• 한국유통학회지:유통연구
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• 제1권1호
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• pp.41-63
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• 1996

In spite of economy has a critical cycle such as, production, distribution and consumption, we hardly concentrated our study to distributional system and behavior. Especially in Korea, Traditional idea had tried to ignore the people who work in this economic value at all. Manufacturers, other than retailers and wholesalers, had a belief that the manufacturing can control distributional channels forever. Unfortunately, technological and educational advances caused the quality equalization among developing and developed countries as well as among big and small manufacturers in their products. By this reason, economists are searching the economists dark continet' mentioned by Peter Drucker as a new source of wealth. According to a report by well-known economic research institute in Switzerland, Korea has classified in the lower level group in terms of international compatitive power. At the same time, business firms complain that they are suffering from lack of SOC and infrastructures. As an important mean to overcome the economic bottleneck, economists suggest in improve our distributional atmosphere. Basically, distributional study has two sub-fields as: commercial and physical distributions, Distributional system mainly concerns about to shorten the distances of time and space between production and consumption. The closer the distances, the higher efficiency can be achieved. Building distributional system will cost, but tile results will save social costs. Based on this idea, economists proposed several ways to cut the distances and to save costs, Naturally, they hope their beliefs can be adapted by business firms and governments. But frequently, their theories doesn't make any fruit. This paper has studied about the composition of joint transportational and distributional systems. And, even though there's no Marshall in tile real world at this point authors are trying to define the transportational and physical distributional costs, the most powerful factor that can impact to economic decision making.

• 대한한방부인과학회지
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• 제20권3호
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• pp.1-12
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• 2007

Purpose: Uterine leiomyomas (fibroids) are common estrogen-dependent uterine tumors. Houttuynia cordata thunberg has cancer-preventing properties and often used in Chinese medicine. In the present study we used Houttuynia cordata thunberg to determine its effect on cell proliferation and apoptosis in human uterine leiomyoma cells. Methods: Primary cultured human uterine leiomyoma cells were treated with Houttuynia cordata thunberg. Cell viability analysis was analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTS) assay and Flow cytometry was performed to ascertain the effects Houttuynia cordata thunberg. Expression of cell cycle related proteins and apoptosis related proteins were evaluated by Western blot analysis. Results: Cell viability was significantly influenced by Houttuynia cordata thunberg treatment in a dose-dependent manner in leiomyoma cells compare to normal myometrial cells. Flow cytometric analysis showed that Houttuynia cordata thunberg induced Sub G1 arrest. DNA fragmentation assay was carried out and apoptosis was detected. Activation of caspase-3, down-regulation of Bcl-2, with concomitant increase in p21 was observed. Houttuynia cordata thunberg treatment of uterine leiomyoma cellsresulted in a concentration-dependent cell death induced via the caspase dependent mechanism. Conclusion: These results suggest that Houttuynia cordata thunberg treatment in uterine leiomyoma cells leads to growth inhibition and induced apoptosis. These results suggest that Houttuynia cordata thunberg will be a promising agent for use in therapeutics agents against human uterine endometrial cancer.

• 대한한방부인과학회지
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• 제20권3호
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• pp.129-136
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• 2007

Purpose: We intended to observe the usefulness of far-infrared radiation functional under inner-wear for dysmenorrhea. Methods: We introduced far-infrared radiation functional under inner-wear to women in childbearing-age by internet portal site. Then, we preliminarily examined dysmenorrhea severity by VAS(visual analogue scale) questionnaire to women interested in far-infrared radiation functional under inner-wear. We selected women scored 5 and above of 10 measurement VAS score. Finally, 121 women were the subject of study and used far-infrared radiation functional under inner-wear for one menstrual cycle. Before and after use of far-infrared radiation functional under inner-wear, we conducted a questionnaire survey of dysmenorrhea severity by VAS. After that, we compared VAS score before and after use. Also, we studied correlation between frequency of far-infrared radiation functional under inner-wear use and ${\Delta}VAS$(VAS score before use minus VAS score after use). For statistics, we used Paired samples test and Spearman's rho correlations, SPSS 13.0 for windows. Results: Before and after use of far-infrared radiation functional under inner-wear, VAS score means were different. Frequency of far-infrared radiation functional under inner-wear use was correlated to ${\Delta}VAS$. Statistically they showed significant result (p<0.05>. Conclusion: The results showed that dysmenorrhea severity by VAS decreased after far-infrared radiation functional under inner-wear use. As frequency of use increased, ${\Delta}VAS$ increased. So we can consider far-infrared radiation functional under inner-wear effects dysmenorrhea severity.

• 대한한방부인과학회지
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• 제21권3호
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• pp.111-120
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• 2008

Purpose: Although premsnstrual syndromes(PMS) have long been recognized, there has been difficulty to evaluate the symtoms. Usually the questionnaire has been used to dignose the PMS. Objective is to investigate the relationship of body temperature between women with PMS and without PMS. Methods: We studied 23 patients visiting ㅇㅇ hospital from 26th December 2005 to 26th April 2006. The Questionnaire for PMS was used to evaluate physical, emotional, and behavioral symptoms accompanying the menstrual cycle of the subjects. The subjects were categorized in two groups, non-PMS(11) and PMS group(12). Body temperature was assessed by Dorex spectrum 9000MB (DOREX Inc.. USA). We measured CV4, CV3, CV12 and CV17 to evaluate the distribution of body temperature, compared the difference of temperature(${\Delta}T$) between CV17-CV4, CV17-CV3, CV17-CV12 and CV12-CV3. We investigated the of temperature and ${\Delta}T$ between two groups by Mann-Whitney U-test. Results: The temperature of CV3 and CV 4 of PMS located in low abdomen were lower than those of non-PMS located in chest. But there was no statistical significance of temperature between two groups. There was lower temperature of low abdomen in PMS group than non-PMS group without statistical significance. Conclusion: The results suggest that DITI could be useful to assess the PMS objectively. But more research should be needed.

• 대한한방부인과학회지
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• 제21권3호
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• pp.99-110
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• 2008

Purpose: Premenstrual syndrome(PMS) is a collection of physical, psychological and emotional symptoms related to a women's menstrual cycle. The symptoms are related with Autonomic Nervous system. The purpose of this study is to investigate the activity of Autonomic Nervous system in women with premenstrual syndrome(PMS) by using Heart Rate Variability(HRV). Methods: We studied 26 patients visiting ㅇㅇ hospital from 26th December 2005 to 26th April 2006. Activity of Autonomic Nervous system was assesed by means of Heart Rate Variability(HRV). The subjects were categorized in two groups, PMS group(10) and non-PMS group(16). We studied the difference of HRV between two groups by Mann-Whitney U-test using SPSS for windows (version 12.0). Results: SDNN of PMS group was non-significantly lower than non-PMS group. RMS-SD of PMS group was significantly lower than non-PMS group. Mean PR of PMS group was non-significantly higher than non-PMS group. TP, VLF, LF, HF norm of PMS group was non-significantly lower than non-PMS group. HF of PMS group was significantly lower than non-PMS group. LF norm, LF/HF ratio of PMS group was non-significantly higher than non-PMS group. Conclusion: The results suggest that PMS can be related to decreased activity of parasympathetic nervous system. HRV can be useful to diagnose PMS. The more studies to diagnose PMS would be needed.

• Nutrition Research and Practice
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• 제15권5호
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• pp.555-567
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• 2021

BACKGROUND/OBJECTIVES: Abeliophyllum distichum is a plant endemic to Korea, containing several beneficial natural compounds. This study investigated the effect of A. distichum leaf extract (ALE) on adipocyte differentiation. MATERIALS/METHODS: The cytotoxic effect of ALE was analyzed using cell viability assay. 3T3-L1 preadipocytes were differentiated using induction media in the presence or absence of ALE. Lipid accumulation was confirmed using Oil Red O staining. The mRNA expression of adipogenic markers was measured using RT-PCR, and the protein expressions of mitogen-activated protein kinase (MAPK) and peroxisome proliferator-activated receptor gamma (PPAR𝛾) were measured using western blot. Cell proliferation was measured by calculating the incorporation of Bromodeoxyuridine (BrdU) into DNA. RESULTS: ALE reduced lipid accumulation in differentiated adipocytes, as indicated by Oil Red O staining and triglyceride assays. Treatment with ALE decreased the gene expression of adipogenic markers such as Ppar𝛾, CCAAT/enhancer binding protein alpha (C/ebp𝛼), lipoprotein lipase, adipocyte protein-2, acetyl-CoA carboxylase, and fatty acid synthase. Also, the protein expression of PPAR𝛄 was reduced by ALE. Treating the cells with ALE at different time points revealed that the inhibitory effect of ALE on adipogenesis is higher in the early period treatment than in the terminal period. Furthermore, ALE inhibited adipocyte differentiation by reducing the early phase of adipogenesis and mitotic clonal expansion. This was indicated by the lower number of cells in the Synthesis phase of the cell cycle (labeled using BrdU assay) and a decrease in the expression of early adipogenic transcription factors such as C/ebp𝛽 and C/ebp𝛿. ALE suppressed the phosphorylation of MAPK, confirming that the effect of ALE was through the suppression of early phase of adipogenesis. CONCLUSIONS: Altogether, the results of the present study revealed that ALE inhibits lipid accumulation and may be a potential agent for managing obesity.

• Annals of Surgical Treatment and Research
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• 제95권5호
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• pp.240-248
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• 2018

Purpose: This study aimed to validate the synergistic effect of ABT-737 on docetaxel using MDA-MB-231, a triple negative breast cancer (TNBC) cell line overexpressing B-cell lymphoma-2 (Bcl-2). Methods: Western blot analysis was performed to assess expression levels of Bcl-2 family proteins and caspase-related molecules. Cell viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell cycle distribution was determined by flow cytometry analysis. Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (z-VAD-fmk) was used for pretreatment to assess the role of caspases. Results: Cell viability of MDA-MB-231 after combination treatment with ABT-737 and docetaxel was significantly lower than that after docetaxel or ABT-737 monotherapy based on MTT assay (both P < 0.001), with a combination index of 0.41. The proportion of sub-G1 population after combination treatment was significantly higher than that after docetaxel or ABT-737 monotherapy (P = 0.001, P = 0.003, respectively). Pretreatment with z-VAD-fmk completely restored cell viability of MDA-MB-231 from apoptotic cell death induced by combination therapy (P = 0.001). Although pro-caspase-8 or Bid did not show significant change in expression level, pro-casepase-9 showed significantly decreased expression after combination treatment. Cleaved caspase-3 showed increased expression while poly (ADP-ribose) polymerase cleavage was induced after combination treatment. However, hypoxia-inducible factor 1-alpha and aldehyde dehydrogenase 1 totally lost their expression after combination treatment. Conclusion: Combination of ABT-737 with docetaxel elicits synergistic therapeutic effect on MDA-MB-231, a TNBC cell line overexpressing Bcl-2, mainly by activating the intrinsic pathway of apoptosis. Therefore, adjunct of ABT-737 to docetaxel might be a new therapeutic option to overcome docetaxel resistance of TNBCs overexpressing Bcl-2.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2007년도 추계학술발표대회
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• pp.1119-1122
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• 2007

최근 전자우편이나 해킹을 통한 피싱과 파밍 등 금융 사기가 많이 발생하고 있다. 이에 이러한 피해로부터 사용자의 경제적 손실 및 개인정보 보호를 위하여 웹 사이트 인증, 전자우편 인증 등의 연구가 진행되고 있다. 기존 인증 방법에서는 WBL (Website Black-List) DB를 사용하였는데, 피싱의 짧은 생명주기(life cycle)로 인해 WBL DB의 유효성은 떨어질 뿐만 아니라, 피싱 사건 발생 후 웹 사이트가 WBL DB에 등록되기 전까지는 확인 불가능하다는 단점을 가지고 있다. 이러한 문제점을 극복하기 위해 WWL (Website White-List) DB를 이용한 연구가 진행 중이지만 아직은 미비한 편이다. 이에 본 논문에서는 기존의 WBL DB와 WWL DB를 이용한 방법이 가지고 있는 한계점을 극복하기 위해 WWL DB 항목을 정의하고, 이를 이용하여 웹사이트 보안 위험도를 정량화할 수 있는 웹사이트 위험도 산정 기법을 제안한다.

• 한국해양공학회지
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• 제35권4호
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• pp.266-272
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• 2021

Mooring systems are among the most important elements employed to control the motion of floating offshore structures on the sea. Considering the use of polymer material, a new method is proposed to address the creep characteristics rather than the method of using a tension load cell for measuring the tension of the mooring line. This study uses a synthetic mooring rope made from a polymer material, which usually consists of three parts: center, eye, and splice, and which makes a joint for two successive ropes. We integrate the optical sensor into the synthetic mooring ropes to measure the rope tension. The different structure of the mooring line in the longitudinal direction can be used to measure the loads with the entire mooring configuration in series, which can be defined as SMART (Smart Mooring and Riser Truncation) mooring. To determine the characteristics of the basic SMART mooring, a SMART mooring with a diameter of 3 mm made of three different polymer materials is observed to change the wavelength that responds as the length changes. By performing the longitudinal tension experiment using three different SMART moorings, it was confirmed that there were linear wavelength changes in the response characteristics of the 3-mm-diameter SMART moorings. A 54-mm-diameter SMART mooring is produced to measure the response of longitudinal tension on the center, eye, and splice of the mooring, and a longitudinal tension of 100 t in step-by-step applied for the Maintained Test and Fatigue Cycle Test is conducted. By performing a longitudinal tension experiment, wavelength changes were detected in the center, eye, and splice position of the SMART moorings. The results obtained from each part of the installed sensors indicated a different strain measurement depending on the position of the SMART moorings. The variation of the strain measurement with the position was more than twice the result of the difference measurement, while the applied external load increased step-by-step. It appears that there is a correlation with an externally generated longitudinal tensional force depending on the cross-sectional area of each part of the SMART mooring.

• 한국융합학회논문지
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• 제13권4호
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• pp.499-511
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• 2022

본 연구는 중년여성의 우울이 인터넷 중독에 미치는 영향에서 사회적지지(정서적지지, 정보적지지, 물질적지지, 평가적지지)의 조절효과를 검증하는 데 목적이 있다. 온라인 설문조사를 통하여 최종 509명의 유효 표본을 선정하고 수집된 자료는 SPSS WIN26.0 프로그램을 사용하여 빈도분석, 기술통계, 상관분석, 위계적 회귀분석을 실시하였다. 분석결과, 우울은 인터넷 중독에 정적영향을 미쳤고, 사회적지지의 조절효과는 정보적지지와 물질적지지만이 조절변수로서 작용하였다. 즉 우울이 높을수록 인터넷 중독도 높아지고, 우울이 인터넷 중독에 미치는 영향은 정보적지지와 물질적지지에 따라 변화됨을 알 수 있었다. 연구결과에 따른 제언으로 중년여성 특성에 맞는 차별화된 복지 서비스와 학제 간 융합연구를 강조하고, 인터넷사용에 대한 올바른 사용습관 등의 인터넷 중독 예방교육에 대한 필요성을 제시하였다.