the used main substances, and the temperature of the Guk. According to the soup stock were divided clear soup, Tojangguk, and Gooumguk. Another classification of Guk by main substances were Yuktang (meat soup), Otang (fish soup), bongtang (poultry soup), Shotang (vegetable soup), Japtang (vary substance soup) and Yonpotang (soybean-curd soup), and by the temperature of the Guk were divided Doounguk (warm soup) and Naengguk (cold soup). In the thesis, according to the kinds of Tojangguk, the reference frequency to them, the adding foods in them, and the variety cooking method in the Tojangguk were analyzed by the cook books published from 1700 to 1988 in Korea. 1. There were 29 kinds of Tojangguk. 2. The main substances of Tojangguk were meat, poultry, fish, shellfish, vegetable, mushrooms and seasonings. 3. The Tojangguk was boiled with the rice water and fermented soybean paste and fermented soybean-pepper powder paste. For the development of taste were added beef, shellfish, dried anchovy, dried small prawn, and soup stock of beef bones in winter. Seasoning substances were green onion, garlic, black pepper, sesame powder and oil.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2007.04a
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• pp.43-46
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• 2007

This study dealt with the influence of the replacement ratio of rapidly-chilled steel slag on fluidity and compressive strength of unsaturated polyester polymer concretes. The rapidly-chilled steel slag used in this study, a by-product which is produced by refining pig iron during the manufacture of steel, was controled by a air-jet method which rapidly cools substance melted at a high temperature. Experimental results show that fluidity and compressive strength of unsaturated polyester polymer concretes increase with increasing replacement ratio of rapidly-chilled steel slag. Use of rapidly-chilled steel slag was found to be effective for improving fluidity and compressive strength of rapidly-chilled steel slag.

• Journal of The Korean Society of Clinical Toxicology
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• v.11 no.2
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• pp.127-129
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• 2013

The imidazopyridine, zolpidem, a non-benzodiazepine hypnotic drug, is widely-prescribed for insomnia. It is regarded as a good alternative to benzodiazepine because of the reduced possibility for abuse and development of dependence. However, more recently, due to the reduced possibility for abuse and development of dependence, it is regarded as a good alternative to benzodiazepine. adverse effects of zolpidem have been recognized. The objective of this report is to provide information on the potential for occurrence of benzodiazepine-like withdrawal seizure in patients who chronically take zolpidem continually. We present and discuss a case of seizure after sudden interruption of the protracted use of an abusively high dose of zolpidem. Zolpidem may not be the ideal drug for longterm pharmacotherapeutic management of insomnia. Clinicians should administer zolpidem at a low-dose for a short period of time for prevention of drug abuse and dependence and the potential for occurrence of benzodiazepine- like withdrawal seizure.