• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.126-126
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• 1998

Studies on natural products are of great interest, due to the limits in development of synthesized medicine and its side effects. Deer antler is the most popular cure-all type drug among Asian folk medicines. In this study, we newly isolated the biologically active components from chloroform extract and 70% ethanol extract of deer antler, and analyzed their structures. First, the structure of monoacetyldiglyceride in deer antler was identified. To investigate the structure-activity relationship of monoacetyldiglycerides, we synthesized diverse substituted glycerides from glycerol, and confirmed their structures by spectroscopic methods. Among seven structurally-interesting compounds tested in this study, compound 1,2,3,5, and 6 showed activity toward [Ca$\^$2+/]$\_$i/ increase in fura-2 loaded rat pancreatic acinar cells. Second, 70% ethanol extract of deer antler stimulated insulin release from rat pancreatic islets. We found the most effective fraction was CN-Es-8 in 70% ethanol extract, and it increased intracellular Ca$\^$2+/ concentration in pancreatic ${\beta}$-cell.

• Proceedings of the Korean Geotechical Society Conference
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• 2009.09a
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• pp.225-232
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• 2009

Infiltration of rainfall causes railway slopes to be unstable and may result in failure. Basic relationship between the rainfall and stability of railway embankment is defined to analyze its stability by rainfall. An experimental study for defining of infiltration rate of rainfall into slope is conducted in the lab. The results of Rainfall infiltration show that rainfall infiltration is not equal to infiltration as like reservoir because rate of rainfall infiltration is controlled by slope angle. Based on these results, boundary condition of rainfall is altered and various numerical analysis are performed. The variation of shear strength, the degree of saturation and pore-water pressure for railway slope during rainfall can be predicted and the safety factor of railway slope can be expressed as the function of rainfall amount, namely rainfall index. And suggested rainfall index is compared with the rail transport operation control which is used in KORAIL. It is judged that this rainfall index can be a good tool for the rail-transport operation control.

• Journal of the Earthquake Engineering Society of Korea
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• v.11 no.2 s.54
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• pp.69-79
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• 2007

In this paper, a technique to detect structural damage and estimate its severity using peaks and zeros of frequency response functions (FRFs) is developed. The peaks in FRFs represent the natural frequencies of the structure and the zeros provide additional information. The characteristics of peaks and zeros are defined and the calculation procedure to obtain the peaks and zeros from the relationship between frequency response function and stiffness and mass matrices are clearly explained. A structural system identification theory which is utilizing the sensitivity of stiffness of a structural member to eigenvalues, i.e., peaks and zeros, is established. The proposed method can identify damage location and its severity, with natural and zero frequencies, by estimating structural stiffness of the structure in the process of making a analytical model The accuracy and feasibility is demonstrated by numerical models of a spring-mass system and a beam structure.

• The Korean Journal of Applied Statistics
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• v.16 no.1
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• pp.87-100
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• 2003

Most of statistical data are generated by a set of dynamic, stochastic, and simultaneous relations. An important question is how to specify statistical models so that they are consistent with the dynamic feature of those data. A general hypothesis is that the lagged effect of a change in an explanatory variable is not felt all at once at a single point in time, but The impact is distributed over a number of future points in time. In other words, current control variables are determined by a function that can be reduced to a distributed lag function of past observations. It is possible to explain the relationship between variables in different points of time and to estimate the long-run impacts of a change in a variable on another if time lag series of explanatory variables are incorporated in the model specification. In this study, distributed lag structure is applied to the domestic stock market model to capture the dynamic response of the market by exogenous shocks. The Domestic market is found more responsive to the changes in foreign market factors both in the short and the long run.

• The Journal of the Korea Contents Association
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• v.16 no.4
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• pp.594-603
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• 2016

This study analyzed that introduction function and program how influence about quality of life local resident and development of region according to real development. Also, it suggested policy implications of area activation plan through complex development of railway station area. In research method, the factor and structure affecting area activation in complex development of railway station area analyzed positively using the PLS structural equation focused on citizen near station area. As a result of study, in regional economic vitalization, the factors of software(marketing support, transfer system support, plan and design support, complex development support, law institution improvement, etc) and the factors of hardware(traffic function, information exchange function, commercial business function, housing features, amenity function, etc) are represented to influence significantly and then, in quality of life of local resident, the factor of hardware analyzed to influence significantly, but the factor of software and network did not. In comparison, the factor of network is represented that it did not contributed in regional economic vitalization and quality of life of local resident. So, political supplementations are needed.

• (The) Research of the performance art and culture
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• no.39
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• pp.701-748
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• 2019

Gwanak-yeongsanhoesang, called as Samhyeon-yeongsanhoesang or Pyojeongmanbangjigok, is played by the musical instrumental organization, Samhyeonyukgak or by a large scale wind ensemble added Sogeum and Ajaeng. This study aims to analyze the structure and form of Piri melody which plays major melody of Sangnyeongsan in Gwanak-yeongsanhoesang, and to examine the relationship between Piri melody and Daegeum yeoneum grasping the structure and function of yeoneum. In Sangnyeongsan of Gwanak-yeongsanhoesang, the criterion for grouping the phrases of Piri melody is yeoneum. Especially, Daegeum yeoneum carries out the function of finishing the phrase of Piri playing the major melody by ornamenting or extending it, and presenting the motives or motive elements of the next phrase while Piri rests. The types of a, b, g, and i in the various shapes of the minimum melodic fragment of Piri are important motive elements that constitute a phrase of Piri melody. Especially, main motive a-type (仲→無) contrasts with b type (林→潢) which forms a strong tension by transposing 2 degrees upward. In addition, a-type gradually descends towards the end of music by changing to g-type (仲→林) or to i-type (太→林) which is 3 degrees below, which is related to the gradual descent cadence of Korean traditional music. A phrase of Piri melody of Sangnyeongsan in Gwanak-yeongsanhoesang consists of a combination of the types a, b, g, i, and cadence (x-type), and each phrase is structured in the repeating tension-relaxation. Looking at the structure of Piri phrases by similar types, each phrase has a logical variation structure through the methods such as omission and addition of notes, and crossing of melodies. The shape of the minimum melodic fragment of Daegeum yeoneum can be divided into a back-yeoneum of a~b types and a front-yeoneum of x1~x3. The x-types ornament Jungnyeo (仲), the cadence tone of Piri melody or are simply used as the extending back-yeoneum, and types a and b have the function of a front-yeoneum that prepares the beginning of the next phrase of Piri melody. The combination types of the minimum melodic fragment of Daegeum yeoneum appear mostly as the shape of back-yeoneum + front-yeoneum. In addition, the front-yeoneum of the type a and b appears independently without back-yeoneum, and the x3 type has a shape of the back-yeoneum without the front-yeoneum. Looking at the structure of Daegeum yeoneum by similar types, it can be seen that Daegeum yeoneum is also composed of a variation structure of omission and addition of notes like Piri melody.

• BMB Reports
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• v.29 no.3
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• pp.225-229
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• 1996

Effects on thrombin by an amphipathic cation, dequalinium, which has been recognized as an anticarcinoma agent were investigated with small chromogenic substrates such as Na-benzoyl-DL-argininep-nitroanilide (BApNA), H-D-phenylalanyl-L-pipecoyl-L-arginine-p-nitroanilide (S-2238), and Na-p-tosyl-L-arginine methyl ester (TAME). Among them, only TAME hydrolysis due to an esterase activity of the enzyme was significantly activated to 81% at 20 ${\mu}M$ dequalinium in the absence of NaCl. This stimulation became even higher in the presence of 0.2 M NaCl to 3.5-fold at 60 ${\mu}M$ dequalinium. This specific activation of thrombin was well correlated with the results of in vitro coagulation tests measuring the activated partial thromboplastin time (APTT) and the prothrombin time (PT) It is pertinent. therefore, to suggest that the esterase activity should be examined in addition to the effects on 5-2238 hydrolysis when especially any regulators not directed to an active site of thrombin need to be studied. We also expect that dequalinium could be a useful tool for studying structure-function relationship of thrombin and blood coagulation.

• Korea-Australia Rheology Journal
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• v.20 no.3
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• pp.165-173
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• 2008

Multiple particle tracking microrheology is used to characterize the viscoelastic properties of biomaterial and synthetic polymer gels near the liquid-solid transition. Probe particles are dispersed in the gel precursors, and their dynamics are measured as a function of the extent of reaction during gel formation. We interpret the dynamics using the generalized Stokes-Einstein relationship (GSER), using a form of the GSER that emphasizes the relationship between the probe particle mean-squared displacement and the material creep compliance. We show that long-standing concepts in gel bulk rheology are applicable to microrheological data, including time-cure superposition to identify the gel point and critical scaling exponents, and the power-law behavior of incipient network's viscoelastic response. These experiments provide valuable insight into the rheology, structure, and kinetics of gelling materials, and are especially powerful for studying the weak incipient networks of dilute gelators, as well as scarce materials, due to the small sample size requirements and rapid data acquisition.

• Biomolecules & Therapeutics
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• v.26 no.2
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• pp.101-108
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• 2018

G protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane receptors and have vital signaling functions in various organs. Because of their critical roles in physiology and pathology, GPCRs are the most commonly used therapeutic target. It has been suggested that GPCRs undergo massive genetic variations such as genetic polymorphisms and DNA insertions or deletions. Among these genetic variations, non-synonymous natural variations change the amino acid sequence and could thus alter GPCR functions such as expression, localization, signaling, and ligand binding, which may be involved in disease development and altered responses to GPCR-targeting drugs. Despite the clinical importance of GPCRs, studies on the genotype-phenotype relationship of GPCR natural variants have been limited to a few GPCRs such as b-adrenergic receptors and opioid receptors. Comprehensive understanding of non-synonymous natural variations within GPCRs would help to predict the unknown genotype-phenotype relationship and yet-to-be-discovered natural variants. Here, we analyzed the non-synonymous natural variants of all non-olfactory GPCRs available from a public database, UniProt. The results suggest that non-synonymous natural variations occur extensively within the GPCR superfamily especially in the N-terminus and transmembrane domains. Within the transmembrane domains, natural variations observed more frequently in the conserved residues, which leads to disruption of the receptor function. Our analysis also suggests that only few non-synonymous natural variations have been studied in efforts to link the variations with functional consequences.

• Journal of Dental Rehabilitation and Applied Science
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• v.26 no.2
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• pp.89-95
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• 2010

This is the third series of article on dental occlusion and relationship to TMD and systemic symptoms. In this part of the series, it will overview the theory, treatment methods, criteria, their limitation of Chirodontics, Dental Distress Syndrome (DDS) and quadrant theorem(QT). Chirodontics has its root on Chiropractic and to maintain the 'healthy status' of TMJ with stable occlusion via dental treatment. Dental distress syndrome on the other hand believes that all the TMD has originated from reduced or collapse of posterior support and incorrect posterior vertical support had caused imbalance of the head and neck structure which eventually affect the whole body symptoms. The analysis and treatment is planned using quadrant theorem where the position of head, rotatory pivot point and occlusal plane is analyzed.