• Genomics & Informatics
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• v.14 no.4
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• pp.216-221
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• 2016

Osteoporotic fractures (OFs) are critical hard outcomes of osteoporosis and are characterized by decreased bone strength induced by low bone density and microarchitectural deterioration in bone tissue. Most OFs cause acute pain, hospitalization, immobilization, and slow recovery in patients and are associated with increased mortality. A variety of genetic studies have suggested associations of genetic variants with the risk of OF. Genome-wide association studies have reported various single-nucleotide polymorphisms and copy number variations (CNVs) in European and Asian populations. To identify CNV regions associated with OF risk, we conducted a genome-wide CNV study in a Korean population. We performed logistic regression analyses in 1,537 Korean subjects (299 OF cases and 1,238 healthy controls) and identified a total of 8 CNV regions significantly associated with OF (p < 0.05). Then, one CNV region located on chromosome 20q13.12 was selected for experimental validation. The selected CNV region was experimentally validated by quantitative polymerase chain reaction. The CNV region of chromosome 20q13.12 is positioned upstream of a family of long non-coding RNAs, LINC01260. Our findings could provide new information on the genetic factors associated with the risk of OF.

• Journal of the Korea institute for structural maintenance and inspection
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• v.21 no.5
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• pp.67-73
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• 2017

The concrete pavement slabs that suffer expansion due to the Alkali-Aggregate Reaction(AAR) increase and the increase consequently causes unexpected displacement of bridge abutment. As the expansion due to the AAR is greater than that due to the temperature change, lethal load can act on bridge abutment. Therefore appropriate preventive measures may be necessary. The degree of expansion by AAR depends on the severity of AAR and geometry condition of concrete pavement and road structure. In order to prevent damage to bridge, it is effective to release the expansion force of the concrete. It would be advantageous to replace the concrete pavement with asphalt for a long section of concrete pavement.

• Carbon letters
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• v.12 no.4
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• pp.229-235
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• 2011

Isotactic polyacrylonitrile (PAN) with triad isotacticity of 0.53, which was determined by $^{13}C$ NMR, using dialkylmagnesium as an initiator, was successfully synthesized. Isothermal treatment of iso-PAN was conducted in air at 200, 220, 250 and $280^{\circ}C$. Structural evolutions and chemical changes were studied with Fourier transformation infrared and wide-angle X-ray diffraction during stabilization. A new parameter $CNF={I_{2240cm}}^{-1}/ ({I_{1595cm}}^{-1}+f^*{I_{1595cm}}^{-1})$ was defined to evaluate residual nitrile groups. Crystallinity and crystal size were calculated with X-ray diffraction dates. The results indicated that the nitrile groups had partly converted into a ladder structure as stabilization proceeded. The rate of reaction increased with treatment temperature; crystallinity and crystal size decreased proportionally to pyrolysis temperature. The iso-conversional method coupled with the Kissinger and Flynn-Wall-Ozawa methods were used to determine kinetic parameters via differential scanning calorimetry analysis with different heating rates. The active energy of the reaction was 171.1 and 169.1 kJ/mol, calculated with the two methods respectively and implied the sensitivity of the reaction with temperature.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2002.04a
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• pp.185-191
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• 2002

In this study a 3-dimensional analytical model is developed, which can analyses dynamic responses of curved bridges subject to moving vehicles. A 5-axle semi-trailer is modeled to simulate the actual tire forces that are redistributed by vehicle rolling effect due to the centrifugal force. The 1-span curved bridge with two steel box girders is modeled using the frame elements. The dynamic response characteristics of curved box girder bridges are examined and compared for two different support conditions. One is the case that two shoes are arranged at the outer sides of box girders with larger space between the two shoes and the other is that two shoes at the center of each box girder. In the curved bridges, the dynamic effect of moving vehicles influences the reaction force much more than other responses, such as displacement or stress, especially the upward reaction of inner-radius shoes. It is more advantageous for the reaction considering dynamic effect when shoes are arranged further at the outer sides of box girders than when shoes at the center of each box. The shoes for curved bridges with two-box girder system should be arranged to have larger distance.

• Journal of Electrochemical Science and Technology
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• v.1 no.1
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• pp.31-38
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• 2010

In this study, we have demonstrated the fine structure effect of PdCo electrocatalyst on oxygen reduction reaction activity with different alloy composition and heat-treatment time. In order to identify the intrinsic factors for the electrocatalytic activity, various X-ray analyses were used, including inductively coupled plasma-atomic emission spectrometer, transmission electron microscopy, X-ray diffractometer, and X-ray Absorption Spectroscopy technique. In particular, extended X-ray absorption fine structure was employed to extract the structural parameters required for understanding the atomic distribution and alloying extent, and to identify the corresponding simulated structures by using FEFF8 code and IFEFFIT software. The electrocatalytic activity of PdCo alloy nanoparticles for the oxygen reduction reaction was evaluated by using rotating disk electrode technique and correlated to the change in structural parameters. We have found that Pd-rich surface was formed on the Co core with increasing heating time over 5 hours. Such core shell structure of PdCo/C showed that a superior oxygen reduction reaction activity than pure Pd/C or alloy phase of PdCo/C electrocatalysts, because the adsorption energy of adsorbates was apparently reduced by lowering the dband center of the Pd skin due to a combination of the compressive strain effect and ligand effect.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2000.04b
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• pp.141-149
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• 2000

This study performs the elastic and viscoelastic analysis of composite continuous beams with flexible shear connectors. Due to creep and shrinkage of the concrete part, the stress redistribution between the concrete slab and steel beam, and the evolution of the redundant restraint reaction occur with time. Using the equation of equilibrium, internal and external compatibility condition, and constitutive relationships, mathematical formulations are formulated. The solution is obtained by means of numerical step-by-step techniques and the finite difference method. Numerical parametric studies are performed to evaluate the stress redistribution, and the evolution of the redundant restraint reaction. The parameters include the stiffness and spacing of shear connectors, the age of concrete at loading, and the relative humidity.

• Structural Engineering and Mechanics
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• v.27 no.5
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• pp.555-574
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• 2007

Static response of an elastic beam on a two-parameter tensionless foundation is investigated by assuming that the beam is symmetrically subjected to a uniformly distributed load and concentrated edge loads. Governing equations of the problem are obtained and solved by pointing out that a concentrated edge foundation reaction in addition to a continuous foundation reaction along the beam axis in the case of complete contact and a discontinuity in the foundation reactions in the case of partial contact come into being as a direct result of the two-parameter foundation model. The numerical solution of the complete contact problem is straightforward. However, it is shown that the problem displays a highly non-linear character when the beam lifts off from the foundation. Numerical treatment of the governing equations is accomplished by adopting an iterative process to establish the contact length. Results are presented in figures to demonstrate the linear and non-linear behavior of the beam-foundation system for various values of the parameters of the problem comparatively.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.35 no.3
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• pp.74-78
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• 2003

The structural property of phenolic and non-phenolic lignin has an effect on the reaction rate of lignin by oxygen and chlorine dioxide respectively. Moreover, the undesirable degradation of cellulose followed by lignin degradation is influenced by chemical charge and reaction time. In this paper, several lignin model compounds were used to illuminate the interaction of oxygen and chlorine dioxide by varying the position of O and D(OD, DO, ODO and DOD), and gas chromatography method was used to investigate the degradation of lignin by determining the content of methoxyl groups in lignin. It was shown that structural properties of lignin models were more influential on the degradation and demethylation of lignin than the above combination. Combination of oxygen and chlorine dioxide, however, was more effective in degradation of lignin than only one stage, and three stages than two stages.

• Proceedings of the Korea Concrete Institute Conference
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• 2006.05b
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• pp.353-356
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• 2006

Hardening of 2 component adhesive such as epoxy resin used in saturating FRP composite is triggered by mixing each component part within a batch. Chemical reactions occur explosively after a certain time after mixing the batch, viscosity and temperature rapidly increase. As a results, bond performance remarkably decreases and workability declines due to increase in viscosity. Therefore, adhesion should be completed before chemical hardening reaction is rapidly going on. This study examined pot life of structural adhesive for FRP composites by means of change in apparent viscosity and means of exothermic reaction temperature proposing in existing test standards. Result of each test method was compared and analyzed, and reasonable test method and evaluation method are suggested.

• Journal of the Korean Society of Visualization
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• v.11 no.1
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• pp.22-27
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• 2013

An investigation into the influence of ultrasonic standing wave on the structural behavior of propane/air premixed flame has been made to get a clue to the combustion reaction acceleration and combustion instability. Visualization technique utilizing the Schlieren photography was employed for the observation of structural variation of the flame reaction zone. Evolutionary characteristics of the flame front were caught by the high-speed Schlieren image, through which local flame velocity of the moving front were analyzed in detail.