• 제목/요약/키워드: strychnine

검색결과 91건 처리시간 0.024초

Central Nervous Depressant Activity of Piperine

  • Woo, Won-Sick;Lee, Eun-Bang;Shin, Kuk-Hyun
    • Archives of Pharmacal Research
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    • 제2권2호
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    • pp.121-125
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    • 1979
  • Piperine showed a central nervous system depressant activity which was characterized by the antagonistic effect against chemoshock seizure as well as potent muscular incoordination in mice.

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억간산(抑肝散)과 억간산가미방(抑肝散加味方)의 진경(鎭痙) 및 진통(鎭痛) 효과(效果)에 관(關)한 실험적(實驗的) 연구(硏究) (Studies on the Effect of AntiConvulsion and Analgesic by Ukgansan and Ukgansangami)

  • 현우천;이상룡
    • 동의신경정신과학회지
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    • 제5권1호
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    • pp.69-79
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    • 1994
  • In order to prove the effectiveness for anticonvulsion and analgesic of Ukgansan, Ukgansan added Jinphi Banha and Ukgansan added Chunma by experiment, experimental animals(mouse) are injected with strychnine, picrotoxin and caffeine to cause convulsion and ovserved the consumed time from convulsion to death. Comparing data with control group and observation data for frequency of writhing syndrome caused by acetic acid and phenylquinone show the results as follows : 1. Anticonvulsion effect on the convulsion induced by strychnine it was significantly effective in all sample groups. 2. Anticonvulsion effect on the convulsion induced by picrotoxin it was significantly effective in sample A and B. 3. Anticonvulsion effect on the convulsion induced by caffeine it was not recognized in all sample groups. 4. Analgesic effect on the pain induced by acetic acid it was significantly effect in sample A and C. 5. Analgesic effect on the pain induced by phenylquinone it was significantly effective in sample A and C. The results show that Ukgansan can be an effectual cure on anticonvulsion and analgrsic, Ukgansan added Jinphi·Banha on anticonvulsion, and Ukgansan added Chunma on analgesic.

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우황포용환(牛黃抱龍丸)과 우황포용환(牛黃抱龍丸) 거(去) 주사석웅황(朱砂石雄黃)의 항경련작용(抗痙攣作用) 및 Hg, As의 간(肝).신장(腎臟)에의 축적(蓄積)에 대(對)한 비교연구(比較硏究) (Comparative Study on Effects of WPH and WPHCR on the anticonvulsive action and Accumulation of Hg & AS in Organ of ICR Mice)

  • 김윤희;이한철
    • 대한한방소아과학회지
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    • 제8권1호
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    • pp.59-74
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    • 1994
  • The Study was performed on the anticonvulsive effects of Woohwangporyonghwan(WPH) and Woohwangporyonghwan except CINNABARIS and REALGAR(WPHCR) in ICR mice pretreated with strychnine, picrotoxin, and caffeine as convulsive agents, and also was done on the accumulation of Hg & AS in organs of ICR mice by ICP hydride generation method. The results were obtained as follows: 1. WPH and WPHCR group showed significant effect in delaying the onset of convulsion induced by strichine, but time to death was effective only in WPHCR group. 2. WPH and WPHCR group were significantly effective in delaying convulsion induced by picrotoxin, and time to death. 3. The anticonvulsive effect of WPH and WPHCR group was not found convulsion induced by caffeine. 4. The accumulation of Hg, AS in liver and kidney of ICR mice was not determined below 50ng/g and below 80ng/g respectively. From the above results it could be concluded that WPH and WPHCR group were effective in the convulsions induced by strychnine and picrotoxin, although the accumulation of Hg & As in liver and kidney was not proved, further study might be necessary to prove the drug safety of WPH included CINNABARIS and REALGAR.

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중추신경계(中樞神經系)에 작용(作用)하는 양심탕(養心湯)의 실험중적(實驗中的) 연구(硏究) (An experimental study of Yangsymtang's effects on the activities of Central Nervous System)

  • 좌승호;이진용;김덕곤;정규만
    • 대한한방소아과학회지
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    • 제10권1호
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    • pp.245-263
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    • 1996
  • In order to investigate the effects of Yangsymtang on the activities of central nervous system, we observed the effects on convulsions induced by pentylenetetrazole, strychnine and picrotoxin. The sedative those on spontaneous motor activity and by rota rod method, the those on sleeping time induced by barbiturate and the alleviative those on pain induced by acetic acid and hind limb pressure also were analyzed. The results were as follows: 1. The solid extracts of Yangsymtang showed no anticonvulsive effects on convulsions induced by pentylenetetrazole, strychnine and picrotoxin. 2. As to the sedative effects by rota rod method, th solid extracts of Yangsymtang were recognized as significance(P<0.01). 3. The sleeping time induced by thiopental sodium was not prolonged by the oral administration of the solid extracts of Yangsymtang. 4. The oral administration of Yangsymtang did not influenced the sleeping induced by pentobarbital sodium significantly. 5. As to the effects on spontaneous motor activity, the oral administration of Yangsymtang made spontaneous motor activity decrease significantly(P<0.05). 6. The oral administration of Yangsymtang was significant on pain induced by acetic acid(P<0.001). 7. As to alleviative effects on pain induced by hind limb pressure. The solid extracts of Yangsymtang were not significant.

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Effects of Anticonvulsants on Acute and Tonic Pains in the Rat

  • Shin, Hong-Kee
    • The Korean Journal of Physiology
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    • 제30권1호
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    • pp.97-104
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    • 1996
  • Different neural substrates have been reported to be implicated in analgesic mechanisms in the acute phasic and the sustained tonic pains. To explore the differential antinociceptive action of diphenylhydantoin (DPH) and carbamazepine (CBZ) on the acute phasic and the tonic pains, changes in tail flick latency, hot plate latency and the formalin-induced nociceptive score were assessed prior to and after intraperitoneal administration of DPH (20 & 40 mg/Kg) and CBZ (20 mg/Kg). In 11 rats, CBZ was administered repeatedly for 6 days at the dose of 20 mg/Kg/day. Also studied were the effects of strychnine and picrotoxin (1 mg/Kg, i.p.) on the CBZ-produced changes in the formalin-induced pain behaviors. The tail flick and hot plate ltencies were not changes after administration of DPH and CBZ. However DPH strongly suppressed the formalin-induced tonic pain. A single and the repeated administration of CBZ inhibited both the early phasic and the late tonic pain responses to formalin in n similar manner. On the other hand, the antinociceptive actions of CBZ were not altered by strychnine or picrotoxin. These experimental findings lead to the conclusion that DPH and CBZ have differential antinociceptive action on the acute and the tonic pains and that their antinociceptive actions are independent of the GABA- and glycine-receptors.

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Glycine induces enhancement of bactericidal activity of neutrophils

  • Kang, Shin-Hae;Ham, Hwa-Yong;Hong, Chang-Won;Song, Dong-Keun
    • The Korean Journal of Physiology and Pharmacology
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    • 제26권4호
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    • pp.229-238
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    • 2022
  • Severe bacterial infections are frequently accompanied by depressed neutrophil functions. Thus, agents that increase the microbicidal activity of neutrophils could add to a direct antimicrobial therapy. Lysophosphatidylcholine augments neutrophil bactericidal activity via the glycine (Gly)/glycine receptor (GlyR) α2/TRPM2/p38 mitogen-activated protein kinase (MAPK) pathway. However, the direct effect of glycine on neutrophil bactericidal activity was not reported. In this study, the effect of glycine on neutrophil bactericidal activity was examined. Glycine augmented bactericidal activity of human neutrophils (EC50 = 238 μM) in a strychnine (a GlyR antagonist)-sensitive manner. Glycine augmented bacterial clearance in mice, which was also blocked by strychnine (0.4 mg/kg, s.c.). Glycine enhanced NADPH oxidase-mediated reactive oxygen species (ROS) production and TRPM2-mediated [Ca2+]i increase in neutrophils that had taken up E. coli. Glycine augmented Lucifer yellow uptake (fluid-phase pinocytosis) and azurophil granule-phagosome fusion in neutrophils that had taken up E. coli in an SB203580 (a p38 MAPK inhibitor)-sensitive manner. These findings indicate that glycine augments neutrophil microbicidal activity by enhancing azurophil granule-phagosome fusion via the GlyRα2/ROS/calcium/p38 MAPK pathway. We suggest that glycine could be a useful agent for increasing neutrophil bacterial clearance.

천궁(Cnidii Rhizoma)의 메탄올 추출물이 GABA 및 Glycine 수용체에 미치는 영향 (EFFECT OF METHANOL EXTRACT OF CNIDII RHIZOMA ON THE FUNCTION OF RECEPTORS FOR GABA AND GLYCINE)

  • 이종태;이긍호;박재홍
    • 대한소아치과학회지
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    • 제32권1호
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    • pp.55-66
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    • 2005
  • 천궁의 메탄올 수용액 추출물의 진정 작용을 밝히기 위하여 staircase test를 시행하였으며, 근육이완 효과를 검색하기 위하여 rotarod test를 시행하였다. 진정 작용의 기전 구명을 위하여 GABA 및 glycine 수용체에 작용하는 약물인 picrotoxin, yohimbine, isoniazid, strychnine 등의 약물을 이용하여 발작 유도에 걸리는 시간을 비교 관찰하였다. 또한 생체에서의 안전성을 검증하기 위하여 Irwin의 행동시험 및 신경세포에 대한 독성을 평가하기 위하여 MTT test를 실시하여 다음의 결과를 얻었다. 1. Staircase 실험에서 천궁 추출물을 10mg/kg 용량으로 경구 투여했을 때 climbing수는 대조군과 차이가 없었으나, rearing수에서는 대조군에 비하여 42%의 감소를 보였다. 2. 30mg/kg의 용량으로 경구 투여했을 때, climbing수는 대조군과 차이가 없었으나, rearing수에서는 51%의 감소를 유발하였다. 3. 근육이완 작용을 탐색하기 위한 rotarod 실험에서는 대조군과 차이를 나타내지 않았다. 4. 천궁 추출물의 투여는 picrotoxin, isoniazid, yohimbine에 의한 발작에서는 큰 변화를 유발하지 않았으나, strychnine에 의한 발작 유도시간은 41%의 증가를 유발하였다. 5. 일반 행동에서도 특이한 변화를 유발하지 않았으며, 신경세포에 적용했을 때 특이한 독성 반응을 나타내지 않았다. 천궁의 메탄을 수용액 추출물은 현저한 진정 작용을 유발하며, 그 작용 기전으로서 glycine의 작용을 증가시켜 chloride ion의 세포내 유입으로 인한 억제성 신경전도를 유도한다고 사료된다. 또한 근육이완 작용도 나타나지 않았으며, 특이한 생체독성도 유발되지 않은 것으로 보아, 향후 치과임상에서 진정요법의 한 수단으로서 사용될 수 있다는 가능성을 제시한다.

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애엽 추출분획(DA-9601)의 일반 약리작용

  • 고석태;유강준;신동숙;강선영
    • 한국응용약물학회:학술대회논문집
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    • 한국응용약물학회 1996년도 춘계학술대회
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    • pp.196-196
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    • 1996
  • Artemisia extract powder (DA-9601)의 일반약리 작용을 mice, rat 및 rabbit에서 검토하였다. DA-9601은 rota-rod test에 의한 운동 협조능, 초산 writhing 반응, tail-flick test 및 randall-sellito test를 이용한 진통작용, thiopental sodium의 수면작용, 장관 수송능, carrageenan의 염증, 현수에 의한 근이완작용, 정상체온, strychnine의 경련작용, 수정관, 자궁각 및 Evans blue의 피부혈관 투과성에 별다른 영향을 미치지 않았다. DA-9601은 토끼의 적출회장 운동을 억제하였고 혈압 강하작용과 이뇨작용을 나타내었다

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재조합 인간 GM-CSF 일반 약리

  • 이은방
    • 한국응용약물학회:학술대회논문집
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    • 한국응용약물학회 1993년도 제2회 신약개발 연구발표회 초록집
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    • pp.67-67
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    • 1993
  • GM-CSF의 중추 신경계에 미치는 영향을 추구하기 위하여 실험동물에 대한 일반 약리 작용실험을 실시하였다. 실험항목과 방법은 hexobarbital-Na(70mg/kg, ip)에 의한 마우스의 수면시간 측정, Dunham 등의 rotarod시험 (12rpm)에서 마우스가 회전봉에 지탱하는 시간의 측정, locomotor activity cage에서의 마우스의 운동 활동성측정, 흰쥐의 정상체온에 미치는 작용, 0.7% HAc(0.1ml/10g, b.w.) 복강투여에 대한 마우스의 writhing의 억제율의 측정 실험, strychnine(1.5mg/kg)을 피하주사시 마우스의 경련성 치사에 미치는 효과, pentetrazole(85mg/kg)의 피하주사에 의한 마우스 경련의 억제실험을 실시하였다.

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